Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC DV1 TFA | 98.5% | 2424.85 | 1 MG
DV1 TFA is a selective antagonist of CXC chemokine receptor 4 (CXCR4). It exhibits antiviral activity by blocking HIV-1 entry through the CXCR4 co-receptor.
- Selective antagonist for CXC chemokine receptor 4 (CXCR4)
- Exhibits antiviral activity
- Blocks HIV-1 entry through the CXCR4 co-receptor
Medchemexpress LLC CPN-351 TFA | 912.11 (free base) | 5 MG
CPN-351 TFA, a pentapeptide, acts as a selective antagonist for human NMUR1, demonstrating a pA2 of 7.35. Its antagonistic effect on human NMUR1 is significantly higher, specifically 10 times greater, than its effect on NMUR2. This compound is suitable for application in inflammation research.
- Selective antagonist of human NMUR1.
- Pentapeptide compound.
- Antagonistic effect on human NMUR1 is 10 times higher than on NMUR2.
- Used in the study of inflammation.
Medchemexpress LLC MPSD TFA (MARCKS-ED TFA) | 99.8% | 3080.76 | 5 MG
MPSD TFA is the TFA salt form of MPSD, a 25-amino acid peptide derived from the effector domain sequence of the intracellular membrane protein myristoylated alanine-rich C-kinase substrate (MARCKS). It functions as a biological probe to study membrane curvature and lipid composition, specifically recognizing phosphatidylserine.
- TFA salt form of MPSD
- 25-amino acid peptide
- Derived from MARCKS protein
- Detects membrane curvature
- Identifies phosphatidylserine
- Useful as a biological probe
- White to off-white solid appearance
- Soluble in DMSO and H2O
Medchemexpress LLC CGGRGD TFA | 98.7% | 677.61 | 5 MG
CGGRGD TFA is a derivative of RGD (Arginine-Glycine-Aspartic acid) that includes cysteine at its N-terminal. This product is intended for research applications only and not for human use. It is referenced in publications regarding the functionalization of PCL fibrous membranes with RGD peptide.
- Biological activity: a derivative of RGD with cysteine at its N-terminal
- Purity: 98.66%
- Molecular weight: 677.61
- Formula: C21H34F3N9O11S
- Appearance: solid
- Color: white to off-white
- Sequence: Cys-Gly-Gly-Arg-Gly-Asp
- Sequence shortening: CGGRGD
- Solubility in vitro: soluble in DMSO at 100 mg/mL (147.58 mM); ultrasonic assistance may be needed, and newly opened DMSO is recommended due to hygroscopic impact on solubility
Medchemexpress LLC Pep2-8 TFA | 98.8% | 1715.85 (free base) | 1 MG
Pep2-8 is a peptide that enhances the antagonistic activity of proprotein convertase subtilin/kexin type 9 (PCSK9). It binds to C-terminally truncated PCSK9 and restored LDL uptake of PCSK9-treated HepG2 cells to approximately 90% of control activity at a concentration of 50 μM.
- Enhances antagonistic activity of proprotein convertase subtilin/kexin type 9 (PCSK9)
- Binds to C-terminally truncated PCSK9
- Restores LDL uptake of PCSK9-treated HepG2 cells to approximately 90% of control activity
- For research use only
Medchemexpress LLC PBP10 TFA | 98.2% | 1826.07 | 1 MG
PBP10 is a cell-permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1. This 10-AA peptide, with rhodamine conjugated at its N-terminus, exhibits bactericidal activity against gram-positive and gram-negative bacteria and mitigates microbial-induced inflammatory effects.
- Cell-permeable
- Selective gelsolin-derived peptide inhibitor of FPR2 over FPR1
- 10-AA peptide with rhodamine conjugated at its N-terminus
- Exerts bactericidal activity against gram-positive and gram-negative bacteria
- Limits microbial-induced inflammatory effects
Medchemexpress LLC Ala-MPSD TFA | 136561-67-6 | 98.02% | 3016.76 (free base) | 1 MG
Ala-MPSD TFA is a control peptide for MPSD. In this peptide, the four serine residues of MPSD are substituted by alanines. This product is intended for research use only.
- Control peptide for MPSD
- Four serine residues substituted by alanines
- For research use only
Medchemexpress LLC G7-18NATE TFA | 98.1% | 1417.5 | 5 MG
G7-18NATE TFA is a peptide inhibitor of Grb7. It binds to the Grb7-SH2 domain with micromolar affinity (Kd = 18.1 μM). G7-18NATE TFA inhibits cell proliferation, motility, cell invasion, and 3D culture formation in several cancer cell lines. For research use only, not sold to patients.
- Peptide inhibitor of Grb7.
- Binds to the Grb7-SH2 domain with micromolar affinity (Kd = 18.1 μM).
- Inhibits cell proliferation, motility, cell invasion, and 3D culture formation in several cancer cell lines.
- Purity: 98.1%.
Medchemexpress LLC Ω-Agatoxin IVA TFA | 99.10% | 5316.27 | 500 UG
ω-Agatoxin IVA TFA is a potent, selective P/Q type Ca2+ (Cav2.1) channel blocker with IC50s of 2 nM and 90 nM for P-type and Q-type Ca2+ channels, respectively. It inhibits glutamate exocytosis and calcium influx elicited by high potassium (IC50, 30-225 nM) and also blocks the high potassium-induced release of serotonin and norepinephrine. ω-Agatoxin IVA TFA has no effect on L-type or N-type calcium channels.
- Potent, selective P/Q type Ca2+ (Cav2.1) channel blocker
- Inhibits glutamate exocytosis and calcium influx
- Blocks release of serotonin and norepinephrine
- No effect on L-type or N-type calcium channels
- Appearance: Solid
- Color: White to off-white
- For research use only
Medchemexpress LLC BRP TFA (BRINP2-related peptide) TFA | 1540.88 (free base) | 5 MG
BRP (BRINP2-related peptide) TFA is a peptide that exhibits anti-obesity activity by activating FOS. It functions independently of leptin, GLP-1 receptor, and melanocortin 4 receptor.
- Exhibits anti-obesity activity
- Activates FOS in the central nervous system
- Functions independently of leptin, GLP-1 receptor, and melanocortin 4 receptor
- Classified as a peptide and therapeutic peptide
- Related to metabolic disease research
- Acts as an AP-1 activator
Medchemexpress LLC Pgk13a TFA | 96.9% | 2004.73 (free base) | 5 MG
pGk13a TFA is an azide-containing amphiphilic membrane labeling probe. It enables high-resolution imaging of cell membranes in the ultrastructural membrane expansion microscopy (umExM) technique, facilitating the observation of membrane-associated structures and proteins. It can be used for neuronal structural studies.
- Azide-containing amphiphilic membrane labeling probe
- Enables high-resolution imaging of cell membranes
- Used in ultrastructural membrane expansion microscopy (umExM)
- Facilitates observation of membrane-associated structures and proteins
- Applicable for neuronal structural studies
Medchemexpress LLC c-Myc Peptide TFA | 2918768-02-0 | 99.97% | 1317.32 | 5 MG
c-Myc Peptide TFA is a synthetic peptide that corresponds to the C-terminal amino acids (410-419) of human c-myc protein. It is involved in the regulation of growth-related gene transcription.
- Synthetic peptide corresponding to C-terminal amino acids (410-419) of human c-myc protein.
- Regulates growth-related gene transcription.
- Plays a critical role in the growth of breast cancer cells in vitro.
Medchemexpress LLC Z-VRPR-FMK TFA | 1926163-57-6 | MFCD18782585 | 95.9% | 790.81 | 1 MG
Z-VRPR-FMK (TFA) (VRPR) is a tetrapeptide and a selective and irreversible MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor. It can protect against influenza A virus (IAV) infection.
- Tetrapeptide
- Selective and irreversible MALT1 inhibitor
- Protects against influenza A virus (IAV) infection
Medchemexpress LLC Clovibactin TFA | 97.1% | 903.08 (free base) | 500 UG
Clovibactin TFA is the TFA salt form of Clovibactin. It acts as an antibiotic against drug-resistant bacterial pathogens without detectable resistance, functioning by inhibiting cell wall synthesis, specifically targeting pyrophosphate of peptidoglycan precursors.
- Inhibits cell wall synthesis.
- Targets pyrophosphate of peptidoglycan precursors.
- Effective against Staphylococcus strains with MICs of 0.125-2 μg/mL.
- For research use only.
- Molecular weight: 903.08 (free base).
- Formula: C43H70N10O11.xC2HF3O2.
- Appearance: Solid, white to off-white.
- Solubility: DMSO: 100 mg/mL (Need ultrasonic).
Medchemexpress LLC LL-37, human TFA | 154947-66-7 | 100.0% | 4493.26 | 5 MG
LL-37, human TFA is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide. It demonstrates a broad spectrum of antimicrobial activity.
- Exhibits broad-spectrum antimicrobial activity.
- May help protect the cornea from infection.
- Modulates wound healing.