Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Batifiban TFA | 00-00-0 | 99.6% | 817.94 g/mol | C34H47N11O9S2 · xC2HF3O2 | 5 MG
Batifiban TFA is a cyclic peptide antagonist of platelet glycoprotein IIb/IIIa that inhibits platelet aggregation by blocking ligand binding such as vitronectin. Supplied as the trifluoroacetate (TFA) salt for research use, it is provided as a high-purity powder suitable for in vitro biochemical and cellular assays.
- Antagonizes platelet glycoprotein IIb/IIIa to inhibit aggregation.
- Blocks vitronectin binding to integrin receptors.
- Supplied as trifluoroacetate (TFA) salt for stability.
- High purity (~99.6%) suitable for biochemical assays.
- Available in small research pack sizes, including 5 mg.
- Store sealed, away from moisture and light; long-term storage at -80°C.
Medchemexpress LLC Valylleucine TFA (Val-Leu TFA) | 27530-02-5 | 99.3% | 344.33 | 5 MG
Valylleucine TFA is a polypeptide identified through peptide screening. Peptide screening serves as a research tool, primarily utilizing immunoassay to pool active peptides. This process is useful for studying protein interaction, functional analysis, and epitope screening, particularly in the development of agents.
- Identified through peptide screening
- Research tool primarily using immunoassay to pool active peptides
- Useful for studying protein interaction, functional analysis, and epitope screening
- Solutions should be aliquoted and stored to prevent inactivation from repeated freeze-thaw cycles
- If water is used as stock solution, dilute to working solution, then filter and sterilize with a 0.22 μm filter before use
Medchemexpress LLC Bio-AMS TFA | 1393881-52-1 | 98.0% | 685.65 | 1 MG
Bio-AMS (TFA) is a potent bacterial biotin protein ligase inhibitor. It exhibits selective activity against *Mycobacterium tuberculosis* (Mtb) and hinders fatty acid and lipid biosynthesis. It is for research use only and not sold to patients.
- Potent bacterial biotin protein ligase inhibitor.
- Selective activity against *Mycobacterium tuberculosis* (Mtb).
- Arrests fatty acid and lipid biosynthesis.
- Excellent antitubercular activity against Mtb H37Rv and MDR/XDR-TB strains with MICs ranging from 0.16 to 0.625 μM.
- Its activity is not affected by changes to the primary carbon source.
- Inhibits growth of Mtb in Mtb-infected mouse macrophages in a concentration-dependent manner (2.5, 5 and 10 μM; 24 h).
- Shows no signs of mitochondrial toxicity.
Medchemexpress LLC Ela-32(human) (tfa) | 99.9% | 3967.82 | 1 MG
ELA-32(human) TFA is a potent, high affinity apelin receptor agonist with an IC50 of 0.27 nM and a Kd of 0.51 nM. This product does not bind to GPR15 and GPR25. It activates the PI3K/AKT pathway, promoting the self-renewal of hESCs via cell-cycle progression and protein translation. Additionally, it potentiates the TGFβ pathway, priming hESCs toward the endoderm lineage, and stimulates angiogenesis in HUVEC cells.
- Potent, high affinity apelin receptor agonist
- IC50 of 0.27 nM and a Kd of 0.51 nM
- Exhibits no binding to GPR15 and GPR25
- Activates the PI3K/AKT pathway
- Promotes self-renewal of hESCs via cell-cycle progression and protein translation
- Potentiates the TGFβ pathway, priming hESCs toward the endoderm lineage
- Stimulates angiogenesis in HUVEC cells
Medchemexpress LLC Guangxitoxin 1E TFA | ≥95.0% | 3948.61 | 100 UG
Guangxitoxin 1E TFA is the trifluoroacetate salt form of Guangxitoxin 1E, a peptide toxin. It functions as a potent and selective blocker of voltage-gated potassium channels KV2.1 and KV2.2, with an IC50 of 1-3 nM. This compound is intended for research purposes only and is not for human therapeutic use.
- Potent and selective blocker of KV2.1 and KV2.2 channels (IC50 of 1-3 nM)
- Inhibits KV4.3 channels (IC50 of 24-54 nM)
- Inhibits 90% of IDR in mouse β-cells
- Shifts voltage dependence of channel activation to more depolarized potentials
- Broadens β-cell action potential
- Enhances glucose-stimulated intracellular calcium oscillations
- Increases insulin secretion from mouse pancreatic islets in a glucose-dependent manner
Medchemexpress LLC Adrixetinib TFA | C27H25F6N5O7 | 25 MG
Adrixetinib TFA is an Axl/Mer/CSF1R inhibitor. This product is supplied as an off-white to light yellow solid, with a purity of 99.82% as determined by HPLC.
- Axl/Mer/CSF1R inhibitor
- High purity (99.82% by HPLC)
- Off-white to light yellow solid appearance
Medchemexpress LLC Ms15 TFA | C66H80F3N11O7S | 5 MG
MS15 TFA is a potent and selective AKT PROTAC degrader for research use only. It effectively inhibits AKT1, AKT2, and AKT3 activities, demonstrating bioavailability in mice through intraperitoneal administration.
- Potent and selective AKT PROTAC degrader
- Inhibits AKT1, -2, and -3 activities
- IC50 values: 798 nM (AKT-1), 90 nM (AKT-2), 544 nM (AKT-3)
- Bioavailable in mice via intraperitoneal administration
- Purity of 99.82%
Medchemexpress LLC Rf470 TFA | 2369899-34-1 | 624.63 | 25 MG
Rf470 TFA is a FMR-probe-D-lysine conjugate (Max Ex: 470 nM; Max Em: 640 nM) that can be covalently incorporated into peptidoglycan by bacteria. It exhibits extremely weak fluorescence in its free state, but its fluorescence significantly increases when it is catalytically incorporated into peptidoglycan by transpeptidases.
- Can be used for real-time monitoring of peptidoglycan biosynthesis.
- Can be used for detection of transpeptidase activity.
- Can be used for screening of antibiotics through fluorescence changes.
Medchemexpress LLC T-Boc-Met-Asp-Gly-Cys-Glu-Leu | 99.2% | 880.90 | 1 MG
Box5 TFA is a potent Wnt5a antagonist. It inhibits Wnt5a signaling and Wnt5a-mediated Ca2+ release, and also inhibits cell migration. It has the potential for the research of melanoma.
- In vitro: decreases the expression of rWnt5a (0.1 μg/mL) stimulated p-MARCKS in A2058 cells.
Medchemexpress LLC QL47B TFA | 96.0% | 992.07 | 1 MG
QL47B TFA is a biotinylated analogue of QL47, functioning as a potent inhibitor of BTK with an IC50 value of 1.3 μM. It has demonstrated anti-tumor activity.
- Potent inhibitor of BTK (IC50 value of 1.3 μM)
- Biotinylated analogue
- Exhibits anti-tumor activity
- Available in various pack sizes
- Purity of 96.03%