Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC N-acetyl-L-valyl-L-alpha-glutamyl-L-isoleucyl-L-aspart-1-al | 00-00-0 | MFCD01318861 | 99.8% | 614.57 g/mol | C24H37F3N4O11 | 5 MG
Ac-VEID-CHO TFA is a peptide-derived aldehyde inhibitor of caspases used in biochemical research to study apoptosis and neurodegenerative disease mechanisms. The trifluoroacetate salt is supplied as a white to off-white solid with high purity and is suitable for assays requiring nanomolar potency against executioner caspases.
- Purity 99.8% by HPLC.
- Potent inhibition of caspase-3, caspase-6, and caspase-7 (IC50: 13.6 nM, 16.2 nM, 162.1 nM).
- Supplied as a solid, white to off-white powder.
- Soluble in water at approximately 1 mg/mL with sonication and warming.
- Storage recommendations include cold, sealed conditions to preserve stability.
- Designed for research applications in apoptosis and neurodegenerative disease models.
- Available in small research-scale quantities for assay development.
Medchemexpress LLC Lys-bradykinin TFA | 99.9% | 1188.38 g/mol | C56H85N17O12 · x C2HF3O2 | 50 MG
Lys-Bradykinin TFA is the trifluoroacetate salt of Lys-Bradykinin (kallidin), a biologically active nonapeptide ligand for bradykinin/kallidin receptors. Supplied as a solid peptide powder for research use, it is commonly used in studies of vascular regulation, inflammation, and receptor pharmacology.
- Trifluoroacetate salt of Lys-Bradykinin (kallidin).
- Purity 99.85%.
- Molecular weight 1188.38 g/mol.
- Available as solid powder, including 50 MG size.
- Storage: powder -80°C for 2 years, -20°C for 1 year; in solvent -80°C for 6 months, -20°C for 1 month.
- Documentation includes COA, RP-HPLC, LCMS, elemental analysis, and SDS.
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid ReagentPlus(R), 99% | 76-05-1 | MFCD00004169 | 1AMP
Trifluoroacetic acid ReagentPlus(R), 99% | Purity: 99% | Mol Wt: 114.02 | 76-05-1 | MFCD00004169 | 1AMP
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid puriss. p.a., for HPLC, 99.0 (GC), 76-05-1, MFCD00004169
Trifluoroacetic acid puriss. p.a., for HPLC, 99.0 (GC)