Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC NTPA TFA | 99.8% | 1773.36 (free base) | 5 MG
NTPA TFA is a polycarboxylic acid ligand that participates in the coordination reaction with metal ions to form complexes. It is intended for research use only.
- Purity of 99.80%
- Molecular weight of 1773.36 (free base)
- Formula: C82H161N31O12.xC2HF3O2
- Appearance: Solid
- Color: White to off-white
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: Sealed storage, away from moisture. Powder: -80°C for 2 years, -20°C for 1 year. In solvent: -80°C for 6 months, -20°C for 1 month (sealed storage, away from moisture)
- Solubility: In vitro: DMSO : 50 mg/mL (need ultrasonic; hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Medchemexpress LLC P4pal10 TFA | 98.25% | 1409.72 | 5 MG
P4pal10 TFA is the TFA salt form of P4pal10. It acts as an antagonist for protease-activated receptor 4 (PAR4). It inhibits platelet aggregation, tissue factor (TF)-induced thrombin generation, and demonstrates anticoagulant and antithrombotic activities. Additionally, it reduces edema and granulocyte infiltration induced by Carrageenan and ameliorates injury in rats with myocardial ischemia/reperfusion (I/R) models.
- Antagonist for protease-activated receptor 4 (PAR4)
- Inhibits platelet aggregation
- Inhibits tissue factor (TF)-induced thrombin generation
- Demonstrates anticoagulant and antithrombotic activities
- Reduces edema and granulocyte infiltration
- Ameliorates injury in myocardial ischemia/reperfusion (I/R) models
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid 99 fo25G
TRIFLUOROACETIC Trifluoroacetic acid 99 fo25G
Medchemexpress LLC Atwlppr peptide tfa | 98.6% | 954.00 | 5 MG
ATWLPPR Peptide TFA is a heptapeptide that acts as a selective neuropilin-1 inhibitor. It prevents VEGF165 binding to NRP-1 and is utilized in angiogenesis research, showing promise in reducing early retinal damage associated with diabetes.
- Inhibits VEGF165 binding to neuropilin-1 by 82% at 100 μM
- Preserves vascular integrity and reduces oxidative stress in vivo
- May decrease early retinal damage associated with diabetes
- Prevents increase of inflammation-associated proteins in the retina
Medchemexpress LLC Semaglutide (TFA) | 99.9% | 4113.58 | 1 MG
Semaglutide (TFA) | 99.9% | 4113.58 | 1 MG
Medchemexpress LLC NH2-UAMC1110 TFA | 2990021-73-1 | C23H24F5N5O5 | 5 MG
NH2-UAMC1110 TFA | 2990021-73-1 | C23H24F5N5O5 | 5 MG
Medchemexpress LLC Survodutide TFA (BI 456906 TFA) | 99.4% | 4231.62 (free base) | 5 MG
Survodutide TFA (BI 456906 TFA) | 99.4% | 4231.62 (free base) | 5 MG
Medchemexpress LLC WDR5-IN-4 TFA | 2749300-35-2 | 98.0% | 612.40 | 1 ML
WDR5-IN-4 TFA (Compound C6) is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a Kd of 0.1 nM. It displaces WDR5 from chromatin and decreases the expression of associated genes, leading to translational inhibition and nucleolar stress. This compound also exhibits anti-cancer activity.
- Inhibits the proliferation of MLL1-rearranged cancer cells MV4:11 and K562 cells with GI50s of 3.20 μM and 25.4 μM respectively, when treated with 0-50 μM for 3 days.
- Arrests the cell cycle of MV4:11 at the sub-G1 phase and induces apoptosis in MV4:11 when treated with 2 μM for 6 days.
- Promotes Hox genes in hindbrains of Rnf220+/- mice at late embryonic stages with an intrauterine injection of 100 μg (single dose).
Hampton Research 50% W/V POLYETHYLENE GL 200ML
HR2-607/50% w/v Polyethylene glycol 10,000 - 200 ml. Please note items from this supplier are non-returnable.
Medchemexpress LLC QL47B TFA | 96.0% | 992.07 | 1 MG
QL47B TFA is a biotinylated analogue of QL47, functioning as a potent inhibitor of BTK with an IC50 value of 1.3 μM. It has demonstrated anti-tumor activity.
- Potent inhibitor of BTK (IC50 value of 1.3 μM)
- Biotinylated analogue
- Exhibits anti-tumor activity
- Available in various pack sizes
- Purity of 96.03%
Medchemexpress LLC Lys-CoA TFA (Lys-coenzyme A) | 98.5% | 1 MG
Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor with an IC50 of 50-500 nM. It demonstrates over 100-fold selectivity for p300 compared to PCAF (IC50=200 μM). This compound works by inhibiting p300 HAT activity-dependent transcriptional activation.
- Selective p300 histone acetyltransferase (HAT) inhibitor
- IC50 of 50-500 nM for p300
- Over 100-fold selectivity for p300 compared to PCAF
- Induces a senescent phenotype in human normal melanocytes at 0.1 and 1 mM concentrations
- Inhibits cyclin E expression in a dose-dependent manner
Medchemexpress LLC Apstatin TFA | 99.4% | 25 MG
Apstatin TFA is a potent aminopeptidase P (APP) inhibitor. It exhibits Ki values of 2.6 μM for rat APP and 0.64 μM for human APP. This compound has also demonstrated cardioprotective effects.
- Potent aminopeptidase P (APP) inhibitor
- Effective at 2.6 μM for rat APP
- Effective at 0.64 μM for human APP
- Shows cardioprotection
- Reduces myocardial infarct size in acute myocardial ischemia models
- For research use only
Medchemexpress LLC Ntpa Tfa | 99.8% | 1773.36 | 1 MG
NTPA TFA is a polycarboxylic acid ligand that participates in the coordination reaction with metal ions to form complexes.
- High purity: 99.80%
- Molecular weight: 1773.36 (free base)
- Appearance: solid
- Color: white to off-white
- Sequence: C17H35CONH-Pro-Lys-Lys-Lys-Arg-Lys-Val-Arg-Arg-Arg-Arg-NH2
- Soluble in DMSO (50 mg/mL)
Strem, An Ascensus Company CAS# 76-05-1. 500g. Trifluoroacetic acid, 99%. MFCD00004169
CAS# 76-05-1. 500g. Trifluoroacetic acid, 99%. MFCD00004169. Molecular Weight: 114.02. Molecular Formula: CF3COOH. Color/form: colorless liq. Strem# 09-7160. http://www.strem.com/catalog/v/09-7160/
Medchemexpress LLC 3x DYKDDDDK Tag (TFA) | 98.17% | 3116.90 | 5 MG
DYKDDDDK peptide (FLAG) is a useful tool for investigating the function and localization of proteins when antibodies are not available. It is often used in a 3X FLAG format for purifying difficult proteins that accumulate in low abundance.
- Useful tool for investigating protein function and localization
- Often used in 3X FLAG format for purifying difficult proteins
- Suitable for proteins that accumulate in low abundance