Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Thymocartin TFA 5mg | 5MG
Thymocartin TFA is the TFA salt form of Thymocartin (HY-105025) Thymocartin TFA inhibits apoptosis of peripheral blood lymphocytes in HIV infected individuals Thymocartin TFA is potential for immunodeficiency diseases research[1 [2
Medchemexpress LLC Alvespimycin trifluoroacetate | 00-00-0 | MFCD08457919 | 99.0% | 730.77 g·mol⁻¹ | C34H49F3N4O10 | 25 MG
Alvespimycin trifluoroacetate (17-DMAG TFA) is the trifluoroacetic acid salt of a semisynthetic geldanamycin derivative that potently inhibits Hsp90. It binds Hsp90 in the low-nanomolar range and is used in cellular and biochemical studies to induce heat-shock response and promote degradation of Hsp90 client proteins, supporting research into proteostasis and targeted oncology pathways.
- Potent Hsp90 inhibition with reported EC50 ≈ 62 nM.
- Promotes Her2 degradation in cancer cell lines (EC50 8 nM in SKBR3, 46 nM in SKOV3).
- Induces Hsp70 expression in cell assays (EC50 4 nM in SKBR3, 14 nM in SKOV3).
- High purity (>98.9%) suitable for in vitro studies.
- Available in small research pack sizes, including 25 MG.
Medchemexpress LLC Frakefamide TFA 25mg | 25MG
Frakefamide TFA is a potent analgesic that acts as a peripheral active -selective receptor agonist Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system[1 [2
Medchemexpress LLC Ceftolozane TFA | 1628046-32-1 | 98.2% | 780.71 | C25H31F3N12O10S2 | 5 MG
Ceftolozane TFA is the trifluoroacetic acid (TFA) salt of a cephalosporin antibiotic supplied as a solid for research use. It is used to study and inhibit Gram-negative bacterial infections and as a synthetic building block for development of new antibiotic derivatives.
- Cephalosporin-class antibiotic active against Gram-negative bacteria.
- Useful as a synthetic intermediate for antibiotic development.
- High purity (98.2%) suitable for analytical and synthetic work.
- White to off-white solid form for easy handling and storage.
- Available in milligram-scale quantities for research applications.
- Store at -20°C sealed; in solvent, store at -80°C up to 6 months or -20°C up to 1 month.
- For research use only; not for human or veterinary use.
Medchemexpress LLC Thymocartin TFA 25mg | 25MG
Thymocartin TFA is the TFA salt form of Thymocartin (HY-105025) Thymocartin TFA inhibits apoptosis of peripheral blood lymphocytes in HIV infected individuals Thymocartin TFA is potential for immunodeficiency diseases research[1 [2
Medchemexpress LLC Galnon (TFA) | 1217448-19-5 | MFCD06798339 | 98.9% | 792.84 g·mol⁻¹ | C42H47F3N4O8 | 25 MG
Galnon TFA is a selective, non-peptide agonist of the galanin receptors GAL1 and GAL2, with reported Ki values of 11.7 μM (GAL1) and 34.1 μM (GAL2). It is used in in vitro and in vivo research to study galanin receptor pharmacology and has demonstrated anticonvulsant and anxiolytic effects.
- Selective galanin receptor agonist with reported Ki values (GAL1 = 11.7 μM, GAL2 = 34.1 μM).
- Non-peptide small-molecule ligand suitable for receptor pharmacology studies.
- Demonstrated anticonvulsant and anxiolytic activity in preclinical studies.
- Supplied at high purity (98.88%) for research use.
- Available in small research-scale quantities, including 25 mg.
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic anhydride ReagentPlus(R), >=99% | 407-25-0 | MFCD00000416 | 25KG
Trifluoroacetic anhydride ReagentPlus(R), >=99% | Purity: >=99% | Mol Wt: 210.03 | 407-25-0 | MFCD00000416 | 25KG
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic anhydride ReagentPlus(R), >=99% | 407-25-0 | MFCD00000416 | 3KG
Trifluoroacetic anhydride ReagentPlus(R), >=99% | Purity: >=99% | Mol Wt: 210.03 | 407-25-0 | MFCD00000416 | 3KG
Medchemexpress LLC Ac-VDVAD-CHO (TFA) | 00-00-0 | 99.2% | 657.59 g·mol⁻¹ | C25H38F3N5O12 | 5 MG
Ac-VDVAD-CHO (TFA) is a peptide aldehyde inhibitor used in biochemical and cell-based research to block caspase-mediated proteolysis and investigate apoptosis pathways.
- Selective caspase-2 and caspase-3 inhibition (IC50 46 nM and 15 nM).
- TFA salt, supplied as a white to off-white solid.
- High purity (99.2%).
- Molecular weight 657.59 g·mol⁻¹; formula C25H38F3N5O12.
- Recommended storage: powder at -80°C (2 years) or -20°C (1 year).
- For research use only; not for human or clinical use.