Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Qtx125 tfa | 2989537-78-0 | 99.9% | 25 MG
QTX125 TFA is the trifluoroacetate salt of QTX125, a potent and highly selective HDAC6 inhibitor with reported antitumor activity. It is supplied as a high-purity off-white to gray solid for biochemical and cell-based research.
- Potent, selective inhibition of HDAC6.
- High purity (99.9%) suitable for research applications.
- Available in 25 MG solid packs for laboratory use.
- Stable when stored sealed away from moisture; recommended storage at 4°C, with longer-term solvent storage at -80°C.
- Applicable to biochemical assays and cell-based antitumor studies.
Medchemexpress LLC Claramine TFA | 3030428-57-7 | 95.0% | 703.02 | 5 MG
Claramine TFA is a steroidal polyamine that regulates the properties of lipid membranes and offers protection to cells against various biological toxins. These toxins include misfolded protein oligomers and those derived from biological proteins.
- Does not affect cell viability in human neuroblastoma cells (sh-sy5y) at concentrations below 10 μM.
- Does not impact cell activity in hek293 cells.
- Protects human neuroblastoma (sh-sy5y) cells from the harmful effects of pore-forming agents, melittin and α-hemolysin, by inhibiting their binding to cell membranes.
Medchemexpress LLC PBX-7011 TFA | 98.6% | 561.46 | 5 MG
PBX-7011 TFA is a derivative of camptothecin. It inhibits expressions of the cancer-related survival genes DDX5, Survivin, Mcl-1, and XIAP in FaDu cells, degrades DDX5 proteins, and exhibits anticancer activity.
- Inhibits expressions of cancer-related survival genes DDX5, Survivin, Mcl-1, and XIAP in FaDu cells.
- Degrades DDX5 proteins.
- Exhibits anticancer activity.
Medchemexpress LLC Gallinamide A TFA | 1352920-57-0 | 706.79 | 1 MG
Gallinamide A TFA is a linearly depositing peptide and a potent inhibitor of cathepsin L (CatL) with an IC50 of 17.6 pM. It inhibits SARS-CoV-2 infection by inhibiting CatL (EC50: 28 nM) and also inhibits Plasmodium falciparum (IC50: 50 nM). It is for research use only and not sold to patients.
- Inhibits cathepsin L, B, V, K, and S.
- Effective against SARS-CoV-2 infection.
- Inhibits P. falciparum.
- Exhibits low cytotoxicity in VeroE6 cells.
- Shows synergistic effects with TMPRSS2 inhibitor Nafamostat.
Medchemexpress LLC MM-401 (TFA) | 1442106-11-7 | 99.3% | 700.75 | 5 MG
MM-401 (TFA) is an inhibitor of MLL1 H3K4 methyltransferase. It works by blocking the interaction between MLL1 and WDR5, thereby inhibiting MLL1 activity with an IC50 of 0.32 μM. This compound can induce cell cycle arrest, apoptosis, and differentiation. It is used in research for MLL leukemia.
- Inhibits MLL1 H3K4 methyltransferase
- Blocks MLL1-WDR5 interaction
- Potent inhibition of MLL1 activity
- Induces cell cycle arrest
- Promotes apoptosis
- Facilitates differentiation
- Useful for research of MLL leukemia
- Specifically inhibits MLL1-dependent H3K4 methylation in cells
- Inhibits growth of MLL leukemia cells
- Affects MLL-AF9 transcriptome
Medchemexpress LLC Achn-975 tfa | 1410809-37-8 | 99.0% | 483.44 | 1 ML
ACHN-975 TFA is a selective LpxC inhibitor that demonstrates subnanomolar LpxC inhibitory activity. It is effective against a broad spectrum of gram-negative bacteria, exhibiting low MIC values (≤1 μg/mL).
- Selective LpxC inhibitor.
- Exhibits subnanomolar LpxC inhibitory activity.
- Active against a wide range of gram-negative bacteria.
- Demonstrates low MIC values (≤1 μg/mL).
Medchemexpress LLC NCGC00138783 TFA | 99.4% | C28H27F4N7O3S | 1 ML
NCGC00138783 TFA is a selective inhibitor targeting the CD47/SIRPα axis. It directly blocks the interaction between CD47 and SIRPα axis.
- Selective inhibitor
- Targets CD47/SIRPα axis
- IC50 of 50 μM
- Blocks CD47 and SIRPα axis interaction
![Medchemexpress LLC Benzamide, N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxy-, 2,2,2-trifluoroacetate | 1336913-03-1 | 99.9% | 404.38 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000438811-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC Benzamide, N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxy-, 2,2,2-trifluoroacetate | 1336913-03-1 | 99.9% | 404.38 | 25 MG
PSEM 89S TFA is a selective and brain penetrant agonist for ion channels, orthogonally selective for Q79G and L141F. It is intended for research use only.
- Activates layer 2/3 cortical neurons expressing PSAML141F,Y115F-5HT3 high conductance.
- Reversibly silences transfected neurons by reducing cellular input resistance.
- Reduces photostimulation-evoked feeding in mice with PSAML141F,Y115F-glycine receptor.
- Demonstrates good brain penetrance in mice after intraperitoneal administration.
- Suppresses fos in ChR2-expressing neurons in Agrp-cre mice.
- Shows rapid rise in serum and brain, cleared within 1 hour in C57BL/6 mice.
Medchemexpress LLC Gln-AMS TFA | 209543-57-7 | >99.85% | 588.47 | 1 MG
Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor. It inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM. It is for research use only.
- Type Ia aminoacyl-tRNA synthetase (AARS) inhibitor
- Inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM
Medchemexpress LLC PBX-7011 TFA | 98.6% | 561.46 | 1 MG
PBX-7011 TFA is a derivative of camptothecin, which inhibits the expressions of cancer-related survival genes DDX5, Survivin, Mcl-1, and XIAP in FaDu cells. It degrades DDX5 proteins and exhibits anticancer activity. This product is for research use only and not sold to patients.
- Inhibits expression of cancer-related survival genes DDX5, Survivin, Mcl-1, and XIAP.
- Degrades DDX5 proteins.
- Exhibits anticancer activity.
- Targets Bcl-2 family and Survivin.
- Involves the apoptosis pathway.
- Is a derivative of camptothecin.
Medchemexpress LLC PBX-7011 TFA | 3003834-30-5 | 98.6% | 561.46 | 1 ML
PBX-7011 TFA is a derivative of camptothecin that inhibits the expression of cancer-related survival genes and degrades DDX5 proteins.
- Inhibits expression of cancer-related survival genes (DDX5, Survivin, Mcl-1, and XIAP in FaDu cells).
- Degrades DDX5 proteins.
- Exhibits anticancer activity.
Medchemexpress LLC Jbsnf-000028 TFA | C13H14F3N3O2 | 5 MG
JBSNF-000028 TFA is an orally active small molecule inhibitor of the tricyclic nicotinamide N-methyltransferase (NNMT). It has demonstrated significant anti-obesity and anti-diabetic activities in diet-induced obesity models and is used for studying metabolic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease.
- Orally active small molecule inhibitor of tricyclic nicotinamide N-methyltransferase (NNMT).
- Inhibits NNMT activity with an EC50 of 2.5 μM in U2OS cells.
- Shows no cytotoxicity against HepG2 cells at 10-100 μM.
- Improves glucose and lipid handling in mice with diet-induced obesity.
- Improves glucose tolerance in NNMT knockout mice with diet-induced obesity.