Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Ceftolozane TFA 1mg | 1628046-32-1 | 1MG
Ceftolozane TFA is a cephalosporin antibiotic that can be used to inhibit Gram-negative bacterial infections Ceftolozane TFA can be used to synthesize new antibiotic that are more potent and safer[1
Covachem Trifluoroacetic Acid | 76-05-1 | MFCD00004169 | 10 x 1 mL
This item has a minimum order quantity of 2 per supplier requirements.
Trifluoroacetic Acid | Mol Wt: 114.02 | 76-05-1 | MFCD00004169 | 10 x 1 mL
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid ReagentPlus, 99, 76-05-1, MFCD00004169
Trifluoroacetic acid ReagentPlus, 99
Cambridge Isotope Laboratories Trifluoroacetic acid-D (D 99 5%) 10 x 0 5mL
Trifluoroacetic acid-D (D 99 5%) 10 x 0 5mL
Medchemexpress LLC Glycyl-exatecan TFA | 1883333-57-0 | 96.9% | 606.52 g/mol | C28H26F4N4O7 | 5 MG
Glycyl-exatecan TFA is a synthetic trifluoroacetate salt derivative of exatecan used as an experimental anticancer compound in research. It is supplied in solid and DMSO solution formats for in vitro and in vivo pharmacology studies; consult supplier documentation and the SDS for handling and storage guidelines.
- Trifluoroacetate salt form.
- Molecular formula C28H26F4N4O7.
- Molecular weight 606.52 g/mol.
- Purity typically around 96.9%.
- Available in small-scale sizes and 10 mM DMSO solutions.
- Intended for research use only in oncology and pharmacology.
- Handle according to SDS and laboratory safety procedures.
Medchemexpress LLC Cpn-267 Tfa | 1279.27 | 5 MG
CPN-267 (compound 7b) TFA is a highly selective agonist for neuromedin U receptor 1 (NMUR1), demonstrating an EC50 of 0.25 nM. This compound has been observed to inhibit body weight gain in mice, making it a valuable tool for research into obesity. It is designated strictly for research applications and is not for sale to patients.
- Selective neuromedin U receptor 1 (NMUR1) agonist
- EC50: 0.25 nM
- Suppresses body weight gain in mice
- Used for the study of obesity
Medchemexpress LLC XStAx-VHLL TFA | 99.9% | 3231.89 | 1 MG
xStAx-VHLL TFA is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of β-catenin. It inhibits the Wnt/β-catenin signaling pathway, can inhibit the proliferation of colon cancer cells, and has anti-tumor activity.
- Promotes ubiquitination and proteasome degradation of β-catenin.
- Inhibits the Wnt/β-catenin signaling pathway.
- Inhibits the proliferation of colon cancer cells.
- Exhibits anti-tumor activity in mouse intestinal tumor models.
- Induces β-catenin degradation and inhibits cell proliferation in colorectal cancer cells.
- Inhibits Wnt/β-catenin signaling in HEK293T cells.
Apexbio Technology LLC 10 mM dNTP Mixture 5x1ml
10 mM dNTP (2 -deoxynucleoside 5 -triphosphate) Mixture is an equimolar premixed aqueous solution containing four nucleotides (dATP dCTP dGTP and dTTP) each at a concentration of 10 mM The product is prepared as an aqueous solution titrated with NaOH to a neutral pH of 7 0
Medchemexpress LLC Melittin TFA | 99.85% | 2960.48 | 5 MG
Melittin TFA is a PLA2 activator that stimulates the activity of low molecular weight PLA2. This cytotoxic peptide from bee venom possesses natural anti-bacterial, anti-viral, and anti-inflammatory properties. It has also shown diverse anticancer effects by inhibiting cell proliferation, inducing apoptosis, and direct necrosis.
- Cytotoxic peptide from bee venom
- Activates low molecular weight PLA2
- Exhibits anti-bacterial, anti-viral, and anti-inflammatory properties
- Induces apoptosis and necrosis in various cancer cell lines
- Inhibits EGF-induced cell invasion by targeting the PI3K/Akt/mTOR pathway
Medchemexpress LLC JPS016 (TFA) | 99.5% | C50H64F3N7O10S | 1 MG
JPS016 (TFA) | 99.5% | C50H64F3N7O10S | 1 MG
Medchemexpress LLC Mtvkpabc-p5 TFA | 98.8% | 1190.22 | C54H74F3N11O16 | 25 MG
MTvkPABC-P5 TFA is the trifluoroacetic acid (TFA) salt of a synthetic Toll-like receptor 7 (TLR7) agonist. It functions as an immune stimulant used in research applications, including the synthesis of immune-stimulating antibody conjugates (ISACs).
- Acts as a TLR7 agonist and immune stimulant.
- Suitable for synthesis of immune-stimulating antibody conjugates (ISACs).
- Provided as a solid TFA salt.
- High purity, 98.8%.
- Molecular weight 1190.22, formula C54H74F3N11O16.
- Available as 25 MG quantity.
Medchemexpress LLC Cl2e-SN38 TFA | 99.1% | 1855.95 | C89H117F3N14O26 | 5 MG
CL2E-SN-38 TFA is an antibody-drug conjugate (ADC) drug-linker consisting of an SN-38 payload attached via a CL2E linker in the trifluoroacetate (TFA) salt form. It is intended for preclinical research into ADCs, where SN-38 functions as a topoisomerase I inhibitor.
- Highly releasable and structurally stable antibody-SN-38 conjugate.
- Contains SN-38 payload, a topoisomerase I inhibitor.
- TFA salt form for improved solubility and handling.
- Available in small research quantities (5 MG).
- High purity suitable for preclinical ADC development.
Medchemexpress LLC MtvkPabc-p5 TFA | 1190.22 | C54H74F3N11O16 | 5 MG
MTvkPABC-P5 TFA is a Toll-like receptor 7 (TLR7) agonist and immune stimulant used as a reagent for synthesizing immune-stimulating antibody conjugates (ISACs). It is supplied as the trifluoroacetic acid (TFA) salt in solid form. Molecular formula: C54H74F3N11O16; molecular weight: 1190.22.
- Acts as a TLR7 agonist and immune stimulant.
- Used to synthesize immune-stimulating antibody conjugates (ISACs).
- Supplied as the trifluoroacetic acid (TFA) salt in solid form.
- Storage: solid -20°C; protect from light; store under nitrogen.
- Available pack sizes: 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg.
Medchemexpress LLC Ampreloxetine trifluoroacetate | 1227056-85-0 | 98.3% | 5 MG
Ampreloxetine trifluoroacetate (TFA) is the trifluoroacetate salt of ampreloxetine, an orally active norepinephrine and serotonin (5-HT) uptake inhibitor investigated for research into neurogenic orthostatic hypotension. Supplied as a white to off-white solid with high purity for laboratory research use only.
- High purity (98.3%) suitable for research applications.
- Trifluoroacetate salt form to improve stability and solubility properties.
- Molecular weight 435.36 g/mol; formula C20H19F6NO3.
- Available in small research pack sizes (e.g., 5 MG) for assay development and preclinical studies.
- Intended for laboratory research use only; not for human or animal therapeutic use.