Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC PBP10 TFA | 98.2% | 1826.07 | 1 MG
PBP10 is a cell-permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1. This 10-AA peptide, with rhodamine conjugated at its N-terminus, exhibits bactericidal activity against gram-positive and gram-negative bacteria and mitigates microbial-induced inflammatory effects.
- Cell-permeable
- Selective gelsolin-derived peptide inhibitor of FPR2 over FPR1
- 10-AA peptide with rhodamine conjugated at its N-terminus
- Exerts bactericidal activity against gram-positive and gram-negative bacteria
- Limits microbial-induced inflammatory effects
Medchemexpress LLC Pep2-8 TFA | 98.8% | 1715.85 (free base) | 1 MG
Pep2-8 is a peptide that enhances the antagonistic activity of proprotein convertase subtilin/kexin type 9 (PCSK9). It binds to C-terminally truncated PCSK9 and restored LDL uptake of PCSK9-treated HepG2 cells to approximately 90% of control activity at a concentration of 50 μM.
- Enhances antagonistic activity of proprotein convertase subtilin/kexin type 9 (PCSK9)
- Binds to C-terminally truncated PCSK9
- Restores LDL uptake of PCSK9-treated HepG2 cells to approximately 90% of control activity
- For research use only
Medchemexpress LLC Difopein TFA | 96.30% | 6387.17 (free acid) | 5 MG
Difopein TFA is a specific and competitive inhibitor of the 14-3-3 protein, a highly conserved eukaryotic regulatory molecule. It functions by blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. This compound is not cell permeable and induces apoptosis, enhancing the ability of Cisplatin to kill cells.
- Specific and competitive inhibitor of 14-3-3 protein
- Blocks 14-3-3 from binding to target proteins
- Inhibits 14-3-3/ligand interactions
- Induces apoptosis
- Enhances cisplatin's ability to kill cells
- Target: 14-3-3 protein
- Soluble in DMSO at ≥ 100 mg/mL
- In vivo soluble at ≥ 2.5 mg/mL with specific protocol
- Recommended storage for powder: -80°C for 2 years; -20°C for 1 year
- Recommended storage in solvent: -80°C for 6 months; -20°C for 1 month
Medchemexpress LLC Norleual TFA | 99.9% | 888.97 | 1 MG
Norleual TFA is an angiotensin (Ang) IV analog and a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC50 of 3 pM. It acts as an AT4 receptor antagonist and demonstrates potent antiangiogenic activities. It significantly reduces HGF-dependent c-Met and Gab1 phosphorylation and attenuates HGF-dependent c-Met activation and downstream signaling. In vivo, Norleual TFA suppresses pulmonary colonization by B16-F10 murine melanoma cells.
- Reduces HGF-dependent c-Met and Gab1 phosphorylation
- Attenuates HGF-dependent c-Met activation and downstream signaling
- Inhibits HGF-dependent signaling, proliferation, migration, and invasion in multiple cell types
- Suppresses pulmonary colonization by B16-F10 murine melanoma cells
Medchemexpress LLC Mans peptide Tfa | 99.88% | 2498.83 | 5 MG
Mans peptide Tfa | 99.88% | 2498.83 | 5 MG
Medchemexpress LLC ω-Agatoxin IVA TFA | 99.1% | 5316.27 | 5 MG
ω-Agatoxin IVA TFA is a potent and selective blocker of P/Q type Ca2+ (Cav2.1) channels. It exhibits IC50s of 2 nM for P-type and 90 nM for Q-type Ca2+ channels. The compound inhibits glutamate exocytosis and calcium influx, as well as the release of serotonin and norepinephrine, when elicited by high potassium. It does not affect L-type or N-type calcium channels.
- Potent and selective P/Q type Ca2+ (Cav2.1) channel blocker.
- IC50s of 2 nM for P-type and 90 nM for Q-type Ca2+ channels.
- Inhibits glutamate exocytosis and calcium influx.
- Blocks high potassium-induced release of serotonin and norepinephrine.
- Has no effect on L-type or N-type calcium channels.
Medchemexpress LLC D2A21 TFA | >95.6% | 2775.42 | 1 MG
D2A21 TFA is an antimicrobial peptide that exhibits significant activity against Pseudomonas and has a bactericidal effect on burn scabs. This peptide also demonstrates antitumor activity, making it a candidate for research in prostate cancer.
- Antimicrobial peptide
- Active against Pseudomonas
- Bactericidal effect on burn scabs
- Antitumor activity
- Used in prostate cancer research
Medchemexpress LLC Psalmotoxin 1 TFA | 880107-52-8 | 99.37% | 4689.39 | 500 UG
Psalmotoxin 1 is a protein toxin that binds at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a). It acts as a potent and selective ASIC1a inhibitor by increasing the apparent affinity for H+ of ASIC1a. Psalmotoxin 1 can induce cell apoptosis and inhibit cell migration, proliferation, and invasion of cancer cells. It is utilized in research concerning cancers and neurological diseases.
- Potent and selective ASIC1a inhibitor with an IC50 of 0.9 nM
- Induces cell apoptosis
- Inhibits cell migration, proliferation, and invasion of cancer cells
- Used in research concerning cancers and neurological diseases
- Neuroprotective in a conscious model of stroke
- Inhibits tumor growth in breast cancer models
Medchemexpress LLC (RXR)4XB TFA | 96.6% | 1904.37 | 1 MG
(RXR)4XB TFA is a cell-penetrating peptide that binds phosphorodiamidate morpholino oligomers (PMOs), forming peptide-conjugated PMOs (PPMOs), and enhances the delivery of PMO into bacterial cells. The (RXR)4XB TFA-PMO conjugate is effective in preventing biofilm formation, inhibiting *Pseudomonas aeruginosa* with an MIC50 of 0.5 to 16 μM, and reducing bacterial burden in mouse acute pneumonia models.
- Forms peptide-conjugated PMOs (PPMOs)
- Enhances delivery of PMO into bacterial cells
- Prevents biofilm formation
- Inhibits *Pseudomonas aeruginosa*
- Reduces bacterial burden in mouse acute pneumonia models
Medchemexpress LLC Cyclorasin 9A5 (TFA) | 1 MG
Cyclorasin 9A5 (TFA) from MedChemExpress is a laboratory chemical intended for research use only. It is presented as a solid and is stable under recommended storage conditions, emphasizing careful handling and storage to maintain its integrity.
- Stable under recommended storage
- Keep sealed in cool, well-ventilated area, away from direct sunlight and ignition
- Powder storage: -80°C for 2 years, -20°C for 1 year
- Solution storage: -80°C for 6 months, -20°C for 1 month
- Ships at room temperature (less than 2 weeks)
- Not classified as hazardous
- Requires personal protective equipment (safety goggles, gloves, impervious clothing, respirator)
- Ensure adequate ventilation, safety shower, and eye wash station
Medchemexpress LLC Spexin (Neuropeptide Q) | 1370290-58-6 | 99.9% | 1619.88 | 1 MG
Spexin (Neuropeptide Q) | 1370290-58-6 | 99.9% | 1619.88 | 1 MG
Medchemexpress LLC YKL-5-124 trifluoroacetate | 2748220-93-9 | 99.7% | 629.63 | C30H34F3N7O5 | 10 MM x 1 ML
YKL-5-124 TFA is the trifluoroacetate salt of a potent, selective, irreversible, covalent cyclin-dependent kinase 7 (CDK7) inhibitor. Supplied as a 10 mM solution in DMSO (1 mL), it is intended for research use in biochemical and cellular assays and is reported to induce cell-cycle arrest and inhibit E2F-driven gene expression while minimally affecting RNA polymerase II phosphorylation.
- Potent, selective CDK7 inhibition
- Irreversible covalent mechanism of action
- Supplied as a 10 mM solution in DMSO, 1 mL vial
- High purity suitable for biochemical and cellular studies
- Molecular formula and mass provided for identification
Medchemexpress LLC Fn-439 TFA | 124168-73-6 | MFCD00237459 | 99.8% | 604.58 g·mol⁻¹ | C25H35F3N6O8 | 5 MG
FN-439 TFA is the trifluoroacetic acid salt of FN-439, a selective small-molecule inhibitor of collagenase-1 (matrix metalloproteinase). It inhibits collagenase-1 with an IC50 of 1 μM and is supplied as a research reagent for in vitro studies of cancer and inflammatory processes.
- Selective collagenase-1 inhibitor with reported IC50 of 1 μM.
- High purity (99.81%) suitable for biochemical assays.
- Trifluoroacetic acid salt form to aid solubility in aqueous systems.
- Supplied in research-scale quantities (e.g., five mg) for assay development.
- Intended for in vitro research applications; not for human use.
Medchemexpress LLC Flonoltinib TFA | 2928093-29-0 | >98.0% | 1 ML
Flonoltinib TFA is a potent and orally active dual JAK2/FLT3 inhibitor with anti-cancer activity, designed for research applications.
- Potent and orally active dual JAK2/FLT3 inhibitor.
- Exhibits anti-cancer activity.
- Down-regulates p-FLT3 in a dose-dependent manner.
- Induces apoptosis and cell cycle arrest in MV4-11 cells.