Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Bio-AMS TFA | 00-00-0 | 98.0% | 685.65 g/mol | C22H30F3N9O9S2 | 5 MG
Bio-AMS TFA is a bacterial biotin protein ligase inhibitor supplied as the trifluoroacetate (TFA) salt for research use. It shows selective activity against Mycobacterium tuberculosis and disrupts fatty acid and lipid biosynthesis.
- Potent biotin protein ligase inhibition.
- Selective activity against Mycobacterium tuberculosis.
- Provided as the TFA salt to aid handling and solubility.
- High purity: 98.0%.
- Molecular weight 685.65 g/mol; formula C22H30F3N9O9S2.
- Available in small research pack sizes, including 5 mg.
- Suitable for biochemical and microbiology research applications.
Medchemexpress LLC Boc-Met-Leu-Phe (trifluoroacetate) | 00-00-0 | MFCD00037435 | 99.5% | 623.68 g/mol | C27H40F3N3O8S | 1 ML
Boc-MLF TFA is a Boc-protected tripeptide (Boc-Met-Leu-Phe as the trifluoroacetate salt) used as a formyl peptide receptor (FPR) antagonist for receptor pharmacology and cell signaling studies. It is supplied as a 10 mM solution in DMSO (1 mL) or as a dry powder and is offered with high reported purity for research applications.
- Acts as a formyl peptide receptor (FPR) antagonist.
- Inhibits formyl peptide receptor like 1 (FPRL1) at higher concentrations.
- Available as a 10 mM solution in DMSO (1 mL) or as dry powder formats.
- High reported purity suitable for biochemical assays (~99.5%).
- Contains Boc-protected Met-Leu-Phe sequence as the trifluoroacetate salt.
Medchemexpress LLC ATX-II (TFA) | 99.65% | 4934.62 (free acid) | 100 UG
ATX-II TFA is a selective sodium channel modulator toxin that enhances late sodium current, prevents full sodium channel inactivation, and generates persistent current fractions. This compound exhibits a pro-arrhythmic effect by slowing intrinsic heart rate, prolonging the QT interval and sinus node recovery time, and inducing sinus pauses and arrests. It is suitable for research related to atrial fibrillation, long QT syndrome, and long QT3 syndrome.
- Enhances tetrodotoxin sensitive resurgent and persistent sodium currents in large diameter mouse DRG neurons.
- Shifts the voltage dependence of activation and steady-state fast inactivation of TTXS sodium channels to more hyperpolarized potentials.
- Increases diastolic tension and arrhythmia score in isolated rat right atrial tissue.
- Significantly increases diastolic intracellular Ca2+ concentrations in isolated rat atrial myocytes.
Medchemexpress LLC Pemvidutide (TFA) | 2538014-94-5 | 98.1% | C182H275N39O54.xC2HF3O2 | 25 MG
Pemvidutide TFA (ALT-801) is a GLP-1R/GCGR dual agonist that causes significant reductions in body weight, liver fat, and serum lipids. It is used in non-alcoholic steatohepatitis (NASH) and obesity research.
- Causes striking reductions in body weight, liver fat, and serum lipids
- Applicable for research in non-alcoholic steatohepatitis (NASH) and obesity
- Improved NASH outcomes in C57BL6/J mice
- Lowered hepatic lipids
- Lowered liver weight
- Reduced biomarkers of liver injury (plasma ALT and AST)
- Decreased the inflammation marker galactin-3
- Reduced the fibrosis marker Col1a1
- Lowered the NAS score
Medchemexpress LLC MI-1061 TFA | 1410737-35-7 | 97.5% | 696.47 | C32H27Cl2F4N3O6 | 10MM 1ML
MI-1061 TFA is the trifluoroacetate salt of MI-1061, a potent, orally bioavailable inhibitor of the MDM2-p53 interaction (reported IC50 = 4.4 nM; Ki = 0.16 nM). The compound is offered as a solid and as a ready-to-use 10 mM solution in DMSO (1 mL) for in vitro assays, and the manufacturer provides solubility and in vivo formulation guidance. Typical uses include biochemical and cell-based studies of p53 pathway modulation.
- Potent MDM2-p53 interaction inhibitor (IC50 4.4 nM).
- Available as solid and as a 10 mM solution in DMSO for immediate use.
- High purity (approximately 97.5%), suitable for research assays.
- Soluble in DMSO (reported solubility 120 mg/mL), enabling concentrated stocks.
- Manufacturer provides recommended stock concentrations and in vivo vehicle guidance.
TARGETMOL CHEMICALS INC Atecegatran TFA 1MG
Also available in 5 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Atecegatran TFA is often used as an anticoagulant and can be used to treat cardiovascular disease. Purity 98.5%
Medchemexpress LLC TD-0212 TFA 10mM | 10MM 1ML
TD-0212 TFA is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor with a pKi of 8 9 for AT1 and a pIC50 of 9 2 for NEP[1]
Medchemexpress LLC Mazdutide TFA | 99.7% | 4563.06 (free base) | 5 MG
Mazdutide TFA is a long-acting synthetic oxyntomodulin analog that acts as a co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR). It binds to both human and mouse GCGR and GLP-1R, stimulating insulin secretion from mouse islets. This compound is utilized in research for conditions such as obesity and type 2 diabetes.
- Functions as a co-agonist of GLP-1R and GCGR.
- Binds to human and mouse GCGR and GLP-1R.
- Stimulates insulin secretion from mouse islets.
- Applicable in studies for obesity and type 2 diabetes.
- Significantly reduces body weight and physical intake in diabetic mice with diet-induced obesity.
Medchemexpress LLC ω-Agatoxin IVA TFA | 99.1% | 5316.27 | 1 MG
ω-Agatoxin IVA TFA is a potent and selective blocker of P/Q-type Ca2+ (Cav2.1) channels. It inhibits glutamate exocytosis and calcium influx induced by high potassium, and blocks the high potassium-induced release of serotonin and norepinephrine. This compound does not affect L-type or N-type calcium channels.
- Potent and selective blocker of P/Q-type Ca2+ (Cav2.1) channels
- Inhibits glutamate exocytosis and calcium influx induced by high potassium
- Blocks high potassium-induced release of serotonin and norepinephrine
- Does not affect L-type or N-type calcium channels
Medchemexpress LLC D2A21 TFA | >95.6% | 2775.42 | 1 MG
D2A21 TFA is an antimicrobial peptide that exhibits significant activity against Pseudomonas and has a bactericidal effect on burn scabs. This peptide also demonstrates antitumor activity, making it a candidate for research in prostate cancer.
- Antimicrobial peptide
- Active against Pseudomonas
- Bactericidal effect on burn scabs
- Antitumor activity
- Used in prostate cancer research
Medchemexpress LLC Z-VRPR-FMK TFA (VRPR) | 95.0% | 790.81 | 200 UG
Z-VRPR-FMK TFA (VRPR) is a tetrapeptide and a selective, irreversible MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor. It can protect against influenza A virus (IAV) infection.
- Selective and irreversible MALT1 inhibitor
- Protects against influenza A virus (IAV) infection