Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
eMolecules 76-05-1 | Trifluoroacetic acid, >=99.995% Trace metals grade | Oakwood Chemical | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 25g | 537709015
Trifluoroacetic acid, >=99.995% Trace metals grade | Oakwood Chemical | 76-05-1 | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 25g | 537709015
Medchemexpress LLC Gmprga Tfa | 98.1% | 587.69 | 1 MG
GMPRGA (TFA) is the trifluoroacetate salt form of GMPRGA, a compound that plays a role in bacterial processes. It is known for its ability to recognize spAimR within the bacterial cytosol, which subsequently induces lysogeny. This product is intended for research applications only and is not suitable for human use.
- Recognizes spAimR in the bacterial cytosol.
- Induces lysogeny in bacteria.
- For research purposes only.
Medchemexpress LLC ω-Agatoxin IVA TFA | 99.1% | 5316.27 | 100 UG
ω-Agatoxin IVA TFA is a potent, selective P/Q type Ca2+ (Cav2.1) channel blocker. It has IC50s of 2 nM for P-type and 90 nM for Q-type Ca2+ channels. It inhibits glutamate exocytosis and calcium influx elicited by high potassium (IC50, 30-225 nM), and blocks the high potassium-induced release of serotonin and norepinephrine. It has no effect on L-type or N-type calcium channels.
- Potent and selective P/Q type Ca2+ (Cav2.1) channel blocker
- Inhibits glutamate exocytosis and calcium influx
- Blocks high potassium-induced release of serotonin and norepinephrine
- Does not affect L-type or N-type calcium channels
Medchemexpress LLC mP6 (TFA) | 2700321-79-3 | 990.15 | 1 MG
mP6 (Myr-FEEERA-OH) is a myristoylated peptide that functions as an Integrin β(3) Inhibitor. It inhibits the interaction of Gα13 with integrin β3 without disrupting talin-dependent integrin function. Additionally, mP6 blocks the GTP usage of Rac1, Rap1, and Rab7, which effectively inhibits the infection of CHO-A24 cells.
- Myristoylated peptide
- Functions as an Integrin β(3) Inhibitor
- Inhibits the interaction of Gα13 with integrin β3
- Does not disrupt talin-dependent integrin function
- Blocks the GTP usage of Rac1, Rap1, and Rab7
- Effectively inhibits the infection of CHO-A24 cells
Medchemexpress LLC 4,7,10,13,16-pentaazanonadecanedioic acid ester (TFA) | MFCD34677028 | 98.6% | 1841.72 (free base) | C93H173N5O20S5·xC2HF3O2 | 5 MG
5A2-SC8 TFA is an ionizable amino lipid provided as the trifluoroacetic acid salt for formulation into lipid nanoparticles (LNPs). It is intended for research use to enable efficient delivery of small RNAs, such as siRNA and miRNA, and has documented low in vivo toxicity and COA-verified purity.
- Ionizable amino lipid suitable for LNP formulation.
- Enhances delivery of siRNA and miRNA to target cells.
- Low in vivo toxicity profile reported.
- Provided as the TFA salt to aid formulation and handling.
- COA-verified purity by HPLC (~98.6%).
- Store at -80 °C and protect from light for stability.
Medchemexpress LLC Huwentoxin IV | 526224-73-7 | >98% | 1 MG
Huwentoxin-IV TFA is a potent and selective sodium channel blocker, inhibiting neuronal Nav1.7, Nav1.2, Nav1.3, and Nav1.4 with IC50s of 26, 150, 338, and 400 nM, respectively.
- Potent and selective sodium channel blocker
- Inhibits neuronal Nav1.7, Nav1.2, Nav1.3, and Nav1.4
- IC50s of 26, 150, 338, and 400 nM, respectively
Apexbio Technology LLC cyclo(RLsKDK) TFA(Synonyms: cyclo(RLsKDK), Cyclic peptide RLsKDK, ADAM8 inhibitor peptide, Cyclo-Arg-Leu-Ser-Lys-Asp-Lys), 5mg.
Cyclo(RLsKDK) TFA is a cyclic pentapeptide inhibitor targeting the metalloproteinase ADAM8 a transmembrane protein frequently dysregulated in pathological conditions such as inflammation cancer and neurodegenerative diseases By specifically inhibiting ADAM8 enzymatic activity cyclo(RLsKDK) TFA may modulate disease-associated cellular processes This molecule holds promise as a research tool for studying ADAM8 function and as a potential therapeutic candidate in inflammatory disorders and oncology
Medchemexpress LLC Cl2e-SN-38 TFA | 99.1% | 1855.95 | C89H117F3N14O26 | 25 MG
CL2E-SN38 TFA is a trifluoroacetate salt of an antibody-linked SN-38 conjugate used for antibody-drug conjugate (ADC) research. It acts as a topoisomerase I inhibitor and is supplied as a high-purity solid characterized for in vitro and in vivo formulation.
- Purity: 99.07% (reported on product page)
- Form: trifluoroacetate salt
- Molecular weight: 1855.95
- Chemical formula: C89H117F3N14O26
- Solubility: soluble in DMSO (example: 100 mg/mL); in vivo formulations reported at ≥2.5 mg/mL
- Storage: protect from light; store under nitrogen; in solvent: -80°C for long term
- Intended use: research reagent for ADC development and topoisomerase I inhibition studies
Medchemexpress LLC Ceftolozane trifluoroacetate salt | 1628046-32-1 | 98.2% | 780.71 g/mol | C25H31F3N12O10S2 | 25 MG
Ceftolozane TFA is the trifluoroacetate salt of ceftolozane, a cephalosporin-class antibiotic active against Gram-negative bacteria. It is provided for research use in antibacterial studies, assay development, and medicinal chemistry where it can serve as a synthetic intermediate for the design and optimization of novel antibiotic candidates.
- Trifluoroacetate salt form for improved stability and handling.
- Active against Gram-negative bacteria.
- Suitable for medicinal chemistry and synthetic applications.
- Available in small research quantities for assay development.
- Characterized with confirmed purity and molecular weight.
Medchemexpress LLC UNC4976 trifluoroacetate | 98.0% | 961.12 g/mol | C49H71F3N6O10 | 5 MG
UNC4976 TFA is the trifluoroacetate salt of UNC4976, a peptidomimetic positive allosteric modulator (PAM) of the CBX7 chromodomain that modulates chromodomain-nucleic acid interactions. It is supplied as a purified research compound intended for in vitro studies in epigenetics and chromatin biology.
- Trifluoroacetate salt form for improved handling and stability.
- High purity suitable for research applications (98.0%).
- Molecular formula C49H71F3N6O10 and molecular weight 961.12 g/mol.
- Available in small pack sizes for screening and assay development.
- Suitable for use in studies of chromodomain function and epigenetic modulation.
- Provided with documentation specifying identity and purity.
Medchemexpress LLC Ela-32(human) (tfa) | 99.9% | 3967.82 | 1 MG
ELA-32(human) TFA is a potent, high affinity apelin receptor agonist with an IC50 of 0.27 nM and a Kd of 0.51 nM. This product does not bind to GPR15 and GPR25. It activates the PI3K/AKT pathway, promoting the self-renewal of hESCs via cell-cycle progression and protein translation. Additionally, it potentiates the TGFβ pathway, priming hESCs toward the endoderm lineage, and stimulates angiogenesis in HUVEC cells.
- Potent, high affinity apelin receptor agonist
- IC50 of 0.27 nM and a Kd of 0.51 nM
- Exhibits no binding to GPR15 and GPR25
- Activates the PI3K/AKT pathway
- Promotes self-renewal of hESCs via cell-cycle progression and protein translation
- Potentiates the TGFβ pathway, priming hESCs toward the endoderm lineage
- Stimulates angiogenesis in HUVEC cells
Medchemexpress LLC LLVK TFA | 585.66 | 25 MG
LLVK TFA is a selective IκB phosphorylation inhibitor. It reduces LPS-induced pro-inflammatory cytokines (IL-1β, IL-6, TNF-α). LLVK TFA is promising for research of inflammatory bowel disease and rheumatoid arthritis.
- Selective IκB phosphorylation inhibitor
- Reduces LPS-induced pro-inflammatory cytokines (IL-1β, IL-6, TNF-α)
- Promising for research of inflammatory bowel disease
- Promising for research of rheumatoid arthritis
Medchemexpress LLC Ceftolozane TFA | 1628046-32-1 | 98.2% | 780.71 g/mol | C25H31F3N12O10S2 | 1 ML
Ceftolozane TFA is a cephalosporin-class antibiotic supplied as a 10 mM solution in DMSO (1 mL). It is intended for use in antibacterial research, analytical method development, and as a building block for synthesis of novel antibiotics. Trifluoroacetate salt; molecular formula C25H31F3N12O10S2; molecular weight 780.71 g/mol.
- Provided as a ready-to-use 10 mM solution in DMSO.
- Suitable for antibacterial activity assays and analytical method development.
- Useful as a synthetic intermediate and reference standard for research.
- High purity suitable for analytical and preparative applications.
- Supplied in a 1 mL vial for small-scale experiments.
Medchemexpress LLC Pemvidutide trifluoroacetate | 98.1% | 3873.35 | C182H275N39O54 | 5 MG
Pemvidutide TFA is a synthetic peptide acting as a dual agonist of the GLP-1 and glucagon receptors. Supplied for research use, it has been investigated for reductions in body weight, liver fat, and serum lipids, and is intended for preclinical and in-vitro studies only.
- Dual GLP-1 and glucagon receptor agonist activity.
- High purity (98.1%).
- Molecular weight 3873.35 Da.
- Provided as the trifluoroacetate salt for peptide stability.
- Available in small milligram sizes for research workflows.
- Store powder at -80°C (up to 2 years) or -20°C (up to 1 year).
Medchemexpress LLC L-Tyrosine, L-tyrosyl-L-lysyl-L-tyrosyl- (TFA) | 98.1% | 749.73 | 5 MG
YKYY TFA is a blood pressure-lowering peptide isolated from the digest of Undaria pinnatifida. This peptide acts as an angiotensin I-converting enzyme (ACE) inhibitor with an IC50 of 64.2 μM. It is suitable for use in hypertension research.
- Antihypertensive peptide
- Angiotensin I-converting enzyme (ACE) inhibitor
- Isolated from the peptic digest of wakame Undaria pinnatifida
- For research use only