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Filtered Search Results
Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000703253 BI-69A11 10MG
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Aobchem AOBCHEM
5000865324 1-IODO-4-METHOXYNAPHTHALENE 5G
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Medchemexpress LLC (R)-1-(Naphthalen-1-yl)ethanamine hydrochloride | 82572-04-1 | 99.8% | C₁₂H₁₄ClN | 1 G
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(R)-1-(Naphthalen-1-yl)ethanamine hydrochloride is a white to off-white solid primarily intended for research use only and has not been fully validated for medical applications.
- Consistent with structure as verified by ¹H NMR spectrum and LCMS.
- High purity of 99.84% (LCMS).
- Store at 4°C under nitrogen.
- For solvent solutions, store at -80°C for 6 months or -20°C for 1 month under nitrogen.
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Ambeed AMBEED
5000867894 6-BROMO-2-CHLORO-18-NAPHTH 1GR
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Medchemexpress LLC BI-0474 | 2750570-55-7 | 99.8% | 587.74 | 100 MG
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BI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. It demonstrates significant anti-proliferative activity against NCI-H358 cells carrying the G12C mutation and shows favorable anti-tumor activity in non-small cell lung cancer xenograft models.
- Potent KRASG12C inhibitor
- Inhibits GDP-KRAS::SOS1 protein-protein interaction with an IC50 of 7.0 nM
- Exhibits anti-proliferative activity against NCI-H358 cells with G12C mutation
- Shows anti-tumor activity in non-small cell lung cancer xenograft models
- Induces programmed cell death in xenograft models
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![Medchemexpress LLC 5-pyrimidineacetic acid, 4,6-bis(dimethylamino)-2-[[4-[[4-(trifluoromethyl)benzoyl]amino]phenyl]methyl]- | 1093108-50-9 | 99.4% | 501.50 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000435968-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC 5-pyrimidineacetic acid, 4,6-bis(dimethylamino)-2-[[4-[[4-(trifluoromethyl)benzoyl]amino]phenyl]methyl]- | 1093108-50-9 | 99.4% | 501.50 | 50 MG
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This product is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2), with IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively. It has potential for the treatment of poorly controlled asthma. It can also significantly inhibit AHR in mice and effectively block edema formation while reducing inflammatory infiltrate and skin pathology in drug vehicle-treated animals.
- Highly specific and potent antagonist of CRTH2.
- Demonstrates low nanomolar potency against human and mouse CRTH2 in transfected cells.
- Shows significant inhibition of airway hyperreactivity (AHR) in mice.
- Effectively blocks edema formation in animal models.
- Reduces inflammatory infiltrate and skin pathology.
- Potential for treating poorly controlled asthma.
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Medchemexpress LLC Migalastat (hydrochloride) | 75172-81-5 | ≥99.0% | 199.63 | 10MM/1ML
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Migalastat hydrochloride is an orally active α-galactosidase A molecular chaperone, with an IC50 value of 0.04 μM for human α-Gal A. It functions by binding to the active site of certain unstable mutant forms of α-galactosidase A, facilitating their transport to the lysosome. After dissociation in the acidic environment, it enables the mutant α-galactosidase A to exhibit biological activity.
- Binds to the active site of certain unstable mutant forms of α-galactosidase A
- Facilitates transport to the lysosome
- Enables mutant α-galactosidase A to exhibit biological activity
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TARGETMOL CHEMICALS INC BI 1015550 5MG
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Also available in 1 mL, 1 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Nerandomilast (BI 1015550) is an orally active PDE4B inhibitor with IC50 of 7.2 nM. BI 1015550 has potential applications in inflammation, allergic diseases, pulmonary fibrosis and chronic obstructive pulmonary disease (COPD) with a good safety profile. Purity 99.71%
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000369773 DELTARASIN HYDROCHL 10MM 1ML
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000369526 DELTARASIN HYDROCHL 100MG
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Apexbio Technology LLC BI-847325 1207293-36-4 25mg
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BI-847325 (CAS 1207293-36-4) is a dual inhibitor targeting MEK1/2 and Aurora kinases with reported IC50 values of 25 nM and 4 nM against MEK1 and MEK2 and 3 nM 25 nM and 15 nM against Aurora A B and C respectively By inhibiting these kinases BI-847325 disrupts the MAPK/ERK and cell cycle signaling pathways that regulate cell proliferation and survival In cellular assays it demonstrates nanomolar EC50 values for inhibition of pERK and pHH3 in KRAS- and BRAF-mutant cancer cell lines and potently suppresses proliferation across a wide range of tumor cell models In xenograft studies it fully blocks tumor growth in BRAF- and KRAS-mutant cancer models This compound is utilized in research on kinase-targeted cancer therapies
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Aobchem AOBCHEM
5000863771 1 2-DIFLUORO-4- 2-PROPEN-1-YL
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Aobchem AOBCHEM
5000863772 1 2-DIFLUORO-4- 2-PROPEN-1-YL
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Aobchem AOBCHEM
5000865529 6-BROMO-1-CHLORO-2-NAPHTHOL 50
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Medchemexpress LLC Clobutinol hydrochloride | 1215-83-4 | 99.86% | 292.24 | 100 MG
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Clobutinol hydrochloride is a compound with anti-tussive effects. It influences heart rate and blood pressure, making it suitable for cough-related research.
- Has anti-tussive effects.
- Influences heart rate and blood pressure.
- Used in cough related research.
- Functions as a potassium channel inhibitor.
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