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Filtered Search Results
Sigma Aldrich Fine Chemicals Biosciences NAPTM 25 Cytiva 17 0852 02
NAP Columns are disposable columns prepacked with Sephadex G-25 DNA Grade and require only gravity to run. Each package includes a complete step-by-step protocol describing the fixed volumes needed for equilibration washing and sample elution.
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AdipoGen 2-Propyl-2-pentenoic acid
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Chemical. CAS 60218-41-9. Formula C8H14O2. MW 142.2. Synthetic A major beta-oxidation metabolite of valproic acid VPA. Exhibits anticonvulsive potency similar to VPA and may be at least partially responsible for its neurological activity. Compound can be used as analytical reference material.
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AdipoGen N-Phenyl-benzimidoyl chloride
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Chemical. CAS 4903-36-0. Formula C13H10ClN. MW 215.68. Synthetic. Building block for synthesis.
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AdipoGen 2-Propyl-2-pentenoic acid
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Chemical. CAS 60218-41-9. Formula C8H14O2. MW 142.2. Synthetic A major beta-oxidation metabolite of valproic acid VPA. Exhibits anticonvulsive potency similar to VPA and may be at least partially responsible for its neurological activity. Compound can be used as analytical reference material.
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AdipoGen 2-Phenylpropionyl chloride
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Chemical. CAS 22414-26-2. Formula C9H9ClO. MW 168.6. Synthetic. Building block for synthesis.
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Sigma Aldrich Fine Chemicals Biosciences 2-Hydroxy-1,4-naphthoquinone 97% | 83-72-7 | MFCD00001678 | 10G
2-Hydroxy-1,4-naphthoquinone 97% | Purity: 97% | Mol Wt: 174.15 | 83-72-7 | MFCD00001678 | 10G
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Sigma Aldrich Fine Chemicals Biosciences Plumbagin from Plumbago indica | 481-42-5 | MFCD00001682 | 100MG
Plumbagin from Plumbago indica | Mol Wt: 188.18 | 481-42-5 | MFCD00001682 | 100MG
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Apexbio Technology LLC AZD 5153(Synonyms: AZD5153, AZD-5153, AZD 5153 dihydrochloride, BRD4 inhibitor AZD5153, AZD5153 BRD4 inhibitor), 5mg, CAS: 1869912-39-9.
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AZD5153 (CAS 1869912-39-9) is a potent selective orally bioavailable inhibitor of the bromodomain and extraterminal (BET) family protein BRD4 Through simultaneous binding of both bromodomains in BRD4 AZD5153 effectively disrupts BRD4-mediated transcriptional regulation In cellular assays AZD5153 demonstrates high activity notably displacing BRD4 with an IC50 of approximately 1 7 nM in U2OS cells It significantly inhibits growth of AML multiple myeloma and diffuse large B-cell lymphoma cell lines reducing mTOR pathway signaling In vivo AZD5153 shows dose-dependent antitumor efficacy in xenograft models of hematologic malignancies indicating its value as a tool compound in cancer research
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Apexbio Technology LLC Empagliflozin (BI 10773) 864070-44-0 100mg
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Empagliflozin (BI 10773 CAS 864070-44-0) is a potent selective inhibitor targeting sodium-glucose cotransporter 2 (SGLT-2) a transmembrane protein primarily expressed in the kidneys and responsible for glucose reabsorption Empagliflozin inhibits SGLT-2 with an IC50 of 3 1 nM demonstrating high selectivity relative to related transporters (SGLT-1 4 5 and 6) In vitro studies using HK2 human proximal tubular cells showed that empagliflozin suppresses high glucose-induced pro-inflammatory signaling pathways including TLR4 NF- B AP-1 and IL-6 secretion Empagliflozin has been widely studied in diabetic animal models such as Zucker diabetic obese rats effectively reducing blood glucose and increasing urinary glucose excretion supporting its application in diabetes research
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Apexbio Technology LLC Empagliflozin (BI 10773) 864070-44-0 5mg
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Empagliflozin (BI 10773 CAS 864070-44-0) is a potent selective inhibitor targeting sodium-glucose cotransporter 2 (SGLT-2) a transmembrane protein primarily expressed in the kidneys and responsible for glucose reabsorption Empagliflozin inhibits SGLT-2 with an IC50 of 3 1 nM demonstrating high selectivity relative to related transporters (SGLT-1 4 5 and 6) In vitro studies using HK2 human proximal tubular cells showed that empagliflozin suppresses high glucose-induced pro-inflammatory signaling pathways including TLR4 NF- B AP-1 and IL-6 secretion Empagliflozin has been widely studied in diabetic animal models such as Zucker diabetic obese rats effectively reducing blood glucose and increasing urinary glucose excretion supporting its application in diabetes research
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Medchemexpress LLC Fluoxetine hydrochloride | 56296-78-7 | 99.97% | 1 ML
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Fluoxetine hydrochloride is an antidepressant and a selective serotonin reuptake inhibitor.
- Cellular effects (in vitro): Fluoxetine hydrochloride blocks downregulation of cell proliferation induced by inescapable shock in hippocampal cells, increases newborn cells and proliferating cells in the prelimbic cortex, accelerates maturation of immature neurons, and enhances neurogenesis-dependent long-term potentiation (LTP) in the dentate gyrus. It also increases norepinephrine and dopamine extracellular levels in the prefrontal cortex.
- Animal studies (in vivo): Treatment with fluoxetine hydrochloride reverses deficits in escape latency. Fluoxetine promotes cell proliferation in the dentate gyrus, and coadministration with olanzapine enhances this effect. The combination also leads to substantial increases in extracellular dopamine and norepinephrine levels.
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Medchemexpress LLC Cysteamine (hydrochloride) | 156-57-0 | 99.3% | C2H8ClNS | 10 G
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Cysteamine (hydrochloride) is an orally active agent used for the treatment of nephropathic cystinosis and as an antioxidant. This compound is intended for research use only.
- Increases intracellular glutathione levels in cystinotic cells, restoring the altered redox state.
- Counteracts increased rates of apoptosis in cystinotic cells.
- Exhibits antioxidant properties by increasing glutathione production.
- Acts as an excellent scavenger of OH and HOCl, and reacts with H2O2.
- Increases the production of several heat shock proteins (HSP).
- Exerts a dose-dependent effect on doxorubicin-induced cancer cell death.
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Medchemexpress LLC Octopamine hydrochloride | 770-05-8 | MFCD00012881 | 99.90% | 5 G
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Octopamine hydrochloride is a biogenic monoamine structurally related to noradrenaline. It functions as a neurohormone, neuromodulator, and neurotransmitter in invertebrates, stimulating alpha2-adrenoceptors. This compound is known to affect various physiological processes, including metabolism and neuroregulation. It achieves its effects by binding to specific G protein-coupled receptors.
- Regulates sensory input desensitization, arousal, and complex behaviors like learning and memory.
- Modulates endocrine gland activity.
- Mobilizes lipids and carbohydrates as a neurohormone.
- Stimulates alpha2-adrenoceptors.
- Increases glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis, and portal perfusion pressure.
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AdipoGen Naphthol AS-E phosphate
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Chemical. CAS 18228-17-6. Formula C17H13ClNO5P. MW 377.72. Synthetic. Histochemical substrate for alkaline phosphatases. Aldolase inhibitor. Small molecule inhibitor. Anticancer compound that directly targets the KIX domain of CBP, resulting in a disrupted CREB-CBP complex, inhibited CREB-target gene induction and inhibited IL-1beta-mediated angiogenic activity in cancer cell lines. Inhibits activity of transcription factor Myb by blocking interaction with KIX domain of coactivator p300 in human leukemia cells. Interferes with the Myb–KIX interaction in vitro and inhibits Myb activity in vivo. Suppresses the expression of Myb target genes and induces myeloid differentiation and apoptosis.
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AdipoGen Naphthol AS phosphate 2Na
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Chemical. CAS 69815-54-9. Formula C17H12NNa2O5P. MW BD9837. Naphthol AS phosphate is a fluorogenic substrate for acid and alkaline phosphatases. Naphthol AS phosphate is converted to naphthol AS displaying excitation/emission spectra of 388/516nm. The fluorescence is a quantitative marker of acid and alkaline phosphatase activity. Acid and alkaline phosphatases are often used as clinical markers of disease, since the concentration of human acid and alkaline phosphatases undergo pronounced changes in particular diseases, resulting in unusually high or low concentrations. It is a histochemical substrate commonly used in conjunction with diazonium salts to form a specific azo dye for immunohistology, immunoblotting, dot blot applications and in situ PCR.
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