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Filtered Search Results
AdipoGen trans-Indole-3-acrylic acid
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Chemical. CAS 29953-71-7. Formula C11H9NO2. MW 187.2. Synthetic. Inflammation suppressor. Tryptophan metabolite produced by human microbiota intestinal commensale Peptostreptococcus sp. Involved in keeping the intestinal barrier intact and works as anti-inflammatory molecule. Patients with Inflammatory bowel Disease IBD have an altered microbiota, with less Peptostreptococcus sp., and therefore reduced production of trans-indole-3-acrylic acid. Chromophoric L-Trp analog used to probe the allosteric properties of the internal aldimine of tryptophan synthas. Also shown to be a moderate inhibitor of tryptophan synthase, trypothan-2,3-dioxygenase, indoleamine-2,3-dioxygenase, L-dopachrome isomerase and xanthine oxidase. Reagent used as a matrix for MALDI-TOF mass spectroscopy in order to characterize and analyze polyphenols and synthetic polymers.
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![eMolecules 3027-38-1 | 3-Nitro-1,8-naphthalic anhydride | Combi-Blocks | MFCD00006926 | 243.174 | C12H5NO5 | 97.000 | [O-][N+](=O)c1cc2C(=O)OC(=O)c3cccc(c1)c23 | 1g | 290702531](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00128114-290702531.PNG-250.jpg)
eMolecules 3027-38-1 | 3-Nitro-1,8-naphthalic anhydride | Combi-Blocks | MFCD00006926 | 243.174 | C12H5NO5 | 97.000 | [O-][N+](=O)c1cc2C(=O)OC(=O)c3cccc(c1)c23 | 1g | 290702531
3-Nitro-1,8-naphthalic anhydride | Combi-Blocks | 3027-38-1 | MFCD00006926 | 243.174 | C12H5NO5 | 97.000 | [O-][N+](=O)c1cc2C(=O)OC(=O)c3cccc(c1)c23 | 1g | 290702531
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Medchemexpress LLC CRA-026440 (hydrochloride) | 847459-98-7 | 98.1% | 456.92 | 25 MG
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CRA-026440 (hydrochloride) | 847459-98-7 | 98.1% | 456.92 | 25 MG
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Medchemexpress LLC Glesatinib hydrochloride | 2319837-80-2 | 98.0% | 656.17 | 25 MG
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Glesatinib hydrochloride | 2319837-80-2 | 98.0% | 656.17 | 25 MG
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Medchemexpress LLC Ranitidine hydrochloride | 66357-59-3 | 99.9% | 500 MG
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Ranitidine hydrochloride is a potent, selective, and orally active histamine H2-receptor antagonist that inhibits gastric secretion. It has demonstrated efficacy in antagonizing histamine-induced effects in various in vitro models and has also shown activity in inhibiting breast tumor development and spread in mice.
- Potent, selective, and orally active histamine H2-receptor antagonist
- Inhibits gastric secretion
- Antagonizes histamine-induced increases and relaxations in various in vitro models
- Inhibits breast tumor development and spread in mice
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Medchemexpress LLC Aceclidine hydrochloride | 6109-70-2 | 98.0% | 205.68 | 1 ML
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Aceclidine hydrochloride is a modulator of the M3 muscarinic acetylcholine receptor and acts as an M1 receptor agonist with an EC50 of 40 μM. It functions as a cycloplegic agent, a surfactant, a tonicity adjustor, and can optionally serve as a viscosity enhancer and an antioxidant. This compound holds potential for research into various disorders, including refractive errors of the eye, xerostomia, Sjogren's syndrome, glaucoma, conjunctivitis, lacrimal gland disease, and esotropia.
- Modulator of M3 muscarinic acetylcholine receptor.
- M1 receptor agonist (EC50: 40 μM).
- Functions as a cycloplegic agent.
- Acts as a surfactant.
- Serves as a tonicity adjustor.
- Can optionally be a viscosity enhancer and an antioxidant.
- Potential for research in disorders such as refractive errors of the eye, xerostomia, Sjogren's syndrome, glaucoma, conjunctivitis, lacrimal gland disease, and esotropia.
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Medchemexpress LLC 1-naphthalenesulfonic acid, 3,4-dihydro-3,4-dioxo-, potassium salt | 5908-27-0 | MFCD00001699 | 99.8% | 276.31 | C10H5KO5S | 1g
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Potassium 1 2-naphthoquinone-4-sulphonate (Compound 16) is a 6-phosphogluconate dehydrogenase (6PGDH) inhibitor with an IC50 of 53 M Potassium 1 2-naphthoquinone-4-sulphonate can be used in the study of human African trypanosomiasis[1]
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Apexbio Technology LLC Empagliflozin (BI 10773) 864070-44-0 50mg
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Empagliflozin (BI 10773 CAS 864070-44-0) is a potent selective inhibitor targeting sodium-glucose cotransporter 2 (SGLT-2) a transmembrane protein primarily expressed in the kidneys and responsible for glucose reabsorption Empagliflozin inhibits SGLT-2 with an IC50 of 3 1 nM demonstrating high selectivity relative to related transporters (SGLT-1 4 5 and 6) In vitro studies using HK2 human proximal tubular cells showed that empagliflozin suppresses high glucose-induced pro-inflammatory signaling pathways including TLR4 NF- B AP-1 and IL-6 secretion Empagliflozin has been widely studied in diabetic animal models such as Zucker diabetic obese rats effectively reducing blood glucose and increasing urinary glucose excretion supporting its application in diabetes research
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Apexbio Technology LLC BI-9564 1883429-22-8 50mg
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BI-9564 (CAS 1883429-22-8) is a small molecule inhibitor selective for the bromodomains BRD9 and BRD7 two structurally related proteins involved in chromatin remodeling BI-9564 demonstrates inhibitory potency with an IC50 of 75 nM for BRD9 and 3 4 M for BRD7 showing higher affinity for BRD9 The compound exhibits minimal off-target activity against BET family proteins In vivo oral administration of BI-9564 in murine tumor xenograft models significantly suppresses tumor growth BI-9564 is widely used in preclinical research to study the biological roles of BRD9/7 in cancer and epigenetic modulation pathways
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Apexbio Technology LLC BI-9564 1883429-22-8 100mg
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BI-9564 (CAS 1883429-22-8) is a small molecule inhibitor selective for the bromodomains BRD9 and BRD7 two structurally related proteins involved in chromatin remodeling BI-9564 demonstrates inhibitory potency with an IC50 of 75 nM for BRD9 and 3 4 M for BRD7 showing higher affinity for BRD9 The compound exhibits minimal off-target activity against BET family proteins In vivo oral administration of BI-9564 in murine tumor xenograft models significantly suppresses tumor growth BI-9564 is widely used in preclinical research to study the biological roles of BRD9/7 in cancer and epigenetic modulation pathways
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Medchemexpress LLC Adiphenine hydrochloride | 50-42-0 | 99.1% | 500 MG
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Adiphenine hydrochloride is a non-competitive inhibitor of the nicotinic acetylcholine receptor (nAChR). It exhibits anticonvulsant effects and has specific IC50 values for various nAChR subtypes including α1, α3β4, α4β2, and α4β4. In vivo, it prevents hindleg tonic-extensor components of maximal electroshock seizures (MES) in mice.
- Non-competitive inhibitor of nicotinic acetylcholine receptor (nAChR)
- Exhibits anticonvulsant effects
- Specific IC50 values for α1, α3β4, α4β2, and α4β4 nAChR subtypes
- Prevents hindleg tonic-extensor components of maximal electroshock seizures (MES) in mice
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Apexbio Technology LLC MK-571 sodium salt hydrate 115103-85-0 50mg
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MK-571 sodium salt hydrate (CAS 115103-85-0) is an antagonist of the cysteinyl-leukotriene type 1 receptor (CysLT1) a cell-surface receptor mediating allergic and hypersensitivity responses via cysteinyl leukotrienes In addition MK-571 acts as an inhibitor of multidrug resistance-associated protein 2 (ABCC2/Mrp2) commonly employed in vitro to investigate Mrp2-mediated efflux of xenobiotics and conjugates in epithelial cells Experimental evidence with Caco-2/TC7 cells indicates MK-571 also inhibits phase-2 conjugation of flavonols interfering competitively with glucuronide formation Its utilization thus spans immune-related receptor signaling studies and characterizing cellular drug transport mechanisms
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Apexbio Technology LLC BI-9564 1883429-22-8 10mg
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BI-9564 (CAS 1883429-22-8) is a small molecule inhibitor selective for the bromodomains BRD9 and BRD7 two structurally related proteins involved in chromatin remodeling BI-9564 demonstrates inhibitory potency with an IC50 of 75 nM for BRD9 and 3 4 M for BRD7 showing higher affinity for BRD9 The compound exhibits minimal off-target activity against BET family proteins In vivo oral administration of BI-9564 in murine tumor xenograft models significantly suppresses tumor growth BI-9564 is widely used in preclinical research to study the biological roles of BRD9/7 in cancer and epigenetic modulation pathways
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000772562 NAPHTHALENE-2 6-DICA 100G
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000772098 1 1 -BI-2-NAPHTHOL 10G
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