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Filtered Search Results
AdipoGen p-Toluenesulfinic acid Na
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Chemical. CAS 824-79-3. Formula C7H7NaO2S. Molecular Weight 178.18. Sodium p-Toluenesulfinate is used as an organic bulding block or intermediate for the preparation of pharmaceuticals and dispersal dyes, as a mild reducing agent and as a polymerization accelerator. It is also used as a discharge medium of dyes and pigments. Used as a photo-redox couple together with methylene blue. Further, it serves as a chemical intermediate in the production of fluorescent pigments and fabric adhesive. In addition to this, it is used as an electroplating brightening agent and curing agent.
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eMolecules 866423-24-7 | 5-Benzyloxypentylmagnesium bromide, 0.50 M in THF | Synthonix281.476 | C12H17BrMgO | 0.000 | [Br-].[Mg+]CCCCCOCc1ccccc1 | 25ml | 844919946
5-Benzyloxypentylmagnesium bromide, 0.50 M in THF | Synthonix | 866423-24-7281.476 | C12H17BrMgO | 0.000 | [Br-].[Mg+]CCCCCOCc1ccccc1 | 25ml | 844919946
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eMolecules 72136-49-3 | (9H-Fluoren-2-yl)magnesium bromide, 0.25 M in THF | Synthonix269.424 | C13H9BrMg | 95.000 | [Br-].[Mg+]c1ccc-2c(Cc3ccccc-23)c1 | 50ml | 818572019
(9H-Fluoren-2-yl)magnesium bromide, 0.25 M in THF | Synthonix | 72136-49-3269.424 | C13H9BrMg | 95.000 | [Br-].[Mg+]c1ccc-2c(Cc3ccccc-23)c1 | 50ml | 818572019
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eMolecules 77047-87-1 | 2-Propylzinc bromide, 0.50 M in THF | Synthonix | MFCD06200639 | 188.370 | C3H7BrZn | 0.000 | [Br-].CC(C)[Zn+] | 50ml | 627353731
2-Propylzinc bromide, 0.50 M in THF | Synthonix | 77047-87-1 | MFCD06200639 | 188.370 | C3H7BrZn | 0.000 | [Br-].CC(C)[Zn+] | 50ml | 627353731
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AdipoGen N N-Bisphosphonomethylglycin
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Chemical. CAS 2439-99-8. Formula C4H11NO8P2. MW 263.08. Synthetic. A glycine-phosphonic acid compound, negatively charged at neutral pH, with immunomodulatory and anti-diabetic properties. Enhances anti-B9-23 TCR-dependent T cell activation by modulating murine class II MHC I-Ag7-mediated B9-23 presentation on APCs. Daily administration of glyphosine is shown to delay the onset of diabetes in NOD mice. Herbicide. A plant growth regulator. Acts as a competitive inhibitor of phoshoenolpyruvate carboxylase in plants.
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Medchemexpress LLC Fedratinib (hydrochloride hydrate) | 1374744-69-0 | 99.9% | 615.62 | 1 G
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Fedratinib hydrochloride hydrate is a potent, selective, ATP-competitive, and orally active inhibitor of JAK2. It exhibits an IC50 of 3 nM for both JAK2 and JAK2V617F kinase and demonstrates significant selectivity over JAK1 (35-fold) and JAK3 (334-fold). This compound has been shown to induce apoptosis in cancer cells and is considered to have potential for research in myeloproliferative disorders.
- Potent, selective, ATP-competitive, and orally active JAK2 inhibitor.
- Targets both JAK2 and JAK2V617F kinase effectively at 3 nM IC50.
- Exhibits high selectivity against JAK1 (35-fold) and JAK3 (334-fold).
- Induces apoptosis in cancer cells.
- Shows promise for research in myeloproliferative disorders.
- Inhibits proliferation of cell lines carrying the JAK2V617F mutation.
- Reduces STAT5 phosphorylation.
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Medchemexpress LLC 2-Oxa-5-azabicyclo[2.2.1]heptane, 5-[2-[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-6-[6-(4-methoxy-3-pyri | 2769715-68-4 | 99.3% | 592.69 | 25 MG
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BI-4732 is an orally active, reversible, ATP-competitive EGFR inhibitor with blood-brain barrier penetration. It inhibits the kinase activity of EGFR L858R, T790M, and C797S with IC50 values of 1 nM, while sparing wild-type EGFR. BI-4732 inhibits EGFR and reduces the phosphorylation of AKT, ERK, and S6K. It demonstrates excellent intracranial anti-tumor efficacy in a YU-1097 xenograft model, making it suitable for studying non-small cell lung cancer (NSCLC).
- Orally active
- Reversible
- ATP-competitive EGFR inhibitor
- Blood-brain barrier penetration
- Inhibits kinase activity of EGFR L858R, T790M, and C797S with IC50 values of 1 nM
- Spares wild-type EGFR
- Reduces phosphorylation of AKT, ERK, and S6K
- Demonstrates intracranial anti-tumor efficacy in YU-1097 xenograft model
- Useful for the study of non-small cell lung cancer (NSCLC)
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Apexbio Technology LLC Linagliptin (BI-1356) 668270-12-0 10mg
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Linagliptin (BI-1356 CAS 668270-12-0) is a potent competitive inhibitor of dipeptidyl peptidase-4 (DPP-4) demonstrating IC50 values of 0 4 1 1 nM in multiple in vitro assays using DPP-4 extracted from Caco-2 cells DPP-4 is a membrane-bound and soluble protease involved in the degradation of incretin hormones such as GLP-1 which enhance pancreatic -cell glucose sensitivity and insulin secretion Linagliptin displays marked selectivity for DPP-4 over related peptidases and serine proteases In vivo linagliptin dose-dependently inhibits plasma DPP-4 activity and sustains glycemic control with prolonged effects observed at pharmacologically relevant doses This compound is widely utilized in studies of glucose metabolism and -cell function
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eMolecules 171860-66-5 | sec-Butylzinc bromide, 0.50 M in THF | Synthonix | MFCD00671990 | 202.400 | C4H9BrZn | 0.000 | [Br-].CCC(C)[Zn+] | 25ml | 627353532
sec-Butylzinc bromide, 0.50 M in THF | Synthonix | 171860-66-5 | MFCD00671990 | 202.400 | C4H9BrZn | 0.000 | [Br-].CCC(C)[Zn+] | 25ml | 627353532
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eMolecules 131379-15-2 | 4-(Ethoxycarbonyl)phenylzinc bromide, 0.50 M in THF | Synthonix294.450 | C9H9BrO2Zn | 0.000 | [Br-].CCOC(=O)c1ccc([Zn+])cc1 | 50ml | 532652815
4-(Ethoxycarbonyl)phenylzinc bromide, 0.50 M in THF | Synthonix | 131379-15-2294.450 | C9H9BrO2Zn | 0.000 | [Br-].CCOC(=O)c1ccc([Zn+])cc1 | 50ml | 532652815
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eMolecules 1025687-41-5 | 2-Fluoro-5-(tributylstannyl)pyridine | Synthonix - Stock | MFCD07787406 | 386.142 | C17H30FNSn | 97.000 | CCCC[Sn](CCCC)(CCCC)c1ccc(F)nc1 | 25g | 525917286
2-Fluoro-5-(tributylstannyl)pyridine | Synthonix - Stock | 1025687-41-5 | MFCD07787406 | 386.142 | C17H30FNSn | 97.000 | CCCC[Sn](CCCC)(CCCC)c1ccc(F)nc1 | 25g | 525917286
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eMolecules 134640-85-0 | 2,3-Dimethylphenylmagnesium bromide, 0.5 M in THF | Synthonix - Stock | MFCD01311494 | 209.369 | C8H9BrMg | 0.000 | [Br-].Cc1cccc([Mg+])c1C | 500ml | 437237099
2,3-Dimethylphenylmagnesium bromide, 0.5 M in THF | Synthonix - Stock | 134640-85-0 | MFCD01311494 | 209.369 | C8H9BrMg | 0.000 | [Br-].Cc1cccc([Mg+])c1C | 500ml | 437237099
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Medchemexpress LLC Paroxetine (hydrochloride) | 78246-49-8 | 100.0% | 1 ML
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Paroxetine hydrochloride is a potent selective serotonin-reuptake inhibitor and a GRK2 inhibitor with an IC50 of 14 μM. It is used in research for depressive disorders and other biological activities.
- Potent selective serotonin-reuptake inhibitor
- GRK2 inhibitor with an IC50 of 14 μM
- Used for research of depressive disorder
- Restrains T cell migration induced by CX3CL1
- Inhibits GRK2 induced activation of ERK
- Reduces pro-inflammatory cytokines in LPS-stimulated BV2 cells
- Inhibits LPS-induced nitric oxide production and iNOS expression in BV2 cells
- Blocks LPS-induced JNK activation
- Attenuates symptoms of CIA rats and prevents histological damage of joints
- Reduces myocyte cross-sectional area in rats and ROS formation
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eMolecules 13291-18-4 | Isopropenylmagnesium bromide, 0.50 M in THF | Synthonix | MFCD00192240 | 145.282 | C3H5BrMg | 0.000 | [Br-].CC([Mg+])=C | 100ml | 649431320
Isopropenylmagnesium bromide, 0.50 M in THF | Synthonix | 13291-18-4 | MFCD00192240 | 145.282 | C3H5BrMg | 0.000 | [Br-].CC([Mg+])=C | 100ml | 649431320
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eMolecules 117269-71-3 | 2-Iodobenzylzinc bromide, 0.50 M in THF | Synthonix | MFCD02260159 | 362.310 | C7H6BrIZn | 0.000 | [Br-].[Zn+]Cc1ccccc1I | 100ml | 532652870
2-Iodobenzylzinc bromide, 0.50 M in THF | Synthonix | 117269-71-3 | MFCD02260159 | 362.310 | C7H6BrIZn | 0.000 | [Br-].[Zn+]Cc1ccccc1I | 100ml | 532652870
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