Phenanthrenes and derivatives
Medchemexpress LLC 2H-1-benzopyran-7-ol, 3,4-dihydro-3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-, (3R,4S)-rel- | 1213777-80-0 | 99.9% | C22H20O4 | 10MG
Triphen diol is a phenol diol derivative reported to have anticancer activity against pancreatic cancer and cholangiocarcinoma. It induces apoptosis through caspase-mediated and caspase-independent mechanisms and is supplied as a high-purity research reagent for laboratory studies.
- Phenol diol derivative with reported anticancer activity.
- Induces apoptosis via caspase-mediated and caspase-independent pathways.
- High purity (~99.9%) suitable for research applications.
- Molecular formula C22H20O4; molecular weight 348.39 g·mol⁻¹.
- Soluble in DMSO (≈100 mg/mL); use freshly opened solvent to ensure solubility.
- Store protected from light; in solvent store short-term at -20°C and long-term at -80°C.
Medchemexpress LLC PROTAC BCR-ABL1 ligand 1 | 2489876-34-6 | 99.2% | 100 MG
PROTAC BCR-ABL1 ligand 1, also known as compound GMB-475, is a PROTAC ligand that allosterically targets the BCR-ABL1 protein. It recruits the E3 ligase Von Hippel-Lindau, leading to ubiquitination and subsequent degradation of BCR-ABL1. It is for research use only and not sold to patients.
- Allosterically targets the BCR-ABL1 protein.
- Recruits the E3 ligase Von Hippel-Lindau for ubiquitination and degradation of BCR-ABL1.
- Exhibits cell proliferation with IC50 values of 1.11, 1.98, and 0.37 μM for BCR-ABL1 WT, T315I, and G250E cells.
- Induces the degradation of BCR-ABL1 and c-ABL1.
- Inhibits downstream signaling via the STAT5 pathway in K562 and Ba/F3 cells.
- Intended for research use only.
Medchemexpress LLC Nilotinib hydrochloride dihydrate | 00-00-0 | 99.9% | 602.01 g/mol | C28H27ClF3N7O3 | 200 MG
Nilotinib hydrochloride dihydrate is the dihydrate salt of nilotinib, a second-generation Bcr-Abl tyrosine kinase inhibitor used in oncology research. Supplied for research and analytical applications, it is intended for laboratory studies of chronic myelogenous leukemia mechanisms and kinase signaling. Not for human therapeutic use.
- Potent Bcr-Abl tyrosine kinase inhibitor.
- Suitable for in vitro and in vivo research models.
- High purity suitable for analytical applications (99.89%).
- Supplied as a solid with molecular weight 602.01 g/mol.
- Available in laboratory pack sizes for experimental use.
Medchemexpress LLC Prazosin (hydrochloride) | 19237-84-4 | 99.9% | 200 MG
Prazosin hydrochloride is a well-tolerated, CNS-active α1-adrenergic receptor antagonist. It is utilized in research for high blood pressure and alcohol use disorders. The compound effectively inhibits Norepinephrine (NE)-stimulated 45Ca efflux with an IC50 of 0.15 nM and also inhibits organic cation transporters OCT-1 and OCT-3 with IC50s of 1.8 and 13 μM, respectively.
- Acts as a CNS-active α1-adrenergic receptor antagonist
- Used in research for high blood pressure
- Used in research for alcohol use disorders
- Potently inhibits Norepinephrine (NE)-stimulated 45Ca efflux
- Inhibits organic cation transporters OCT-1 and OCT-3
Medchemexpress LLC Aristolochic acid A | 313-67-7 | MFCD00004996 | 99.9% | 10 MG
Aristolochic acid A is a nitrophenanthrene carboxylic acid supplied as a high-purity research reagent for biochemical and cell-based studies. It is commonly used to investigate NF-κB and AP-1 signaling pathways and for mechanistic studies of nephrotoxicity and carcinogenesis.
- High purity (99.9%).
- Molecular formula C17H11NO7; molecular weight 341.27 g/mol.
- Typically supplied as a 10 mg quantity suitable for research use.
- Used in studies of NF-κB and AP-1 inhibition and mechanisms of nephrotoxicity and carcinogenicity.
- Handle as a toxic and carcinogenic compound with appropriate safety precautions.
Medchemexpress LLC Docosahexaenoic acid | 6217-54-5 | 98.8% | 200 MG
Docosahexaenoic acid (DHA) is an omega-3 fatty acid abundantly present in the brain and retina, crucial for development and maintaining normal function. Obtained from fish oil and maternal milk, DHA plays a vital role in cognitive abilities and neurological health.
- Essential for infant brain growth and functional development
- Maintains normal adult brain function
- Improves learning ability and memory
- Required for neural cell proliferation, migration, differentiation, and synaptogenesis
- Unique structure supports effective cell signaling
- Potent RXR ligand, activating RXRα at low micromolar concentrations
- Reduces reference memory errors
- Increases DHA content and DHA/arachidonic acid ratio in brain regions
- Exhibits neuroprotective actions in Parkinson's disease models
Medchemexpress LLC Aristolochic acid D (Aristolochic acid-IVa) | 17413-38-6 | 357.27 | 1 MG
Aristolochic acid D (Aristolochic acid-IVa) is an orally active PDE2 and CDK2 inhibitor isolated from *Aristolochia indica L.* It exhibits anti-inflammatory activity and can be used in the research of inflammation and tumor-related diseases.
- Orally active PDE2 inhibitor
- Orally active CDK2 inhibitor
- Isolated from *Aristolochia indica L.*
- Exhibits anti-inflammatory activity
- Non-carcinogenic
- Non-nephrotoxic
- Can be used in inflammation research
- Can be used in tumor-related diseases research
Medchemexpress LLC Aristolochic acid A | 313-67-7 | 341.27 | 5 MG
Aristolochic acid A is the main component of plant extract Aristolochic acids, found in various herbal plants of the genus Aristolochia and Asarum. This product is an analytical standard intended for research and analytical applications. It significantly reduces both activator protein 1 (AP-1) and NF-κB activities, and reduces BLCAP gene expression in human cell lines.
- Reduces both activator protein 1 (AP-1) and NF-κB activities.
- Reduces BLCAP gene expression in human cell lines.
![Sigma Aldrich Fine Chemicals Biosciences Benzo[a]pyrene | 50-32-8 | MFCD00003602 | 100mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/501848401.jpg-250.jpg)
Sigma Aldrich Fine Chemicals Biosciences Benzo[a]pyrene | 50-32-8 | MFCD00003602 | 100mg
Benzo[a]pyrene | Purity: 96% | Mol Wt: 252.31 | 50-32-8 | MFCD00003602 | 100mg
