Saturated hydrocarbons
Medchemexpress LLC Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, (t-4)-tetrathioxomolybdate(2-) (2:1) | 649749-10-0 | 98.0% | 432.56 | 100 MG
ATN-224 is an orally active Cu2+/Zn2+-superoxide dismutase 1 (SOD1) inhibitor that inhibits SOD1 activity in endothelial cells in a dose-dependent manner with an IC50 of 17.5 nM.
- Specific and high affinity for copper ions.
- Inhibits the proliferation of HUVEC (IC50=1.4±0.3 μM).
- Inhibits the activity of purified bovine SOD1 with an IC50 of 0.33±0.03 μM.
- SOD1 inhibition is time-dependent, reaching maximal inhibition by depleting copper.
- Inhibits FGF-2-induced ERK1/2 phosphorylation.
- Orally-available inorganic small molecule that inhibits Cu/Zn-SOD1 in endothelial and tumor cells.
- Significantly inhibits angiogenesis in the Matrigel plug model in mice.
- Angiogenesis inhibition occurs independently of copper depletion.
Medchemexpress LLC 18-Azido-stearic acid | 1529763-58-3 | C18H35N3O2 | 50 MG
18-Azido-stearic acid is a click chemistry reagent that features an azide group. It serves as a hydrophobic bioconjugation linker, allowing for modification at the azido-position using various click chemistry techniques. These include copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne groups, and ring strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups.
- Contains an azide group for click chemistry applications.
- Functions as a hydrophobic bioconjugation linker.
- Modifiable via copper-catalyzed azide-alkyne cycloaddition (CuAAc).
- Compatible with ring strain-promoted alkyne-azide cycloaddition (SPAAC).
Medchemexpress LLC 18-Azido-stearic acid | 1529763-58-3 | C18H35N3O2 | 5 MG
18-Azido-stearic acid is a versatile click chemistry reagent featuring an azide group. It functions as a hydrophobic bioconjugation linker, particularly when utilized with N-Myristoyltransferase, allowing for further modifications via Click-chemistry. It effectively participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules and ring strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups.
- Contains an azide group for click chemistry applications
- Functions as a hydrophobic bioconjugation linker
- Can be further modified via click-chemistry
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Participates in ring strain-promoted alkyne-azide cycloaddition (SPAAC)
Medchemexpress LLC 18-Azido-stearic acid | 1529763-58-3 | C18H35N3O2 | 100 MG
18-Azido-stearic acid is a click chemistry reagent featuring an azide group. It functions as a hydrophobic bioconjugation linker, modifiable at the azido-position using Click-chemistry. This reagent can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules and ring strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN group-containing molecules.
- Click chemistry reagent with an azide group
- Functions as a hydrophobic bioconjugation linker
- Can be modified at the azido-position via Click-chemistry
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Participates in ring strain-promoted alkyne-azide cycloaddition (SPAAC)
Medchemexpress LLC Bis(choline)tetrathiomolybdate | 649749-10-0 | 98.0% | 432.56 g/mol | C10H28MoN2O2S4 | 10 MG
ATN-224 (bis(choline)tetrathiomolybdate) is an orally active Cu2+/Zn2+-dependent superoxide dismutase 1 (SOD1) inhibitor used in research to modulate copper-dependent enzymatic activity and angiogenesis. It inhibits SOD1 activity in endothelial and tumor cells and has been characterized in cellular and in vivo models.
- Orally active Cu2+/Zn2+ SOD1 inhibitor with reported IC50 ~17.5 nM in endothelial cells.
- High affinity copper binder, showing selectivity against Ca, Fe, Mg, Zn, and Mn up to 1 mM.
- Inhibits proliferation of HUVEC cells (IC50 ~1.4 μM) and purified SOD1 (IC50 ~0.33 μM after 24 h).
- Time-dependent SOD1 inhibition, reaching maximal effect at ~16 hours.
- Demonstrated inhibition of angiogenesis in Matrigel plug models in mice.
Medchemexpress LLC 18-Azido-stearic acid | 1529763-58-3 | C18H35N3O2 | 25 MG
18-Azido-stearic acid is a click chemistry reagent containing an azide group. It can be used as a hydrophobic bioconjugation linker and further modified at the azido-position using Click-chemistry. It can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups or ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
- Purity: 95.0%
- Appearance: Solid
- Color: White to off-white
- Solubility (in vitro): DMSO: 100 mg/mL (307.23 mM; need ultrasonic)
Medchemexpress LLC MD-224 10mM | 10MM 1ML
MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept MD-224 consists of ligands for Cereblon and MDM2 MD-224 induces rapid degradation of MDM2 at concentrations 1 nM in human leukemia cells and achieves an IC50 value of 1 5 nM in inhibition of growth of RS4 11 cells MD-224 has the potential to be a new class of anticancer agent[1] MD-224 is a click chemistry reagent it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Medchemexpress LLC 18-azido-stearic acid | 1529763-58-3 | MFCD35066654 | ≥95.0% | 325.49 g/mol | C18H35N3O2 | 10 MG
18-Azido-stearic acid is an azide-functionalized long-chain fatty acid used as a hydrophobic bioconjugation linker for click chemistry. It enables efficient attachment of lipophilic tags or cargos to biomolecules via copper-catalyzed or strain-promoted azide-alkyne cycloaddition, and is supplied as a stable powder for laboratory research use.
- Contains a terminal azide functional group for click reactions.
- Compatible with CuAAC and SPAAC bioconjugation methods.
- Hydrophobic stearic backbone facilitates membrane incorporation or lipophilic tagging.
- Solid powder form with recommended storage for long-term stability.
- Available in small milligram pack sizes suitable for research applications.