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ATN-224 (bis(choline)tetrathiomolybdate) is an orally active Cu2+/Zn2+-dependent superoxide dismutase 1 (SOD1) inhibitor used in research to modulate copper-dependent enzymatic activity and angiogenesis. It inhibits SOD1 activity in endothelial and tumor cells and has been characterized in cellular and in vivo models.
Orally active Cu2+/Zn2+ SOD1 inhibitor with reported IC50 ~17.5 nM in endothelial cells.
High affinity copper binder, showing selectivity against Ca, Fe, Mg, Zn, and Mn up to 1 mM.
Inhibits proliferation of HUVEC cells (IC50 ~1.4 μM) and purified SOD1 (IC50 ~0.33 μM after 24 h).
Time-dependent SOD1 inhibition, reaching maximal effect at ~16 hours.
Demonstrated inhibition of angiogenesis in Matrigel plug models in mice.
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MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept MD-224 consists of ligands for Cereblon and MDM2 MD-224 induces rapid degradation of MDM2 at concentrations 1 nM in human leukemia cells and achieves an IC50 value of 1 5 nM in inhibition of growth of RS4 11 cells MD-224 has the potential to be a new class of anticancer agent[1] MD-224 is a click chemistry reagent it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
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18-Azido-stearic acid is an azide-functionalized long-chain fatty acid used as a hydrophobic bioconjugation linker for click chemistry. It enables efficient attachment of lipophilic tags or cargos to biomolecules via copper-catalyzed or strain-promoted azide-alkyne cycloaddition, and is supplied as a stable powder for laboratory research use.
Contains a terminal azide functional group for click reactions.
Compatible with CuAAC and SPAAC bioconjugation methods.
Hydrophobic stearic backbone facilitates membrane incorporation or lipophilic tagging.
Solid powder form with recommended storage for long-term stability.
Available in small milligram pack sizes suitable for research applications.
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