C24-propyl sterols and derivatives
Stigmasterol 90.0+%, TCI America™
CAS: 83-48-7 Molecular Formula: C29H48O Molecular Weight (g/mol): 412.70 MDL Number: MFCD00003630 InChI Key: HCXVJBMSMIARIN-PHZDYDNGSA-N Synonym: stigmasterol,stigmasterin,beta-stigmasterol,stigmasta-5,22-dien-3beta-ol,24s-5,22-stigmastadien-3beta-ol,unii-99wuk5d0y8,stigmasta-5,22e-dien-3beta-ol,stigmasta-5,22-dien-3-beta-ol,3beta,22e-stigmasta-5,22-dien-3-ol,stigmasta-5,22-dien-3-ol, 3b,22e PubChem CID: 5280794 ChEBI: CHEBI:28824 IUPAC Name: (1R,3aS,3bS,7S,9aR,9bS,11aR)-1-[(2R,3E,5S)-5-ethyl-6-methylhept-3-en-2-yl]-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-ol SMILES: CC[C@H](\C=C\[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C
Stigmasterol, 95%, Thermo Scientific Chemicals
CAS: 83-48-7 Molecular Formula: C29H48O Molecular Weight (g/mol): 412.70 MDL Number: MFCD00003630 InChI Key: HCXVJBMSMIARIN-PHZDYDNGSA-N Synonym: stigmasterol,stigmasterin,beta-stigmasterol,stigmasta-5,22-dien-3beta-ol,24s-5,22-stigmastadien-3beta-ol,unii-99wuk5d0y8,stigmasta-5,22e-dien-3beta-ol,stigmasta-5,22-dien-3-beta-ol,3beta,22e-stigmasta-5,22-dien-3-ol,stigmasta-5,22-dien-3-ol, 3b,22e PubChem CID: 5280794 ChEBI: CHEBI:28824 IUPAC Name: (3S,8S,9S,10R,13R,14S,17R)-17-[(E,2R,5S)-5-ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol SMILES: CC[C@H](\C=C\[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C
Kyfora Bio Stigmasterol 1 GR
Stigmasterol is a naturally occurring phytosterol lipid that is growing in the bioprocessing space for its ability to improve lipid nanoparticle (LNP) uptake efficiency. LNPs are well known for facilitating the safe and effective delivery of mRNA to target cells, thus enabling therapeutic action. Cholesterol derivatives like stigmasterol offer two major benefits to LNP formulations: they can improve the stability of the LNP and they can increase the cellular uptake efficiency both in cell cultures and in vivo. Kyfora Bio's high purity, transfection grade stigmasterol can be used in conjunction with our other cationic lipid products to provide reliable performance for a variety of bioprocessing applications.Key application(s): LNP, mRNA vaccine
AdipoGen Stigmasterol (1 g)
Chemical. CAS: 83-48-7. Formula: C29H48O. MW: 412.7. Synthetic. Originally isolated from various plants and marine organisms. Anti-hypercholestrolemic compound. Anti-inflammatory and immune-modulating effects. Anticancer compound. Chemopreventive. Cytostatic. Cell growth inhibitor. Antimutagenic. Potent in vitro antagonist of FXR (farnesoid X receptor). DNA polymerase beta inhibitor. Potent antioxidant, hypoglycemic and thyroid inhibiting agent. Anti-osteoarthritic. Decreases the expression of matrix metalloproteinases. Neuroprotective. Is used as a precursor for synthetic progesterone and vitamin D3 and is an intermediate in the biosynthesis of androgens, estrogens and corticoids.
Kyfora Bio STEMS (Stigmasterol Hemisuccinate) 1 GR
Stigmasterol hemisuccinate (STEMS) is a stigmasterol derivative that is responsive to changes in pH. Stigmasterol is a naturally occurring phytosterol lipid that is growing in the bioprocessing space for its ability to improve lipid nanoparticle (LNP)-based mRNA transfection efficiency. Conjugation to hemiscuccinate has been shown to improve the cellular uptake in acidic microenvironments, such as those around tumors.Key application(s): LNP, acid-delivery systems
Indofine Chemical STIGMASTEROL, Lipid Research, 83-48-7, 98+%, 1 gm
STIGMASTEROL, Lipid Research, 83-48-7, 98+%, 1 gm
Medchemexpress LLC Sertraline hydrochloride | 79559-97-0 | MFCD00895772 | 99.9% | 1 ML
Sertraline hydrochloride is an antidepressant classified as a selective serotonin reuptake inhibitor (SSRI). It is currently being researched for the treatment of various conditions, including major depressive disorder and obsessive-compulsive disorder.
- Shows spermicidal activity against human spermatozoa.
- Inhibits microglial activation and inflammatory mediator production.
- Produces anti-depression effects in CUMS-exposed mice.
- Reduced immobility time during forced swim test in female animals.
Medchemexpress LLC Stigmasta-5,22-dien-3-ol, (3β,22E)- | 83-48-7 | 98.5% | 412.69 | 1 G
Stigmasterol is an orally active, immunomodulatory agent with anti-inflammatory and neuroprotective effects. It can cross the blood-brain barrier. It activates AMPK, inhibiting NF-κB and NLRP3 signaling pathways. Stigmasterol reduces microglia-mediated neuroinflammation and alleviates cognitive impairment and Alzheimer's disease. It also regulates M1/M2 polarization of microglia through the TLR4/NF-κB pathway, reducing neuropathic pain.
- Orally active immunomodulatory agent
- Exhibits anti-inflammatory effects
- Neuroprotective properties
- Crosses the blood-brain barrier
- Activates AMPK
- Inhibits NF-κB and NLRP3 signaling pathways
- Reduces microglia-mediated neuroinflammation
- Alleviates cognitive impairment and Alzheimer's disease
- Regulates M1/M2 polarization of microglia
- Reduces neuropathic pain
Medchemexpress LLC Stigmasterol-d6 | 97.2% | 418.73 | C29H42D6O | 2.5mg
Stigmasterol-d6 is deuterium-labeled Stigmasterol (HY-N0131)[1]
Selleck Chemical LLC Sertraline HCl S4053-10mg
Sertraline HCl (CP-51974-1) is a 5-HT antagonist with Ki of 13 nM
Selleck Chemical LLC Sertraline HCl S4053-50mg
Sertraline HCl (CP-51974-1) is a 5-HT antagonist with Ki of 13 nM
TARGETMOL CHEMICALS INC Sertraline hydrochloride 25MG
Also available in 1 mL, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg and bulk. Please contact Fisher for quotes. Sertraline hydrochloride (Sertraline HCl) is a selective serotonin uptake inhibitor that is used in the treatment of depression. Purity 99.86%
Medchemexpress LLC Sertraline hydrochloride | 79559-97-0 | >99.9% | 342.69 | 10 MG
Sertraline hydrochloride is an antidepressant classified as a selective serotonin reuptake inhibitor (SSRI). It is researched for various conditions such as major depressive disorder and obsessive-compulsive disorder.
- Functions as a selective serotonin reuptake inhibitor (SSRI) antidepressant.
- Researched for major depressive disorder and obsessive-compulsive disorder.
- Inhibits high mobility group box 1 (HMGB1)- or tumor necrosis factor-α (TNF-α)-induced microglial activation.
- Produces optimal anti-depression effects in chronic unpredictable mild stress (CUMS)-exposed mice.
- Significantly reduces immobility time during forced swim test in female animals.
- Does not alter spontaneous locomotor activity in all three genotypes regardless of sex difference.