Organic phosphoric acids and derivatives
Medchemexpress LLC KN-93 (phosphate) | 1913269-12-1 | C26H32CIN2O8PS | 100 MG
KN-93 phosphate is a cell-permeable, reversible, and competitive inhibitor of calmodulin-dependent kinase type II (CaMKII) with a Ki of 370 nM. It is intended for research use only and is not sold to patients.
- Cell cycle arrest: after 2 days of KN-93 treatment, 95% of cells are arrested in G1.
- Growth inhibition: blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts.
- H+, K+-ATPase inhibition: inhibits H+, K+-ATPase activity, strongly dissipates the proton gradient formed in gastric membrane vesicles, and reduces the volume of luminal space.
- Early afterdepolarization prevention: prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations, and prevents the increase in Ca2+-independent CaM kinase activity.
TARGETMOL CHEMICALS INC KN-92 PHOSPHATE 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. KN-92 phosphate (KN92-H3PO4) is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII) competitively blocking CaM binding to the kinase (Ki = 370 nM). purity: 99%
Apexbio Technology LLC Sitagliptin phosphate monohydrate 654671-77-9 10mM (in 1mL DMSO)
Sitagliptin phosphate monohydrate (CAS 654671-77-9) is a phosphate salt hydrate form of sitagliptin a selective inhibitor of dipeptidyl peptidase-4 (DPP-4) DPP-4 catalyzes the hydrolysis of peptides with proline or alanine residues at their N-terminal ends By inhibiting DPP-4 (IC50 18 nM) without interacting with related enzymes such as DPP-8 and DPP-9 sitagliptin increases circulating levels of glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP) It is actively explored in studies investigating therapeutic interventions for type 2 diabetes
Medchemexpress LLC L-Glutamic acid, N-(3-carboxy-1-oxopropyl)-, 1,5-dihexadecyl ester | 125401-63-0 | C41H77NO7 | 250 MG
1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate is a lipid utilized in the synthesis of phospholipid vesicles. It collaborates with other lipids to transform polydisperse vesicles into uniformly sized vesicles through freeze-thaw and extrusion techniques. This compound has the capability to enhance protein encapsulation efficiency, making it suitable for drug delivery and various biochemical applications.
- Used in the synthesis of phospholipid vesicles.
- Collaborates with other lipids to convert polydisperse vesicles into uniformly sized vesicles.
- Utilizes freeze-thaw and extrusion techniques for vesicle formation.
- Enhances protein encapsulation efficiency.
- Suitable for drug delivery.
- Suitable for biochemical applications.
Apexbio Technology LLC Baricitinib phosphate(Synonyms: Baricitinib phosphate, Olumiant phosphate, LY3009104 phosphate, INCB028050 phosphate), 50mg, CAS: 1187595-84-1.
Baricitinib phosphate (CAS 1187595-84-1) known as INCB028050 is an orally bioavailable small molecule inhibitor targeting Janus kinases JAK1 and JAK2 It selectively inhibits JAK1 and JAK2 with IC50 values of approximately 5 9 nM and 5 7 nM respectively exhibiting roughly 10-fold lower potency towards JAK3 and Tyk2 and lacking inhibition against c-Met and Chk2 By suppressing JAK1/2-mediated signaling baricitinib phosphate reduces signal transduction induced by proinflammatory cytokines such as IL-6 and IL-23 in vitro Preclinical studies in rodent arthritis models indicate notable therapeutic activity with minimal evidence of adverse hematological or immunosuppressive effects This compound is used widely in biomedical research for investigating inflammatory pathways in autoimmune disease models
![eMolecules 1147124-23-9 | 6,6'-Dibromo-1,1'-bis(2-ethylhexyl)-[3,3'-biindolinylidene]-2,2'-dione | MFCD28125575 | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502132861.JPG-250.jpg)
eMolecules 1147124-23-9 | 6,6'-Dibromo-1,1'-bis(2-ethylhexyl)-[3,3'-biindolinylidene]-2,2'-dione | MFCD28125575 | 1g
ChemScene | 3-Bromo-2-(methylsulfonyl)pyridine | 1g | 632307110 | CS-0162546 | 1209459-95-9 | 236.080 | C6H6BrNO2S
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Medchemexpress LLC Rucaparib phosphate | 459868-92-9 | 99.7% | 421.36 g/mol | C19H21FN3O5P | 10 MG
Rucaparib phosphate is the phosphate salt of rucaparib, a potent orally active inhibitor of poly(ADP-ribose) polymerases (PARP-1, PARP-2, PARP-3) used in preclinical research. Supplied as a high-purity solid with recommended sealed storage, the product is available in multiple pack sizes including a 10 mg solid and DMSO solutions for assay use.
- Potent inhibitor of PARP-1, PARP-2, and PARP-3 with low nanomolar activity.
- High purity suitable for biochemical and cell-based assays.
- Available as small solid packs and ready-to-use DMSO solutions.
- Stable when stored sealed and kept away from moisture.
- Suitable for research on DNA damage response and cancer models.