Organic sulfuric acids and derivatives
Medchemexpress LLC Netilmicin (sulfate) | 56391-57-2 | 98.0% | C21H41N5O7.5/2H2SO4 | 5 MG
Netilmicin (sulfate) | 56391-57-2 | 98.0% | C21H41N5O7.5/2H2SO4 | 5 MG
Medchemexpress LLC Chondroitin sulfate | 9007-28-7 | 98.6% | 1 G
Chondroitin sulfate | 9007-28-7 | 98.6% | 1 G
Medchemexpress LLC S65487 sulfate | 2416937-01-2 | 99.35% | 815.33 | 25 MG
S65487 sulfate is a potent and selective Bcl-2 inhibitor and a proagent of S55746. It is active on BCL-2 mutations like G101V and D103Y, but shows poor affinity with MCL-1, BFL-1, and BCL-XL. This compound induces apoptosis and exhibits anticancer activities.
- Potent and selective Bcl-2 inhibitor
- Proagent of a related compound
- Active on BCL-2 mutations (e.g., G101V, D103Y)
- Shows poor affinity with MCL-1, BFL-1, and BCL-XL
- Induces apoptosis in hematological cancer cell lines
- Inhibits cell proliferation with IC50s in the low nM range
- Induces complete regression in BCL-2-dependent RS4;11 tumors in vivo
- Causes strong and persistent tumor regression in xenograft models of lymphoid malignancies when combined with a MCL-1 specific inhibitor
Chem-Impex International, Inc. Ethylenesulfate | 1072-53-3 | MFCD00221769 | 25G
Ethylenesulfate, 1072-53-3, MFCD00221769, 25G
Chemscene ChemScene | Diethyl (difluoromethyl)phosphonate | 25G | CS-0094054 | 0.98 | 1478-53-1| MFCD00192023 | 188.11
ChemScene | Diethyl (difluoromethyl)phosphonate | 25G | CS-0094054 | 0.98 | 1478-53-1| MFCD00192023 | 188.11
Medchemexpress LLC Selumetinib sulfate | 943332-08-9 | 99.58% | C17H17BrClFN4O7S | 1 G
Selumetinib sulfate is a selective, non-ATP-competitive oral MEK1/2 inhibitor, with an IC50 of 14 nM for MEK1. It inhibits ERK1/2 phosphorylation and can penetrate the blood-brain barrier (BBB).
- Causes a time- and dose-dependent reduction in DNA synthesis and cell viability
- Induces growth arrest and apoptosis associated with the inactivation of ERK in primary cells
- Shows anti-proliferative effects through G0/G1 arrest
- Results in growth inhibition of cell lines containing B-Raf and Ras mutations
- Decreases the growth rate of xenografts in a dose-dependent manner
- Suppresses the growth of xenografts
- Inhibits ERK1/2 phosphorylation and growth of xenograft tumors in nude mice
- Tumor regressions observed in xenograft models
Medchemexpress LLC Colistin, sulfate (salt) | 1264-72-8 | >98.0% | C52H98N16O13.2.5H2O4S | 1 ML
Colistin sulfate is a polypeptide antibiotic that inhibits gram-negative bacteria by binding to lipopolysaccharides and phospholipids in their outer cell membrane. It is intended for research use only.
- Polypeptide antibiotic
- Inhibits gram-negative bacteria by binding to lipopolysaccharides and phospholipids in their outer cell membrane, and by electrostatically interfering with the outer membrane by competitively displacing divalent cations from the negatively charged phosphate groups of membrane lipids
- Bactericidal to gram-negative bacteria with a narrow spectrum of activity
- Associated with slow development of resistance for treating infections caused by multidrug-resistant gram-negative bacteria
- Available as colistin (sulfate) mainly for topical use, and colistin methanesulfonate (sodium) for parenteral use
Medchemexpress LLC Bleomycin (sulfate) | 9041-93-4 | 99.9% | 1523 | 1 G
Bleomycin sulfate is a DNA synthesis inhibitor, a DNA damaging agent, and an antitumor antibiotic. It causes DNA lesions such as single and double-strand breaks and apurinic/apyrimidinic sites. It is considered a radiomimetic compound due to its genetic effects similar to ionizing radiation. It can be used to induce pulmonary fibrosis models.
- DNA synthesis inhibitor
- DNA damaging agent
- Antitumor antibiotic
- Induces DNA lesions like single and double-strand breaks
- Radiomimetic compound
- Used to induce pulmonary fibrosis models
- High bioavailability
- High plasma elimination and urinary excretion rates
Medchemexpress LLC Dextran sulfate sodi 500mg | 9011-18-1 | 16,000-24,000 Da | 500 MG
Dextran sulfate sodium salt (MW 16,000-24,000) is a sulfated polysaccharide reagent used in research to modulate innate immune signaling, reported to induce STING polymerization and TBK1 activation. It is supplied as a white to off-white solid and is formulated for laboratory use with defined solubility and storage conditions.
- Polymer average molecular weight 16,000-24,000.
- White to off-white solid form.
- High water solubility: 100 mg/mL (requires ultrasonic).
- Low DMSO solubility: <1 mg/mL.
- Recommended storage: powder -20°C (3 years) or 4°C (2 years).
- Intended for research use only.
Medchemexpress LLC Minoxidil sulfate | 83701-22-8 | 98.0% | 25 MG
Minoxidil sulfate is a potent and ATP-sensitive K+ channel opener. It is the sulfated metabolite of minoxidil and is considered a vasodilator that promotes hair growth in vivo.
- Potent and ATP-sensitive K+ channel opener
- Sulfated metabolite of minoxidil
- Considered a vasodilator to promote hair growth in vivo