Azobenzenes
Medchemexpress LLC WWL113 | 947669-86-5 | 99.7% | 466.53 | 1 ML
WWL113 is a selective and orally active Ces3 and Ces1f inhibitor, with IC50 values of 120 nM and 100 nM for Ces3 and Ces1f, respectively. It appears to show excellent selectivity for the 60-kDa serine hydrolase (or hydrolases).
- Inhibits mouse recombinant Ces1, Ces1c, and ABHD6 at 10 μM.
- Significantly increases UCP1 protein expression in brown adipocytes at 1 μM.
- Has a partial, statistically significant inhibitory effect on blocking the buildup of PGE2.
- Results in major improvement of multiple features of metabolic syndrome and ameliorated obesity-diabetes in mice with lowered levels of nonesterified free fatty acids (NEFAs), triglycerides (TGs), total cholesterol and fasted glucose as well as enhanced glucose tolerance (30 mg/kg, orally once a day).
- Ameliorates obesity-diabetes in mice.
Medchemexpress LLC PR5-LL-CM01, a protein arginine methyltransferase 5 (PRMT5) inhibitor | 1005307-86-7 | 98.4% | 401.51 | 1 ML
PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 7.5 μM. It exhibits anti-tumor activities. It has a range of IC50 at 2-4 μM in PDAC cells (PANC1, MiaPaCa2 and AsPC1) and 10-11 μM in CRC cells (HT29, HCT116 and DLD1). PR5-LL-CM01 specifically inhibits cancer cells with low toxicity in normal cells and strongly inhibits colony forming ability in PANC1 and HT29 cells. It also inhibits NF-κB activation and its target gene expression, dramatically decreasing TNFα and IL8 expression in both PANC1 and HT29 cells.
- Potent PRMT5 inhibitor.
- Exhibits anti-tumor activities.
- Low toxicity in normal cells.
- Strongly inhibits colony forming ability in PANC1 and HT29 cells.
- Inhibits NF-κB activation and its target gene expression.
- Decreases TNFα and IL8 expression.
Sigma Aldrich Fine Chemicals Biosciences 4-(Phenylazo)diphenylamine 97% | 101-75-7 | MFCD00003023 | 5G
4-(Phenylazo)diphenylamine 97% | Purity: 97% | Mol Wt: 273.33 | 101-75-7 | MFCD00003023 | 5G
Sigma Aldrich Fine Chemicals Biosciences Azobenzene 98% | 103-33-3 | MFCD00003022 | 25G
Azobenzene 98% | Purity: 98% | Mol Wt: 182.22 | 103-33-3 | MFCD00003022 | 25G
Medchemexpress LLC Methylglyoxal-bis(guanylhydrazone) | 459-86-9 | MFCD00067519 | ≥98.0% | 184.20 g·mol⁻¹ | C5H12N8 | 50 MG
Mitoguazone (methylglyoxal-bis(guanylhydrazone)) is a small-molecule research reagent that competitively inhibits S-adenosyl-methionine decarboxylase (SAMDC) and disrupts polyamine biosynthesis. It is used in biochemical and cellular studies to probe polyamine-dependent processes, mitochondrial effects, and apoptosis. Chemical identifiers include CAS 459-86-9, formula C5H12N8, and molecular weight 184.20 g·mol⁻¹.
- Competitive inhibitor of S-adenosyl-methionine decarboxylase (SAMDC).
- Disrupts polyamine biosynthesis for pathway and apoptosis research.
- Reported to be brain-penetrant and useful in cellular assays.
- Characterized chemical identifiers: CAS 459-86-9, formula C5H12N8, MW 184.20 g·mol⁻¹.
- Recommended storage sealed and away from moisture; in solvent: -80°C long-term, -20°C short-term.
- Reported supplier purity commonly ≥98% for research-grade material.
![Medchemexpress LLC 7-fluoro-6-methoxy-4-[6-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]quinol | 2248154-85-8 | MFCD32859311 | 99.4% | C26H30FN7O | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000260000.png-250.jpg)
Medchemexpress LLC 7-fluoro-6-methoxy-4-[6-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]quinol | 2248154-85-8 | MFCD32859311 | 99.4% | C26H30FN7O | 10MG
KER047 (ALK2-IN-4) is a potent small-molecule inhibitor of activin receptor-like kinase-2 (ALK2) intended for research use in the study of ALK2-mediated signaling and metabolic disorders such as fibrodysplasia ossificans progressiva (FOP). The compound is provided in solid and solution formats for in vitro and preclinical investigations.
- Potent ALK2 inhibitor with demonstrated activity in research assays.
- Suitable for research into metabolic disease models, including FOP.
- High purity (99.4%) for reproducible experimental results.
- Available as solid powder and 10 mM solutions in DMSO for flexible dosing.
- Chemical formula C26H30FN7O and molecular weight 475.56 g/mol.
- Stable storage recommendations: powder at -20°C or 4°C; in solvent at -80°C or -20°C.
eMolecules 21272-85-5 | Ambeed | Nitromethylphenylsulfone | 250mg | 686660269 | A592579 | MFCD00015928 | 201.2 | C7H7NO4S
Medchem Express | NNMTi | 5mg | 569407541 | HY-131042 | 42464-96-0 | 286.116 | C10H11IN2
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eMolecules 102562-86-7 | 3-(AMINOMETHYL)BENZAMIDE | AstaTech | MFCD07186292 | 150.181 | C8H10N2O | 96.000 | NCc1cccc(c1)C(N)=O | 0.25g | 416218579
3-(AMINOMETHYL)BENZAMIDE | AstaTech | 102562-86-7 | MFCD07186292 | 150.181 | C8H10N2O | 96.000 | NCc1cccc(c1)C(N)=O | 0.25g | 416218579
eMolecules 20197-86-8 | ChemScene | 2-Chloro-67-dimethoxyquinazolin-4(3H)-one | 100mg | 718356728 | CS-0226197 | MFCD08458256 | 240.64 | C10H9ClN2O3
Ambeed | 5-Amino-1-(tert-butyl)-1H-pyrazol-3-ol | 250mg | 491641310 | A210752 | 359867-35-9 | MFCD14607822 | 155.201 | C7H13N3O
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Medchemexpress LLC 2-(3-oxo-1-phenyl-3-(4-(trifluoromethyl)phenyl)propyl)malonic acid | 1221962-86-2 | 98.0% | 10 MG
PS210 is a small-molecule activator of PDK1 provided for research use. It binds the PIF-binding pocket of PDK1 and is supplied as a solid or as a 10 mM solution in DMSO for in vitro studies.
- Small-molecule PDK1 activator for research use.
- Solid and 10 mM DMSO solution formats available.
- High purity (~98.0%) confirmed by supplier analytical data.
- Molecular weight 380.31 g/mol; formula C19H15F3O5.
- Supplied in small milligram quantities suitable for biochemical assays.
Medchemexpress LLC 1-(3-fluorophenyl)-5-methylpyridin-2(1H)-one | 848353-85-5 | 99.8% | 50 MG
Fluorofenidone (AKF-PD) is an orally active small-molecule research compound with reported anti-fibrotic, antioxidant, and anti-inflammatory effects. Supplied as a purified analytical standard suitable for in vitro and in vivo studies and commonly provided as a 50 mg pack.
- Orally active small molecule with anti-fibrotic and anti-inflammatory activity.
- Demonstrated cellular effects (e.g., NIH/3T3 IC50 ~2.75 mM) and in vitro activity in lung and cancer cell lines.
- Shows protective effects in rodent models of lung injury, cholestasis, and fibrosis.
- High purity suitable for analytical and preclinical research applications.
- Molecular formula C12H10FNO; molecular weight 203.21 g/mol.
Medchemexpress LLC PR5-LL-CM01 | 1005307-86-7 | 98.4% | 401.51 | 50 MG
PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 7.5 μM. It exhibits anti-tumor activities and demonstrates efficacy in inhibiting cancer cells while showing low toxicity in normal cells.
- Has IC50 values ranging from 2-4 μM in PDAC cells (PANC1, MiaPaCa2, and AsPC1) and 10-11 μM in CRC cells (HT29, HCT116, and DLD1).
- Strongly inhibits colony-forming ability in both PANC1 and HT29 cells.
- Inhibits NF-κB activation and its target gene expression in PDAC and CRC cells.
- Significantly decreases TNFα and IL8 expression in both PANC1 and HT29 cells (at 0-15 μM).
- Shows significant anti-tumor effects in PANC1 and HT29 xenografted mice in vivo (20 mg/kg; i.p.; 3 times per week) without visibly affecting their body weight.
eMolecules 2374958-85-5 | Ambeed | (4S4S)-44-Diisopropyl-11-di-m-tolyl-4455-tetrahydro-1H1H-22-biimidazole | 100mg | 714083376 | A1501171 | 402.586 | C26H34N4
Pharmablock | 2-methoxy-4-methyl-1H-pyrimidin-6-one | 25mg | 784547466 | PBT8844 | 55996-28-6 | MFCD16988156 | 140.142 | C6H8N2O2
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Medchemexpress LLC KG5 | 877874-85-6 | C20H16F3N7OS | 100 MG
KG5 is an orally active dual PDGFRβ and B-Raf allosteric inhibitor, also inhibiting Flt3, KIT, and c-Raf. It demonstrates anticancer and antiangiogenic activities.
- Inhibits vascular smooth muscle cells and endothelial cells viability
- Selectively blocks S338 phosphorylation
- Inhibits PDGFRα, PDGFRβ, Flt3, and KIT
- Prevents tumor growth in an orthotopic renal cell carcinoma model
- Completely blocks angiogenesis in mice
- Disrupts angiogenesis during zebrafish embryogenesis
eMolecules 944904-85-2 | ChemScene | 1-(5-(Trifluoromethyl)pyridin-3-yl)ethanone | 100mg | 632294631 | CS-0155107 | MFCD10696266 | 189.137 | C8H6F3NO
ChemScene | 1-(5-(Trifluoromethyl)pyridin-3-yl)ethanone | 100mg | 632294631 | CS-0155107 | 944904-85-2 | MFCD10696266 | 189.137 | C8H6F3NO