Azobenzenes
amino]-N-phenyl | 2305052-86-0 | 98.8% | C21H17ClN4O2 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC 2-Pyridinecarboxamide, 5-[[(6-chloro-2-pyridinyl)methyl](1-oxo-2-propen-1-yl)amino]-N-phenyl | 2305052-86-0 | 98.8% | C21H17ClN4O2 | 100 MG
BPK-25 is an active acrylamide that promotes the degradation of nucleosome remodeling and deacetylation (NuRD) complex proteins through a post-translational mechanism involving covalent protein engagement. It also inhibits TMEM173 activation by the cyclic dinucleotide ligand cGAMP.
- Promotes degradation of NuRD complex proteins.
- Inhibits TMEM173 activation.
- Active acrylamide.
- Intended for research and analytical applications.
![Medchemexpress LLC 2-methylsulfanyl-6-[4-[3-[3-(trifluoromethyl)anilino]-1H-1,2,4-triazol-5-yl]phenoxy]pyrimidin-4-amin | 877874-85-6 | MFCD22124522 | 99.8% | 459.45 | C20H16F3N7OS | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000287497.png-250.jpg)
Medchemexpress LLC 2-methylsulfanyl-6-[4-[3-[3-(trifluoromethyl)anilino]-1H-1,2,4-triazol-5-yl]phenoxy]pyrimidin-4-amin | 877874-85-6 | MFCD22124522 | 99.8% | 459.45 | C20H16F3N7OS | 10 MG
KG5 is an orally active small-molecule allosteric inhibitor that targets PDGFRβ and B-Raf, with additional inhibitory activity against Flt3, KIT, and c-Raf. It demonstrates anticancer and antiangiogenic effects in cellular and animal models, including inhibition of MEK/ERK signaling and suppression of tumor growth and angiogenesis in vivo.
- Orally active allosteric inhibitor of PDGFRβ and B-Raf.
- Also inhibits Flt3, KIT, and c-Raf, broadening kinase coverage.
- Demonstrated anticancer and antiangiogenic activity in vitro and in vivo.
- Disrupts MEK/ERK phosphorylation and blocks S338 phosphorylation in endothelial cells.
- Potent cellular activity with EC50 values near 0.5-0.6 μM in vascular and endothelial cells.
- High purity suitable for research applications.
- Soluble in DMSO at high concentration and formulatable for in vivo dosing.
- Stable under recommended storage conditions to preserve activity.
Medchemexpress LLC Ker047 (ALK2-IN-4) | 2248154-85-8 | 98.8% | 475.56 | 50 MG
KER047 (ALK2-IN-4) is a potent activin receptor-like kinase-2 (ALK2) inhibitor. It can be used for research into metabolic diseases such as fibrodysplasia ossificans progressiva (FOP).
- Potent activin receptor-like kinase-2 (ALK2) inhibitor.
- Used for research of metabolic disease, specifically fibrodysplasia ossificans progressiva (FOP).
Medchemexpress LLC Lys006 hydrochloride | 2619563-79-8 | 429.23 | 50 MG
LYS006 hydrochloride is a potent inhibitor of leukotriene A4 hydrolase (LTA4H) with an IC50 of 2 nM. It is extracted from patent WO2015092740A1, example 29, and is for research use only. It can be used for the research of inflammatory and autoimmune disorders.
- Potent inhibitor of LTA4H hydrolase
- IC50 of 2 nM
- Used for research on inflammatory and autoimmune disorders
- Currently in Phase 2 clinical trials for inflammatory acne, ulcerative colitis, hidradenitis suppurativa, and non-alcoholic fatty liver disease/nonalcoholic steatohepatitis
Medchemexpress LLC Nimbin | 5945-86-8 | 5 MG
Nimbin is an orally active intermediate limonoid found in Azadirachta. It prevents tau aggregation, increases cell viability, and effectively inhibits the envelope protein of the dengue virus. It possesses anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer, and anti-viral properties, showing promise for research into neurodegenerative diseases and viral infections.
- Orally active intermediate limonoid
- Prevents tau aggregation and increases cell viability
- Effective inhibitor of the dengue virus envelope protein
- Anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer, and anti-viral properties
- Promising for research of neurodegenerative diseases and viral infections
Medchemexpress LLC Valategrast (R-411 free base) | 220847-86-9 | 97.1% | C30H32Cl3N3O4 | 50 MG
Valategrast (R-411 free base) is a potent and orally active integrin α4β1 (VLA-4) and α4β7 dual antagonist. It is being investigated for its potential in treating Chronic Obstructive Pulmonary Disease (COPD) and asthma. It contains a common l-phenylalanine-N-aroyl motif where the carboxylic acid binds to the metal ion in the metal-ion-dependent adhesion site (MIDAS).
- Potent and orally active integrin α4β1 (VLA-4) and α4β7 dual antagonist.
- Potential for treating Chronic Obstructive Pulmonary Disease (COPD).
- Potential for treating asthma.
- Contains an l-phenylalanine-N-aroyl motif for binding to the metal ion in the MIDAS site.
Medchemexpress LLC Manool | 596-85-0 | 290.48 | 100 MG
Manool is a diterpene derived from *Salvia officinalis*. It selectively induces cytotoxicity in cancer cells and arrests them at the G(2)/M phase of the cell cycle. For research use only.
- Diterpene from *Salvia officinalis*.
- Induces selective cytotoxicity in cancer cells.
- Arrests cancer cells at the G(2)/M phase of the cell cycle.
- Exhibits higher cytotoxic activity against HeLa (IC50=6.7 μg/mL) and U343 (IC50=6.7 μg/mL) cells.
- Shows a protective effect against chromosome damage induced by MMS in HepG2 cells.
Cayman Chemical Sulfasalazine 5g
A prodrug form of 5-aminosalicylic acid; inhibits TNF-α and LPS-induced NF-κB activation in SW620 colon cancer cells at 0.1-5 mM; inhibits cystine uptake through the system xc- cysteine-glutamate transporter at 0.25 mM and inhibits the growth of U-87MG glioma cells in an NF-κB independent manner at 0.25-1 mM; decreases diarrhea, increases food intake, and reverses body weight decreases in a mouse model of colitis at 100 mg/kg; suppresses antigen-induced arthritis in mice
Chemscene ChemScene | Methyl 6-formylnicotinate | 5G | CS-D0517 | 0.98 | 10165-86-3| MFCD08275010 | 165.15
ChemScene | Methyl 6-formylnicotinate | 5G | CS-D0517 | 0.98 | 10165-86-3| MFCD08275010 | 165.15
Medchemexpress LLC GSK1702934A | 924377-85-5 | 99.11% | 395.52 | 10 MG
GSK1702934A is a selective agonist for TRPC3, a transient receptor potential canonical channel. It plays a role in modulating cardiac contractility and arrhythmogenesis through the activation of TRPC3. In vitro studies have shown its ability to induce TRPC3/6-currents in HEK293 cells, with EC50 values of 0.08 mM for TRPC3 and 0.44 mM for TRPC6. It also induces transient, non-selective conductance and prolonged action potentials in TRPC3-overexpressing myocytes, and promotes NCX currents. In vivo, GSK1702934A has been observed to transiently increase blood pressure in conscious Sprague Dawley rats at doses ranging from 0.3-3 mg/kg.
- Acts as a selective agonist for TRPC3.
- Modulates cardiac contractility and arrhythmogenesis by activating TRPC3.
- Induces TRPC3/6-currents in HEK293 cells.
- Promotes NCX currents in TRPC3-overexpressing myocytes.
- Increases blood pressure in vivo in animal models.
![Medchemexpress LLC 5-chloro-2-fluoro-4-[(1S,2R)-2-(2-methylpyrazol-3-yl)cyclohexyl]oxy-N-pyrimidin-4-ylbenzenesulfonamide | 1450595-86-4 | Not found on authoritative sources | 99.6% | C20H21ClFN5O3S | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000259338.png-250.jpg)
Medchemexpress LLC 5-chloro-2-fluoro-4-[(1S,2R)-2-(2-methylpyrazol-3-yl)cyclohexyl]oxy-N-pyrimidin-4-ylbenzenesulfonamide | 1450595-86-4 | Not found on authoritative sources | 99.6% | C20H21ClFN5O3S | 10MG
DS-1971a is a potent, selective, and orally active NaV1.7 inhibitor used in pain research. It shows low-nanomolar inhibition of human NaV1.7, activity in rodent models, and has demonstrated analgesic effects in preclinical studies.
- Potent NaV1.7 inhibition: hNaV1.7 IC50 = 22.8 nM; mNaV1.7 IC50 ≈ 59.4 nM.
- Orally active with reported analgesic effects in preclinical models.
- High purity, typically 99.6% by supplier specification.
- Defined chemical identity: CAS 1450595-86-4; formula C20H21ClFN5O3S; MW 465.93 g·mol⁻¹.
- Soluble in DMSO and compatible with common in vivo formulation vehicles.
- Stable as a solid with recommended refrigerated or frozen storage for long-term retention.
Medchemexpress LLC Ker047 (ALK2-IN-4) | 2248154-85-8 | 98.8% | 475.56 | 100 MG
Ker047 (ALK2-IN-4) is a potent activin receptor-like kinase-2 (ALK2) inhibitor. It is utilized in the research of metabolic diseases, including fibrodysplasia ossificans progressiva (FOP).
- High purity of 98.8%
- Soluble in DMSO at 10 mg/mL
- Stable as powder for up to 3 years at -20°C
- Stable in solvent for up to 2 years at -80°C
- Documentation available for data, safety, and handling
![Medchemexpress LLC 7-fluoro-6-methoxy-4-[6-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]quinol | 2248154-85-8 | MFCD32859311 | 99.4% | C26H30FN7O | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000260000.png-250.jpg)
Medchemexpress LLC 7-fluoro-6-methoxy-4-[6-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]quinol | 2248154-85-8 | MFCD32859311 | 99.4% | C26H30FN7O | 10MG
KER047 (ALK2-IN-4) is a potent small-molecule inhibitor of activin receptor-like kinase-2 (ALK2) intended for research use in the study of ALK2-mediated signaling and metabolic disorders such as fibrodysplasia ossificans progressiva (FOP). The compound is provided in solid and solution formats for in vitro and preclinical investigations.
- Potent ALK2 inhibitor with demonstrated activity in research assays.
- Suitable for research into metabolic disease models, including FOP.
- High purity (99.4%) for reproducible experimental results.
- Available as solid powder and 10 mM solutions in DMSO for flexible dosing.
- Chemical formula C26H30FN7O and molecular weight 475.56 g/mol.
- Stable storage recommendations: powder at -20°C or 4°C; in solvent at -80°C or -20°C.
Medchemexpress LLC Catalposide | 6736-85-2 | 5 MG
Catalposide is an iridoid glycoside isolated from Catalpa ovata G. Don (Bignoniaceae). It inhibits the production of TNF-α, IL-1β, and IL-6, and also suppresses NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages. It is intended for research use only.
- Purity of 98.0%
- Inhibits TNF-α, IL-1β, and IL-6 production
- Suppresses NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages
- Displays IC50 > 10 μM against human A2780, A549, BGC-823, Bel-7402, and HT-29 cells
- Isolated from Catalpa ovata G. Don (Bignoniaceae)
eMolecules 2374958-85-5 | Ambeed | (4S4S)-44-Diisopropyl-11-di-m-tolyl-4455-tetrahydro-1H1H-22-biimidazole | 100mg | 714083376 | A1501171 | 402.586 | C26H34N4
Pharmablock | 2-methoxy-4-methyl-1H-pyrimidin-6-one | 25mg | 784547466 | PBT8844 | 55996-28-6 | MFCD16988156 | 140.142 | C6H8N2O2
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