Azobenzenes
amino]-N-phenyl | 2305052-86-0 | MFCD06761688 | 99.9% | C21H17ClN4O2 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000259801.png-250.jpg)
Medchemexpress LLC 2-pyridinecarboxamide, 5-[[(6-chloro-2-pyridinyl)methyl](1-oxo-2-propen-1-yl)amino]-N-phenyl | 2305052-86-0 | MFCD06761688 | 99.9% | C21H17ClN4O2 | 10MG
BPK-25 is an acrylamide-containing small-molecule research reagent that promotes degradation of nucleosome remodeling and deacetylation (NuRD) complex proteins and inhibits TMEM173 (STING) activation, resulting in modulation of NF-κB signaling. Supplied as a high-purity solid for in vitro and biochemical research; not intended for human use.
- Promotes NuRD complex protein degradation by covalent protein engagement.
- Inhibits STING (TMEM173) activation by the cyclic dinucleotide cGAMP.
- High purity suitable for biochemical assays and in vitro studies.
- Supplied as an off-white to light yellow solid for convenient handling.
- Recommended storage: 4°C under nitrogen; in solvent: -80°C (6 months) or -20°C (1 month).
- For research use only; not for clinical or human use.
Medchemexpress LLC Valategrast (R-411 free base) | 220847-86-9 | 97.1% | C30H32Cl3N3O4 | 50 MG
Valategrast (R-411 free base) is a potent and orally active integrin α4β1 (VLA-4) and α4β7 dual antagonist. It is being investigated for its potential in treating Chronic Obstructive Pulmonary Disease (COPD) and asthma. It contains a common l-phenylalanine-N-aroyl motif where the carboxylic acid binds to the metal ion in the metal-ion-dependent adhesion site (MIDAS).
- Potent and orally active integrin α4β1 (VLA-4) and α4β7 dual antagonist.
- Potential for treating Chronic Obstructive Pulmonary Disease (COPD).
- Potential for treating asthma.
- Contains an l-phenylalanine-N-aroyl motif for binding to the metal ion in the MIDAS site.
Medchemexpress LLC Licarin A | 51020-86-1 | MFCD20260801 | 5 MG
Licarin A is a neolignan found in various plants, known for its anti-allergic and anti-inflammatory effects. It reduces TNF-α and PGD2 production by inhibiting PKCα/βII and p38 MAPK pathways.
- Significantly reduces TNF-α production in DNP-HSA-stimulated RBL-2H3 cells
- Exhibits anti-allergic effects
- Reduces PGD2 production and COX-2 expression
- Demonstrates anti-inflammatory effects
- Inhibits PKCα/βII and p38 MAPK pathways
- Found in plants like Aristolochia taliscana, Machilus thunbergii, and Myristica fragrans
Sigma Aldrich Fine Chemicals Biosciences 4-(Phenylazo)diphenylamine 97% | 101-75-7 | MFCD00003023 | 5G
4-(Phenylazo)diphenylamine 97% | Purity: 97% | Mol Wt: 273.33 | 101-75-7 | MFCD00003023 | 5G
Medchemexpress LLC Catalposide | 6736-85-2 | MFCD28015867 | 1 MG
Catalposide is an iridoid glycoside isolated from Catalpa ovata G. Don (Bignoniaceae). It inhibits TNF-α, IL-1β, and IL-6 productions, and NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages. This product is for research use only.
- Solid appearance
- White to yellow color
- Store at 4°C, protect from light
- In solvent, store at -80°C for 6 months or -20°C for 1 month, protect from light
![eMolecules 75265-85-9 | 2-OXOCYCLOHEXANECARBOXYLIC ACID SODIUM SALT | AstaTech | MFCD30530423 | 164.136 | C7H9NaO3 | 95.000 | [Na+].[O-]C(=O)C1CCCCC1=O | 0.25g | 296378971](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502468377.JPG-250.jpg)
eMolecules 75265-85-9 | 2-OXOCYCLOHEXANECARBOXYLIC ACID SODIUM SALT | AstaTech | MFCD30530423 | 164.136 | C7H9NaO3 | 95.000 | [Na+].[O-]C(=O)C1CCCCC1=O | 0.25g | 296378971
2-OXOCYCLOHEXANECARBOXYLIC ACID SODIUM SALT | AstaTech | 75265-85-9 | MFCD30530423 | 164.136 | C7H9NaO3 | 95.000 | [Na+].[O-]C(=O)C1CCCCC1=O | 0.25g | 296378971
Medchemexpress LLC Valategrast (R-411 free base) | 220847-86-9 | 97.1% | C30H32Cl3N3O4 | 100 MG
Valategrast (R-411 free base) is a potent and orally active dual antagonist of integrin α4β1 (VLA-4) and α4β7, showing potential for treating Chronic Obstructive Pulmonary Disease (COPD) and asthma. It features a l-phenylalanine-N-aroyl motif, with its carboxylic acid binding to the metal ion in the metal-ion-dependent adhesion site (MIDAS).
- CAS no.: 220847-86-9
- Molecular weight: 604.95
- Formula: C30H32Cl3N3O4
- Appearance: Off-white to light yellow solid
- Solubility: ≥ 4.25 mg/mL (7.03 mM) in various in vivo dissolution methods
- Storage: -80°C, stored under nitrogen
Medchemexpress LLC 2-Pyridinecarboxamide, 5-[[(6-chloro-2-pyridinyl)methyl](1-oxo-2-propen-1-yl)amino]-N-phenyl | 2305052-86-0 | 98.8% | C21H17ClN4O2 | 100 MG
BPK-25 is an active acrylamide that promotes the degradation of nucleosome remodeling and deacetylation (NuRD) complex proteins through a post-translational mechanism involving covalent protein engagement. It also inhibits TMEM173 activation by the cyclic dinucleotide ligand cGAMP.
- Promotes degradation of NuRD complex proteins.
- Inhibits TMEM173 activation.
- Active acrylamide.
- Intended for research and analytical applications.
Medchemexpress LLC N-cycloheptyl-6,7-dimethoxy-2-(4-piperidin-1-ylpiperidin-1-yl)quinazolin-4-amine | 864289-85-0 | 100.0% | 467.65 g/mol | C27H41N5O2 | 50 MG
C-021 is a small-molecule antagonist of CC chemokine receptor 4 (CCR4) developed for research applications; it blocks CCR4-mediated signaling and functional chemotaxis, with low-nanomolar activity in binding and cell-based assays.
- Potent CCR4 antagonist with low-nanomolar binding activity.
- Prevents CCL22-derived [35S]GTPγS binding to CCR4 (IC50 18 nM) and inhibits functional chemotaxis (human 140 nM, mouse 39 nM).
- Molecular formula C27H41N5O2; molecular weight 467.65 g/mol.
- High purity (~99.95%).
- Solid form with recommended storage: powder -20°C (long term) or 4°C (short term); in solvent store at -80°C.
- Intended for research use only; not for human use.
eMolecules 25109-86-8 | ChemScene | Methyl 2-(2-bromoethyl)benzoate | 250mg | 536865715 | CS-W022777 | MFCD21340317 | 243.1 | C10H11BrO2
Ambeed | 4-Nitrobenzo-15-crown-5 | 1g | 572962026 | A480372 | 60835-69-0 | MFCD00060713 | 313.306 | C14H19NO7
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Medchemexpress LLC Lupiwighteone | 104691-86-3 | 5 MG
Lupiwighteone is an isoflavone from wild-growing plants with antioxidant, antimicrobial, and anticancer properties. It induces apoptosis in human breast cancer cells by inhibiting the PI3K/Akt/mTOR pathway. For research use only.
- Antioxidant and antimicrobial effects.
- Anticancer properties: induces apoptosis in breast cancer cells by inhibiting PI3K/Akt/mTOR.
- Cytotoxicity against various cell lines (e.g., DU-145, SGC-7901).
- Induces cell cycle arrest and apoptosis in DU-145 cells.
- Dose-dependent reduction of cell cycle proteins (CDK1, 2, 4, 6, cyclinD1, B1) and increased ROS production.
- Activates mitochondria-based intrinsic apoptosis, up-regulating cytochrome c and caspase-3, and down-regulating p-Akt/Akt and VEGF.
![Medchemexpress LLC Ethyl 4'-((methyl(3-(pyridin-4-yl)benzyl)carbamoyl)oxy)-[1,1'-biphenyl]-4-carboxylate | 947669-86-5 | MFCD28160857 | 99.7% | 466.53 | C29H26N2O4 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000263530.png-250.jpg)
Medchemexpress LLC Ethyl 4'-((methyl(3-(pyridin-4-yl)benzyl)carbamoyl)oxy)-[1,1'-biphenyl]-4-carboxylate | 947669-86-5 | MFCD28160857 | 99.7% | 466.53 | C29H26N2O4 | 5 MG
WWL113 is a selective, orally active small-molecule inhibitor of carboxylesterases Ces3 and Ces1f used in biochemical and in vivo research to probe lipid metabolism and metabolic syndrome. It has shown efficacy in mouse models, improving lipid and glucose parameters after oral dosing.
- Selective Ces3 and Ces1f inhibitor with potent activity.
- Demonstrated in vivo efficacy in metabolic disease models.
- High purity suitable for research applications.
- Soluble in DMSO and formulatable for in vivo dosing protocols.
- Applicable to biochemical, cell-based, and animal studies.
Medchemexpress LLC Methylglyoxal-bis(guanylhydrazone) | 459-86-9 | MFCD00067519 | ≥98.0% | 184.20 g·mol⁻¹ | C5H12N8 | 50 MG
Mitoguazone (methylglyoxal-bis(guanylhydrazone)) is a small-molecule research reagent that competitively inhibits S-adenosyl-methionine decarboxylase (SAMDC) and disrupts polyamine biosynthesis. It is used in biochemical and cellular studies to probe polyamine-dependent processes, mitochondrial effects, and apoptosis. Chemical identifiers include CAS 459-86-9, formula C5H12N8, and molecular weight 184.20 g·mol⁻¹.
- Competitive inhibitor of S-adenosyl-methionine decarboxylase (SAMDC).
- Disrupts polyamine biosynthesis for pathway and apoptosis research.
- Reported to be brain-penetrant and useful in cellular assays.
- Characterized chemical identifiers: CAS 459-86-9, formula C5H12N8, MW 184.20 g·mol⁻¹.
- Recommended storage sealed and away from moisture; in solvent: -80°C long-term, -20°C short-term.
- Reported supplier purity commonly ≥98% for research-grade material.
eMolecules 1918125-85-5 | Ambeed | (4S5S)-2-(2-(Diphenylphosphanyl)phenyl)-45-diphenyl-45-dihydrooxazole | 100mg | 633660447 | A1352088 | 483.551 | C33H26NOP
Ambeed | (S)-2-Methylpiperidine | 1g | 552802083 | A714691 | 3197-42-0 | MFCD01862169 | 99.177 | C6H13N
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Medchemexpress LLC Chromeceptin 10mg | 331859-86-0 | 10 MG
Chromeceptin is a small-molecule IGF signaling pathway inhibitor for research use that suppresses IGF2 expression and reduces phosphorylation of AKT and mTOR. Supplied as a high-purity solid suitable for biochemical and cell-based studies.
- High purity suitable for biochemical assays and cell-based studies.
- Inhibits IGF signaling and suppresses IGF2 expression.
- Reduces phosphorylation of AKT and mTOR in target cells.
- Available as a 10 mg powder with recommended low-temperature storage.
- Soluble in common organic solvents for assay preparation.