Azobenzenes

eMolecules​ AstaTech / IMIDAZO[12-A]PYRAZIN-8-OL / 0.25g / 268500354 / 72211 / 95.000 / 434936-85-3 / MFCD11846490 / 135.126 / C6H5N3O

AstaTech / IMIDAZO[12-A]PYRAZIN-8-OL / 0.25g / 268500354 / 72211 / 95.000 / 434936-85-3 / MFCD11846490 / 135.126 / C6H5N3O

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Medchemexpress LLC PR5-LL-CM01 | 1005307-86-7 | 98.4% | 401.51 | 200 MG

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PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 7.5 μM. It exhibits anti-tumor activities. This compound demonstrates higher efficacy in specifically inhibiting cancer cells and shows low toxicity in normal cells.

• Potent PRMT5 inhibitor (IC50 = 7.5 μM)
• Exhibits anti-tumor activities
• Higher efficacy in inhibiting cancer cells with low toxicity in normal cells
• Inhibits colony-forming ability in PANC1 and HT29 cells
• Inhibits NF-κB activation and target gene expression in PDAC and CRC cells
• Decreases TNFα and IL8 expression in PDAC and CRC cells
• Displays significant anti-tumor effect in PANC1 and HT29 xenografted mice without visibly affecting body weight

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eMolecules​ Ambeed / Anthra[219-def6510-def]diisoquinoline-13810(2H9H)-tetrone 29-bis[3-(dimethyloxidoamino)propyl]- / 100mg / 633419517 / A1156199 / / 1558023-86-1 / [null] / 592.652 / C34H32N4O6

Ambeed / Anthra[219-def6510-def]diisoquinoline-13810(2H9H)-tetrone 29-bis[3-(dimethyloxidoamino)propyl]- / 100mg / 633419517 / A1156199 / / 1558023-86-1 / [null] / 592.652 / C34H32N4O6

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Medchemexpress LLC GSK1702934A | 924377-85-5 | 99.11% | 395.52 | 10 MG

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GSK1702934A is a selective agonist for TRPC3, a transient receptor potential canonical channel. It plays a role in modulating cardiac contractility and arrhythmogenesis through the activation of TRPC3. In vitro studies have shown its ability to induce TRPC3/6-currents in HEK293 cells, with EC50 values of 0.08 mM for TRPC3 and 0.44 mM for TRPC6. It also induces transient, non-selective conductance and prolonged action potentials in TRPC3-overexpressing myocytes, and promotes NCX currents. In vivo, GSK1702934A has been observed to transiently increase blood pressure in conscious Sprague Dawley rats at doses ranging from 0.3-3 mg/kg.

• Acts as a selective agonist for TRPC3.
• Modulates cardiac contractility and arrhythmogenesis by activating TRPC3.
• Induces TRPC3/6-currents in HEK293 cells.
• Promotes NCX currents in TRPC3-overexpressing myocytes.
• Increases blood pressure in vivo in animal models.

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Medchemexpress LLC PR5-LL-CM01, a protein arginine methyltransferase 5 (PRMT5) inhibitor | 1005307-86-7 | 98.4% | 401.51 | 1 ML

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PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 7.5 μM. It exhibits anti-tumor activities. It has a range of IC50 at 2-4 μM in PDAC cells (PANC1, MiaPaCa2 and AsPC1) and 10-11 μM in CRC cells (HT29, HCT116 and DLD1). PR5-LL-CM01 specifically inhibits cancer cells with low toxicity in normal cells and strongly inhibits colony forming ability in PANC1 and HT29 cells. It also inhibits NF-κB activation and its target gene expression, dramatically decreasing TNFα and IL8 expression in both PANC1 and HT29 cells.

• Potent PRMT5 inhibitor.
• Exhibits anti-tumor activities.
• Low toxicity in normal cells.
• Strongly inhibits colony forming ability in PANC1 and HT29 cells.
• Inhibits NF-κB activation and its target gene expression.
• Decreases TNFα and IL8 expression.

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Medchemexpress LLC Rhodojaponin V | 37720-86-8 | MFCD01724481 | 1 MG

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Rhodojaponin V is a diterpenoid isolated from the leaves of *Rhododendron molle*. This compound exhibits anti-inflammatory activity and is identified as the C-14 acetylation product of Rhodojaponen III. It is intended for research use only.

• Diterpenoid compound
• Isolated from *Rhododendron molle*
• Exhibits anti-inflammatory activity
• C-14 acetylation product of Rhodojaponen III
• For research use only

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Medchemexpress LLC HSDVHK-NH2 | 848644-86-0 | 99.5% | 720.78 | 10 MG

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HSDVHK-NH2 is an antagonist of the integrin αvβ3-vitronectin interaction. It has an IC50 of 1.74 μg/mL (2.414 pM) and shows strong antagonism against αvβ3-GRGDSP interaction. This compound inhibits HUVEC proliferation by inducing cell death through caspases activations, which is linked to increased p53 expression.

• Antagonist of integrin αvβ3-vitronectin interaction
• Inhibits bFGF-induced cell migration
• Shows strong antagonism against αvβ3-GRGDSP interaction
• Inhibits HUVEC proliferation
• Induces HUVEC cell death via caspases activations
• Mechanism related to increased p53 expression

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Medchemexpress LLC 5-chloro-2-fluoro-4-[(1S,2R)-2-(2-methylpyrazol-3-yl)cyclohexyl]oxy-N-pyrimidin-4-ylbenzenesulfonamide | 1450595-86-4 | Not found on authoritative sources | 99.6% | C20H21ClFN5O3S | 10MG

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DS-1971a is a potent, selective, and orally active NaV1.7 inhibitor used in pain research. It shows low-nanomolar inhibition of human NaV1.7, activity in rodent models, and has demonstrated analgesic effects in preclinical studies.

• Potent NaV1.7 inhibition: hNaV1.7 IC50 = 22.8 nM; mNaV1.7 IC50 ≈ 59.4 nM.
• Orally active with reported analgesic effects in preclinical models.
• High purity, typically 99.6% by supplier specification.
• Defined chemical identity: CAS 1450595-86-4; formula C20H21ClFN5O3S; MW 465.93 g·mol⁻¹.
• Soluble in DMSO and compatible with common in vivo formulation vehicles.
• Stable as a solid with recommended refrigerated or frozen storage for long-term retention.

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Medchemexpress LLC Orismilast | 1353546-86-7 | 99.9% | 510.29 | C19H15Cl2F2NO7S | 10 MG

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Orismilast is an orally active, selective phosphodiesterase 4 (PDE4) inhibitor used for research into inflammatory diseases. It demonstrates potent inhibition of PDE4B and PDE4D subtypes and is provided as a solid research reagent for preclinical in vitro and in vivo studies. Not for human use.

• Selective inhibition of PDE4B and PDE4D, targeting inflammatory pathways.
• Orally active small molecule suitable for preclinical pharmacology studies.
• High chemical purity (≈99.9%) and defined molecular weight (510.29 g/mol).
• Molecular formula C19H15Cl2F2NO7S; suitable for screening and mechanistic studies.
• Supplied as a solid research reagent; follow safety and handling guidelines.

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Medchemexpress LLC 1-(3-fluorophenyl)-5-methylpyridin-2(1H)-one | 848353-85-5 | 99.8% | 50 MG

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Fluorofenidone (AKF-PD) is an orally active small-molecule research compound with reported anti-fibrotic, antioxidant, and anti-inflammatory effects. Supplied as a purified analytical standard suitable for in vitro and in vivo studies and commonly provided as a 50 mg pack.

• Orally active small molecule with anti-fibrotic and anti-inflammatory activity.
• Demonstrated cellular effects (e.g., NIH/3T3 IC50 ~2.75 mM) and in vitro activity in lung and cancer cell lines.
• Shows protective effects in rodent models of lung injury, cholestasis, and fibrosis.
• High purity suitable for analytical and preclinical research applications.
• Molecular formula C12H10FNO; molecular weight 203.21 g/mol.

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eMolecules​ Pharmablock / 3-(4-iodophenoxy)benzoic acid / 25mg / 586151192 / PBU2299 / 0.000 / 1406352-85-9 / MFCD19551768 / 340.116 / C13H9IO3

Pharmablock / 3-(4-iodophenoxy)benzoic acid / 25mg / 586151192 / PBU2299 / 0.000 / 1406352-85-9 / MFCD19551768 / 340.116 / C13H9IO3

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Medchemexpress LLC EPQpYEEIPIYL | 147612-86-0 | 99.5% | 1473.52 | 1 MG

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EPQpYEEIPIYL is a phosphopeptide that functions as a Src homology 2 (SH2) domain ligand. It activates members of the Src family, such as Lck, Hck, and Fyn, by binding to their SH2 domains. The phosphopeptide pY324, derived from hmT with the sequence EPQpYEEIPIYL, exhibits high-affinity binding to GST fusion proteins of the Lck SH2 domain and the Src SH2 domain. This product is used in cancer and cancer targeted therapy research, and is related to the protein tyrosine kinase/RTK pathway.

• Phosphopeptide and Src homology 2 (SH2) domain ligand
• Activates Src family members such as Lck, Hck, and Fyn
• High-affinity binding to GST fusion proteins of Lck SH2 domain and Src SH2 domain
• Soluble in H2O at 2 mg/mL (1.36 mM) with ultrasonic treatment and pH adjustment to 2 with HCl
• Used in cancer and cancer targeted therapy research
• Related to the protein tyrosine kinase/RTK pathway

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Medchemexpress LLC Atuliflapon (AZD5718) | 2041075-86-7 | 99.0% | 50 MG

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Atuliflapon (AZD5718) is a reversible inhibitor of 5-lipoxygenase activating protein (FLAP) developed for investigation of leukotriene-mediated inflammation and cardiovascular indications. It shows nanomolar potency against FLAP and has been evaluated in first-in-human and Phase 2a clinical studies. The compound is provided as a solid research sample for in vitro and translational research.

• Reversible FLAP inhibitor with FLAP IC50 ≈ 2 nM.
• Inhibits LTB4 production in human whole blood (IC50 ≈ 39 nM).
• High purity research sample (98.97%).
• Molecular weight 446.50 g/mol; chemical formula C24H26N6O3.
• Suitable for in vitro and translational/clinical research; not for clinical use.
• Pack size typically 50 mg solid sample.

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Medchemexpress LLC D5D-IN-326 | 1236767-85-3 | 99.9% | 473.27 | C17H11F8N3O4 | 5 MG

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D5D-IN-326 is a selective, orally active delta-5 desaturase (D5D) inhibitor (CAS 1236767-85-3) with reported nanomolar potency in enzymatic and cell-based assays and demonstrated activity in preclinical metabolic disease models. The compound is supplied for research use in multiple formats and sizes and is characterized by high purity and defined storage stability.

• Selective inhibitor of delta-5 desaturase with nanomolar potency.
• Reduces insulin resistance and body weight in preclinical models.
• High purity (99.9%) for reliable experimental results.
• Available as powder and solution formats for flexible dosing.
• Stable under recommended storage conditions for long-term use.
• Supplied in small research quantities suitable for in vitro and in vivo studies.

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eMolecules​ Ambeed / Methyl 3-amino-2-benzo[b]furancarboxylate / 250mg / 525177991 / A301059 / / 57805-85-3 / MFCD00466275 / 191.186 / C10H9NO3

Ambeed / Methyl 3-amino-2-benzo[b]furancarboxylate / 250mg / 525177991 / A301059 / / 57805-85-3 / MFCD00466275 / 191.186 / C10H9NO3

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