Azolines
Medchemexpress LLC 1H-Benzimidazole, 2-(2-pyridinyl)- | 1137-68-4 | 99.9% | 195.22 | 10 G
2-(2′-Pyridyl)benzimidazole is a potentially tridentate ligand capable of forming stable complexes with various transition metal ions. It functions as an anti-inflammatory agent and effectively inhibits Escherichia coli methionine aminopeptidase, making it suitable for biochemical research. This compound appears as a solid, ranging from pale purple to purple or colorless to light pink and is intended for research use only.
- Functions as an anti-inflammatory agent
- Inhibits Escherichia coli methionine aminopeptidase
- IC50 of 13.3 μM in inhibiting human MetAP2 expressed in Sf9 cells
- Molecular formula: C12H9N3
- Molecular weight: 195.22
- Purity: 99.88%
- Ships at room temperature
- Stable for up to 3 years at room temperature
- Consistent with 1H NMR spectrum and LCMS
Medchemexpress LLC Thiol-PEG2-acid | 1379649-73-6 | 96.0% | 194.25 | 50 MG
Thiol-PEG2-acid is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These innovative molecules exploit the intracellular ubiquitin-proteasome system for selective degradation of target proteins. Comprising two distinct ligands connected by a linker, PROTACs offer a promising approach for targeted therapeutic development by actively removing disease-causing proteins. Thiol-PEG2-acid serves as a crucial linker component in assembling these complex PROTAC structures.
- Peg-based protac linker
- Used in the synthesis of protacs
- Facilitates targeted protein degradation via the ubiquitin-proteasome system
Medchemexpress LLC VH032 thiol | 2098836-54-3 | 95.9% | 490.64 | 1 ML
VH032 thiol (VHL ligand 6) is a VHL ligand. It binds to pan-BET inhibitor JQ1 via a linker to form PROTAC. VHL is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. It is also one of the most popular E3 ligases recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein.
- Binds to JQ1 to form PROTACs.
- Recruits VHL E3 ligase for protein degradation.
- Useful in the study of Proteolysis-targeting chimeras.
Biotium Antibody Labeling Kits Antibody and Protein Labeling Kits Mix n Stain Antibody Labeling Kits CF680 1/EA
Mix-n-Stain CF Dye Nanobody Thiol Labeling Kits are optimized for labeling nanobodies with bright and photostable CF dyes in 2 hours with no purification Kits tolerate common stabilizers Far-red/near-IR CF680 dye has Ex/Em at 681/698 nm One labeling of 5-20 ug Nanobody Thiol per kit
Sigma Aldrich Fine Chemicals Biosciences Methimazole United States Pharmacopeia (USP) Reference Standard | 60-56-0 | MFCD00179321 | 200MG
Methimazole United States Pharmacopeia (USP) Reference Standard | Mol Wt: 114.17 | 60-56-0 | MFCD00179321 | 200MG
eMolecules 1415232-65-3 | 2-(6-CHLORO-1H-BENZO[D][1,2,3]TRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLISOURONIUM HEXAFLUOROPHOSPHATE(V) | AstaTech | MFCD04973268 | 413.690 | C11H15ClF6N5OP | 95.000 | F[P-](F)(F)(F)(F)F.CN(C)C(On1nnc2ccc(Cl)cc12)=[N+](C)C | 100g | 449750937
2-(6-CHLORO-1H-BENZO[D][1,2,3]TRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLISOURONIUM HEXAFLUOROPHOSPHATE(V) | AstaTech | 1415232-65-3 | MFCD04973268 | 413.690 | C11H15ClF6N5OP | 95.000 | F[P-](F)(F)(F)(F)F.CN(C)C(On1nnc2ccc(Cl)cc12)=[N+](C)C | 100g | 449750937
Medchemexpress LLC m-PEG-thiol | 134874-49-0 | MFCD21363241 | 90.0% | 750 Da (average) | (C2H4O)nC3H8OS | 500 MG
m-PEG-thiol (MW 750) is a methoxy-terminated polyethylene glycol with a terminal thiol group used for bioconjugation and surface modification. It provides a hydrophilic spacer for attaching biomolecules and for stabilizing or functionalizing metal nanoparticles via thiol-metal chemistry.
- Average molecular weight 750 Da.
- Thiol-terminated methoxy polyethylene glycol for surface attachment.
- Suitable for DNA thiolation and gold nanoparticle functionalization.
- Purity 90.0%.
- Liquid, colorless to light yellow; store cold (pure form -20°C) to preserve stability.
Medchemexpress LLC Thiol-PEG-CH2COOH (MW 5000) | 95.0% | SMILES: SCCOCC(O)=O.[MW 5000].[n] | 50 MG
Thiol-PEG-CH2COOH (MW 5000) is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are composed of two distinct ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other targeting the protein intended for degradation, leveraging the intracellular ubiquitin-proteasome system for selective protein degradation.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Leverages the intracellular ubiquitin-proteasome system
- Enables selective degradation of target proteins
Medchemexpress LLC M-PEG-thiol (MW 2000) | 134874-49-0 | >98.0% | COCCOCCS.[MW 2000].[n] | 250 MG
M-PEG-thiol (MW 2000) is a PEG-based PROTAC linker designed for research use only, specifically in the synthesis of PROTACs. It presents as a white to yellow solid with an average molecular weight of 2000.
- PEG-based PROTAC linker
- For research use only
- White to yellow solid appearance
- Average molecular weight of 2000
- Can be used in the synthesis of PROTACs
eMolecules 92806-98-9 | 6-Hydroxy-2-mercaptobenzimidazole | MFCD26131865 | 1g
WuXi ChemSupply | 6-Hydroxy-2-mercaptobenzimidazole | 1g | 599167443 | LN01286296 | 95.000 | 92806-98-9 | MFCD26131865 | 166.200 | C7H6N2OS
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Medchemexpress LLC 2,4-Dimethyl-1H-imidazole-5-carbaldehyde | 68282-52-0 | 99.9% | C6H8N2O | 250 MG
2,4-Dimethyl-1H-imidazole-5-carbaldehyde is a drug intermediate for the synthesis of various active compounds.
- Solid appearance
- Light yellow to yellow color
- Molecular weight: 124.14
- Store at -20°C, sealed, away from moisture
- In solvent, store at -80°C for 6 months or -20°C for 1 month (sealed storage, away from moisture)
- Shipping at room temperature (continental US)
Medchemexpress LLC DSPE-thiol | 144735-82-0 | 90.0% | 836.19 g/mol | C44H86NO9PS | 10 MG
DSPE-thiol is a distearoylphosphatidylethanolamine lipid functionalized with a terminal thiol (-SH) group. It introduces reactive thiol chemistry to lipid assemblies, enabling covalent linkage to maleimide-containing molecules and the creation of phospholipid dimers for nanocarrier and membrane research.
- Provides reactive thiol functionality for selective conjugation with maleimide reagents.
- Facilitates liposome surface functionalization and targeted delivery studies.
- Enables synthesis of phospholipid dimers and cross-linked lipid structures.
- Integrates into lipid bilayers to impart stable, hydrophobic anchoring.
- Supplied in small research-scale quantities for laboratory use.