Omeprazole is a proton pump inhibitor (PPI) used to treat acid-related gastrointestinal disorders. It works by competitively inhibiting CYP2C19 activity. Additionally, Omeprazole inhibits the growth of Gram-positive and Gram-negative bacteria and is identified as a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor. This acid-labile compound is used in the treatment of various conditions including dyspepsia, peptic ulcer disease, and gastroesophageal reflux disease.
- Proton pump inhibitor
- Competitively inhibits CYP2C19 activity (Ki of 2 to 6 μM)
- Inhibits growth of Gram-positive and Gram-negative bacteria
- Potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor
- Inhibits gastric acid secretion
- Used for treating acid-related gastrointestinal disorders