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Benzodiazepines

Aromatic organic heterocyclic compounds that consist of benzene fused with a diazepine ring; diazepine rings are seven-membered heterocyclic compounds with two nitrogen atoms.
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16 – 30 of 119 results
16

Medchemexpress LLC FAUC 365 5mg | 474432-66-1 | 462.44 g/mol | C23H25Cl2N3OS | 5 MG
SDP

FAUC 365 is a research-grade small molecule that acts as a highly selective dopamine D3 receptor antagonist (CAS 474432-66-1). It is supplied as a high-purity solid and is used in biochemical and pharmacological studies related to dopaminergic signaling.

  • Highly selective D3 receptor antagonist with sub-nanomolar affinity (Ki ≈ 0.5 nM)
  • High purity (~98.75%), suitable for in vitro assays
  • Available as a solid and as a 10 mM solution in DMSO for convenience
  • Off-white to light yellow solid, stable under recommended storage
  • Intended for neuroscience research, including schizophrenia and Parkinson's disease models

ENCOMPASS_PREFERRED
17

TARGETMOL CHEMICALS INC Coelenterazine h 1MG
SDP

Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Coelenterazine H is a synthetic derivative of coelenterazine (a light-emitting biomolecule).Coelenterazine h (CLZN-h) is more sensitive to Ca 2+ than is the native complex, thus providing a valuable tool for measuring small changes in Ca 2+ concentrations. Purity 99.49%

ENCOMPASS_PREFERRED
18

Gold Biotechnology Inc Coelenterazine 10 mg
SDP

Coelenterazine is a luminophore found in aquatic organisms and is the substrate for many luciferase enzymes, including Renilla reniformis, Gaussia and aequorins. It is commonly used for bioluminescent calcium detection and the monitoring of reporter genes in BRET (Bioluminescence Resonance Energy Transfer), ELISA and HTS methods as well as chemiluminescent detection of superoxide anions and peroxynitrite in cells or tissues.

ENCOMPASS_PREFERRED
19

Abcam N-Desmethyl clozapine (Normethylclozapine), Clozapine metabolite. M1 agonist. D2/D3 agonist., 10MG

MW 312.8 Da, Purity >99%. Brain penetrant metabolite of the atypical antipsychotic clozapine. Broad range of actions. Potent allosteric M1 partial agonist (IC50 = 55 nM for inhibition of [3H]-NMS binding). D2/D3 partial agonist. Also displays affinity at 5-HT1 and 5-HT2.

The product is subject to the following: Abcam Restricted Use Statement

ENCOMPASS_PREFERRED
20

eMolecules​ ChemScene / 2-Methyl-4-(2345-tetrahydro-1H-benzo[b]azepine-1-carbonyl)benzonitrile / 100mg / 596091023 / CS-0159427 / 0.000 / 335155-20-9 / [null] / 290.366 / C19H18N2O

ChemScene / 2-Methyl-4-(2345-tetrahydro-1H-benzo[b]azepine-1-carbonyl)benzonitrile / 100mg / 596091023 / CS-0159427 / 0.000 / 335155-20-9 / [null] / 290.366 / C19H18N2O

ENCOMPASS_PREFERRED
21

Alkali Scientific ALKALI SCIENTIFIC INC
SDP

5000661508 COELENTERAZINE LUMINESCENT SUB

ENCOMPASS
22

Medchemexpress LLC Coelenterazine | 55779-48-1 | 98.5% | 423.46 | 1 G
SDP

Coelenterazine serves as a luminescent enzyme substrate for both apoaequorin and Renilla luciferase. It has been utilized as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) for detecting protein-protein interactions. Additionally, coelenterazine is a superoxide anion-sensitive chemiluminescent probe and can be employed in the chemiluminescent detection of peroxynitrite (Ex/Em = 429/466 nm).

  • Luminescent enzyme substrate for apoaequorin and Renilla luciferase.
  • Used as a bioluminescence donor in BRET to detect protein-protein interactions.
  • Superoxide anion-sensitive chemiluminescent probe.
  • Can be used in chemiluminescent detection of peroxynitrite (Ex/Em = 429/466 nm).

ENCOMPASS_PREFERRED
23

Medchemexpress LLC Clozapine N-oxide dihydrochloride | 2250025-93-3 | 99.7% | 415.74 | 5 MG
SDP

Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and acts as an agonist for human muscarinic designer receptors (DREADDs). It activates the DREADD receptors hM3Dq and hM4Di. While it cannot cross the blood-brain barrier, its parent compound, Clozapine, is a potent dopamine antagonist and a selective muscarinic M4 receptor agonist (EC50=11 nM).

  • Activates hM3Dq and hM4Di DREADD receptors.
  • Does not cross the blood-brain barrier.
  • Undergoes reverse-metabolism to clozapine.
  • Exhibits long biological effects (6-10 h) in mice.

ENCOMPASS_PREFERRED
24

Medchemexpress LLC Coelenterazine | 55779-48-1 | 98.59% | 423.46 | 1 MG
SDP

Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. It is used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Coelenterazine is also a superoxide anion-sensitive chemiluminescent probe and can be used in chemiluminescent detection of peroxynitrite (Ex/Em = 429/466 nm).

  • Luminescent enzyme substrate for apoaequorin and Renilla luciferase.
  • Used as a bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions.
  • Superoxide anion-sensitive chemiluminescent probe.
  • Can be used in chemiluminescent detection of peroxynitrite (Ex/Em = 429/466 nm).
  • Measurement of free radical production.

ENCOMPASS_PREFERRED
25

eMolecules​ ChemScene / 8-Bromo-2345-tetrahydro-1H-benzo[c]azepin-1-one / 100mg / 572298740 / CS-0114317 / 0.000 / 187833-72-3 / MFCD15526843 / 240.100 / C10H10BrNO

ChemScene / 8-Bromo-2345-tetrahydro-1H-benzo[c]azepin-1-one / 100mg / 572298740 / CS-0114317 / 0.000 / 187833-72-3 / MFCD15526843 / 240.100 / C10H10BrNO

ENCOMPASS_PREFERRED
26

Medchemexpress LLC Coelenterazine | 55779-48-1 | 98.5% | 423.46 | 250 MG
SDP

Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. It has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Additionally, Coelenterazine functions as a superoxide anion-sensitive chemiluminescent probe and is applicable in the chemiluminescent detection of peroxynitrite (Ex/Em = 429/466 nm).

  • Luminescent enzyme substrate for apoaequorin and Renilla luciferase
  • Bioluminescence donor in BRET for protein-protein interaction detection
  • Superoxide anion-sensitive chemiluminescent probe
  • Used in chemiluminescent detection of peroxynitrite
  • Applicable for measurement of free radical production
  • Utilized in in vitro and in vivo studies

ENCOMPASS_PREFERRED
27

Medchemexpress LLC Clozapine N-oxide | 34233-69-7 | 99.98% | 342.82 | 5 MG
SDP

Clozapine N-oxide is a major metabolite of Clozapine and acts as an agonist for human muscarinic designer receptors (DREADDs), activating hM3Dq and hM4Di. It does not cross the blood-brain barrier. Its parent compound, Clozapine, is a potent dopamine antagonist and a selective muscarinic M4 receptor agonist. Clozapine N-oxide is used for research purposes only.

  • Activates DREADD receptors hM3Dq and hM4Di.
  • Does not cross the blood-brain barrier.
  • Major metabolite of Clozapine.
  • Used in research as a DREADDs agonist.
  • Hygroscopic DMSO significantly impacts solubility, use newly opened DMSO.
  • Store powder at -20°C for 3 years, 4°C for 2 years.
  • Store in solvent at -80°C for 1 year, -20°C for 6 months.

ENCOMPASS_PREFERRED
28

Medchemexpress LLC Clozapine N-oxide | 34233-69-7 | 99.9% | 342.82 | 25 MG
SDP

Clozapine N-oxide is a major metabolite of Clozapine, acting as an agonist for human muscarinic designer receptors (DREADDs). It activates the hM3Dq and hM4Di DREADD receptors, but it cannot cross the blood-brain barrier. Its parent compound, Clozapine, is a potent dopamine antagonist and a selective muscarinic M4 receptor agonist.

  • Activates DREADD receptors hM3Dq and hM4Di
  • Cannot cross the blood-brain barrier
  • Metabolite of Clozapine
  • Solid appearance
  • Light yellow to yellow color

ENCOMPASS_PREFERRED
29

eMolecules​ Pharmablock / 7-chloro-2345-tetrahydro-1H-1-benzazepin-5-one / 25mg / 784549693 / SYN0084 / 0.000 / 160129-45-3 / MFCD06738694 / 195.650 / C10H10ClNO

Pharmablock / 7-chloro-2345-tetrahydro-1H-1-benzazepin-5-one / 25mg / 784549693 / SYN0084 / 0.000 / 160129-45-3 / MFCD06738694 / 195.650 / C10H10ClNO

ENCOMPASS_PREFERRED
30

eMolecules​ ChemScene / 8-Methoxy-2345-tetrahydro-1H-benzo[c]azepine / 50mg / 633679727 / CS-0150342 / 0.000 / 247133-22-8 / MFCD08236791 / 177.247 / C11H15NO

ChemScene / 8-Methoxy-2345-tetrahydro-1H-benzo[c]azepine / 50mg / 633679727 / CS-0150342 / 0.000 / 247133-22-8 / MFCD08236791 / 177.247 / C11H15NO

ENCOMPASS_PREFERRED