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FAUC 365 is a small-molecule dopamine D3 receptor-selective antagonist used in neuropharmacology research. It shows high affinity for the D3 receptor (Ki ≈ 0.5 nM) and is supplied as a high-purity powder for in vitro and in vivo studies.
High affinity for dopamine D3 receptor (Ki ≈ 0.5 nM).
Demonstrates selectivity over D2 and D4 receptor subtypes.
High purity suitable for research applications (purity reported ~98.75%).
Available in small pack sizes, including 10 mg.
Soluble in DMSO; in vivo formulation protocols provided.
Store powder at recommended temperatures to maintain stability.
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Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Clozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration [1]. It is produced by the action of cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4 whose activities in turn can be affected by drugs and disease [2]. Clozapine N-oxide is normally biologically inactive. However it can be used in designer receptor exclusively activated by designer drugs also known as DREADDs technology to modulate synthetic receptors in vivo [3]. purity: 99%
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MW 312.8 Da, Purity >99%. Brain penetrant metabolite of the atypical antipsychotic clozapine. Broad range of actions. Potent allosteric M1 partial agonist (IC50 = 55 nM for inhibition of [3H]-NMS binding). D2/D3 partial agonist. Also displays affinity at 5-HT1 and 5-HT2.