Biotin and derivatives
Medchemexpress LLC Mal-PEG2-NHS ester | 1433997-01-3 | 98.6% | 354.31 g/mol | C15H18N2O8 | 1 G
Mal-PEG2-NHS ester is a non-cleavable ADC linker combining a maleimide reactive group, a two-unit polyethylene glycol spacer, and an N-hydroxysuccinimide (NHS) ester for amine coupling. It is supplied as a purified reagent for bioconjugation and linker chemistry applications.
- Non-cleavable maleimide-NHS bifunctional linker
- PEG2 spacer improves solubility and reduces steric hindrance
- NHS ester enables efficient coupling to primary amines
- Maleimide group enables thiol-selective conjugation
- High purity suitable for ADC synthesis and bioconjugation
Medchemexpress LLC Azido-PEG8-NHS ester | 1204834-00-3 | 99.5% | 564.58 g/mol | C23H40N4O12 | 50 MG
Azido-PEG8-NHS ester is an azide-functional PEG8 N-hydroxysuccinimide (NHS) ester used as a cleavable linker and bioconjugation reagent for click chemistry and the synthesis of antibody-drug conjugates and PROTAC linkers. It is supplied as a colorless to light yellow liquid with high purity and is intended for research use.
- Azide functionality enables copper-catalyzed and strain-promoted click reactions.
- Peg8 spacer increases hydrophilicity and reduces steric hindrance.
- NHS ester readily reacts with primary amines for bioconjugation.
- High reported purity suitable for synthetic and bioconjugation workflows.
- Storage stability: stable as a pure compound at -20°C for up to 3 years.
- Solubility: soluble in DMSO (100 mg/mL); ultrasonic agitation may be required.
Medchemexpress LLC Biotin-EDA | 111790-37-5 | 97.5% | 100 MG
Biotin-EDA is an alkyl chain-based PROTAC linker used in the synthesis of PROTACs, which consist of two different ligands connected by a linker. These PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Alkyl chain-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs leverage the intracellular ubiquitin-proteasome system
- PROTACs selectively degrade target proteins
Sigma Aldrich Fine Chemicals Biosciences Biotin, 58-85-5, MFCD00005541, 1g
Empirical Formula (Hill Notation) C10H16N2O3S, ≥99% (HPLC), Molecular Weight 244.31, lyophilized powder, Synonym: D-Biotin, Bios II, Coenzyme R, Vitamin B7, Vitamin H; Biotin may be used to elute proteins from avidin/streptavidin resins.
![Medchemexpress LLC Carbonic acid, bicyclo[2.2.1]hept-5-en-2-yl (2,5-dioxo-1-pyrrolidinyl) ester | 1888335-48-5 | 92.1% | 251.24 g/mol | C12H13NO5 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000286309.png-250.jpg)
Medchemexpress LLC Carbonic acid, bicyclo[2.2.1]hept-5-en-2-yl (2,5-dioxo-1-pyrrolidinyl) ester | 1888335-48-5 | 92.1% | 251.24 g/mol | C12H13NO5 | 10 MG
Norbornene-NHS is a click-chemistry reagent that functions as a norbornene-derived NHS carbonate dienophile for inverse electron-demand Diels-Alder (IEDDA) conjugation with tetrazines. It is provided for research use to enable efficient amine bioconjugation and labeling applications.
- Dienophile for inverse electron-demand Diels-Alder (IEDDA) conjugation with tetrazines.
- NHS carbonate functional group enables efficient coupling to primary amines.
- Available in small quantities suitable for labeling and bioconjugation experiments.
- Typical purity about 92.1% and molecular weight 251.24 g/mol.
- Store sealed and away from moisture; solid at -20°C; in solvent: -80°C for up to 6 months, -20°C for 1 month.
- Supplied for research use only.
Medchemexpress LLC Irdye 800CW NHS ester | 956579-01-4 | >80.0% | 10 MG
IRDye 800CW NHS ester is a near-infrared fluorescent dye supplied as an NHS ester for covalent labeling of primary and secondary amines, including lysine residues in proteins, peptides, and oligonucleotides. It is formulated for research use and is suitable for antibody and protein conjugation workflows.
- Near-infrared fluorescent dye for low-background imaging and deep tissue detection.
- NHS-ester reactive group enables covalent labeling of primary and secondary amines.
- Absorption maxima ~774-778 nm and emission maxima ~789-794 nm for NIR applications.
- High water solubility compatible with protein and peptide conjugation.
- Available in multiple milligram sizes to accommodate small- and large-scale experiments.
Medchemexpress LLC Biotin-PEG-thiol (MW 2000) | 98.0% | 2000 (Average) | 100 MG
Biotin-PEG-Thiol (MW 2000) is an active compound. It is pegylated by binding to streptavidin or antibiotin with high affinity and specificity, allowing it to modify biomolecules, proteins, peptides, and other small molecule materials. This compound is widely used in the research of agent release and nano new materials.
- Purity: 98.0%
- Molecular weight: 2000 (Average)
- Target: Fluorescent dye
- Pathway: Others
- In vitro solubility: DMSO: 125 mg/mL (Need ultrasonic)
- Storage conditions: -20°C, protect from light, stored under nitrogen. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen).