Biotin and derivatives
Medchemexpress LLC Biotin-PEG8-amine | 2183447-27-8 | 99.8% | C28H54N4O10S | 100 MG
Biotin-PEG8-amine is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs. This product is provided as a solid, white to off-white in appearance.
- High purity: 99.84%
- Soluble in DMSO (in vitro)
- Multiple in vivo solubility protocols available
Medchemexpress LLC NHS-PEG1-SS-PEG1-NHS | 1688598-83-5 | 98.0% | 436.41 | 200 MG
NHS-PEG1-SS-PEG1-NHS is a reversible linker for biomacromolecule link with active small molecules.
- Functions as a reversible linker
- Enables biomacromolecule linkage with active small molecules
- Applicable in proteins
- Applicable in liposomes
- Applicable in nanoparticles
Medchemexpress LLC Biotin-PEG7-amine | 1334172-76-7 | 98.0% | C26H50N4O9S | 25 MG
Biotin-PEG7-amine is a PEG-based PROTAC linker used in the synthesis of Proteolysis Targeting Chimeras (PROTACs). PROTACs function by exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins, by connecting an E3 ubiquitin ligase ligand to a target protein ligand via a linker.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Biotin-PEG-Biotin | 194920-55-3 | 99.3% | C26H44N6O6S2 | 25 MG
Biotin-PEG-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
- PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Medchemexpress LLC M-PEG-NHS ester (MW 20000) | 92451-01-9 | 98.0% | (C2H4O)nC7H9NO5 | 25 MG
M-PEG-NHS ester (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs are compounds that consist of two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets the protein of interest. This mechanism allows PROTACs to utilize the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- Peg-based protac linker
- Used in the synthesis of protacs
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Biotin-PEG12-NHS ester | 1934296-88-4 | 99.31% | C41H72N4O18S | 25 MG
Biotin-PEG12-NHS ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs consist of two different ligands connected by a linker; one ligand is for an E3 ubiquitin ligase and the other is for the target protein. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Utilizes intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Bis-PEG10-NHS ester | 2221949-02-4 | 95.0% | 752.76 | C32H52N2O18 | 100 MG
Bis-PEG10-NHS ester is a PEG-based linker containing two N-hydroxysuccinimide (NHS) ester groups. It is used as a cleavable linker in the synthesis of antibody-drug conjugates (ADCs) and PROTACs to enable conjugation to primary amines.
- Contains two NHS ester functional groups for amine conjugation.
- Purity typically 95.0%.
- Molecular weight approximately 752.76; formula C32H52N2O18.
- CAS number 2221949-02-4 for unambiguous identification.
- Available in multiple pack sizes, including 100 mg.
- Storage: pure form at -20°C; in solvent store at -80°C for longer-term stability.
Medchemexpress LLC DBCO-N-bis(PEG4-NHS ester) | 2639395-38-1 | 96.2% | 995.03 | C49H62N4O18 | 5 MG
DBCO-N-bis(PEG4-NHS ester) is a PEG-based bifunctional linker that contains two PEG4-NHS ester groups and a dibenzocyclooctyne (DBCO) moiety. It is designed for bioconjugation and protein labeling via NHS-ester chemistry and for copper-free click conjugation with azide-containing partners through strain-promoted alkyne-azide cycloaddition (SPAAC).
- Contains two PEG4-NHS ester groups and a DBCO functional group.
- Enables protein modification through NHS-ester conjugation to primary amines.
- Supports copper-free SPAAC click chemistry with azide partners.
- Suitable for small-scale research use; available in 5 mg and larger sizes.
- Molecular weight 995.03; CAS number 2639395-38-1.
Medchemexpress LLC Mal-PEG6-NHS ester | 1599472-25-9 | MFCD20926374 | 98.0% | 530.52 g/mol | C23H34N2O12 | 1 G
Mal-PEG6-NHS ester is a non-cleavable ADC linker containing a maleimide reactive group, a six-unit polyethylene glycol (PEG6) spacer, and an N-hydroxysuccinimide (NHS) ester for amine coupling. It is supplied for research use in synthesis and bioconjugation workflows.
- Purity 98.0%.
- Cas number 1599472-25-9.
- Molecular weight 530.52 g/mol.
- Chemical formula C23H34N2O12.
- Soluble in DMSO at 100 mg/mL (in vitro; ultrasonic recommended).
- Suggested in vivo formulations provided for dosing preparations.
- For research use only; not for use in patients.
- Pack quantity 1 G.
Medchemexpress LLC Mal-PEG6-NHS ester | 1599472-25-9 | MFCD20926374 | 98.0% | 530.52 g/mol | C23H34N2O12 | 5 G
Mal-PEG6-NHS ester is a non-cleavable linker containing a maleimide reactive group, a six-unit polyethylene glycol (PEG6) spacer, and an N-hydroxysuccinimide (NHS) ester for thiol and amine bioconjugation. Supplied as a solid with typical purity of 98.0%, it is used in antibody-drug conjugate and PROTAC linker synthesis and general bioconjugation workflows.
- Non-cleavable linker for stable bioconjugation.
- Maleimide group enables thiol-specific conjugation.
- NHS ester allows amine coupling.
- PEG6 spacer increases solubility and reduces aggregation.
- Typical purity 98.0%.
- Soluble in DMSO at 100 mg/mL; in vivo formulation protocols documented.
- Supplied as a 5 g pack for research use.
Medchemexpress LLC Biotin-PEG1-azide | 1204085-48-2 | 99.9% | 356.44 | C14H24N6O3S | 25 MG
Biotin-PEG1-azide is a biotinylated, single-unit polyethylene glycol (PEG) linker terminating in an azide functional group. It is used for bioconjugation and antibody-drug conjugate (ADC) synthesis through click chemistry reactions (CuAAC and SPAAC).
- Cleavable single-unit PEG linker for controlled spacing and solubility.
- Azide functional group enables CuAAC with alkynes and strain-promoted cycloaddition with DBCO/BCN.
- Suitable for ADC synthesis, protein labeling, and bioconjugation workflows.
- High purity (99.9%), characterized by H NMR, RP-HPLC, and MS.
- Available in small-scale packs for research use (e.g., 25 mg).
Medchemexpress LLC Biotin-PEG-amine (MW 2000) | 90.0% | 25 MG
Biotin-PEG-amine (MW 2000) is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. This product is intended for research purposes only and is not for patient use. PROTACs utilize two distinct ligands joined by a linker, one targeting an E3 ubiquitin ligase and the other targeting the protein of interest. This mechanism exploits the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- For research use only
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
- Appearance: Solid
- Color: White to off-white
Medchemexpress LLC PC biotin-PEG3-NHS ester | 2353409-93-3 | MFCD07110334 | 95.0% | 840.89 g/mol | C36H52N6O15S | 25 MG
PC Biotin-PEG3-NHS ester is a cleavable 3-unit polyethylene glycol (PEG) linker bearing a biotin tag and an N-hydroxysuccinimide (NHS) ester reactive group. It is used to attach biotin to primary amines and as an ADC linker in bioconjugation workflows.
- Cleavable 3-unit PEG spacer provides hydrophilicity and spacing.
- NHS ester enables efficient coupling to primary amines.
- Biotin tag enables affinity capture and detection.
- Molecular weight 840.89 g/mol, formula C36H52N6O15S, CAS 2353409-93-3.
- Typical purity 95.0%.
- Powder storage at -20 °C; in solution store at -80 °C for long-term stability.
- Available in small research pack sizes suitable for conjugation optimization.