Biotin and derivatives
Medchemexpress LLC AMT-NHS | 2925268-86-4 | 98.7% | 443.47 g·mol⁻¹ | C22H21NO7S | 10 MG
AMT-NHS is an RNA-protein crosslinker that combines a psoralen intercalator with an N-hydroxysuccinimide (NHS) ester to covalently capture RNA-protein interactions. It is cell-permeable and has been used in living cells to map diverse RNA-protein contacts, producing distinct crosslinking patterns for single- and double-stranded RNA regions.
- Enables dual reactivity: psoralen-mediated photo-crosslinking of RNA and NHS-ester conjugation to protein amines.
- Cell-permeable for in vivo crosslinking applications.
- Soluble in DMSO at high concentration; may require warming and sonication to dissolve.
- High supplied purity supports reproducible crosslinking experiments.
- Stable as a powder under low-temperature storage; solution storage times are defined for sample handling.
Medchemexpress LLC Biotin-PEG7-maleimide | 1898221-65-2 | 99.4% | 745.88 g/mol | C33H55N5O12S | 25 MG
Biotin-PEG7-maleimide is a thiol-specific biotinylation reagent that introduces a biotin tag through a PEG7 spacer by reacting with free thiol (-SH) groups. It is used for selective cysteine labeling, affinity capture and detection, and for constructing drug-linker conjugates in bioconjugation workflows.
- Thiol-reactive maleimide group for selective cysteine labeling.
- PEG7 spacer provides flexibility and improved solubility.
- Biotin tag enables affinity capture and detection.
- High purity (99.4%) suitable for sensitive assays.
- Powder stable at -20°C for up to 3 years.
- Available as 25 MG quantity.
Medchemexpress LLC 4,7,12-Trioxa-10-azatetradecanoic acid, 13,13-dimethyl-11-oxo-, 2,5-dioxo-1-pyrrolidinyl ester | 2183440-73-3 | ≥98.0% | C16H26N2O8 | 250 MG
Boc-NH-PEG2-C2-NHS ester is an alkyl/ether-based PROTAC linker designed for use in the synthesis of PROTACs. These compounds exploit the intracellular ubiquitin-proteasome system to achieve selective degradation of target proteins, offering a novel approach for targeted therapy.
- Utilized in the synthesis of PROTACs
- Leverages the ubiquitin-proteasome system
- Enables selective degradation of target proteins
- Alkyl/ether-based linker
Medchemexpress LLC NOTA-NHS ester | 1338231-09-6 | MFCD30747764 | 90.0% | 400.38 | C16H24N4O8 | 10 MG
NOTA-NHS ester is an N-hydroxysuccinimide (NHS) ester used to conjugate a NOTA chelator to biomolecules for subsequent fluorescent or radioactive nuclide labeling in research applications. It is supplied as a solid reagent with defined molecular characteristics for use in radiopharmaceutical and probe development.
- Provides an NHS-ester functional group for amine conjugation.
- Suitable for fluorescent labeling and radioactive nuclide labeling applications.
- Documented molecular formula C16H24N4O8 and molecular weight 400.38.
- Available in small research pack sizes for synthesis and probe preparation.
- Typically soluble in DMSO for conjugation reactions.
Medchemexpress LLC Amine-PEG3-Biotin | 359860-27-8 | 99.8% | 418.55 | 100 MG
Amine-PEG3-Biotin is a signal amplification label that contains a biotin group and a terminal primary amine group.
- Signal amplification label.
- Contains a biotin group.
- Contains a terminal primary amine group.
- Used in electrochemical immunosensors for N6-methyladenosine detection in human cell lines based on a biotin-streptavidin system and silver-SiO2 signal amplification.
Medchemexpress LLC Bis-PEG25-NHS ester | 2221948-96-3 | MFCD21363290 | 99.8% | 1413.55 | C62H112N2O33 | 25 MG
Bis-PEG25-NHS ester is a PEG/alkyl/ether-based homobifunctional linker containing two N-hydroxysuccinimide (NHS) ester groups, used for conjugation in the synthesis of PROTACs and as a cleavable linker for antibody-drug conjugates (ADCs). It is provided as a hydrophilic solid for use in organic solvents and should be stored sealed at -20°C.
- Contains two amine-reactive NHS ester groups for conjugation.
- PEG spacer increases hydrophilicity and solubility in aqueous media.
- Suitable as a cleavable linker for ADC and PROTAC synthesis.
- Provided as a solid with recommended cold, sealed storage to preserve stability.
Medchemexpress LLC m-PEG-NHS ester (MW 5000) | 92451-01-9 | 95.0% | (C2H4O)nC7H9NO5 | 50 MG
m-PEG-NHS ester (MW 5000) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This solid, white to off-white compound boasts a purity of 95.0% and is intended strictly for research purposes.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- For research use only
- Solid appearance
- White to off-white color
- 95.0% purity
Medchemexpress LLC Biotin-PEG7-maleimide | 1898221-65-2 | 99.4% | 745.88 g/mol | C33H55N5O12S | 5 MG
Biotin-PEG7-Maleimide is a biotinylation reagent that reacts specifically with thiol (-SH) groups via a maleimide linker. It is used to attach biotin to thiol-containing molecules and as a linker in drug-linker conjugates such as antibody-drug conjugates (ADCs).
- Reacts selectively with thiol groups (-SH).
- Contains a PEG7 spacer to improve solubility and flexibility.
- Facilitates biotinylation for detection, pull-down, and affinity capture.
- Suitable for drug-linker conjugates, including ADC development.
- Molecular weight 745.88 g/mol.
- CAS number 1898221-65-2.
- Purity 99.4%.
Medchemexpress LLC CCND3 protein, human (biotinylated, MBP, His, Flag) | >85.0% | 20UG
Recombinant human CCND3 protein, biotinylated and fused to an N-terminal MBP with His and Flag tags, expressed in E. coli. The construct corresponds to CCND3 residues M1-L292 and is supplied in small research quantities (example: 20 μg). Characterization by reducing SDS-PAGE shows an apparent molecular weight of ~80 kDa and purity greater than 85%; consult the Certificate of Analysis for lot-specific data and storage instructions.
- Biotinylated for affinity capture and detection.
- N-terminal MBP fusion improves solubility.
- His and Flag tags enable purification and detection.
- Includes CCND3 residues M1-L292 for target-specific studies.
- Characterized by SDS-PAGE with >85% purity.
- Provided in small research-use quantities suitable for assay development.
Medchemexpress LLC Biotin-LC-LC-NHS | 89889-52-1 | 98.0% | 567.70 g/mol | C26H41N5O7S | 100 MG
Biotin-LC-LC-NHS is an amino-reactive N-hydroxysuccinimide (NHS) ester used to biotinylate primary amines on proteins, antibodies, and small molecules. It contains an extended LC-LC spacer arm to improve accessibility of the biotin tag and is supplied as a solid for laboratory conjugation and cross-linking applications.
- Reacts with primary amines for stable biotinylation.
- Extended LC-LC spacer improves tag accessibility.
- Provided as a solid, white to light yellow powder.
- Soluble in DMSO at 100 mg/mL; compatible with common in vivo formulation vehicles.
- Store protected from light under nitrogen at -20°C; in solution, store at -80°C for long-term storage.
Medchemexpress LLC GSPT1 protein, human (biotinylated, Avi tag) | 92.0% | 10UG
Recombinant human GSPT1 protein is expressed in Sf9 insect cells and site-specifically biotinylated via an Avi tag. Supplied as a 0.22 μm filtered solution in 50 mM HEPES, pH 7.5, with 1 mM DTT, 200 mM NaCl, and 20% glycerol, the product is provided frozen and shipped on dry ice for storage at -80°C.
- Human-derived sequence spanning residues D2-D637; approx. 70.8 kDa.
- Site-specific Avi biotinylation for consistent streptavidin-based applications.
- High purity (92.0% by reducing SDS-PAGE) suitable for biochemical assays.
- Formulated with glycerol and reducing agent for enhanced stability.
- Available in small-scale sizes to support assay development and screening.
- Shipped on dry ice; recommended long-term storage at -80°C.
Medchemexpress LLC LAIR1 Human Biotin 100ug
LAIR1 protein has a negative regulatory effect on NK cells B cells and T cells It activates the phosphatases PTPN6 and PTPN11 inhibits calcium increases in B cells and regulates cytokine production in CD4 T cells LAIR1 Protein Human (Biotinylated HEK293 Avi-His) is the recombinant human-derived LAIR1 protein expressed by HEK293 with C-Avi C-6 His labeled tag
Medchemexpress LLC Cyanine5.5 NHS ester chloride | 1469277-96-0 | MFCD28385524 | 95.7% | 716.31 g·mol-1 | C44H46ClN3O4 | 5 MG
Cyanine5.5 NHS ester chloride is a near-infrared reactive dye supplied as a solid NHS-activated ester that covalently labels primary amines in proteins, peptides, antibodies, and small molecules for fluorescence detection and imaging. The reagent is provided with analytical documentation to support purity and identity.
Medchemexpress LLC Cy3B NHS ester | 228272-52-4 | 97.8% | 10 MG
Cy3B NHS ester is a fluorescent labeling reagent that covalently attaches a cyanine-like fluorophore to primary amines via NHS-ester chemistry, enabling bright and photostable labeling of biomolecules for detection and imaging.
- Reactive N-hydroxysuccinimide (NHS) ester for efficient coupling to primary amines.
- Bright, photostable cyanine-like fluorophore for fluorescence detection.
- High purity (97.8%) for reliable labeling performance.
- Molecular weight 657.73 and CAS number 228272-52-4.
- Available in multiple package sizes, including 10 mg.
Medchemexpress LLC Bis-PEG13-NHS ester | 2221949-00-2 | MFCD21363287 | 98.0% | 884.92 | C38H64N2O21 | 10 MG
Bis-PEG13-NHS ester is a PEG/alkyl/ether-based bifunctional linker bearing NHS ester reactive groups for conjugation to primary amines. It is used as a cleavable linker for antibody-drug conjugates and as a linker in PROTAC synthesis to enable targeted bioconjugation and protein degradation.
- Contains two NHS ester reactive groups for conjugation to primary amines.
- Suitable as cleavable linker for antibody-drug conjugates and PROTAC synthesis.
- High purity, typically 98.0%.
- Molecular weight 884.92 and formula C38H64N2O21.
- Store sealed, away from moisture; in solvent: -80°C (6 months), -20°C (1 month).