Cycloheptathiophenes
Medchemexpress LLC Cevipabulin fumarate (TTI-237 fumarate) | 849550-67-0 | 99.9% | 580.89 | 1 ML
Cevipabulin fumarate (TTI-237 fumarate) is an oral, microtubule-active, antitumor compound. It inhibits the binding of [3H]NSC 49842 to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell lines. It is for research use only.
- Inhibits tubulin binding with IC50 values of 18-40 nM in human tumor cells.
- Active against ovarian, breast, prostate, and cervical tumor cell lines.
- Induces sub-G1 nuclei at 20-40 nM and G2-M block above 50 nM.
- Demonstrates in vitro cytotoxicity (IC50 18-40 nM) in human cancer cell lines.
- Active in vivo via i.v. and p.o. administration against human tumor xenografts.
- Shows dose-dependent antitumor activity in mouse xenograft models.
Medchemexpress LLC Ocifisertib (fumarate) | 1616420-30-4 | 99.3% | 650.72 g/mol | C37H38N4O7 | 100MG
Ocifisertib (fumarate) is the fumarate salt form of a potent and selective ATP-competitive inhibitor of polo-like kinase 4 (PLK4) supplied for laboratory research. It is provided as a solid research reagent with molecular formula C37H38N4O7 and molecular weight 650.72 g/mol.
Apexbio Technology LLC Ketotifen Fumarate 34580-14-8 200mg
Ketotifen fumarate is a noncompetitive antagonist of histamine H1 receptors and functions additionally as a mast cell stabilizer It inhibits histamine-mediated allergic responses through preventing histamine receptor activation and limiting mast cell degranulation Its pharmacological activity involves suppression of calcium influx into mast cells thus inhibiting histamine release Ketotifen fumarate is extensively utilized in biomedical research focusing on allergy and asthma pathophysiology to assess mast-cell-mediated mechanisms and histamine signaling pathways In vitro studies report its IC50 values ranging approximately from 0 8 to 2 5 M depending on assay parameters and cell types This compound commonly serves as a pharmacological tool when investigating allergic inflammation asthma and histamine-dependent cellular events
Medchemexpress LLC Dofequidar Fumarate | 153653-30-6 | 98.0% | 597.66 | 1 ML
Dofequidar fumarate (MS-209) is an orally active quinoline compound that blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1). It has a highly potent reversing effect on multidrug-resistant tumor cells. Dofequidar fumarate competitively inhibits ABCB1/P-gp and ABCC1/MRP-1, blocking the efflux of chemotherapeutic agents, increasing drug concentration in cancer cells, and enhancing the chemotherapeutic effect. It is for research use only and not sold to patients.
- Orally active quinoline compound
- Blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1)
- Highly potent reversing effect on multidrug-resistant tumor cells
- Competitively inhibits ABCB1/P-gp, ABCC1/MRP-1
- Blocks efflux of chemotherapeutic agents
- Increases drug concentration in cancer cells
- Enhances chemotherapeutic effect
Apexbio Technology LLC Bedaquiline fumarate 845533-86-0 50mg
Bedaquiline fumarate (CAS 845533-86-0) is a small-molecule inhibitor targeting ATP synthase of Mycobacterium tuberculosis It is designed to inhibit mycobacterial ATP synthase thereby disrupting ATP biosynthesis and bacterial energy metabolism Bedaquiline fumarate exerts its biological activity primarily through selective inhibition of ATP synthase In biochemical assays bedaquiline fumarate demonstrates potent inhibitory activity with an IC50 value of approximately 30 nM against M tuberculosis ATP synthase Based on these pharmacological properties bedaquiline fumarate holds research potential in studying tuberculosis pathogenesis mechanisms of antibiotic resistance and evaluating therapeutic strategies for mycobacterial infections
Medchemexpress LLC Formoterol fumarate | 43229-80-7 | >99.9% | C19H24N2O4 . 1/2C4H4O4 | 1 ML
Formoterol fumarate is a selective β2-adrenoceptor agonist, demonstrating similar β2-adrenoceptor selectivity to Salbutamol and Terbutaline. This compound is known for its ability to abolish the contraction induced by Acetylcholine in bronchioles. It is commonly utilized in research applications for conditions such as chronic obstructive pulmonary disease and bronchial asthma.
- Selective β2-adrenoceptor agonist
- Abolishes acetylcholine-induced contraction in bronchioles
- Used in research for chronic obstructive pulmonary disease
- Utilized in research for bronchial asthma
Medchemexpress LLC Diethyl fumarate | 623-91-6 | 99.0% | 172.18 | 10 G
Diethyl fumarate is a decomposition product of Malathion 9 and a reactant in the Diels-Alder reaction. It is a reputed skin irritant and can cause non-immunologic contact urticaria on the skin. Diethyl fumarate and Curcumin hybridize to exert neuroprotective effects.
- Decomposition product of Malathion 9.
- Reactant in Diels-Alder reaction.
- Causes dose-dependent swelling of ears in guinea pigs.
- Curcumin hybrids show neuroprotective effects in C. elegans model of PD.
- For research use only.
Apexbio Technology LLC Ro 60-0175 fumarate 169675-09-6 10mg
Ro 60-0175 fumarate (CAS 169675-09-6) is a selective agonist of the 5-HT2C serotonin receptor known to specifically activate serotonergic signaling pathways By targeting 5-HT2C receptors it modulates neurotransmitter release and neuronal circuitry influencing processes such as appetite regulation mood stabilization and cognitive function Ro 60-0175 fumarate is widely utilized in neuropharmacological research to investigate central nervous system mechanisms and to assess the pharmacological properties and therapeutic potential of 5-HT2C receptor agonists in models of depression anxiety obesity and related neuropsychiatric conditions
Medchemexpress LLC Diroximel fumarate | 1577222-14-0 | ≥98.0% | 255.23 g/mol | C11H13NO6 | 50 MG
Diroximel fumarate is supplied as a research-grade small-molecule reagent intended for laboratory studies. This listing represents a 50 MG pack of the prodrug of monomethyl fumarate and is provided for experimental and analytical use in research settings; it is not for clinical or human use.
- For research use only, not for human or clinical use.
- Supplied as a small 50 MG pack suitable for laboratory testing.
- High purity, typically ≥98.0%.
- Molecular weight 255.23 g/mol and formula C11H13NO6.
- Useful for studies of fumarate metabolism and related biochemical pathways.
Medchemexpress LLC Fumarate hydratase-I 10mM 1mL
Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2 2 M1]
Medchemexpress LLC Clemastine fumarate | 14976-57-9 | 99.96% | 1 ML
Clemastine fumarate is an orally active, blood-brain barrier-permeable H1 histamine receptor antagonist with potent antiallergic effects. It also antagonizes muscarinic acetylcholine receptors (mAChR), particularly the M1 and M4 subtypes. Beyond antihistamine effects, Clemastine fumarate shows various pharmacological activities.
- Promoting remyelination in the central nervous system
- Activating autophagy and pyroptosis
- Exerting anti-apoptotic and neuroprotective effects
- Suppressing inflammation
TARGETMOL CHEMICALS INC APLINDORE FUMARATE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Aplindore Fumarate (DAB-452) is a small molecule dopamine D2 receptor partial agonist.Aplindore Fumarate exhibits high affinity for dopamine D2 and D3 receptors and low affinity for dopamine D4 5-hydroxytryptophan (5-HT2) and (alpha)1-adrenergic receptors.Aplindore Fumarate is used in the study of Parkinson's disease and schizophrenia. Fumarate can be used to study Parkinson's and schizophrenia. purity: 100%
Medchemexpress LLC Rupatadine fumarate | 182349-12-8 | MFCD00926499 | 97.3% | C30H30ClN3O4 | 10MG
Rupatadine fumarate is an analytical reference standard supplied as a 10 mg pack for research and analytical applications. It corresponds to CAS 182349-12-8, has a molecular formula of C30H30ClN3O4, a molecular weight of 532.03, and is provided with a stated purity of approximately 97.3%. For laboratory research use only.
- Intended for analytical, method development, and validation use.
- Available in a 10 mg pack size.
- Molecular formula C30H30ClN3O4 and molecular weight 532.03.
- Listed purity 97.3%.
- Provided for laboratory research use only.
Apexbio Technology LLC GR 89696 fumarate 126766-32-3 50mg
GR 89696 fumarate (CAS 126766-32-3) is a selective agonist of the 2-opioid receptor By specifically activating 2 subtypes this small molecule modulates neural signaling pathways implicated in sensory processing particularly pain and pruritus Experimental studies have demonstrated that GR 89696 fumarate induces physiological effects in the nervous system through 2-opioid receptor activation This compound has been widely utilized as a pharmacological tool in the investigation of neurocutaneous disorders and the underlying mechanisms of opioid receptor-mediated modulation of somatosensory functions