Cycloheptathiophenes
![Ethyl 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate, 96%](https://assets.fishersci.com/TFS-Assets/CCG/Chemical-Structures/chemical-structure-cas-40106-13-6.jpg-250.jpg)
Ethyl 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate, 96%
CAS: 40106-13-6 Molecular Formula: C12H17NO2S Molecular Weight (g/mol): 239.333 MDL Number: MFCD00216932 InChI Key: XTUHIGALMIGZST-UHFFFAOYSA-N Synonym: ethyl 2-amino-5,6,7,8-tetrahydro-4h-cyclohepta b thiophene-3-carboxylate,ethyl 2-amino-4h,5h,6h,7h,8h-cyclohepta b thiophene-3-carboxylate,ethyl 2-amino-5,6,7,8-tetrahydro-4h-cyclohepta-b thiophene-3-carboxylate,ethyl 2-amino-4,5,6,7,8-pentahydrocyclohepta 1,2-b thiophene-3-carboxylate,2-amino-5,6,7,8-tetrahydro-4h-cyclohepta b thiophene-3-carboxylic acid ethyl ester,ethyl 2-aminocyclohepta b thiophene-3-carboxylate,aronis24232,ethyl 2-aminocycloheptathiophene-3-carboxylate,2-amino-3-ethoxy-carbonyl-4,5-pentamethylenethiophene PubChem CID: 292644 IUPAC Name: ethyl 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate SMILES: CCOC(=O)C1=C(SC2=C1CCCCC2)N
Ketotifen fumarate, 99%
CAS: 34580-14-8 Molecular Formula: C23H23NO5S Molecular Weight (g/mol): 425.499 MDL Number: MFCD00079394 InChI Key: YNQQEYBLVYAWNX-WLHGVMLRSA-N Synonym: ketotifen fumarate,zaditen,ketotifen hydrogen fumarate,alaway,unii-hbd503woro,hc 20,511 fumarate,ketotifen fumarate usan:jan,ketotifen fumarate salt,hbd503woro PubChem CID: 5282408 IUPAC Name: (E)-but-2-enedioic acid;10-(1-methylpiperidin-4-ylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one SMILES: CN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1.C(=CC(=O)O)C(=O)O
Ketotifen Hydrogen Fumarate, EP, 98.5-101%, Spectrum™ Chemical
CAS: 34580-14-8 Molecular Formula: C23H23NO5S Molecular Weight (g/mol): 425.50 InChI Key: YNQQEYBLVYAWNX-WLHGVMLRSA-N IUPAC Name: (2E)-but-2-enedioic acid; 2-(1-methylpiperidin-4-ylidene)-6-thiatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,10,12-pentaen-8-one SMILES: OC(=O)\C=C\C(O)=O.CN1CCC(CC1)=C1C2=C(SC=C2)C(=O)CC2=CC=CC=C12
Ketotifen Fumarate 98.0+%, TCI America™
CAS: 34580-14-8 Molecular Formula: C23H23NO5S Molecular Weight (g/mol): 425.499 MDL Number: MFCD00079394 InChI Key: YNQQEYBLVYAWNX-WLHGVMLRSA-N Synonym: ketotifen fumarate,zaditen,ketotifen hydrogen fumarate,alaway,unii-hbd503woro,hc 20,511 fumarate,ketotifen fumarate usan:jan,ketotifen fumarate salt,hbd503woro PubChem CID: 5282408 IUPAC Name: (E)-but-2-enedioic acid;10-(1-methylpiperidin-4-ylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one SMILES: CN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1.C(=CC(=O)O)C(=O)O
Pizotifen 98.0+%, TCI America™
CAS: 15574-96-6 Molecular Formula: C19H21NS Molecular Weight (g/mol): 295.444 MDL Number: MFCD00864192 InChI Key: FIADGNVRKBPQEU-UHFFFAOYSA-N Synonym: 4-[9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene]-1-methylpiperidine, Sandomigran PubChem CID: 27400 ChEBI: CHEBI:50212 IUPAC Name: 4-(4,5-dihydrobenzo[1,2]cyclohepta[3,4-b]thiophen-10-ylidene)-1-methylpiperidine SMILES: CN1CCC(=C2C3=C(CCC4=CC=CC=C42)SC=C3)CC1
Medchemexpress LLC Diroximel fumarate | 1577222-14-0 | 99.9% | 255.22 g/mol | C11H13NO6 | 1 ML
Diroximel fumarate is an orally active prodrug of monomethyl fumarate used in preclinical research to probe Nrf2 pathway modulation and multiple sclerosis-related biology. Supplied as a ready-to-use solution, it is intended for laboratory research use only and not for human or clinical applications.
- Ready-to-use 10 mM solution in DMSO for immediate experimental use.
- High purity (99.90%) suitable for biochemical and cellular assays.
- Molecular weight 255.22 g/mol, molecular formula C11H13NO6.
- Prodrug of monomethyl fumarate for Nrf2 pathway and MS-related research.
- Provided in a 1 mL volume for small-scale assays and dose-response studies.
- For research use only; not for human or clinical use.
Apexbio Technology LLC Clemastine Fumarate 14976-57-9 200mg
Clemastine Fumarate (CAS 14976-57-9) is a small molecule that functions as a selective antagonist of the histamine H1 receptor It demonstrates high affinity for the receptor with an inhibitory concentration (IC50) of 3 nM By blocking histamine H1 receptor-mediated signaling clemastine fumarate is utilized in research to study histaminergic pathways and allergic responses It is also employed to investigate the pharmacological modulation of H1 receptor activity in various cellular and in vivo models
Medchemexpress LLC Bedaquiline (fumarate) | 845533-86-0 | 99.99% | 671.58 | 25 MG
Bedaquiline (fumarate) is a diarylquinoline antibiotic that targets ATP synthase and is effective for the treatment of Mycobacterium tuberculosis infections. It inhibits the growth of TDR M. tuberculosis strains and shows high activity against Mycobacterium avium and moderate activity against NTM species. This product is for research use only.
- Targets ATP synthase
- Effective for treating Mycobacterium tuberculosis infections
- Inhibits growth of TDR M. tuberculosis strains
- High activity against Mycobacterium avium
- Moderate activity against NTM species
- For research use only
Medchemexpress LLC Ro60-0175 fumarate | 169675-09-6 | MFCD06798313 | 99.5% | 342.75 g/mol | C15H16ClFN2O4 | 1 ML
Ro60-0175 fumarate is a selective agonist of the serotonin 5-HT2C receptor used in neuroscience and pharmacology research. It is provided as a ready-to-use 10 mM solution in DMSO (1 mL) and in solid quantities; reported purity is 99.47%, with molecular formula C15H16ClFN2O4 and molecular weight 342.75 g/mol.
- Selective 5-HT2C receptor agonist for pharmacology studies.
- Available as 10 mM solution in DMSO (1 mL) and as solids (5, 10, 50 mg).
- High purity (~99.5%) suitable for research applications.
- Soluble in DMSO; in vitro solubility approximately 100 mg/mL.
- Storage guidance provided for powder and solutions to preserve stability.
Medchemexpress LLC Cevipabulin fumarate (TTI-237 fumarate) | 849550-67-0 | 99.9% | 580.89 | 1 ML
Cevipabulin fumarate (TTI-237 fumarate) is an oral, microtubule-active, antitumor compound. It inhibits the binding of [3H]NSC 49842 to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell lines. It is for research use only.
- Inhibits tubulin binding with IC50 values of 18-40 nM in human tumor cells.
- Active against ovarian, breast, prostate, and cervical tumor cell lines.
- Induces sub-G1 nuclei at 20-40 nM and G2-M block above 50 nM.
- Demonstrates in vitro cytotoxicity (IC50 18-40 nM) in human cancer cell lines.
- Active in vivo via i.v. and p.o. administration against human tumor xenografts.
- Shows dose-dependent antitumor activity in mouse xenograft models.
Apexbio Technology LLC Formoterol fumarate 43229-80-7 10mg
Formoterol fumarate (CAS 43229-80-7) is a long-acting 2-adrenergic receptor agonist that selectively binds to 2-adrenergic receptors on bronchial smooth muscle inducing relaxation and bronchodilation Through this mechanism it modulates airway smooth muscle tone leading to sustained improvement in airflow This compound is widely utilized in research exploring pathways of bronchoconstriction receptor signaling and the pharmacological management of obstructive airway diseases such as asthma and chronic obstructive pulmonary disease (COPD)
Medchemexpress LLC Dofequidar Fumarate | 153653-30-6 | 98.0% | 597.66 | 1 ML
Dofequidar fumarate (MS-209) is an orally active quinoline compound that blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1). It has a highly potent reversing effect on multidrug-resistant tumor cells. Dofequidar fumarate competitively inhibits ABCB1/P-gp and ABCC1/MRP-1, blocking the efflux of chemotherapeutic agents, increasing drug concentration in cancer cells, and enhancing the chemotherapeutic effect. It is for research use only and not sold to patients.
- Orally active quinoline compound
- Blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1)
- Highly potent reversing effect on multidrug-resistant tumor cells
- Competitively inhibits ABCB1/P-gp, ABCC1/MRP-1
- Blocks efflux of chemotherapeutic agents
- Increases drug concentration in cancer cells
- Enhances chemotherapeutic effect
Medchemexpress LLC Crozbaciclib fumarate | 2567494-39-5 | 99.4% | 604.65 | 10 MG
Crozbaciclib fumarate is a potent CDK4/6 inhibitor, demonstrating significant anti-proliferative effects by arresting the U87MG cell line exclusively in G1. It has shown promising results in vivo, including substantial tumor growth inhibition in orthotopic xenograft mouse models of glioblastoma multiforme.
- Potent CDK4/6 inhibitor with IC50s of 3 nM (CDK4) and 1 nM (CDK6).
- Acts as an anti-proliferative agent, arresting U87MG cells in G1.
- Exhibits tumor growth inhibition from 62% to 99% in glioblastoma multiforme xenograft models.
- Increases lifespan by 162% in mice at a dose of 50 mg/kg.
Medchemexpress LLC 2-Butenedioic acid (2E)-, 1-ethyl ester | 2459-05-4 | MFCD00002699 | 99.6% | 144.13 g/mol | C6H8O4 | 25 G
Monoethyl fumarate (2-Butenedioic acid (2E)-, 1-ethyl ester) is the monoethyl ester of fumaric acid supplied as a research reagent. It functions as an NRF2 activator and is used in biochemical and pharmacological studies to probe Keap1-Nrf2 signaling and inflammatory responses. Analytical documentation and high-purity material are provided for reproducible experiments.
- High purity suitable for research applications.
- Documented analytical data (COA, SDS, datasheet) available.
- Useful as an NRF2 activator probe in Keap1-Nrf2 pathway studies.
- Applicable to biochemical, pharmacological, and inflammation/immunology research.
- Available in multiple sizes for flexible experimental scaling.