Cycloheptathiophenes
![Ethyl 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate, 96%](https://assets.fishersci.com/TFS-Assets/CCG/Chemical-Structures/chemical-structure-cas-40106-13-6.jpg-250.jpg)
Ethyl 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate, 96%
CAS: 40106-13-6 Molecular Formula: C12H17NO2S Molecular Weight (g/mol): 239.333 MDL Number: MFCD00216932 InChI Key: XTUHIGALMIGZST-UHFFFAOYSA-N Synonym: ethyl 2-amino-5,6,7,8-tetrahydro-4h-cyclohepta b thiophene-3-carboxylate,ethyl 2-amino-4h,5h,6h,7h,8h-cyclohepta b thiophene-3-carboxylate,ethyl 2-amino-5,6,7,8-tetrahydro-4h-cyclohepta-b thiophene-3-carboxylate,ethyl 2-amino-4,5,6,7,8-pentahydrocyclohepta 1,2-b thiophene-3-carboxylate,2-amino-5,6,7,8-tetrahydro-4h-cyclohepta b thiophene-3-carboxylic acid ethyl ester,ethyl 2-aminocyclohepta b thiophene-3-carboxylate,aronis24232,ethyl 2-aminocycloheptathiophene-3-carboxylate,2-amino-3-ethoxy-carbonyl-4,5-pentamethylenethiophene PubChem CID: 292644 IUPAC Name: ethyl 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate SMILES: CCOC(=O)C1=C(SC2=C1CCCCC2)N
Ketotifen fumarate, 99%
CAS: 34580-14-8 Molecular Formula: C23H23NO5S Molecular Weight (g/mol): 425.499 MDL Number: MFCD00079394 InChI Key: YNQQEYBLVYAWNX-WLHGVMLRSA-N Synonym: ketotifen fumarate,zaditen,ketotifen hydrogen fumarate,alaway,unii-hbd503woro,hc 20,511 fumarate,ketotifen fumarate usan:jan,ketotifen fumarate salt,hbd503woro PubChem CID: 5282408 IUPAC Name: (E)-but-2-enedioic acid;10-(1-methylpiperidin-4-ylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one SMILES: CN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1.C(=CC(=O)O)C(=O)O
Ketotifen Hydrogen Fumarate, EP, 98.5-101%, Spectrum™ Chemical
CAS: 34580-14-8 Molecular Formula: C23H23NO5S Molecular Weight (g/mol): 425.50 InChI Key: YNQQEYBLVYAWNX-WLHGVMLRSA-N IUPAC Name: (2E)-but-2-enedioic acid; 2-(1-methylpiperidin-4-ylidene)-6-thiatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,10,12-pentaen-8-one SMILES: OC(=O)\C=C\C(O)=O.CN1CCC(CC1)=C1C2=C(SC=C2)C(=O)CC2=CC=CC=C12
Ketotifen Fumarate 98.0+%, TCI America™
CAS: 34580-14-8 Molecular Formula: C23H23NO5S Molecular Weight (g/mol): 425.499 MDL Number: MFCD00079394 InChI Key: YNQQEYBLVYAWNX-WLHGVMLRSA-N Synonym: ketotifen fumarate,zaditen,ketotifen hydrogen fumarate,alaway,unii-hbd503woro,hc 20,511 fumarate,ketotifen fumarate usan:jan,ketotifen fumarate salt,hbd503woro PubChem CID: 5282408 IUPAC Name: (E)-but-2-enedioic acid;10-(1-methylpiperidin-4-ylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one SMILES: CN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1.C(=CC(=O)O)C(=O)O
Pizotifen 98.0+%, TCI America™
CAS: 15574-96-6 Molecular Formula: C19H21NS Molecular Weight (g/mol): 295.444 MDL Number: MFCD00864192 InChI Key: FIADGNVRKBPQEU-UHFFFAOYSA-N Synonym: 4-[9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene]-1-methylpiperidine, Sandomigran PubChem CID: 27400 ChEBI: CHEBI:50212 IUPAC Name: 4-(4,5-dihydrobenzo[1,2]cyclohepta[3,4-b]thiophen-10-ylidene)-1-methylpiperidine SMILES: CN1CCC(=C2C3=C(CCC4=CC=CC=C42)SC=C3)CC1
Apexbio Technology LLC Bedaquiline fumarate 845533-86-0 10mM (in 1mL DMSO)
Bedaquiline fumarate (CAS 845533-86-0) is a small-molecule inhibitor targeting ATP synthase of Mycobacterium tuberculosis It is designed to inhibit mycobacterial ATP synthase thereby disrupting ATP biosynthesis and bacterial energy metabolism Bedaquiline fumarate exerts its biological activity primarily through selective inhibition of ATP synthase In biochemical assays bedaquiline fumarate demonstrates potent inhibitory activity with an IC50 value of approximately 30 nM against M tuberculosis ATP synthase Based on these pharmacological properties bedaquiline fumarate holds research potential in studying tuberculosis pathogenesis mechanisms of antibiotic resistance and evaluating therapeutic strategies for mycobacterial infections
Selleck Chemical LLC Bedaquiline fumarate S4854-25mg
Bedaquiline fumarate (TMC-207) an oral diarylquinoline is a bactericidal antimycobacterial drug It is a proton-translocating ATP synthetase inhibitor
Selleck Chemical LLC Ketotifen Fumarate S2024-50mg
Ketotifen Fumarate(HC 20511 fumarate) is a fumaric acid salt of ketotifen which is a H1-antihistamine and mast cell stabilizer
Selleck Chemical LLC Ibutilide Fumarate S2118-10mg
Ibutilide Fumarate (U-70226E Corvert Fumarate) is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current which prolongs action potential and refractory period of myocardial cells
Medchemexpress LLC Ro 48-8071 | 189197-69-1 | 99.1% | 564.44 | 100 MG
Ro 48-8071 is an inhibitor of Oxidosqualene cyclase (OSC) with an IC50 of approximately 6.5 nM. It is intended for research use only.
- Inhibits cholesterol synthesis in HepG2 cells (IC50 ~1.5 nM).
- Reduces viability of PC-3 prostate cancer cells, not normal prostate cells.
- Induces apoptosis in LNCaP, C4-2, castration-resistant PC-3, and DU145 cell lines.
- Reduces AR protein expression; increases ERβ protein expression dose-dependently.
- Inhibits 17β-estradiol (E2)-induced ERα responsive luciferase activity (IC50 ~10 μM).
- Lowers LDL-C by ~60% in hamsters without affecting HDL-C.
- Increases MOS in liver; significantly reduces VLDL secretion in hamsters.
- Reduces in vivo tumor growth in mice without weight loss; can eradicate tumors.
- Sustains and selectively suppresses intestinal cholesterol synthesis in BALB/c mice.
Apexbio Technology LLC Dimethyl Fumarate 624-49-7 5g
Dimethyl fumarate (CAS 624-49-7) is a small-molecule activator targeting the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway It is designed to promote Nrf2 nuclear translocation and induce transcription of antioxidant response genes thereby modulating oxidative stress response pathways Dimethyl fumarate exerts its biological activity primarily through activation of Nrf2-mediated antioxidant gene expression In cell-based assays dimethyl fumarate demonstrates Nrf2 activation activity with an IC50 value of approximately 5 M Based on these pharmacological properties dimethyl fumarate holds research potential in the study of oxidative stress inflammation and related pathophysiological processes
Medchemexpress LLC Fesoterodine fumarate | 286930-03-8 | 99.5% | C30H41NO7 | 10 MM * 1 ML
Fesoterodine Fumarate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist. It has pKi values of 8.0, 7.7, 7.4, 7.3, and 7.5 for M1, M2, M3, M4, and M5 receptors, respectively. It is used for the treatment of overactive bladder (OAB).
- Decreases micturition frequency, urgency severity, and urgency incontinence episodes.
- Increases the volume voided with each micturition.
- Rapidly and extensively hydrolyzed in plasma to Desfesoterodine (an active metabolite of Fesoterodine) after oral administration.
- Reduces micturition pressure.
- Increases bladder capacity and intercontraction intervals (ICIs) at a dose of 0.01 mg/kg in bladders from female Sprague-Dawley rats.
Apexbio Technology LLC Clemastine Fumarate 14976-57-9 500mg
Clemastine Fumarate (CAS 14976-57-9) is a small molecule that functions as a selective antagonist of the histamine H1 receptor It demonstrates high affinity for the receptor with an inhibitory concentration (IC50) of 3 nM By blocking histamine H1 receptor-mediated signaling clemastine fumarate is utilized in research to study histaminergic pathways and allergic responses It is also employed to investigate the pharmacological modulation of H1 receptor activity in various cellular and in vivo models
Apexbio Technology LLC Dimethyl Fumarate 624-49-7 10mM (in 1mL DMSO)
Dimethyl fumarate (CAS 624-49-7) is a small-molecule activator targeting the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway It is designed to promote Nrf2 nuclear translocation and induce transcription of antioxidant response genes thereby modulating oxidative stress response pathways Dimethyl fumarate exerts its biological activity primarily through activation of Nrf2-mediated antioxidant gene expression In cell-based assays dimethyl fumarate demonstrates Nrf2 activation activity with an IC50 value of approximately 5 M Based on these pharmacological properties dimethyl fumarate holds research potential in the study of oxidative stress inflammation and related pathophysiological processes
Medchemexpress LLC Fumarate hydratase-I 10mg
Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2 2 M1]