Epoxides
Medchemexpress LLC 11-epi-mogroside V | 2146088-12-0 | 5 MG
11-epi-mogroside V is a mogroside found in the fruit of *Siraitia grosvenori*. It shows considerable bioactivity in promoting glucose uptake in human HepG2 cells *in vitro*.
- For research use only.
- Exhibits considerable bioactivity in promoting glucose uptake in human HepG2 cells in vitro.
Medchemexpress LLC 5-Pyrimidinecarboxamide, 2-[4-[[[2-(2,5-dimethyl-3-furanyl)-6,7-dimethoxy-4-quinolinyl]amino] | 2256079-39-5 | 98.4% | 532.59 | 1 ML
CM-1758 is a histone deacetylase (HDAC) inhibitor. It inhibits tumor growth in vivo and induces acetylation of non-histone proteins in acute myeloid leukemia cells.
- Histone deacetylase (HDAC) inhibitor
- Inhibits tumor growth in vivo
- Induces acetylation of non-histone proteins in acute myeloid leukemia cells
![Medchemexpress LLC 5-Pyrimidinecarboxamide, 2-[4-[[[2-(2,5-dimethyl-3-furanyl)-6,7-dimethoxy-4-quinolinyl]amino]methyl | 2256079-39-5 | 98.4% | 532.59 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000391895.png-250.jpg)
Medchemexpress LLC 5-Pyrimidinecarboxamide, 2-[4-[[[2-(2,5-dimethyl-3-furanyl)-6,7-dimethoxy-4-quinolinyl]amino]methyl | 2256079-39-5 | 98.4% | 532.59 | 25 MG
CM-1758 is a histone deacetylase (HDAC) inhibitor. It inhibits tumor growth in vivo and induces acetylation of non-histone proteins in acute myeloid leukemia cells.
- Histone deacetylase (HDAC) inhibitor
- Inhibits tumor growth in vivo
- Induces acetylation of non-histone proteins in acute myeloid leukemia cells
- For research use only
Medchemexpress LLC 11-epi-mogroside V | 2146088-12-0 | 1 MG
11-epi-mogroside V is a mogroside found in the fruit of Siraitia grosvenorii. This compound exhibits considerable bioactivity in promoting glucose uptake in human HepG2 cells in vitro. It is classified under terpenoids, specifically triterpenes, and originates from plants within the Cucurbitaceae family.
- Promotes glucose uptake in human HepG2 cells in vitro.
- Derived from the fruit of Siraitia grosvenorii.
- Classified as a triterpene.
- Suitable for research use only.
Medchemexpress LLC Mogroside V | 88901-36-4 | 1287.43 | 50 MG
Mogroside V is the major active constituent of a traditional Chinese medicine, Siraitiae Fructus. It reduces intracellular reactive oxygen species (ROS) levels and enhances mitochondrial function. It has anti-oxidative, anti-diabetic, and anti-carcinogenic effects and can be used for diabetic diseases research.
- Reduces intracellular reactive oxygen species (ROS) levels
- Enhances mitochondrial function
- Exhibits anti-oxidative, anti-diabetic, and anti-carcinogenic effects
- Promotes apoptosis and cell cycle arrest of pancreatic cancer cells through regulating the STAT3 signaling pathway
Medchemexpress LLC Cm-1758 | 2256079-39-5 | 98.4% | 532.59 g/mol | C28H32N6O5 | 10 MG
CM-1758 is a small-molecule histone deacetylase (HDAC) inhibitor for laboratory research; it has reported in vivo antitumor activity and induces acetylation of non-histone proteins in acute myeloid leukemia cells.
- Histone deacetylase (HDAC) inhibitor with reported in vivo antitumor activity.
- Induces acetylation of non-histone proteins in acute myeloid leukemia cells.
- Molecular weight 532.59 g/mol and formula C28H32N6O5.
- High purity (98.44% by HPLC) suitable for research applications.
- Soluble in DMSO (100 mg/mL) for in vitro use; formulations available for in vivo dosing.
- Powder storage: -20°C (3 years) or 4°C (2 years); follow recommended storage for solutions.
Medchemexpress LLC Trodusquemine lactate | 1309370-86-2 | 98.8% | 1 ML
MSI-1436 lactate (trodusquemine lactate) is a selective, non-competitive inhibitor of protein-tyrosine phosphatase 1B (PTP1B), with an IC50 of 1 μM and approximately 200-fold selectivity over TCPTP. Supplied as a 10 mM stock solution (1 mL), it is intended for research use in biochemical and cell-based assays targeting PTP1B-regulated pathways.
- Selective PTP1B inhibition, IC50 = 1 μM.
- Approximately 200-fold selectivity over TCPTP.
- Supplied as a 10 mM stock solution in 1 mL vial.
- High purity as verified by HPLC.
- CAS number 1309370-86-2 for substance identification.
- Suitable for biochemical and cell-based assays.
Medchemexpress LLC (3S,4S)-A2-32-01 | 00-00-0 | 98.4% | 301.42 | C19H27NO2 | 5 MG
(3S,4S)-A2-32-01 is the (S,S)-enantiomer of a known ClpP inhibitor and is provided for research use. It is supplied as an oil or as ready-to-use DMSO solutions, and is intended for use in biochemical and cell-based studies involving caseinolytic peptidase protease (ClpP). Store protected from light at recommended temperatures.
Medchemexpress LLC (3S,4S)-A2-32-01 | 98.4% | 301.42 | 100 MG
(3S,4S)-A2-32-01 (compound 24(S,S)) is identified as a less active (S,S)-enantiomer of A2-32-01. A2-32-01 is a potent inhibitor of caseinolytic protein proteases (ClpP). This product is for research use only and is not sold to patients.
- Target is ClpP
- Pathway is Cell Cycle/DNA Damage
- Stored at -20°C, protect from light
- In solvent stored at -80°C for 6 months or -20°C for 1 month (protect from light)
- Soluble in DMSO (100 mg/mL; needs ultrasonic)
- Soluble in various in vivo dissolution protocols
Medchemexpress LLC (3S,4S)-A2-32-01 | 98.4% | 301.42 | 100 MG
(3S,4S)-A2-32-01 (compound 24(S,S)) is described as a less active (S,S)-enantiomer of A2-32-01. A2-32-01 itself is a potent caseinolytic protein proteases (ClpP) inhibitor. This product is for research use only.
- Less active (S,S)-enantiomer of A2-32-01
- Potent caseinolytic protein proteases (ClpP) inhibitor
- Target: ClpP
- Pathway: Cell cycle/DNA damage
- Store at -20°C, protect from light
- In solvent: -80°C for 6 months; -20°C for 1 month (protect from light)
Medchemexpress LLC Rebaudioside M | 1220616-44-3 | 10 MG
Rebaudioside M is a non-calorie sweetener isolated from *Stevia rebaudiana*. It is a glycoside of the *ent*-kaurene diterpenoid aglycone, over 350 times sweeter than sucrose, and suitable for use in food and beverages. This compound exhibits antidiabetic, antihypertension, anti-inflammatory, antioxidant, anticaries, and anticancer benefits. It is intended for research use only.
- Non-calorie sweetener extracted from *Stevia rebaudiana*
- Over 350 times sweeter than sucrose
- Applicable in food and beverages
- Demonstrates antidiabetic, antihypertension, anti-inflammatory, and antioxidant benefits
- Supports β-cell activity and insulin secretion
- Inhibits PI3K/Akt and Wnt/catenin signaling pathways
- Helps lower blood glucose and blood pressure
Medchemexpress LLC MSI-1436 lactate | 1309370-86-2 | 98.8% | 1000.17 | 5 MG
MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B), with an IC50 of 1 μM, demonstrating a 200-fold preference over TCPTP (IC50 of 224 μM). It is intended for research use only and not for sale to patients.
- Selective, non-competitive inhibitor of PTP1B
- 200-fold preference over TCPTP
- Restores ERK phosphorylation in F11 neuronal cells.
- Rescues DHPG-induced holding currents and restores DSI in LMO4KO BLA neurons.
- Blocks PTP1B activity (0.1-100 μM).
- Reduces obesity-dependent body weight, total body fat, and adipocyte size in mice (10 mg/kg, i.p.).
- Exhibits anxiolytic effect via endocannabinoid (eCB) signaling in amygdala.
- Anti-diabetic effect in mice, suppresses food intake and causes weight loss (5 mg/kg, i.p.).