Lactams
Medchemexpress LLC Thalidomide-C2-amido-C2-COOH | 2353496-84-9 | 98.5% | 416.38 g/mol | C19H20N4O7 | 5 MG
Thalidomide-C2-amido-C2-COOH is an E3 ligase ligand-linker conjugate that incorporates a cereblon-binding thalidomide-derived moiety and a carboxylic acid linker. It is intended for use as a research reagent in PROTAC design and related chemical biology studies; not for human or clinical use.
- CAS number: 2353496-84-9.
- Molecular formula: C19H20N4O7.
- Molecular weight: 416.38 g/mol.
- Purity: 98.45% (typical by supplier).
- Solubility: DMSO up to 100 mg/mL (may require sonication).
- Storage: powder at -20°C; stock solutions at -80°C for long term.
- Intended use: CRBN ligand for PROTAC design and E3 ligase studies.
- Available in small mg quantities for research use.
Medchemexpress LLC Thalidomide-4-O-CH2-COO(t-Bu) | 1950635-36-5 | 99.3% | 388.37 | 50 MG
Thalidomide-4-O-CH2-COO(t-Bu) is a t-Bu modified Thalidomide, serving as the final intermediate in the synthesis of Thalidomide-4-OH. It functions as a Cereblon ligand, recruiting CRBN proteins. The t-Bu protecting group can be removed under acidic conditions to facilitate the synthesis of PROTAC molecules. This compound is a crucial intermediate for synthesizing CRBN-based designed PROTAC molecules.
- Functions as a Cereblon ligand
- Recruits CRBN proteins
- t-Bu protecting group can be removed under acidic conditions
- Key intermediate for synthesizing CRBN-based designed PROTAC molecules
![Medchemexpress LLC 6H-Thieno[3,2-f]triazolo[4,3-a]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, cyclopropyl ester, (6S)- | 3077900-08-1 | 98.31% | 440.95 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000386961-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 6H-Thieno[3,2-f]triazolo[4,3-a]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, cyclopropyl ester, (6S)- | 3077900-08-1 | 98.31% | 440.95 | 50 MG
DDL-357 is a potent secreted clusterin enhancer. It reduces phospho-tau in the brain and improves memory in the murine 3xTg-AD model.
- Reduces phospho-tau in brain.
- Improves memory in the murine 3xTg-AD model.
Medchemexpress LLC 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-methyl- | 40313-92-6 | 99.9% | 272.26 | 25 MG
Thalidomide-5-methyl is a cereblon (CRBN) ligand derived from Thalidomide, used for recruiting CRBN protein. It can be utilized in the synthesis of PROTACs.
- Thalidomide-based cereblon (CRBN) ligand.
- Used in the recruitment of CRBN protein.
- Can be used to synthesize PROTACs.
Medchemexpress LLC Thalidomide-O-PEG4-amine hydrochloride | 2820929-03-9 | C23H32ClN3O9 | 250MG
Thalidomide-O-PEG4-amine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide-based cereblon ligand and a linker used in PROTAC technology. This compound is designed to exploit the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Used in PROTAC technology
- Designed for selective degradation of target proteins
Medchemexpress LLC Thalidomide-5-O-C2-NH2 hydrochloride | 2694727-89-2 | 99.6% | 353.76 | 5MG
Thalidomide-5-O-C2-NH2 hydrochloride is a cereblon ligand based on Thalidomide, designed for the recruitment of CRBN protein. This compound can be linked to a protein ligand via a linker to form PROTACs, which are relevant in cancer targeted therapy and metabolism research.
- Used for the recruitment of CRBN protein
- Can be connected to a protein ligand by a linker to form PROTACs
- Target is Cereblon
- Involved in E3 ligase ligand-linker conjugates, apoptosis, and autophagy research
Medchemexpress LLC DDL-357 | 3077900-08-1 | 98.3% | 440.95 | 100 MG
DDL-357 is a potent secreted clusterin enhancer that reduces phospho-tau in the brain and improves memory in the murine 3xTg-AD model. It is for research use only and not sold to patients.
- Potent secreted clusterin enhancer
- Reduces phospho-tau in brain
- Improves memory in the murine 3xTg-AD model
- For research use only
Medchemexpress LLC 1H-Isoindole-1,3(2H)-dione, 5-[2-(2-chloroethoxy)ethoxy]-2-(2,6-dioxo-3-piperidinyl)- | 2230956-57-5 | 96.6% | 380.78 | 25 MG
Thalidomide-5-PEG2-Cl is a thalidomide-based cereblon ligand that facilitates the recruitment of CRBN protein. It can be linked to a target protein ligand to create PROTACs, which are designed to harness the intracellular ubiquitin-proteasome system for selective protein degradation.
- Functions as a thalidomide-based cereblon ligand
- Used in the recruitment of CRBN protein
- Can be connected to a protein ligand via a linker to form PROTACs
- PROTACs utilize the ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thalidomide-O-PEG4-azide | 2380318-57-8 | 98.0% | C23H29N5O9 | 50 MG
Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that integrates a Thalidomide-based cereblon ligand with a linker used in PROTAC technology. This compound is intended for research use only.
- Acts as a click chemistry reagent due to its Azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups
Medchemexpress LLC Glycine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]- | 2412056-27-8 | 95.0% | C15H13N3O6 | 25 MG
Thalidomide-5-NH2-CH2-COOH (compound 114) is a potent and selective inhibitor of tropomyosin receptor kinase (trk) and functions as a ligand of E3 ligase. This PROTAC leverages the intracellular ubiquitin-proteasome system to selectively degrade target proteins, holding potential for researching various diseases, as extracted from patent WO2021170109A1. This product is for research use only.
- Potent and selective inhibitor of tropomyosin receptor kinase (trk)
- Functions as a ligand for E3 ligase
- PROTAC (proteolysis-targeting chimera) technology
- Utilizes the ubiquitin-proteasome system to degrade target proteins
- Potential for researching various diseases
Medchemexpress LLC Thalidomide-propargyl | 2098487-39-7 | 99.97% | 312.28 | 100MG
Thalidomide-propargyl is a Thalidomide-based Cereblon ligand used to recruit the CRBN protein. It can be linked to a target protein ligand via a linker to form IMiD-containing PROTACs. It is also a click chemistry reagent containing an Alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
- Used to recruit the Cereblon protein
- Can be linked to a target protein ligand to form IMiD-containing PROTACs
- Click chemistry reagent containing an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition with azide-containing molecules
Medchemexpress LLC Thalidomide-piperazine-PEG2-COOH | 2797430-20-5 | 99.8% | 502.52 | 25 MG
Thalidomide-Piperazine-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide based cereblon ligand
- Used as a linker in PROTAC technology
- Related to PROTACs, an emerging therapeutic modality in precision medicine
- Related to cereblon-based small-molecule compounds for controlling neural stem cell proliferation in regenerative medicine
eMolecules 2797619-65-7 | Medchem Express | Thalidomide-Propargyne-PEG2-COOH | 50mg | 626717252 | HY-138777 | 428.397 | C21H20N2O8
Ambeed | N2-Isobutyryl-5-O-(44-dimethoxytrityl)-2-deoxyguanosine | 1g | 490507231 | A135681 | 68892-41-1 | MFCD00010059 | 639.709 | C35H37N5O7
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Medchemexpress LLC Thalidomide-O-COOH | 1061605-21-7 | MFCD31560477 | >98.0% | 332.27 | C15H12N2O7 | 10 G
Thalidomide-O-COOH is a thalidomide-derived cereblon (CRBN) ligand used as an E3 ligase recruiting moiety in PROTAC and targeted protein degradation design. The compound is supplied as a solid with molecular formula C15H12N2O7 and molecular weight 332.27 g/mol (CAS 1061605-21-7).
- Serves as a cereblon (CRBN) binding ligand for PROTAC construction.
- Suitable for medicinal chemistry and chemical biology research.
- Provided in multiple laboratory-scale pack sizes for synthesis and screening.
- Characterized by manufacturer datasheet and SDS for handling and storage guidance.
Medchemexpress LLC Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride | 2341841-02-7 | MFCD32705133 | 99.3% | 410.81 | 50 MG
Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride is a chemical compound designed for the development of PROTACs (Proteolysis Targeting Chimeras). It functions by incorporating a cereblon (CRBN) ligand, which is essential for E3 ubiquitin ligase binding, alongside a linker. This product is strictly for research purposes and is not intended for patient use or clinical applications.
- Incorporates a cereblon (CRBN) ligand for E3 ubiquitin ligase binding
- Features a versatile linker for PROTAC design
- A key component for PROTAC research and development
- Facilitates targeted protein degradation studies
- Suitable for chemical biology and drug discovery research