Lactams
Medchemexpress LLC Thalidomide-4-F,5-Br | 2740657-28-5 | 99.4% | 355.12 g·mol⁻¹ | C13H8BrFN2O4 | 50 MG
Thalidomide-4-F,5-Br is a thalidomide analogue used as a cereblon (CRBN) E3 ligase ligand in biochemical research. It is provided as a purified powder for use in degradation studies, PROTAC design, and related cell biology and biochemical assays.
- Acts as a cereblon E3 ligase ligand for targeted protein ubiquitination and degradation.
- Suitable for PROTAC synthesis and biochemical assay development.
- Supplied as a powder form for convenient handling and storage.
- High purity (~99%) suitable for research applications.
- Molecular weight approximately 355.12 g·mol⁻¹.
- Available in multiple small package sizes for laboratory use.
Apexbio Technology LLC Thalidomide-O-amido-C4-NH2 TFA 1799711-25-3 50mg
Thalidomide-O-amido-C4-NH2 TFA (CAS 1799711-25-3) is a synthetic small molecule composed of a thalidomide-derived cereblon ligand conjugated to a chemical linker This compound selectively binds to cereblon (CRBN) a substrate receptor of the CRL4CRBN E3 ubiquitin ligase complex By facilitating the recruitment of target proteins to the CRBN complex it enables their ubiquitination and subsequent proteasomal degradation Thalidomide-O-amido-C4-NH2 TFA serves as a molecular tool in the development of proteolysis targeting chimeras (PROTACs) and other targeted protein degradation strategies in biomedical research
Medchemexpress LLC Thalidomide-5-PEG4-NH2 hydrochloride | 2743434-24-2 | 95.2% | 485.92 | 50 MG
Thalidomide-5-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide-based cereblon ligand and a linker, and is used in PROTAC technology. This product is intended for research use only and is not sold to patients.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Utilizes a linker for PROTAC technology
- For research use only
Medchemexpress LLC Thalidomide-pyrrolidine (hydrochloride) | 2616553-35-4 | 98.0% | 335.74 g/mol | C15H14ClN3O4 | 10 MG
Thalidomide-pyrrolidine hydrochloride is a thalidomide-derived E3 ligase ligand supplied for laboratory research. It serves as a building block for the synthesis of proteolysis targeting chimeras (PROTACs) and related chemical probes. The compound is provided as a solid hydrochloride salt intended for research use only.
- E3 ligase ligand suitable for PROTAC synthesis.
- Hydrochloride salt form for improved stability and handling.
- Off-white to gray solid for solid-phase handling.
- High purity appropriate for research applications.
- Supplied in small pack sizes for synthesis and screening.
Cayman Chemical -ThalIdomIde 500mg
An immunomodulatory compound with diverse biological activities; prevents PMN chemotaxis at 1, 10, and 100 UG/ml; increases IL-2-induced proliferation and IFN-γ production in primary human T cells in vitro; enhances NK cell-mediated cytotoxicity in MM.1S multiple myeloma cells; reduces lung IL-6, TGF-β, VEGF, angiopoietin-1, angiopoietin-2, and collagen type Iα1 expression, inhibits pulmonary angiogenesis, and attenuates fibrosis in a mouse model of bleomycin-induced pulmonary fibrosis at 4 mg/animal; induces apoptosis in primary human embryonic fibroblasts (EC50 = 8.9 µM) and induces limb and eye defects in chicken embryos (EC50 = 50 UG/kg egg weight)
Medchemexpress LLC Thalidomide-O-amido-C4-N3 | 2098488-36-7 | MFCD31560486 | 98.4% | 428.40 g/mol | C19H20N6O6 | 10 MG
Thalidomide-O-amido-C4-N3 is a thalidomide-derived cereblon ligand-linker conjugate used as a building block in proteolysis-targeting chimera (PROTAC) and E3 ligase ligand research. It is provided with analytical characterization and storage guidance for research applications.
- Used as a cereblon ligand-linker conjugate for PROTAC and E3 ligase research.
- Molecular formula C19H20N6O6; molecular weight 428.40 g/mol.
- CAS number 2098488-36-7 for unambiguous identification.
- Purity 98.4% by LCMS (as supplied).
- Supplied in small research quantities (for example, 10 mg) and as stock solution preparations.
- Soluble in DMSO and compatible solvent systems for formulation.
- Store at 4°C under nitrogen; in solution, store at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Thalidomide-NH-CBP/p300 ligand 2 (P-007) | 2484739-21-9 | 98.6% | 922.03 | 100 MG
Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based CBP and p300 degrader, extracted from patent WO2020173440. This product is for research use only.
- PROTAC-based CBP and p300 degrader
- Extracted from patent WO2020173440
- For research use only
- Targets cereblon
Medchemexpress LLC Thalidomide-PEG4-COOH | 2828438-28-2 | 95.4% | 478.45 | 25 MG
Thalidomide-PEG4-COOH is a synthesized E3 ligase ligand-linker conjugate, incorporating a Thalidomide-based cereblon ligand and a linker utilized in PROTAC technology. This product is intended for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a Thalidomide-based cereblon ligand
- Utilized in PROTAC technology
- Targets cereblon
- Associated with cancer, cancer targeted therapy, cancer metabolism, and metastasis research
- Relevant to autophagy and apoptosis studies
- Functions as an inhibitor