Lactams
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | MFCD32701934 | 95.1% | C26H34N2O7 | 10MG
Thalidomide-O-C8-Boc is a thalidomide-derived Cereblon (CRBN) ligand intended for use as the E3 ligase-recruiting moiety in PROTAC design. It features an O-linked eight-carbon spacer with a Boc-protected terminus to enable linker attachment. Manufacturer data report molecular formula C26H34N2O7, molecular weight 486.56, and typical purity ~95%.
- Provides an O-linked C8 spacer with a Boc-protected terminus for linker attachment.
- Suitable for recruiting Cereblon (CRBN) as the E3 ligase in degrader strategies.
- Reported purity approximately 95.1%.
- High solubility in DMSO (100 mg/mL); manufacturer lists example in vivo formulations.
- Recommended storage: solid at -20°C under nitrogen; in solution -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | 95.1% | 25 MG
Thalidomide-O-C8-Boc is a thalidomide-based Cereblon ligand used for the recruitment of CRBN protein. It can be connected to a ligand for protein by a linker to form PROTACs.
- Thalidomide-based Cereblon ligand
- Used in the recruitment of CRBN protein
- Can be used to form PROTACs when connected to a ligand for protein by a linker
- Appearance: Solid, white to off-white
- For research use only
Medchemexpress LLC Thalidomide-O-COOH | 1061605-21-7 | MFCD31560477 | 99.9% | 332.27 g·mol⁻¹ | C15H12N2O7 | 1 G
Thalidomide-O-COOH is a thalidomide-derived small-molecule ligand that recruits the CRBN E3 ubiquitin ligase and is commonly used as the E3 ligase component in PROTAC design and other chemical biology applications.
- Used as a cereblon (CRBN) E3 ligase ligand for PROTAC construction.
- CAS number 1061605-21-7; molecular formula C15H12N2O7; molecular weight 332.27 g·mol⁻¹.
- Reported high purity suitable for research and synthesis workflows.
- Functional handle (carboxylic acid) enables conjugation to linkers and building blocks.
- Supplied as a solid for storage and handling in synthetic and analytical protocols.
Medchemexpress LLC Thalidomide-4-O-CH2-COO(t-Bu) | 1950635-36-5 | 99.3% | 388.37 | 25 MG
Thalidomide-4-O-CH2-COO(t-Bu) is a t-Bu modified thalidomide that functions as a Cereblon ligand, recruiting CRBN proteins. This compound serves as a final intermediate in the synthesis of Thalidomide-4-OH. Its t-Bu protecting group can be removed under acidic conditions, making it suitable for participation in PROTAC molecule synthesis and a key intermediate for CRBN-based designed PROTAC molecules.
- t-Bu modified thalidomide
- Intermediate in Thalidomide-4-OH synthesis
- Functions as a Cereblon ligand
- Recruits CRBN proteins
- t-Bu protecting group is removable under acidic conditions
- Key intermediate for CRBN-based PROTAC molecule synthesis
Medchemexpress LLC Thalidomide-propargyl | 2098487-39-7 | 99.97% | 312.28 | 2 MG
Thalidomide-propargyl is a Cereblon ligand derived from Thalidomide that facilitates the recruitment of the CRBN protein. It can be linked to other ligands to form IMiD-containing PROTACs. This compound is a click chemistry reagent, featuring an Alkyne group that allows it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Azide groups.
- Thalidomide-based cereblon ligand.
- Used in the recruitment of CRBN protein.
- Can be connected to ligands for protein to form IMiD containing PROTACs.
- Click chemistry reagent.
- Contains an alkyne group.
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups.
Medchemexpress LLC Thalidomide-O-amido-C6-NH2 hydrochloride | 2376990-31-5 | 99.3% | 466.92 | 100 MG
Thalidomide-O-amido-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, and can be used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- E3 ligase ligand-linker conjugate
- Incorporates thalidomide based cereblon ligand and a linker
- Used in the synthesis of PROTACs
- Appearance: Solid
- Color: White to off-white
Medchemexpress LLC Thalidomide-NH-PEG1-NH2 hydrochloride | 2154342-56-8 | 99.2% | C17H21ClN4O5 | 10MG
Thalidomide-NH-PEG1-NH2 hydrochloride is a thalidomide-derived cereblon E3 ligase ligand-linker conjugate supplied as the hydrochloride salt and intended as a building block for PROTAC design and small-molecule degradation strategies. It couples a cereblon-recruiting moiety with a short PEG1 diamine linker to facilitate conjugation to target-binding ligands and streamline synthesis workflows.
- Provides thalidomide-based cereblon recruiting moiety.
- Includes a short PEG1 diamine linker for flexibility in conjugation.
- Supplied as hydrochloride salt for improved stability and handling.
- High purity suitable for synthetic applications (99.2%).
- Available in small milligram quantities for early-stage research.
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | MFCD32701934 | 95.1% | 486.56 g·mol⁻¹ | C26H34N2O7 | 5 MG
Thalidomide-O-C8-Boc is a thalidomide-derived Cereblon (CRBN) ligand for targeted protein degradation research. It is designed to be connected to a protein-targeting ligand via a linker to form PROTAC molecules and is provided as a research-grade chemical with manufacturer-reported purity (~95.1%).
- Acts as a cereblon ligand to recruit CRBN.
- Designed for conjugation via a linker to form PROTACs.
- Supplied at research-grade purity (~95.1%).
- Molecular formula C26H34N2O7; molecular weight 486.56 g·mol⁻¹.
- Available in milligram-scale quantities suitable for synthesis and screening.
Medchemexpress LLC Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride | 2376990-30-4 | 498.91 | 100 MG
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride incorporates an E3 ligase ligand and a linker, and can be an immunomodulator for the treatment of cancer. It is for research use only and not sold to patients. PROTACs contain two different ligands connected by a linker, one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Incorporates an E3 ligase ligand and a linker
- Can be an immunomodulator for the treatment of cancer
- Utilizes the intracellular ubiquitin-proteasome system to selectively degrade target proteins
eMolecules 1799711-24-2 | Thalidomide-O-acetamido-C4-amine HCl salt | Broadpharm402.407 | C19H22N4O6 | 0.000 | NCCCCNC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 | 100mg | 686681011
Thalidomide-O-acetamido-C4-amine HCl salt | Broadpharm | 1799711-24-2402.407 | C19H22N4O6 | 0.000 | NCCCCNC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 | 100mg | 686681011
Medchemexpress LLC Thalidomide | 50-35-1 | MFCD00153873 | 100.0% | C13H10N2O4 | 10MG
Thalidomide (analytical standard) is a high-purity reference compound (CAS 50-35-1) intended for research and analytical applications. It serves as a cereblon inhibitor standard for assay calibration, method development, and reference testing. Consult the certificate of analysis and safety data sheet for batch-specific purity and handling instructions.
- High purity (99.96%) suitable for analytical standards.
- Provided in small, laboratory-scale quantities for method development.
- Supplied with certificate of analysis and safety data sheet.
- Intended for research and analytical use only.
- Suitable for assays targeting cereblon-related activity.
Medchemexpress LLC Thalidomide-1-me,4-oh | 2244568-06-5 | ≥98.0% | 288.26 g·mol-1 | C14H12N2O5 | 100 MG
Thalidomide-1-Me,4-OH is a thalidomide analogue bearing a 4-hydroxy substituent and an N-1 methyl group. It serves as a cereblon/E3 ligase ligand scaffold for research into ubiquitin-mediated proteolysis and is supplied as a solid research reagent.
- Small-molecule cereblon/E3 ligase ligand used in biochemical and cell-based assays
- High purity suitable for research applications
- Powder form with defined storage recommendations for long-term stability
- Includes chemical identifiers for traceability, including CAS and molecular formula
- Applicable for studies of targeted protein degradation and ligand design
Medchemexpress LLC Thalidomide-o-amido-peg3-c2-nh2 (TFA) | 1957236-21-3 | MFCD31656717 | 99.6% | 620.53 g/mol | C25H31F3N4O11 | 50 MG
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a Thalidomide-based cereblon E3 ligase ligand-linker conjugate provided as the trifluoroacetate salt. It contains a three-unit polyethylene glycol (PEG3) linker and a terminal C2 primary amine for conjugation, and is intended as a building block for PROTAC synthesis and cereblon recruitment studies.
- Cereblon-binding thalidomide ligand with a three-unit PEG linker.
- Terminal primary amine (C2) for facile conjugation to targeting ligands.
- Provided as a trifluoroacetate (TFA) salt for handling stability.
- High purity confirmed by LCMS (~99.6%).
- Molecular weight 620.53 g/mol and CAS 1957236-21-3 for unambiguous identification.
Medchemexpress LLC 5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | 2230957-36-3 | 290.25 | C14H11FN2O4 | 250 MG
Thalidomide-1-Me,5-F is a fluorinated thalidomide derivative used as an E3 ubiquitin ligase activator in research. Supplied as a solid for laboratory use, it functions as a synthetic building block for further derivatization and for studies that probe E3 ligase-mediated pathways. Consult the product datasheet for lot-specific purity and analytical data.
- Fluorinated E3 ligase activator suitable for biochemical assays
- Reactive position enables SNAr derivatization for synthesis
- Supplied as a solid in multiple laboratory scales
- Molecular formula C14H11FN2O4; molecular weight 290.25
- Powder storage: -20°C (long term) or 4°C (short term)
- Data sheet and certificate of analysis available for purity and handling
Medchemexpress LLC VH 101 phenol-alkylC4-amine dihydrochloride | 2564467-03-2 | >95.0% | 676.67 g/mol | C30H44Cl2FN5O5S | 5 MG
VH 101 phenol-alkylC4-amine dihydrochloride is a functionalized von Hippel-Lindau (VHL) E3 ligase ligand supplied as the dihydrochloride salt. It is designed as a building block for PROTAC (proteolysis-targeting chimera) synthesis and degrader design, offering a linker-equipped ligand with a terminal amine for conjugation and medicinal chemistry applications.
- Functionalized VHL ligand for PROTAC synthesis.
- Dihydrochloride salt for improved stability and handling.
- Terminal amine compatible with common coupling chemistries.
- Alkyl C4 linker suitable for assembling bifunctional degraders.
- Available in small milligram quantities for medicinal chemistry research.