Lactams
TARGETMOL CHEMICALS INC ACY-957 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ACY-957 (HDAC Inhibitor C001) is an orally active and selective inhibitor of HDAC1 and HDAC2 (IC50s 7 nM 18 nM and 1300 nM against HDAC1/2/3) and shows no inhibition on HDAC4/5/6/7/8/9. purity: 98%
Medchemexpress LLC Tazobactam sodium | 89785-84-2 | 99.7% | 322.27 | 50 MG
Tazobactam sodium is an antibiotic from the beta-lactamase inhibitor class. It broadens the activity of ceftolozane against many ESBL-producing Enterobacteriaceae and some Bacteroides species. This product is intended for research use only and not for sale to patients.
- Causes oxidative stress and mitochondrial damage, leading to apoptosis in HK-2 cells when used with piperacillin.
- Exhibits direct nephrotoxicity, including tubular damage and mitochondrial structural alteration, in C57BL/6 mouse models.
Medchemexpress LLC Thalidomide 4-chloro | 244057-36-1 | MFCD30188071 | 96.0% | 292.68 g·mol⁻¹ | C13H9ClN2O4 | 1 G
Thalidomide 4-chloro is a chlorinated thalidomide derivative that functions as a cereblon (E3 ligase) ligand and E3 ligase activator. It is used in PROTAC development and as a synthetic building block for further derivatization via substitution at the 4-chloro position. The compound is supplied as a solid and is characterized for research applications.
- Molecular formula: C13H9ClN2O4.
- Molecular weight: 292.68 g·mol⁻¹.
- CAS number: 244057-36-1.
- Appearance: solid (powder).
- Purity: 96.0%.
- Intended use: E3 ligase (cereblon) ligand for PROTAC design and derivatization.
- Storage: powder -20 °C (3 years) or 4 °C (2 years); in solvent -80 °C (6 months) or -20 °C (1 month).
Medchemexpress LLC Thalidomide 4-fluoride | 835616-60-9 | 99.9% | 276.22 | 5 G
Thalidomide 4-fluoride is a Thalidomide-based Cereblon ligand that recruits CRBN protein and can be linked to the ligand for IRAK4 protein to create PROTAC IRAK4 degrader-1. This compound targets cereblon (CRBN), a ubiquitous protein involved in the cullin-4 E3 ubiquitin ligase complex CRL4, facilitating the ubiquitination and subsequent proteasomal degradation of target proteins.
- Recruits CRBN protein.
- Can be linked to IRAK4 protein ligand.
- Targets cereblon (CRBN).
- Facilitates ubiquitination and proteasomal degradation of target proteins.
- Molecular weight: 276.22.
- Physical state: solid.
- Color: off-white to gray.
- Soluble in DMSO.
- Store powder at -20°C for 3 years or 4°C for 2 years.
- Store in solvent at -80°C for 2 years or -20°C for 1 year.
- Avoid repeated freeze-thaw cycles after preparation into solution.
Medchemexpress LLC Thalidomide-NH-PEG3-NH-Boc | 2204246-03-5 | 548.59 | 50 MG
Thalidomide-NH-PEG3-NH-Boc is a laboratory chemical intended for research use only. It is suitable for the manufacture of substances and should be handled by suitably qualified and experienced scientists in appropriately equipped and authorized facilities.
- For laboratory use
- For research purposes only
- To be handled by experienced personnel
- Requires appropriately equipped and authorized facilities
Medchemexpress LLC S-thalidomide-4-OH | 2357105-36-1 | MFCD03699892 | 98.0% | 274.23 | C13H10N2O5 | 25 MG
(S)-Thalidomide-4-OH is the S-enantiomer of thalidomide-4-OH, a thalidomide-based cereblon (CRBN) ligand used in chemical biology and proteolysis-targeting chimera (PROTAC) design. Supplied as a high-purity powder, it is intended for research use in CRBN recruitment studies and degrader synthesis.
- High purity (98.0%) for research applications.
- S-enantiomer for stereospecific biochemical studies.
- Useful cereblon ligand for PROTAC conjugation.
- Available in small milligram quantities for screening and synthesis.
- Stable when stored under recommended conditions.
Medchemexpress LLC 1H-isoindole-4-carboxylic acid, 2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo | 1547163-38-1 | MFCD32063448 | 98.0% | 302.24 g·mol-1 | C14H10N2O6 | 500 MG
Thalidomide acid is a thalidomide-derived cereblon (CRBN) ligand bearing a carboxylic acid functional group, supplied as a solid research reagent. It is intended for use as an E3 ligase recruiting moiety in PROTAC design and related chemical biology and synthetic applications.
- Ligand for E3 ligase (CRBN) used in targeted protein degradation research.
- Carboxylic acid handle enables amide coupling and linker attachment.
- High purity (98.0%) suitable for analytical and synthetic work.
- Solid powder form for convenient handling and formulation.
- Molecular weight 302.24 g·mol-1; formula C14H10N2O6.
- Identified by CAS number 1547163-38-1 for unambiguous chemical lookup.
Medchemexpress LLC 1H-Isoindole-1,3(2H)-dione, 4-[(6-azidohexyl)oxy]-2-(2,6-dioxo-3-piperidinyl)- | 2411389-65-4 | 99.10% | 399.40 | 25 MG
Thalidomide-O-C6-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates a Thalidomide-based cereblon ligand and a linker used in PROTAC technology. It functions as a click chemistry reagent, containing an Azide group, which allows it to undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules that have Alkyne groups. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a cereblon ligand
- Functions as a click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Exploits intracellular ubiquitin-proteasome system for selective target protein degradation
Medchemexpress LLC Thalidomide | 50-35-1 | MFCD00078028 | 99.98% | 258.23 | 500 MG
Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of approximately 250 nM. It possesses immunomodulatory, anti-inflammatory, and anti-angiogenic cancer properties. Thalidomide can also function as a molecular glue to potentiate substrate.
- Inhibits cereblon (CRBN), a component of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1.
- Demonstrates immunomodulatory, anti-inflammatory, and anti-angiogenic properties.
- Functions as a molecular glue to potentiate substrate.
- Potentiates the anti-tumor activity of Icotinib against PC9 and A549 cell proliferation.
- Inhibits EGFR and VEGF-R2 pathways in PC9 cells.
- Alleviates RILF by suppressing ROS and down-regulating the TGF-β/Smad pathway.