Lactams
Medchemexpress LLC Deoxy-thalidomide-5-iodine | 2291364-01-5 | MFCD32853043 | 98.0% | 370.14 g/mol | C13H11IN2O3 | 250 MG
Deoxy-thalidomide-5-iodine is a thalidomide analog used as a cereblon-binding ligand in targeted protein degradation and PROTAC research. It is provided as a characterized small-molecule building block suitable for conjugation in bifunctional degrader synthesis and related chemical biology applications.
- Used as cereblon-binding ligand for PROTAC development.
- High reported purity: 98.0% (NMR).
- Molecular weight 370.14 g/mol and formula C13H11IN2O3.
- Solid; store at 4°C and protect from light.
- Available in multiple package sizes, including 250 mg.
Medchemexpress LLC 2,6-piperidinedione, 3-(1,3-dihydro-5-iodo-1-oxo-2H-isoindol-2-yl) | 2291364-01-5 | MFCD32853043 | 98.0% | 370.14 g·mol⁻¹ | C13H11IN2O3 | 1 G
Deoxy-thalidomide-5-iodine is a thalidomide analogue used as an E3 ligase ligand in PROTAC research and cereblon-targeting studies. Supplied as a high-purity solid, it is commonly used as a building block for synthesis of degraders and chemical probes.
- High purity suitable for research (98.0%).
- Chemical formula C13H11IN2O3.
- Molecular weight 370.14 g·mol⁻¹.
- Useful as an E3 ligase (cereblon) ligand in PROTAC design.
- Solid form for ease of handling and storage.
- Store protected from light at refrigerated temperatures; in solvent: -80°C (6 months), -20°C (1 month).
Medchemexpress LLC Thalidomide-NH-PEG2-COOH | 2412056-45-0 | MFCD34368531 | ≥95.0% | 433.41 g/mol | C20H23N3O8 | 5 MG
Thalidomide-NH-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon (CRBN) ligand with a short PEG2 carboxylic acid linker. It is designed as a building block for PROTAC (proteolysis targeting chimera) synthesis and related chemical biology research. For research use only.
- Provides CRBN engagement via a thalidomide-derived ligand.
- Contains a PEG2 spacer terminating in a carboxylic acid for linker conjugation.
- Suitable as a building block for PROTAC synthesis and E3 ligase recruitment studies.
- Characterized by analytical data, including HPLC, LC-MS, and NMR files.
- Available in small research-scale quantities for medicinal chemistry applications.
Medchemexpress LLC IFN-epsilon Human 50ug
Recombinant human interferon-epsilon (IFN-ε) bearing an N-terminal His tag, expressed in Escherichia coli and purified for laboratory research. This product supports studies of type I interferon signaling and mucosal host defense mechanisms, particularly in the female reproductive tract.
- Recombinant protein expressed in E. coli.
- N-terminal 6xHis tag enables affinity purification and detection.
- Approximate molecular weight 26.1 kDa.
- Purity greater than 90% as determined by reducing SDS-PAGE.
- Available in small research amounts, including a 50 μg vial.
- Stable when stored at -20°C; aliquot and store at -80°C for long-term preservation.
- Activity not specified on the product page.
Selleck Chemical LLC Thalidomide 200mg 50-35-1
Thalidomide was introduced as a sedative drug, immunomodulatory agent and also is investigated for treating symptoms of many cancers. Thalidomide inhibits an E3 ubiquitin ligase, which is a CRBN-DDB1-Cul4A complex. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Apexbio Technology LLC Brucine 20mg
N1490 is a small-molecule inhibitor designed for biomedical research It exerts its effects by selectively targeting and modulating specific intracellular signaling pathways implicated in disease progression N1490 has been explored in cellular assays for its ability to interfere with relevant molecular interactions resulting in altered downstream signaling events This compound serves as a valuable tool for investigating cellular mechanisms regulated by these pathways and may facilitate the discovery of novel therapeutic strategies in areas such as oncology immunology or metabolic research
Medchemexpress LLC Thalidomide-5-CH2-NH2 hydrochloride | 1010100-22-7 | MFCD32666042 | 98.6% | 323.73 g/mol | C14H14ClN3O4 | 25 MG
Thalidomide-5-CH2-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as a hydrochloride salt. It provides a reactive primary amine at the 5-position for linker attachment and is used as an E3 ligase recruiting moiety in PROTAC design and related chemical biology research. Suitable for medicinal chemistry and linker-conjugation workflows.