Lactams
Medchemexpress LLC Thalidomide-PEG2-C2-NH2 hydrochloride | 2245697-87-2 | 99.9% | 440.88 g·mol⁻1 | C19H25ClN4O6 | 5 MG
Thalidomide-PEG2-C2-NH2 hydrochloride is a thalidomide-based cereblon E3 ligase ligand-linker conjugate provided as the hydrochloride salt for research use. It combines a thalidomide cereblon-binding moiety with a two-unit polyethylene glycol spacer and a C2 amino termination, designed for incorporation into PROTAC constructs and linker chemistry in targeted protein degradation studies.
- Provides a thalidomide-derived cereblon binding motif suitable for E3 ligase recruitment.
- Contains a PEG2 spacer to improve solubility and linker flexibility.
- Terminates in a C2 amino handle for straightforward conjugation chemistry.
- Supplied as the hydrochloride salt for enhanced stability and handling.
- Characterized with reported molecular weight and purity for research applications.
Medchemexpress LLC Thalidomide-4-o-c10-nh2 hydrochloride | 2460022-53-9 | 50 MG
Thalidomide-4-O-C10-NH2 hydrochloride is a thalidomide-based cereblon ligand used in the recruitment of CRBN protein. It is intended for use as a laboratory chemical and for the manufacture of substances, strictly for research purposes. This product has not been fully validated for medical applications.
- Thalidomide-based cereblon ligand
- Used in the recruitment of CRBN protein
- For research use only
- Intended for use as laboratory chemicals
- Intended for the manufacture of substances
- Recommended storage temperature: -20°C (solid)
- For solutions, store at -80°C for 6 months or -20°C for 1 month
- Shipped at room temperature if transit is less than 2 weeks
- Store away from moisture and light
Medchemexpress LLC Thalidomide-O-C6-azide | 2411389-65-4 | 99.1% | 399.40 g·mol⁻¹ | C19H21N5O5 | 10 MG
Thalidomide-O-C6-azide is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a six-carbon azide-containing linker. It is intended as a building block for PROTAC design and related targeted protein degradation research, providing a clickable azide handle for conjugation or labeling in chemical biology applications.
- High purity suitable for research applications (≈99.1%).
- Azide functional group enables copper-free and copper-catalyzed click chemistry.
- Six-carbon linker provides flexible spacing for bifunctional molecule design.
- Storage-stable when sealed at low temperature, with extended stability in solvent at -80°C.
- Available in multiple small-scale quantities for synthesis and assay development.
Medchemexpress LLC Thalidomide-4-O-C11-NH2 hydrochloride | 99.9% | 480.00 g·mol⁻¹ | C24H34ClN3O5 | 10 MG
Thalidomide-4-O-C11-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for research use in targeted protein degradation and PROTAC development. It is intended as an E3 ligase ligand-linker conjugate for synthesis and biochemical studies involving CRBN recruitment.
- High purity (99.94%) suitable for synthetic applications.
- Hydrochloride salt form for improved handling and solubility.
- Molecular formula C24H34ClN3O5; molecular weight 480.00 g·mol⁻¹.
- Available in small mg-scale pack sizes for research workflows.
- Designed for use as a cereblon ligand in PROTAC design and E3 ligase recruitment studies.
eMolecules 1950635-17-2 | Thalidomide-5-(C6-amine) | Broadpharm400.435 | C20H24N4O5 | 98.000 | NCCCCCCNC(=O)c1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1 | 100mg | 713699636
Thalidomide-5-(C6-amine) | Broadpharm | 1950635-17-2400.435 | C20H24N4O5 | 98.000 | NCCCCCCNC(=O)c1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1 | 100mg | 713699636
Medchemexpress LLC Thalidomide 4-fluoride | 835616-60-9 | 99.8% | 276.22 | 1 G
Thalidomide 4-fluoride (Cereblon ligand 4) is a Thalidomide-based Cereblon ligand utilized in the recruitment of the CRBN protein. It can be linked to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1. Thalidomide targets cereblon (CRBN), a protein that is part of the cullin-4 E3 ubiquitin ligase complex, CUL4-RBX1-DDB1 (CRL4), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The product appears as an off-white to gray solid.
- Thalidomide-based Cereblon ligand
- Used in the recruitment of CRBN protein
- Can be connected to the ligand for IRAK4 protein to form PROTAC IRAK4 degrader-1
- Targets cereblon (CRBN), part of the CUL4-RBX1-DDB1 E3 ubiquitin ligase complex
- Mediates ubiquitination and proteasomal degradation of target proteins
Medchemexpress LLC Thalidomide | 50-35-1 | MFCD00153873 | 99.96% | 258.23 | 100 MG
Thalidomide (Standard) is an analytical standard intended for research and analytical applications. It inhibits cereblon (CRBN), part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, and possesses immunomodulatory, anti-inflammatory, and anti-angiogenic cancer properties. It can also act as a molecular glue to potentiate substrate. This analytical standard is suitable for various assays and commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Inhibits cereblon (CRBN)
- Possesses immunomodulatory, anti-inflammatory, and anti-angiogenic cancer properties
- Can act as a molecular glue to potentiate substrate
- Suitable for assays
- Used in HPLC, GC, and MS experiments
Medchemexpress LLC Tetrazine-tagged thalidomide | 2087490-42-2 | 98.6% | 571.58 g/mol | C29H29N7O6 | 100 MG
Tz-Thalidomide is a tetrazine-tagged derivative of thalidomide used in bioorthogonal click-chemistry and as an E3 ligase ligand for biochemical research. It contains a reactive tetrazine group for rapid conjugation via inverse electron demand Diels-Alder reactions and has been characterized for binding to BRD4.
- Tetrazine moiety enables rapid inverse electron demand Diels-Alder (iEDDA) click reactions.
- Functions as an E3 ligase ligand for targeted protein interaction studies.
- Documented binding affinity to BRD4 in biochemical assays.
- High purity suitable for research applications.
- Available as a solid and as a 10 mM solution in DMSO for experimental flexibility.
Medchemexpress LLC Thalidomide-4-O-C4-NH2 hydrochloride | 2376990-29-1 | MFCD32705123 | 99.4% | 381.81 | C17H20ClN3O5 | 5 MG
Thalidomide-4-O-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate supplied as the hydrochloride salt for use in PROTAC research. It couples a thalidomide-derived cereblon ligand to a four-carbon alkyl linker terminating in a primary amine, enabling conjugation to target-binding moieties. The material is intended for laboratory research use only.
- High purity (99.35%).
- Hydrochloride salt form for handling and stability.
- Molecular weight 381.81.
- Molecular formula C17H20ClN3O5.
- Available in small research quantities (5 mg and up).
- Intended for use in PROTAC design and cereblon-based degrader development.
Medchemexpress LLC Thalidomide 5-fluoride | 835616-61-0 | 100.0% | 276.22 | C13H9FN2O4 | 1 ML
Thalidomide 5-fluoride is a thalidomide-derived cereblon ligand used as a building block in targeted protein degradation (PROTAC) research and related chemical biology applications. It is supplied as both solid material and pre-formulated DMSO solutions to facilitate linker conjugation and assay use.
- Thalidomide-based cereblon ligand for CRBN recruitment.
- Cas number: 835616-61-0.
- Molecular formula C13H9FN2O4; molecular weight 276.22 g/mol.
- Purity reported at 99.96% (analytical).
- Available as 10 mM solution in DMSO (1 mL) and as solid in multiple package sizes.
- Storage: powder at -20°C or 4°C; in solvent at -80°C or -20°C.
Medchemexpress LLC 5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione | 26166-92-7 | MFCD30188073 | 98.4% | 337.13 | C13H9BrN2O4 | 100 MG
Thalidomide-5-Br is a brominated thalidomide derivative supplied for research use in studies of inflammation, tumor biology, and neurology. It is provided as a solid research reagent; consult lot-specific documentation for analytical details.
- Contains a bromodomain; used as a tool compound in biochemical and pharmacological research.
- Reported purity approximately 98% (see product documentation for lot-specific certificate of analysis).
- Solid, off-white to gray appearance suitable for analytical and synthetic applications.
- Storage recommendations: room temperature for shipping; in solution store at -80°C (2 years) or -20°C (1 year).
- Available in multiple pack sizes including 100 mg.