Lactams
Medchemexpress LLC Thalidomide-C2-amido-C2-COOH | 2353496-84-9 | 98.5% | C19H20N4O7 | 10MG
Thalidomide-C2-amido-C2-COOH is a thalidomide-derived cereblon (CRBN) ligand-linker conjugate for research use. Supplied as a powder, it is intended as a building block for design and synthesis of PROTAC degraders and other molecules that recruit the CRBN E3 ubiquitin ligase.
- Incorporates a cereblon-binding thalidomide moiety for E3 ligase recruitment.
- Contains a short C2-amido-C2-COOH linker for conjugation to target ligands.
- High purity (98.5%) suitable for synthetic and analytical work.
- Molecular formula and weight provided to support design calculations.
- Soluble in DMSO for preparation of concentrated stock solutions.
- Powder form allows long-term frozen storage for stability.
Medchemexpress LLC Thalidomide-pinacolborane | 2229725-98-6 | N/A | 97.0% | 384.19 g/mol | C19H21BN2O6 | 5 MG
Thalidomide-pinacolborane is a thalidomide analogue bearing a pinacolborane (Bpin) group, used as a synthetic intermediate and as a ligand for E3 ligase in PROTAC research. Molecular formula C19H21BN2O6, molecular weight 384.19 g/mol. Manufacturer documentation lists CAS 2229725-98-6 and purity 97.0%. Recommended storage is -20°C under nitrogen; in solvent, -80°C (up to 6 months) or -20°C (up to 1 month) under nitrogen.
- Functionalized thalidomide analogue useful as a synthetic intermediate.
- Serves as a ligand for E3 ligase in PROTAC applications.
- High purity (97.0%) suitable for research use.
- Stable when stored under nitrogen at recommended temperatures.
- Available in small research sizes down to 5 mg.
Medchemexpress LLC 2,6-piperidinedione, 3-(1,3-dihydro-5-iodo-1-oxo-2H-isoindol-2-yl)- | 2291364-01-5 | MFCD32853043 | 98.0% | 370.14 g/mol | C13H11IN2O3 | 500 MG
Deoxy-thalidomide-5-iodine is a thalidomide analog used as a cereblon-binding ligand scaffold in PROTAC and chemical biology research. Provided as a research-grade small molecule with reported purity suitable for biochemical and cell-based studies.
- Purity reported as 98.0%.
- Suitable for PROTAC ligand development and E3 ligase recruitment studies.
- Iodinated scaffold enables further functionalization or conjugation chemistry.
- Available in multiple pack sizes, including 500 mg, for scale flexibility.
- Molecular formula C13H11IN2O3; molecular weight 370.14 g/mol.
Medchemexpress LLC S-thalidomide-4-OH | 2357105-36-1 | MFCD03699892 | 98.0% | 274.23 | C13H10N2O5 | 25 MG
(S)-Thalidomide-4-OH is the S-enantiomer of thalidomide-4-OH, a thalidomide-based cereblon (CRBN) ligand used in chemical biology and proteolysis-targeting chimera (PROTAC) design. Supplied as a high-purity powder, it is intended for research use in CRBN recruitment studies and degrader synthesis.
- High purity (98.0%) for research applications.
- S-enantiomer for stereospecific biochemical studies.
- Useful cereblon ligand for PROTAC conjugation.
- Available in small milligram quantities for screening and synthesis.
- Stable when stored under recommended conditions.
Medchemexpress LLC Thalidomide-propargyl | 2098487-39-7 | 99.97% | 312.28 | 10 MG
Thalidomide-propargyl is a Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. It can be connected to a ligand for protein by a linker to form IMiD containing PROTACs. It is a click chemistry reagent containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Thalidomide-based Cereblon ligand
- Used in the recruitment of CRBN protein
- Can form IMiD containing PROTACs when connected to a ligand for protein by a linker
- Click chemistry reagent
- Contains an Alkyne group
- Can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Medchemexpress LLC Thalidomide-O-C2-acid | 2369068-42-6 | 95.0% | C16H14N2O7 | 10MG
Thalidomide-O-C2-acid is an E3 ligase ligand-linker conjugate that pairs a thalidomide-derived cereblon ligand with a two-carbon linker. It is designed as a research building block for proteolysis targeting chimera (PROTAC) construction and targeted protein degradation studies, and is supplied with analytical data supporting its identity and purity.
- Contains a thalidomide-derived cereblon ligand for CRBN recruitment.
- Includes a short two-carbon linker suitable for conjugation.
- Provided with reported purity and molecular characterization.
- Available in multiple small pack sizes for research-scale synthesis.
- Intended for use as a building block in PROTAC synthesis and chemical biology studies.
- Supplied with an accessible datasheet and safety documentation.
Cayman Chemical ThalIdomIde 25mg
An active enantiomer of (±)-thalidomide; enhances TPA-induced TNF-α production in HL-60 cells from 0.1-100 µM; preincubation of isolated RIR chicken donor blood reduces recipient chicken embryo splenomegaly in a model of graft versus host disease at 10 mg/ml; induces fetal malformations when administered to pregnant female rabbits at 150 mg/kg
Sigma Aldrich Fine Chemicals Biosciences Pomalidomide | 19171-19-8 | MFCD12756407 | 5mg
Pomalidomide | 98% (HPLC) | 273.24 | 19171-19-8 | MFCD12756407 | 5mg
Medchemexpress LLC Vh 101 phenol-alkylc6-amine dihydrochloride | 2564467-16-7 | 704.72 | 50 MG
VH 101 phenol-alkylC6-amine dihydrochloride is a functionalized von-Hippel-Lindau (VHL) protein-ligand. This compound is suitable for PROTAC synthesis.
- Functionalized von-Hippel-Lindau (VHL) protein-ligand
- Can be used for PROTAC synthesis
Medchemexpress LLC VH 101 phenol-alkylC4-amine dihydrochloride | 2564467-03-2 | 676.67 | 25 MG
VH 101 phenol-alkylC4-amine dihydrochloride is a von-Hippel-Lindau protein ligand (VHL). It incorporates an E3 ligase ligand and an alkylC4 linker.
- Von-Hippel-Lindau protein ligand (VHL)
- Incorporates an E3 ligase ligand
- Incorporates an alkylC4 linker
- Can be used for PROTAC research (extracted from patent WO2022051326A1)