Lactams
Medchemexpress LLC Thalidomide-O-C6-COOH | 2169266-69-5 | 99.3% | 25 MG
Thalidomide-O-C6-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the thalidomide based cereblon ligand and a linker used in PROTAC technology. This conjugate exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins and is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Used in PROTAC technology
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Related to cancer, cancer targeted therapy, cancer metabolism and metastasis
- Related to autophagy and apoptosis
Medchemexpress LLC 5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | 2230957-36-3 | >98.0% | 290.25 | C14H11FN2O4 | 500 MG
5-Fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione is a fluorinated thalidomide analogue described as an E3 ligase activator for research use. Supplied as a powder, it can serve as a synthetic building block for further derivatization, particularly by nucleophilic aromatic substitution (SNAr).
- Fluorinated thalidomide analogue useful for E3 ligase activation studies.
- Suitable as a synthetic building block for derivatization via SNAr.
- Supplied as a powder suitable for laboratory handling and storage.
- High purity; commonly listed as >98.0%.
- Typical pack sizes: 100 mg-1 g.
Medchemexpress LLC Thalidomide-NH-C4-NH-Boc | 2093388-52-2 | 99.6% | 25 MG
Thalidomide-NH-C4-NH-Boc (compound 15) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and a linker used in PROTAC technology. This product is for research use only.
- Targets cereblon
- Molecular weight: 444.48
- Chemical formula: C22H28N4O6
- Appearance: Solid
- Color: Yellow to green
- Solubility in DMSO: 100 mg/mL (224.98 mM)
- Shipping at room temperature in continental US
- Storage at 4°C, protected from light
- Storage in solvent: -80°C for 6 months; -20°C for 1 month (protected from light)
![Medchemexpress LLC Tert-butyl 4-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]piperazine-1-carboxylate | 2222114-64-7 | MFCD32705088 | 98.8% | C22H26N4O6 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000259258.png-250.jpg)
Medchemexpress LLC Tert-butyl 4-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]piperazine-1-carboxylate | 2222114-64-7 | MFCD32705088 | 98.8% | C22H26N4O6 | 10MG
Thalidomide-piperazine-Boc is a Boc-protected piperazine derivative of thalidomide used as a synthetic intermediate for assembling E3 ligase ligand-linker conjugates such as PROTACs. It is supplied as a high-purity research reagent with defined solubility and storage recommendations.
- High purity (98.8%).
- Boc-protected piperazine for linker attachment.
- Soluble in DMSO (~41.7 mg/mL) with ultrasonic assistance.
- Powder stable at -20°C for long-term storage; solvent storage recommendations apply.
- Intended for research use only.
Medchemexpress LLC Thalidomide-nh-c4-nh-boc | 2093388-52-2 | 99.6% | 444.48 g/mol | C22H28N4O6 | 5 MG
Thalidomide-NH-C4-NH-Boc is a thalidomide-derived E3 ligase ligand-linker conjugate developed for PROTAC research. It combines a cereblon-binding thalidomide moiety with a Boc-protected four-carbon linker to facilitate targeted protein degradation studies. For research use only.
- High purity: 99.64% by analytical HPLC.
- Appropriate for PROTAC development as a cereblon ligand-linker conjugate.
- Soluble in DMSO at 100 mg/mL; ultrasonic assistance recommended.
- Storage: store at 4°C and protect from light; in solvent, -80°C (6 months) or -20°C (1 month).
- Available in small mg quantities suitable for medicinal chemistry applications.
eMolecules 17557-84-5 | Azetidin-3-one hydrochloride | AA Blocks LLC | MFCD01861742 | 107.540 | C3H6ClNO | 0.000 | Cl.O=C1CNC1 | 5g | 410156345
Azetidin-3-one hydrochloride | AA Blocks LLC | 17557-84-5 | MFCD01861742 | 107.540 | C3H6ClNO | 0.000 | Cl.O=C1CNC1 | 5g | 410156345
eMolecules 17557-84-5 | Azetidin-3-one hydrochloride | AA Blocks LLC | MFCD01861742 | 107.540 | C3H6ClNO | 0.000 | Cl.O=C1CNC1 | 25g | 410156347
Azetidin-3-one hydrochloride | AA Blocks LLC | 17557-84-5 | MFCD01861742 | 107.540 | C3H6ClNO | 0.000 | Cl.O=C1CNC1 | 25g | 410156347
Medchemexpress LLC Thalidomide-4,5-F | 2222115-19-5 | 98.0% | 294.21 g·mol⁻¹ | C13H8F2N2O4 | 100 MG
Thalidomide-4,5-F is a fluorinated analogue of thalidomide supplied for laboratory research. It promotes protein ubiquitinylation and serves as a cereblon-binding ligand; the fluorine substitutions allow further chemical derivatization. Intended for scientific research use only.
- Fluorinated thalidomide analogue enabling further derivatization.
- Promotes ubiquitinylation and binds cereblon for E3 ligase recruitment.
- High purity (98.0%) suitable for research applications.
- Available in multiple package sizes from 25 mg to 10 g.
- White to off-white solid, suitable for storage and handling.
- Recommended storage: powder at -20°C (up to 3 years) or 4°C (up to 2 years).
Medchemexpress LLC 5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | 2230957-36-3 | 97.0% | 290.25 g/mol | C14H11FN2O4 | 5 G
A fluorinated thalidomide analogue that functions as an E3 ligase (Cereblon) activator and a synthetic building block for targeted protein degradation research. Suitable for recruiting CRBN in PROTAC design and for further chemical derivatization via nucleophilic aromatic substitution (SNAr).
- Fluorinated thalidomide analogue
- Acts as an E3 ligase (Cereblon) activator
- Useful as a PROTAC ligand building block
- Compatible with SNAr derivatization
- Typical purity approximately 97.0%
- Molecular formula C14H11FN2O4; molecular weight 290.25 g/mol
Medchemexpress LLC 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-methyl- | 40313-92-6 | 99.9% | 272.26 | 25 MG
Thalidomide-5-methyl is a cereblon (CRBN) ligand derived from Thalidomide, used for recruiting CRBN protein. It can be utilized in the synthesis of PROTACs.
- Thalidomide-based cereblon (CRBN) ligand.
- Used in the recruitment of CRBN protein.
- Can be used to synthesize PROTACs.
Medchemexpress LLC Thalidomide-4-F,5-Br | 2740657-28-5 | MFCD34180776 | 99.4% | 355.12 g·mol⁻1 | C13H8BrFN2O4 | 25 MG
Thalidomide-4-F,5-Br is a halogenated thalidomide analogue that functions as an E3 ligase recruiting ligand for targeted protein degradation research. Supplied as a powder in small pre-weighed quantities, it is intended for research use in PROTAC development and studies of ubiquitin-mediated proteolysis.
- Halogenated thalidomide derivative (fluoro and bromo substitutions).
- Acts as a cereblon (CRBN) E3 ligase recruiting ligand for PROTAC applications.
- High purity suitable for research (approximately 99.4%).
- Provided as a powder for easy handling and formulation.
- Available in small pre-weighed quantities for screening and synthesis workflows.
Medchemexpress LLC Thalidomide-NH-C10-COOH | 2428400-33-1 | 97.5% | 100 MG
Thalidomide-NH-C10-COOH (compound 6b) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based CRBN ligand and a linker used in PROTAC technology. It has a molecular weight of 457.52 and the formula C24H31N3O6. It appears as a light yellow to yellow solid. It is for research use only and not sold to patients.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based CRBN ligand
- Used in PROTAC technology
- Molecular weight: 457.52
- Formula: C24H31N3O6
- Appearance: Light yellow to yellow solid
- Purity: 97.5%
- Target: Cereblon
- Solubility in DMSO: 50 mg/mL (109.28 mM)
Medchemexpress LLC 3-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)ethoxy)propanoic acid | 2731007-11-5 | 99.2% | C22H26N4O7 | 10MG
Thalidomide-Piperazine-PEG1-COOH is an E3 ligase ligand-linker conjugate combining a thalidomide-derived cereblon ligand with a short PEG1-piperazine linker terminated by a carboxylic acid. It is provided as a solid research reagent intended for use as a CRBN-binding module in PROTAC design and conjugation studies.
- Enables CRBN engagement via a thalidomide-derived ligand.
- Features a PEG1-piperazine linker with a terminal carboxylic acid for conjugation.
- High reported purity enables reliable analytical and synthetic work.
- Solid, white-to-yellow appearance for easy handling and storage.
- Recommended storage at -20°C under inert gas to preserve integrity.
- Available in small milligram quantities suitable for early-stage research.