Lactams
Medchemexpress LLC 14-3-3 epsilon antibody (YA2629) | 10 UL
This 14-3-3 epsilon antibody (YA2629) is a rabbit-derived, non-conjugated IgG monoclonal antibody that specifically targets the 14-3-3 epsilon protein. It is suitable for a diverse array of immunological applications.
- Host species: rabbit
- Reactivity: human, mouse, rat
- Conjugation: non-conjugated
- Predicted and observed molecular weight: 29 kDa
- Purity: affinity chromatography
- Storage: -20°C for 1 year; avoid repeated freeze/thaw cycles
- Appearance: liquid
- Applications include Western Blot (WB), Immunohistochemistry (IHC-P), Immunocytochemistry/Immunofluorescence (ICC/IF), and Flow Cytometry (FC)
- Formulation: rabbit IgG in 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA
- SwissProt ID: P62258
- Research field: neuroscience
Apexbio Technology LLC Tazobactam (sodium salt) 89785-84-2 250mg
Tazobactam sodium salt (CAS 89785-84-2) is a small-molecule inhibitor targeting -lactamases It is designed to irreversibly bind to -lactamases thereby preventing the enzyme-mediated hydrolysis of -lactam antibiotics Tazobactam sodium salt exerts its biological activity primarily through -lactamase inhibition In microbiological assays tazobactam demonstrates intrinsic antibacterial activity against several Acinetobacter strains typically with MIC values of 8 mg/L (range 2 32 mg/L) Based on these pharmacological properties tazobactam sodium salt holds research potential in microbiological assessments and efficacy evaluations of -lactam antibiotic combinations
Medchemexpress LLC N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt | 1799711-25-3 | MFCD31560484 | 99.9% | 516.42 g·mol⁻¹ | C21H23F3N4O8 | 2 G
Thalidomide-O-amido-C4-NH2 TFA is a thalidomide-derived cereblon ligand-linker conjugate provided as the trifluoroacetate (TFA) salt for use in PROTAC design and other chemical biology applications. It is supplied as a white to off-white solid with high analytical purity and a molecular weight of 516.42 g·mol⁻¹.
- Thalidomide-derived cereblon ligand-linker conjugate.
- Provided as the trifluoroacetate (TFA) salt.
- High purity by LCMS (reported 99.92%).
- White to off-white solid appearance.
- Molecular formula C21H23F3N4O8; molecular weight 516.42 g·mol⁻¹.
- Intended for research use only; not for human or diagnostic use.
Medchemexpress LLC Thalidomide-O-COOH | 1061605-21-7 | MFCD31560477 | 99.9% | 332.27 g·mol⁻¹ | C15H12N2O7 | 1 G
Thalidomide-O-COOH is a thalidomide-derived small-molecule ligand that recruits the CRBN E3 ubiquitin ligase and is commonly used as the E3 ligase component in PROTAC design and other chemical biology applications.
- Used as a cereblon (CRBN) E3 ligase ligand for PROTAC construction.
- CAS number 1061605-21-7; molecular formula C15H12N2O7; molecular weight 332.27 g·mol⁻¹.
- Reported high purity suitable for research and synthesis workflows.
- Functional handle (carboxylic acid) enables conjugation to linkers and building blocks.
- Supplied as a solid for storage and handling in synthetic and analytical protocols.
Medchemexpress LLC Thalidomide-4-O-C4-NH2 hydrochloride | 2376990-29-1 | MFCD32705123 | 99.4% | 381.81 | C17H20ClN3O5 | 5 MG
Thalidomide-4-O-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate supplied as the hydrochloride salt for use in PROTAC research. It couples a thalidomide-derived cereblon ligand to a four-carbon alkyl linker terminating in a primary amine, enabling conjugation to target-binding moieties. The material is intended for laboratory research use only.
- High purity (99.35%).
- Hydrochloride salt form for handling and stability.
- Molecular weight 381.81.
- Molecular formula C17H20ClN3O5.
- Available in small research quantities (5 mg and up).
- Intended for use in PROTAC design and cereblon-based degrader development.
Medchemexpress LLC Thalidomide-o-amido-C3-COOH | 2308035-51-8 | 98.4% | 417.37 | C19H19N3O8 | 2 G
Thalidomide-O-amido-C3-COOH is an E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a short C3 linker terminating in a carboxylic acid. It is intended for use as a CRBN-recruiting building block in PROTAC synthesis and related targeted protein degradation research.
- used as a cereblon (CRBN) recruiting building block in PROTAC synthesis
- terminates in a carboxylic acid for conjugation to target ligands
- reported purity 98.43% by LCMS
- molecular weight 417.37; formula C19H19N3O8
- storage: 4°C under nitrogen; in solution store at -80°C (6 months) or -20°C (1 month)
Medchemexpress LLC Aztreonam (Standard) | 78110-38-0 | 99.6% | 50 MG
Aztreonam (Standard) is an analytical standard intended for research and analytical applications. It is a synthetic monocyclic beta-lactam antibiotic, also known as SQ-26,776, which demonstrates a high affinity for penicillin-binding protein 3 (PBP-3). This product is suitable for qualitative, quantitative, and methodological research experiments, including HPLC, GC, and MS.
- Analytical standard for research and analytical applications
- Synthetic monocyclic beta-lactam antibiotic
- High affinity for penicillin-binding protein 3 (PBP-3)
- Suitable for HPLC, GC, and MS research experiments
Medchemexpress LLC Aztreonam (Standard) | 78110-38-0 | 99.6% | 5 MG
Aztreonam (Standard) is the analytical standard of Aztreonam, intended for research and analytical applications. This synthetic monocyclic beta-lactam antibiotic has a very high affinity for penicillin-binding protein 3 (PBP-3).
- Reference standard supplied assay
- Used in qualitative research experiments
- Used in quantitative research experiments
- Used in methodological research experiments
- Suitable for HPLC
- Suitable for GC
- Suitable for MS
Apexbio Technology LLC Sulbactam 68373-14-8 10mM (in 1mL DMSO)
Sulbactam (CAS 68373-14-8) is a small-molecule inhibitor targeting bacterial -lactamase enzymes It is designed to inhibit -lactamase-mediated hydrolytic inactivation of -lactam antibiotics thereby enhancing antibiotic stability and efficacy Sulbactam exerts its biological activity primarily through competitive irreversible inhibition by covalently binding to the -lactamase active site Experimental studies report an IC50 value in the low micromolar range for inhibition of various bacterial -lactamase enzymes Based on these pharmacological properties Sulbactam holds research potential in investigating resistance mechanisms to -lactam antibiotics assessing combined therapeutic regimens and exploring novel clinical strategies for infections caused by -lactamase-producing pathogens
Medchemexpress LLC Thalidomide-o-amido-c4-n3 | 2098488-36-7 | MFCD31560486 | ≥98.0% | 428.40 g·mol⁻¹ | C19H20N6O6 | 5 MG
Thalidomide-O-amido-C4-N3 is a thalidomide-derived cereblon ligand-linker conjugate that contains an azide functional group. It is supplied as a research-grade building block for the design and synthesis of proteolysis-targeting chimeras (PROTACs) and for click-chemistry bioconjugation, compatible with copper-catalyzed azide-alkyne cycloaddition and strain-promoted azide-alkyne cycloaddition.
- Contains an azide functional group for copper-catalyzed and strain-promoted azide-alkyne cycloadditions.
- Suitable for PROTAC synthesis and E3 ligase recruitment studies.
- Research-grade building block with defined molecular formula and molecular weight.
- Forms a clear solution when dissolved in common organic solvents.
- Recommended storage: store solid at 4°C under inert atmosphere; in solution -80°C for up to 6 months or -20°C for up to 1 month.
TARGETMOL CHEMICALS INC Tazobactam 1G
Also available in 1 mL, 100 mg, 200 mg, 500 mg and bulk. Please contact Fisher for quotes. Tazobactam (YTR-830H) is an antibacterial penicillin derivative which inhibits the action of bacterial beta-lactamases. Purity 100%
Medchemexpress LLC Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride | 2245697-84-9 | MFCD31656717 | 98.3% | 542.97 | C23H31ClN4O9 | 250 MG
Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is a thalidomide-derived cereblon ligand-linker conjugate used as an intermediate in the design and synthesis of PROTACs and targeted protein degraders. Supplied as the hydrochloride salt, it is provided as an off-white to yellow solid with high reported purity for research applications.
- High purity suitable for research and synthetic use.
- Hydrochloride salt form for improved handling and stability.
- Good solubility in DMSO and water; may require ultrasonic aid.
- Available in multiple package sizes, including 250 mg.
- Recommended storage at -20°C sealed, away from moisture.
Medchemexpress LLC Aztreonam | 78110-38-0 | 99.6% | 1 ML
Aztreonam is a synthetic monocyclic beta-lactam antibiotic with a high affinity for penicillin-binding protein 3 (PBP-3). It was approved by the U.S. Food and Drug Administration in 1986. This antibiotic is resistant to some beta-lactamases but can be inactivated by extended-spectrum beta-lactamases. It shows no useful activity against gram-positive or anaerobic microorganisms. Aztreonam inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking. It has a mild affinity for PBP-1a and is largely ineffective against gram-positive and anaerobic bacteria due to poor binding to their penicillin-binding proteins. Aztreonam is bactericidal, though less so than some cephalosporins.
- Synthetic monocyclic beta-lactam antibiotic
- High affinity for penicillin-binding protein 3 (PBP-3)
- Resistant to some beta-lactamases
- Inhibits mucopeptide synthesis in the bacterial cell wall
- Bactericidal
Medchemexpress LLC IFN-epsilon Human 10ug | 10ug
IFN- protein is a type I interferon that is critical for maintaining baseline levels of IFN-regulated genes (such as 2 -5 -oligoadenylate synthetase IRF7 and ISG15) in the female reproductive tract It acts as a direct mediator providing protection against viral and bacterial genital infections IFN-epsilon Protein Human (His) is the recombinant human-derived IFN-epsilon protein expressed by E coli with N-6 His labeled tag