Lactams
Medchemexpress LLC Thalidomide-NH-PEG2-COOH | 2412056-45-0 | 99.0% | 433.41 | 100 MG
Thalidomide-NH-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate designed for PROTAC technology. It incorporates a Thalidomide-based cereblon ligand and is intended for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Utilized in PROTAC technology
- High purity: 99.0%
- Molecular weight: 433.41
- Molecular formula: C20H23N3O8
- Appearance: Light green to green solid
- Recommended storage: -20°C, sealed, away from moisture and light
- For research use only
Medchemexpress LLC Thalidomide-piperazine-PEG1-NH2 (diTFA) | 2984178-51-8 | 99.4% | 657.52 | 25 MG
Thalidomide-Piperazine-PEG1-NH2 (diTFA) is a chemical compound suitable for laboratory research. It is stable under recommended storage conditions and is not classified as a hazardous substance.
- Molecular formula: C25H29F6N5O9
- Molecular weight: 657.52
- Purity: 99.4%
- Appearance: White to yellow solid
- Storage conditions: 4°C sealed, away from moisture; in solvent: -80°C for 6 months, -20°C for 1 month
- For research use only
Medchemexpress LLC Thalidomide-PEG5-NH2 hydrochloride | 2703775-06-6 | C23H31N3O9 | 10MG
Thalidomide-PEG5-NH2 hydrochloride is a thalidomide-derived cereblon ligand-linker conjugate intended for PROTAC development and related chemical biology applications. It links a thalidomide-based CRBN-binding moiety to a PEG5 primary amine, enabling coupling to target-binding warheads while providing documentation for synthetic and screening use.
- Thalidomide-based cereblon ligand for CRBN recruitment.
- PEG5 amine linker enabling facile conjugation to warheads.
- Provided as a hydrochloride salt for the amine functionality.
- Available in small milligram quantities suitable for medicinal chemistry.
- Supplied with purity documentation and safety data sheet.
Medchemexpress LLC 5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | 2230957-36-3 | >98.0% | 290.25 | C14H11FN2O4 | 500 MG
5-Fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione is a fluorinated thalidomide analogue described as an E3 ligase activator for research use. Supplied as a powder, it can serve as a synthetic building block for further derivatization, particularly by nucleophilic aromatic substitution (SNAr).
- Fluorinated thalidomide analogue useful for E3 ligase activation studies.
- Suitable as a synthetic building block for derivatization via SNAr.
- Supplied as a powder suitable for laboratory handling and storage.
- High purity; commonly listed as >98.0%.
- Typical pack sizes: 100 mg-1 g.
Medchemexpress LLC Thalidomide-4-o-c2-nh2 hydrochloride | 2341840-99-9 | 99.4% | 353.76 | 50 MG
Thalidomide-4-O-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates the thalidomide-based cereblon ligand and a linker used in PROTAC technology. This product is intended for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide based cereblon ligand
- Utilizes a linker used in PROTAC technology
- For research use only
Cayman Chemical AzIdo-ThalIdomIde 5mg
A PROTAC building block; contains thalidomide, which is a ligand for the E3 ubiquitin ligase cereblon, and can be conjugated to alkynylated ligands for target proteins via click chemistry; has been used in the synthesis of a SirReal-based PROTAC for the degradation of Sirt2 in cells
Medchemexpress LLC VH 101 phenol-alkylC4-amine dihydrochloride | 2564467-03-2 | >95.0% | 676.67 g/mol | C30H44Cl2FN5O5S | 5 MG
VH 101 phenol-alkylC4-amine dihydrochloride is a functionalized von Hippel-Lindau (VHL) E3 ligase ligand supplied as the dihydrochloride salt. It is designed as a building block for PROTAC (proteolysis-targeting chimera) synthesis and degrader design, offering a linker-equipped ligand with a terminal amine for conjugation and medicinal chemistry applications.
- Functionalized VHL ligand for PROTAC synthesis.
- Dihydrochloride salt for improved stability and handling.
- Terminal amine compatible with common coupling chemistries.
- Alkyl C4 linker suitable for assembling bifunctional degraders.
- Available in small milligram quantities for medicinal chemistry research.