Lactams
Medchemexpress LLC Thalidomide-4-O-CH2-COO(t-Bu) | 1950635-36-5 | 99.3% | 388.37 | 50 MG
Thalidomide-4-O-CH2-COO(t-Bu) is a t-Bu modified Thalidomide, serving as the final intermediate in the synthesis of Thalidomide-4-OH. It functions as a Cereblon ligand, recruiting CRBN proteins. The t-Bu protecting group can be removed under acidic conditions to facilitate the synthesis of PROTAC molecules. This compound is a crucial intermediate for synthesizing CRBN-based designed PROTAC molecules.
- Functions as a Cereblon ligand
- Recruits CRBN proteins
- t-Bu protecting group can be removed under acidic conditions
- Key intermediate for synthesizing CRBN-based designed PROTAC molecules
![Medchemexpress LLC 6H-Thieno[3,2-f]triazolo[4,3-a]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, cyclopropyl ester, (6S)- | 3077900-08-1 | 98.31% | 440.95 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000386961-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 6H-Thieno[3,2-f]triazolo[4,3-a]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, cyclopropyl ester, (6S)- | 3077900-08-1 | 98.31% | 440.95 | 50 MG
DDL-357 is a potent secreted clusterin enhancer. It reduces phospho-tau in the brain and improves memory in the murine 3xTg-AD model.
- Reduces phospho-tau in brain.
- Improves memory in the murine 3xTg-AD model.
Medchemexpress LLC Thalidomide-O-PEG4-amine hydrochloride | 2820929-03-9 | C23H32ClN3O9 | 250MG
Thalidomide-O-PEG4-amine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide-based cereblon ligand and a linker used in PROTAC technology. This compound is designed to exploit the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Used in PROTAC technology
- Designed for selective degradation of target proteins
Medchemexpress LLC Thalidomide-5-OH | 64567-60-8 | 98.23% | 274.23 | 5 G
Thalidomide-5-OH is a thalidomide-based cereblon ligand used in the recruitment of CRBN protein. It can be linked to a target protein ligand via a linker to create PROTACs. This product is intended for research use only.
- Utilized in the recruitment of CRBN protein
- Can be linked to a ligand for protein by a linker to form PROTACs
- For research use only
- Target cereblon
- Solid appearance
- Color ranges from gray to brown
- Soluble in DMSO at 62.5 mg/mL
Medchemexpress LLC Thalidomide-O-amido-C6-NH2 hydrochloride | 2376990-31-5 | 99.32% | 466.92 | 50 MG
Thalidomide-O-amido-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker. It can be used in the synthesis of PROTACs. This product is for research use only.
- E3 ligase ligand-linker conjugate
- Incorporates cereblon ligand and a linker
- Can be used in the synthesis of PROTACs
Medchemexpress LLC Thalidomide-1-Me-5-NH2 | 1468761-60-5 | >98.0% | 287.27 g/mol | C14H13N3O4 | 100 MG
Thalidomide-1-Me-5-NH2 is an aminated thalidomide analogue used as an E3 ligase ligand building block in the design of PROTAC molecules; supplied in small milligram pack sizes for research use.
- Aminated thalidomide analogue suitable as an E3 ligase ligand.
- Primary amine available for derivatization and linker attachment.
- High purity suitable for research applications.
- Supplied in milligram-scale pack sizes for synthetic use.
- Confirmed identity with a CAS registry number for unambiguous reference.
Medchemexpress LLC Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride | 2245697-84-9 | MFCD31656717 | 98.3% | 542.97 | C23H31ClN4O9 | 250 MG
Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is a thalidomide-derived cereblon ligand-linker conjugate used as an intermediate in the design and synthesis of PROTACs and targeted protein degraders. Supplied as the hydrochloride salt, it is provided as an off-white to yellow solid with high reported purity for research applications.
- High purity suitable for research and synthetic use.
- Hydrochloride salt form for improved handling and stability.
- Good solubility in DMSO and water; may require ultrasonic aid.
- Available in multiple package sizes, including 250 mg.
- Recommended storage at -20°C sealed, away from moisture.
Medchemexpress LLC 1H-Isoindole-1,3(2H)-dione, 5-[2-(2-chloroethoxy)ethoxy]-2-(2,6-dioxo-3-piperidinyl)- | 2230956-57-5 | 96.6% | 380.78 | 25 MG
Thalidomide-5-PEG2-Cl is a thalidomide-based cereblon ligand that facilitates the recruitment of CRBN protein. It can be linked to a target protein ligand to create PROTACs, which are designed to harness the intracellular ubiquitin-proteasome system for selective protein degradation.
- Functions as a thalidomide-based cereblon ligand
- Used in the recruitment of CRBN protein
- Can be connected to a protein ligand via a linker to form PROTACs
- PROTACs utilize the ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thalidomide-O-PEG4-azide | 2380318-57-8 | 98.0% | C23H29N5O9 | 50 MG
Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that integrates a Thalidomide-based cereblon ligand with a linker used in PROTAC technology. This compound is intended for research use only.
- Acts as a click chemistry reagent due to its Azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups
Medchemexpress LLC HY-126457 5mg Medchemexpress, Thalidomide-propargyl CAS:2098487-39-7 Purity:>98%
Medchemexpress, HY-126457 5mg Thalidomide-propargyl CAS:2098487-39-7 Thalidomide-propargyl is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-propargyl can be connected to the ligand for protein by a linker to form the IMiD containing PROTACs. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
eMolecules Thalidomide-5-(PEG4-amine) | Broadpharm |520.539 | C24H32N4O9 | 0.000 | NCCOCCOCCOCCOCCNC(=O)c1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1 | 100mg | 713699642
Thalidomide-5-(PEG4-amine) | Broadpharm |520.539 | C24H32N4O9 | 0.000 | NCCOCCOCCOCCOCCNC(=O)c1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1 | 100mg | 713699642