Lactams
Medchemexpress LLC Thalidomide-4-o-c10-nh2 hydrochloride | 2460022-53-9 | 50 MG
Thalidomide-4-O-C10-NH2 hydrochloride is a thalidomide-based cereblon ligand used in the recruitment of CRBN protein. It is intended for use as a laboratory chemical and for the manufacture of substances, strictly for research purposes. This product has not been fully validated for medical applications.
- Thalidomide-based cereblon ligand
- Used in the recruitment of CRBN protein
- For research use only
- Intended for use as laboratory chemicals
- Intended for the manufacture of substances
- Recommended storage temperature: -20°C (solid)
- For solutions, store at -80°C for 6 months or -20°C for 1 month
- Shipped at room temperature if transit is less than 2 weeks
- Store away from moisture and light
Medchemexpress LLC Thalidomide-O-C6-azide | 2411389-65-4 | 99.1% | 399.40 g·mol⁻¹ | C19H21N5O5 | 10 MG
Thalidomide-O-C6-azide is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a six-carbon azide-containing linker. It is intended as a building block for PROTAC design and related targeted protein degradation research, providing a clickable azide handle for conjugation or labeling in chemical biology applications.
- High purity suitable for research applications (≈99.1%).
- Azide functional group enables copper-free and copper-catalyzed click chemistry.
- Six-carbon linker provides flexible spacing for bifunctional molecule design.
- Storage-stable when sealed at low temperature, with extended stability in solvent at -80°C.
- Available in multiple small-scale quantities for synthesis and assay development.
Medchemexpress LLC Thalidomide-4-O-C11-NH2 hydrochloride | 99.9% | 480.00 g·mol⁻¹ | C24H34ClN3O5 | 10 MG
Thalidomide-4-O-C11-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for research use in targeted protein degradation and PROTAC development. It is intended as an E3 ligase ligand-linker conjugate for synthesis and biochemical studies involving CRBN recruitment.
- High purity (99.94%) suitable for synthetic applications.
- Hydrochloride salt form for improved handling and solubility.
- Molecular formula C24H34ClN3O5; molecular weight 480.00 g·mol⁻¹.
- Available in small mg-scale pack sizes for research workflows.
- Designed for use as a cereblon ligand in PROTAC design and E3 ligase recruitment studies.
Medchemexpress LLC Thalidomide-NH-C6-NH-Boc | 2093536-13-9 | 96.1% | 250 MG
Thalidomide-NH-C6-NH-Boc is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide-based cereblon ligand and a linker that was utilized in the synthesis of MI-389 (compound 22). MI-389 is recognized as a potent phthalimide PROTAC degrader, derived from the multi-targeted receptor tyrosine kinase inhibitor sunitinib (HY-10255A). This product is intended for research use only and is not sold to patients.
- E3 ligase ligand-linker conjugate: contains a Thalidomide-based cereblon ligand.
- PROTAC component: the linker is used in the synthesis of MI-389, a potent phthalimide PROTAC degrader.
- Research use only: exclusively for research purposes.
Medchemexpress LLC Thalidomide-O-C6-COOH | 2169266-69-5 | 99.29% | 50 MG
Thalidomide-O-C6-COOH is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide-based cereblon ligand and a linker, which is used in PROTAC (Proteolysis-Targeting Chimera) technology. This compound is intended for research use only.
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Composed of two different ligands connected by a linker
Medchemexpress LLC Thalidomide-iodo | 2509137-01-1 | MFCD31735039 | 98.0% | 384.13 g/mol | C13H9IN2O4 | 250 MG
Thalidomide-iodo is an iodinated derivative of thalidomide that functions as an E3 ligase activator for chemical biology and medicinal chemistry research. It is supplied as a solid research reagent and can be used as a synthetic building block for further derivatization via substitution of the iodine atom.
- Iodinated thalidomide derivative suitable for E3 ligase activation studies.
- Useful as a synthetic building block for iodine substitution and derivatization.
- High purity (≥98.0%) appropriate for research applications.
- Molecular weight 384.13 g/mol; formula C13H9IN2O4.
- CAS number 2509137-01-1 for unambiguous identification.
Medchemexpress LLC VH 101 phenol-alkylC6-amine dihydrochloride | 2564467-16-7 | 704.72 | 100 MG
VH 101 phenol-alkylC6-amine dihydrochloride is a functionalized von-Hippel-Lindau (VHL) protein-ligand that can be used for PROTAC synthesis.
- Functionalized von-Hippel-Lindau (VHL) protein-ligand
- Can be used for PROTAC synthesis
Medchemexpress LLC Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride | 2341841-02-7 | 99.3% | 410.81 | 25 MG
Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. This compound is suitable for designing PROTACs.
- Incorporates a cereblon (CRBN) ligand for E3 ubiquitin ligase
- Contains a linker
- Suitable for designing PROTACs
- Relevant to cancer targeted therapy, cancer metabolism, and metastasis
- Related to PROTAC research
- Involved in autophagy studies
- Used in apoptosis research
- Applicable to E3 ligase ligand-linker conjugates
Medchemexpress LLC Thalidomide-Piperazine-PEG3-COOH | 2797619-63-5 | 99.89% | 546.57 | 25 MG
A synthesized ligand-linker conjugate is described as incorporating a cereblon ligand and a linker often employed in protein degradation technology. This conjugate is intended for research applications only and not for patient use.
- Synthesized conjugate.
- Incorporates a cereblon ligand.
- Utilizes a linker as part of protein degradation technology.
- Composed of two distinct ligands joined by a linker.
- One ligand targets an E3 ubiquitin ligase.
- The other ligand targets a specific protein.
- Leverages the intracellular ubiquitin-proteasome system.
- Aims for selective degradation of target proteins.
- For research purposes only.
eMolecules 1061605-21-7 | Thalidomide-O-C1-acid | Broadpharm332.268 | C15H12N2O7 | 98.000 | OC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 | 1g | 550804650
Thalidomide-O-C1-acid | Broadpharm | 1061605-21-7332.268 | C15H12N2O7 | 98.000 | OC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 | 1g | 550804650
Medchemexpress LLC Thalidomide-NH-C5-NH2 hydrochloride | 2375194-03-7 | 99.9% | 394.85 | 250 MG
Thalidomide-NH-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is for research use only and not sold to patients.
- Targets cereblon.
- Utilizes PROTAC technology for selective degradation of target proteins.
- Soluble in DMSO at 250 mg/mL (633.15 mM) with ultrasonication.
- In vivo dissolution protocols available for clear solutions.
- Ships at room temperature in continental US.
- Solid storage at -20°C, sealed, away from moisture and light.
- Storage in solvent at -80°C for 6 months or -20°C for 1 month.
Medchemexpress LLC Thalidomide-NH-C10-COOH | 2428400-33-1 | 97.5% | 100 MG
Thalidomide-NH-C10-COOH (compound 6b) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based CRBN ligand and a linker used in PROTAC technology. It has a molecular weight of 457.52 and the formula C24H31N3O6. It appears as a light yellow to yellow solid. It is for research use only and not sold to patients.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based CRBN ligand
- Used in PROTAC technology
- Molecular weight: 457.52
- Formula: C24H31N3O6
- Appearance: Light yellow to yellow solid
- Purity: 97.5%
- Target: Cereblon
- Solubility in DMSO: 50 mg/mL (109.28 mM)
Medchemexpress LLC Thalidomide-NH-CBP/p300 ligand 2 | 2484739-21-9 | 98.6% | 922.03 | 25 MG
Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based CBP and p300 degrader, as extracted from patent WO2020173440. This compound is intended for research use only.
- Protac-based CBP and p300 degrader
- Extracted from patent WO2020173440
- For research use only
Sigma Aldrich Fine Chemicals Biosciences Pomalidomide >=98% (HPLC) | 19171-19-8 | MFCD12756407 | 25MG
Pomalidomide >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 273.24 | 19171-19-8 | MFCD12756407 | 25MG
Medchemexpress LLC Thalidomide-pinacolborane | 2229725-98-6 | 97.0% | 384.19 g·mol⁻1 | C19H21BN2O6 | 25 MG
Thalidomide-pinacolborane is a thalidomide-derived boronic pinacol ester used as a cereblon (CRBN) ligand for E3 ligase recruitment in PROTAC design and for synthetic transformations such as Suzuki cross-coupling. It is supplied as a solid research reagent intended for use in ligand design, chemical synthesis, and targeted protein degradation studies.
- Contains boronic pinacol ester (Bpin) functionality for Suzuki coupling.
- Functions as a cereblon E3 ligase ligand suitable for PROTAC applications.
- Molecular formula C19H21BN2O6; molecular weight 384.19 g·mol⁻1.
- CAS number 2229725-98-6.
- Purity 97.0% as listed by the supplier.
- Provided as a 25 MG research pack.