Lactams
Medchemexpress LLC CD3 epsilon Human 100ug
Recombinant human CD3 epsilon protein supplied as a lyophilized powder, expressed in HEK293 cells and carrying a C-terminal 6xHis tag. The protein is intended for T-cell signaling research, assay development, and biochemical characterization; it offers high purity and low endotoxin to support sensitive in vitro and cell-based assays.
- Lyophilized powder for convenient storage and transport.
- Expressed in HEK293 cells for human-like post-translational modifications.
- C-terminal 6xHis tag facilitates purification and detection.
- Purity greater than 95% as determined by reducing SDS-PAGE.
- Endotoxin level below 1 EU/μg, suitable for sensitive assays.
- Available in 10 μg, 50 μg, 100 μg, and 500 μg sizes.
- Recommended reconstitution at ≥100 μg/mL; refer to lot-specific COA for buffer details.
Medchemexpress LLC Thalidomide 5-fluoride | 835616-61-0 | 100.0% | 276.22 | C13H9FN2O4 | 1 ML
Thalidomide 5-fluoride is a thalidomide-derived cereblon ligand used as a building block in targeted protein degradation (PROTAC) research and related chemical biology applications. It is supplied as both solid material and pre-formulated DMSO solutions to facilitate linker conjugation and assay use.
- Thalidomide-based cereblon ligand for CRBN recruitment.
- Cas number: 835616-61-0.
- Molecular formula C13H9FN2O4; molecular weight 276.22 g/mol.
- Purity reported at 99.96% (analytical).
- Available as 10 mM solution in DMSO (1 mL) and as solid in multiple package sizes.
- Storage: powder at -20°C or 4°C; in solvent at -80°C or -20°C.
Medchemexpress LLC Thalidomide | 50-35-1 | MFCD00153873 | 100.0% | C13H10N2O4 | 10MG
Thalidomide (analytical standard) is a high-purity reference compound (CAS 50-35-1) intended for research and analytical applications. It serves as a cereblon inhibitor standard for assay calibration, method development, and reference testing. Consult the certificate of analysis and safety data sheet for batch-specific purity and handling instructions.
- High purity (99.96%) suitable for analytical standards.
- Provided in small, laboratory-scale quantities for method development.
- Supplied with certificate of analysis and safety data sheet.
- Intended for research and analytical use only.
- Suitable for assays targeting cereblon-related activity.
Cayman Chemical -ThalIdomIde 100mg
An immunomodulatory compound with diverse biological activities; prevents PMN chemotaxis at 1, 10, and 100 UG/ml; increases IL-2-induced proliferation and IFN-γ production in primary human T cells in vitro; enhances NK cell-mediated cytotoxicity in MM.1S multiple myeloma cells; reduces lung IL-6, TGF-β, VEGF, angiopoietin-1, angiopoietin-2, and collagen type Iα1 expression, inhibits pulmonary angiogenesis, and attenuates fibrosis in a mouse model of bleomycin-induced pulmonary fibrosis at 4 mg/animal; induces apoptosis in primary human embryonic fibroblasts (EC50 = 8.9 µM) and induces limb and eye defects in chicken embryos (EC50 = 50 UG/kg egg weight)
Medchemexpress LLC Thalidomide-5-peg2-cl | 2230956-57-5 | 96.6% | C17H17ClN2O6 | 10MG
Thalidomide-5-PEG2-Cl is a thalidomide-derived cereblon (CRBN) ligand featuring a short PEG2 spacer and a terminal chloride. It is supplied as a research-grade building block for conjugation in PROTAC design and other CRBN-targeting chemical biology applications, with documented molecular formula and purity.
- Provides a CRBN-recruiting moiety suitable for PROTAC assembly.
- Contains a PEG2 linker for flexible conjugation to ligands.
- Terminal chloride enables straightforward chemical derivatization.
- Supplied with referenced purity and characterization data.
- Available in small research-friendly pack sizes for early-stage work.