Lactams
Medchemexpress LLC Thalidomide-Piperazine 5-fluoride | 2222114-22-7 | 96.5% | 360.34 | 1 G
Thalidomide-Piperazine 5-fluoride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide based cereblon ligand
- Utilizes linker in PROTAC technology
- For research use only
- Recommended storage at 4°C, protected from light
- Targets E3 Ligase Ligand-Linker Conjugates, Apoptosis, and Autophagy pathways
- Appears as a light yellow to green yellow solid
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | 95.1% | 50 MG
Thalidomide-O-C8-Boc is a thalidomide-based cereblon ligand that is used to recruit the CRBN protein. It can be linked to a protein ligand by a linker to create PROTACs. This product is intended for research use only.
- Functions as a thalidomide-based cereblon ligand
- Utilized for recruitment of CRBN protein
- Connects to protein ligands via a linker to form PROTACs
- Targets cereblon
Medchemexpress LLC Thalidomide-5-O-C13-NH2 (hydrochloride) | 99.9% | 508.05 | 5 MG
Thalidomide-5-O-C13-NH2 hydrochloride is a cereblon ligand based on Thalidomide. It is utilized in the recruitment of CRBN protein and can be connected to a protein ligand by a linker to form PROTACs.
- Cereblon ligand
- Used in the recruitment of CRBN protein
- Can be connected to a protein ligand by a linker
- Forms PROTACs
Medchemexpress LLC Thalidomide-O-C6-COOH | 2169266-69-5 | 99.3% | 100 MG
Thalidomide-O-C6-COOH is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide-based cereblon ligand and a linker, designed for use in PROTAC technology. PROTACs function by connecting two ligands: one for an E3 ubiquitin ligase and another for a target protein, enabling the selective degradation of target proteins via the intracellular ubiquitin-proteasome system. This product is intended for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide based cereblon ligand
- Designed for PROTAC technology applications
- Selectively degrades target proteins via ubiquitin-proteasome system
- Off-white to light yellow solid
- Soluble in DMSO at ≥ 100 mg/mL
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | 95.1% | 1 ML
Thalidomide-O-C8-Boc is a Thalidomide-based Cereblon ligand utilized for the recruitment of CRBN protein. It can be linked to a target protein ligand via a linker to create PROTACs.
- Cereblon ligand
- Used for recruitment of CRBN protein
- Can be linked to a target protein ligand via a linker to create PROTACs
- For research use only
Medchemexpress LLC Thalidomide-PEG2-C2-NH2 (TFA) | 2097509-36-7 | 99.1% | 50 MG
Thalidomide-PEG2-C2-NH2 (TFA) is a chemical compound characterized by its solid, light yellow to yellow appearance. With a molecular weight of 518.44 and a high purity of 99.1% (HPLC), this product is designated for laboratory chemical applications, substance manufacturing, and general research purposes. It requires specific storage conditions to ensure its stability and effectiveness.
- High purity (99.1% by HPLC)
- Solid form
- Suitable for laboratory chemical and research applications
- Requires cold storage to maintain integrity
Medchemexpress LLC Thalidomide-4-O-C12-NH2 hydrochloride | 95.6% | 494.02 | C25H36ClN3O5 | 10 MG
Thalidomide-4-O-C12-NH2 hydrochloride is a thalidomide-derived cereblon ligand provided as the hydrochloride salt for use in chemical biology and medicinal chemistry applications. It functions as a CRBN E3 ligase recruiter for targeted protein degradation and is intended for use in PROTAC and ligand-linker conjugation studies. Store protected from light at recommended temperatures.
Medchemexpress LLC Thalidomide-C2-amido-C2-COOH | 2353496-84-9 | 98.5% | C19H20N4O7 | 10MG
Thalidomide-C2-amido-C2-COOH is a thalidomide-derived cereblon (CRBN) ligand-linker conjugate for research use. Supplied as a powder, it is intended as a building block for design and synthesis of PROTAC degraders and other molecules that recruit the CRBN E3 ubiquitin ligase.
- Incorporates a cereblon-binding thalidomide moiety for E3 ligase recruitment.
- Contains a short C2-amido-C2-COOH linker for conjugation to target ligands.
- High purity (98.5%) suitable for synthetic and analytical work.
- Molecular formula and weight provided to support design calculations.
- Soluble in DMSO for preparation of concentrated stock solutions.
- Powder form allows long-term frozen storage for stability.
Medchemexpress LLC Thalidomide-NH-C6-NH2 TFA | 2093386-51-5 | 99.8% | 1 G
Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate, incorporating a Thalidomide-based cereblon ligand and a linker used in PROTAC technology. This compound is characterized by its high purity of 99.8%.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Features a linker used in PROTAC technology
- Designed for use in PROTACs that exploit the intracellular ubiquitin-proteasome system
Medchemexpress LLC N-Me-thalidomide 4-fluoride | 2244520-92-9 | MFCD34563580 | 99.4% | 290.25 g/mol | C14H11FN2O4 | 1 G
N-Me-Thalidomide 4-fluoride is a research-grade small molecule ligand for E3 ligase used in chemical biology and PROTAC development. It functions as a building block in the synthesis of targeted degraders and related small-molecule tools. Supplied for laboratory research use only.
- Ligand for E3 ligase.
- Useful building block for synthesis of targeted degraders and anti-inflammatory agents.
- High reported purity (99.41%).
- Molecular formula C14H11FN2O4; molecular weight 290.25 g/mol.
- Available in research pack sizes suitable for small-scale synthesis.
Medchemexpress LLC Thalidomide-Piperazine-PEG2-NH2 (diTFA) | 99.7% | 701.57 | 25 MG
Thalidomide-Piperazine-PEG2-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and a linker used in PROTAC technology. It is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Includes a linker used in PROTAC technology
- Targets Cereblon
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Thalidomide-iodo | 2509137-01-1 | MFCD31735039 | 98.0% | 384.13 | C13H9IN2O4 | 100 MG
Thalidomide-iodo is an iodinated derivative of thalidomide supplied as a research reagent. It acts as an E3 ligase activator and is suitable as a synthetic building block for further derivatization via substitution of the iodine. Typical specifications include CAS 2509137-01-1, molecular formula C13H9IN2O4, molecular weight 384.13, and reported purity of 98.0%.
- Iodinated E3 ligase activator for probe and degrader research.
- Synthetic building block amenable to substitution of iodine.
- High purity suitable for analytical and synthetic workflows.
- Available in multiple pack sizes for small-scale research.
- Intended for laboratory research use only.
Medchemexpress LLC Thalidomide-5-O-CH2-COOH | 2467425-53-0 | MFCD34186095 | 95.0% | 332.26 | C15H12N2O7 | 5 MG
Thalidomide-5-O-CH2-COOH is an E3 ligase ligand-linker conjugate used as a cereblon (CRBN) ligand and an intermediate in PROTAC and conjugate synthesis. The compound is fully characterized (CAS 2467425-53-0, C15H12N2O7, MW 332.26) and is provided in small milligram quantities for research use with supporting analytical documentation.
- Functions as a cereblon (CRBN) ligand for E3 ligase recruitment.
- Serves as an intermediate for PROTAC and ligand-linker conjugation.
- Characterized by CAS 2467425-53-0 and formula C15H12N2O7.
- Supplied with datasheet, certificate of analysis, SDS, and spectral data.
- Typical purity approximately 95.0% by HPLC.
- Available in milligram pack sizes suitable for medicinal chemistry research.
Medchemexpress LLC Thalidomide-O-C4-COOH | 2169266-67-3 | 97.0% | 250 MG
Thalidomide-O-C4-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is for research use only. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Incorporates Thalidomide based cereblon ligand
- Used in PROTAC technology
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Thalidomide-5-peg4-nh2 | 2743434-16-2 | 95.21% | 449.45 | 100 MG
This compound is an E3 ligase ligand-linker conjugate that uses a Thalidomide-based cereblon ligand and a PROTAC linker. It is intended for research use only, with a recommendation to use its more stable hydrochloride salt form due to the free compound's instability.
- Designed for PROTAC technology.
- Incorporates a cereblon ligand.
- Contains a versatile linker.
- Suitable for research applications.
- Available in a more stable salt form.