Lactams
Medchemexpress LLC 5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | 2230957-36-3 | 290.25 | C14H11FN2O4 | 250 MG
Thalidomide-1-Me,5-F is a fluorinated thalidomide derivative used as an E3 ubiquitin ligase activator in research. Supplied as a solid for laboratory use, it functions as a synthetic building block for further derivatization and for studies that probe E3 ligase-mediated pathways. Consult the product datasheet for lot-specific purity and analytical data.
- Fluorinated E3 ligase activator suitable for biochemical assays
- Reactive position enables SNAr derivatization for synthesis
- Supplied as a solid in multiple laboratory scales
- Molecular formula C14H11FN2O4; molecular weight 290.25
- Powder storage: -20°C (long term) or 4°C (short term)
- Data sheet and certificate of analysis available for purity and handling
Medchemexpress LLC 5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | 2230957-36-3 | >98.0% | 290.25 | C14H11FN2O4 | 1 G
Thalidomide-1-Me,5-F is a fluorinated thalidomide derivative (5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione) described as an E3 ligase activator. It is provided as a research chemical for use as a biochemical probe, synthetic building block, or starting material for further derivatization.
- Acts as an E3 ligase activator useful in targeted protein degradation studies.
- Contains a fluorine atom enabling SNAr reactions and further derivatization.
- Supplied in small-quantity packages suitable for research and synthesis.
- Well-defined chemical identity with CAS 2230957-36-3.
- Chemical formula C14H11FN2O4 and molecular weight 290.25.
Medchemexpress LLC 5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | 2230957-36-3 | >98.0% | 290.25 | C14H11FN2O4 | 500 MG
5-Fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione is a fluorinated thalidomide analogue described as an E3 ligase activator for research use. Supplied as a powder, it can serve as a synthetic building block for further derivatization, particularly by nucleophilic aromatic substitution (SNAr).
- Fluorinated thalidomide analogue useful for E3 ligase activation studies.
- Suitable as a synthetic building block for derivatization via SNAr.
- Supplied as a powder suitable for laboratory handling and storage.
- High purity; commonly listed as >98.0%.
- Typical pack sizes: 100 mg-1 g.
Medchemexpress LLC 5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | 2230957-36-3 | 97.0% | 290.25 g/mol | C14H11FN2O4 | 5 G
A fluorinated thalidomide analogue that functions as an E3 ligase (Cereblon) activator and a synthetic building block for targeted protein degradation research. Suitable for recruiting CRBN in PROTAC design and for further chemical derivatization via nucleophilic aromatic substitution (SNAr).
- Fluorinated thalidomide analogue
- Acts as an E3 ligase (Cereblon) activator
- Useful as a PROTAC ligand building block
- Compatible with SNAr derivatization
- Typical purity approximately 97.0%
- Molecular formula C14H11FN2O4; molecular weight 290.25 g/mol
Medchemexpress LLC 5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | 2230957-36-3 | MFCD30188075 | 99.9% | 276.22 g/mol | C13H9FN2O4 | 100 MG
5-Fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione is a fluorinated thalidomide derivative that functions as an E3 ligase (cereblon) ligand. It is provided as a high-purity solid and is intended for use as a chemical building block in targeted protein degradation research and for further derivatization via nucleophilic aromatic substitution (SNAr).
- Functions as an E3 ligase (cereblon) ligand.
- Useful as a building block for PROTAC and targeted protein degradation design.
- Fluorinated position enables SNAr-based further derivatization.
- Supplied as a high-purity small-molecule solid suitable for synthetic chemistry.
- Molecular formula C13H9FN2O4; molecular weight 276.22 g/mol.
Medchemexpress LLC Thalidomide 4-chloro | 244057-36-1 | MFCD30188071 | 96.0% | 292.68 g·mol⁻¹ | C13H9ClN2O4 | 1 G
Thalidomide 4-chloro is a chlorinated thalidomide derivative that functions as a cereblon (E3 ligase) ligand and E3 ligase activator. It is used in PROTAC development and as a synthetic building block for further derivatization via substitution at the 4-chloro position. The compound is supplied as a solid and is characterized for research applications.
- Molecular formula: C13H9ClN2O4.
- Molecular weight: 292.68 g·mol⁻¹.
- CAS number: 244057-36-1.
- Appearance: solid (powder).
- Purity: 96.0%.
- Intended use: E3 ligase (cereblon) ligand for PROTAC design and derivatization.
- Storage: powder -20 °C (3 years) or 4 °C (2 years); in solvent -80 °C (6 months) or -20 °C (1 month).