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Organic heterocyclic compounds that consist of a cyclic carboximidic acid characterized by a carbon-nitrogen double bond within the ring; they are tautomeric with the lactams.
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(S,R,S)-AHPC-C5-NH2 dihydrochloride is the dihydrochloride salt of an AHPC-derived E3 ligase ligand, provided as a solid for research use in studies of VHL E3 ubiquitin ligase recruitment and targeted protein degradation.
Dihydrochloride salt form for improved stability.
High purity of 97.8%.
Molecular weight 616.64 g/mol.
Molecular formula C28H43Cl2N5O4S.
Suitable as an E3 ligase ligand-linker component in PROTAC designs.
Storage: sealed, away from moisture; in solvent: -80°C up to 6 months, -20°C up to 1 month.
Documentation available: datasheet, COA, SDS.
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Dibromomaleimide-C5-COOH is a bifunctional dibromomaleimide linker used in antibody-drug conjugate synthesis to connect payloads such as MMAF. It is supplied as a white to off-white solid with high purity and is soluble in DMSO.
Bifunctional dibromomaleimide linker for ADC synthesis.
High purity (99.4%) suitable for research applications.
Molecular weight 369.01 g/mol and formula C10H11Br2NO4.
Soluble in DMSO at ≥100 mg/mL.
Available in small-scale quantities (5-200 mg) for conjugation workflows.
Store at 4°C under nitrogen; in solvent store at -80°C (6 months) or -20°C (1 month).
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Recombinant human Complement C5 produced in HEK293 cells with a C-terminal His tag. C5 is cleaved into C5a and C5b during complement activation and contributes to membrane attack complex formation. Supplied lyophilized from PBS with trehalose, this protein is intended for biochemical and immunological assays.
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Cycloheximide is an antibiotic produced by Streptomyces sp. that activates against yeasts and fungi. It inhibits protein synthesis thru DNA translation arrest in eukaryotes. Cycloheximide also inhibits chain initiation and chain elongation by acting on 60S subunits of eukaryote ribosome.
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(S,R,S)-AHPC-C5-NH2 dihydrochloride is a VHL ligand-linker conjugate supplied as the dihydrochloride salt for use as a PROTAC building block in research. It contains a C5 linker terminating in a primary amine and is provided as a solid intended for laboratory synthesis and biological studies.
Purity 97.8%.
Off-white to light yellow solid appearance.
Chemical formula C28H43Cl2N5O4S.
Molecular weight 616.64 g/mol.
Recommended storage: -20°C, sealed and away from moisture.
In solvent stability: -80°C for 6 months; -20°C for 1 month.
For research use only; not for human use.
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Cycloheximide cryst. pure Glutarimide antibiotic isolated from Streptomyces griseus; active against fungi and yeasts, but not against bacteria. Inhibits eukaryotic protein synthesis by blocking the translocation step in the elongation cycle (1,3,8). Blocks tra
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Cycloheximide cryst. pure Glutarimide antibiotic isolated from Streptomyces griseus; active against fungi and yeasts, but not against bacteria. Inhibits eukaryotic protein synthesis by blocking the translocation step in the elongation cycle (1,3,8). Blocks tra
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BODIPY FL C5-HPC is a lipophilic green fluorescent dye with excitation/emission maxima near 500/510 nm, intended for labeling membranes and lipophilic structures in fluorescence microscopy and flow cytometry.
Excitation/emission: 500/510 nm for green fluorescence.
Lipophilic dye suitable for membrane and lipid labeling.
High purity: 99.4% (HPLC).
Molecular weight: 797.76 g/mol; CAS: 161106-88-3.
Supplied in low-mass vials suitable for laboratory use and custom assays.
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Pomalidomide-C5-azide is an E3 ubiquitin ligase cereblon (CRBN) ligand-linker conjugate bearing a terminal azide for bioorthogonal click chemistry. It is used as a synthetic building block for PROTACs and related chemical biology probes, enabling attachment of linkers or payloads via azide-alkyne cycloaddition. Intended for research use only.
Terminal azide suitable for copper-catalyzed and strain-promoted click reactions.
Cereblon-binding ligand enables E3 ligase recruitment in degrader constructs.
Useful building block for PROTAC synthesis and chemical biology probe development.
High purity (≈97.5%) appropriate for research applications.
Solid, light yellow appearance; store cold, protected from light, under inert gas when possible.
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