Lactones
Apexbio Technology LLC Butyrolactone 3 778649-18-6 5mg
Butyrolactone 3 (CAS 778649-18-6) is a small-molecule inhibitor that targets the histone acetyltransferase Gcn5 a member of the GNAT family with specificity for histone H3 acetylation In vitro studies demonstrate that Butyrolactone 3 inhibits Gcn5 activity with an IC50 of 100 M while showing minimal inhibition of CBP The binding affinity of Butyrolactone 3 to Gcn5 is comparable to that of histone H3 and its inhibition is non-irreversible indicating it does not act via a Michael addition mechanism Structurally modification at position 2 has been suggested as a basis for structure activity relationship (SAR) studies Currently Butyrolactone 3 is utilized in preclinical research aimed at modulating Gcn5-mediated histone acetylation
Selleck Chemical LLC Gamma-Oryzanol S3957-25mg
Gamma-oryzanol (GO) a nutriactive phytochemical naturally occurring in crude rice bran oil is an antioxidant compound used to treat hyperlipidemia disorders of menopause and to increase the muscle mass -Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice -Oryzanol significantly inhibits the activities of DNMT1 (IC50 3 2 M) DNMT3a (IC50 22 3 M)
Medchemexpress LLC Gamma-secretase modulator 6 | 1255700-88-9 | 99.7% | 442.51 | 1 ML
gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. It inhibits Aβ42 secretion in HEK cell line stably expressing APP (Aβ amyloid precursor protein) (pIC50: 8.1), making it suitable for research.
- Used for research of Alzheimer's disease
- Inhibits Aβ42 secretion in HEK cell lines stably expressing APP
Medchemexpress LLC Simvastatin acid ammonium | 139893-43-9 | 99.7% | 50 MG
Simvastatin acid ammonium is the ammonium salt of simvastatin hydroxy acid, a potent HMG-CoA reductase inhibitor used as a research reagent to study cholesterol biosynthesis and related pathways. Supplied as a high-purity solid for laboratory research use; not for human consumption.
- Ammonium salt of simvastatin hydroxy acid used for research purposes.
- CAS 139893-43-9.
- Molecular formula C25H43NO6, molecular weight 453.61 g·mol⁻¹.
- High purity: 99.7%.
- Supplied as a 50 MG quantity.
- Activity: HMG-CoA reductase inhibitor relevant to cholesterol metabolism studies.
Medchemexpress LLC Simvastatin acid ammonium | 139893-43-9 | 99.7% | 5 MG
Simvastatin acid ammonium is the ammonium salt form of simvastatin hydroxy acid, a potent HMG-CoA reductase inhibitor supplied as a high-purity research reagent for biochemical and pharmacological studies.
- High purity (99.7%).
- Chemical formula C25H43NO6.
- Molecular weight 453.61 g/mol.
- Provided as a solid powder suitable for dissolution or formulation.
- Available in small research pack sizes for laboratory use.
