Oxazinanes
Medchemexpress LLC S1ra (hydrochloride) | 1265917-14-3 | 99.9% | 373.88 | 250 MG
S1RA (E-52862) hydrochloride is an orally active and selective sigma-1 receptor (σ1R) antagonist with a Ki value of 17 nM. It demonstrates good selectivity against σ2R (Ki >1000 nM). This compound is also identified as a human 5-HT2B receptor antagonist with an IC50 value of 4.7 μM. S1RA hydrochloride has been shown to inhibit neuropathic pain and activity-induced spinal sensitization.
- Orally active and selective sigma-1 receptor (σ1R) antagonist
- High affinity for human and guinea pig σ1Rs
- Good selectivity against sigma-2 receptors (σ2R)
- Acts as a human 5-HT2B receptor antagonist
- Inhibits neuropathic pain
- Reduces activity-induced spinal sensitization
- Demonstrates analgesic effects on formalin-evoked nociceptive behaviors in mice
- Reverses capsaicin-induced mechanical hypersensitivity in mice
Medchemexpress LLC 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, hydrochloride (1:2), (6S)- | 104632-25-9 | 98.0% | 284.25 | 5 MG
Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist. It is used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS).
- Selective dopamine D2-type receptor agonist
- Blood-brain barrier penetrant
- Used for Parkinson's disease research
- Used for restless legs syndrome research
- Has Ki values for D2-type, D2, D3, and D4 receptors
Medchemexpress LLC Pramipexole dihydrochloride | 104632-25-9 | 99.7% | 284.25 | 1 ML
Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist. It can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS).
- Selective dopamine D2-type receptor agonist
- BBB penetrant
- Useful for research into Parkinson's disease (PD) and restless legs syndrome (RLS)
- Cytoprotective properties
- Reduces infarction volume
- Improves neurological recovery
- Prevents ischemic cell death
Medchemexpress LLC Bomedemstat dihydrochloride | 99.6% | 592.54 g/mol | C28H36Cl2FN7O2 | 5 MG
Bomedemstat dihydrochloride is the dihydrochloride salt of bomedemstat, an irreversible lysine-specific demethylase 1 (LSD1) inhibitor supplied for research use. It is provided as a white to light yellow solid intended for biochemical and cell-based studies of epigenetic regulation and oncology-related research. Store sealed, away from moisture at -20°C; stability in solution: -80°C up to 6 months, -20°C up to 1 month.
Medchemexpress LLC Brilliant black BN | 2519-30-4 | 10 MG
Brilliant black BN (E151) is an azo dye and a food colorant with potential as an antiviral agent against EV71 infection. It operates by inhibiting the interaction between EV71 and its cellular uncoating factor cyclophilin A. This substance holds promise for the investigation of contagious diseases.
- Inhibits interaction between EV71 and cyclophilin A.
- Inhibits EV71-GFP infection in vitro.
- Exhibits dose-dependent inhibition of EV71-GFP in infected RD cells.
- Able to inhibit all tested 28 EV71, CVA16, and CVA6 strains.
- Shows protective effect in EV71 challenged AG129 mice in vivo.
Medchemexpress LLC 1,2-dihydro dexamethasone | 426-17-5 | MFCD22683747 | 1mg
1 2-Dihydro dexamethasone is a Dexamethasone (HY-14648) impurity
Medchemexpress LLC 1,2-dihydro dexamethasone | 426-17-5 | MFCD22683747 | 10mg
1 2-Dihydro dexamethasone is a Dexamethasone (HY-14648) impurity
Medchemexpress LLC Bay 61-3606 dihydrochloride | 648903-57-5 | MFCD08276916 | 99.5% | 463.32 g·mol^-1 | C20H20Cl2N6O3 | 10 MG
BAY 61-3606 dihydrochloride is a potent, ATP-competitive, reversible, and highly selective inhibitor of spleen tyrosine kinase (Syk), provided as the dihydrochloride salt for research use. It is intended for biochemical and cell-based studies of kinase signaling and apoptosis, and has reported biochemical potency (Ki = 7.5 nM; IC50 ≈ 10 nM) and high purity for reliable experimental results.
- High biochemical potency (Ki = 7.5 nM; IC50 ≈ 10 nM).
- High reported purity (≈99.5%).
- Provided as dihydrochloride salt suitable for cell-based assays.
- Characterized by COA, HNMR, and LC-MS documentation.
- Useful for studying Syk-dependent signaling and apoptosis.
Medchemexpress LLC 9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregn-4-ene-3,20-dione | 426-17-5 | MFCD22683747 | 5mg
1 2-Dihydro dexamethasone is a Dexamethasone (HY-14648) impurity
Medchemexpress LLC 5,6-Dihydro-5-methyluracil | 696-04-8 | 250 MG
5,6-Dihydro-5-methyluracil, also known as Dihydrothymine, is an intermediate breakdown product of thymine found in animals and plants. This substance is intended for laboratory use and research purposes only, and can be toxic at abnormally high levels.
- Intermediate breakdown product of thymine
- Found in animals and plants
- Can be toxic at abnormally high levels
- For research use only
- Appears as a white to off-white solid
- Stable under recommended storage conditions
Medchemexpress LLC 5,6-dihydro-5-fluorouracil | 696-06-0 | MFCD00871150 | 99.9% | C4H5FN2O2 | 10MG
5,6-Dihydro-5-fluorouracil is a fluorinated dihydropyrimidine metabolite used as a research reagent and analytical standard in biochemical and medicinal chemistry studies. It is supplied as a solid, high-purity material suitable for in vitro assays, metabolite profiling, and method development.
- High purity of 99.9% for analytical reliability.
- Solid, white to off-white appearance for easy handling.
- Molecular formula C4H5FN2O2 and molecular weight 132.09 g/mol.
- Available in small pack sizes including 10 mg for scarce-sample experiments.
- Stable as a powder at -20°C for long-term storage.
- Includes structural identifier (SMILES) for informatics and modeling.
Medchemexpress LLC Prexasertib (dihydrochloride) | 1234015-54-3 | 99.4% | 438.31 | 25 MG
Prexasertib (dihydrochloride) | 1234015-54-3 | 99.4% | 438.31 | 25 MG
![eMolecules 366789-02-8 | Rivaroxaban | Ambeed | MFCD11974010 | 435.88 | C19H18ClN3O5S | 98 | Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O | 1g | 525213664](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC2228454.JPG-250.jpg)
eMolecules 366789-02-8 | Rivaroxaban | Ambeed | MFCD11974010 | 435.88 | C19H18ClN3O5S | 98 | Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O | 1g | 525213664
Ambeed | 3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-24(1H3H)-dione | 250mg | 525031551 | A128495 | 871700-22-0 | MFCD18207184 | 401.180 | C14H13FIN3O2
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