Oxazinanes
Medchemexpress LLC (6S)-CP-470711 | 300552-09-4 | 98.8% | 358.44 | 25 MG
(6S)-CP-470711 (Compound 8) is an inhibitor of sorbitol dehydrogenase (SDH), with IC50 values of 19 nM for human SDH and 27 nM for rat SDH. It has been shown to improve Streptozotocin-induced diabetes in rat models.
- Inhibits human and rat sorbitol dehydrogenase (SDH) with IC50 values of 19 nM and 27 nM, respectively.
- Ameliorates streptozotocin-induced diabetes in rat models.
- Solid appearance, white to off-white color.
- For research use only.
Medchemexpress LLC Ipatasertib dihydrochloride | 1396257-94-5 | C24H34Cl3N5O2 | 200 MG
Ipatasertib dihydrochloride is a highly selective and ATP-competitive pan-Akt inhibitor, with IC50s of 5, 18, and 8 nM for Akt1, Akt2, and Akt3 respectively. It demonstrates potent efficacy in xenograft models where Akt is activated due to genetic alterations, leading to tumor growth delay, stasis, or regression. This compound is intended for research use only.
- Highly selective and ATP-competitive pan-Akt inhibitor.
- IC50s of 5, 18, and 8 nM for Akt1, Akt2, and Akt3.
- Significant selectivity for Akt1 compared to closely related kinases.
- Effective in xenograft models with Akt activation due to genetic alterations.
- Induces tumor growth delay, stasis, or regression in vivo.
- Enhances tumor regression and stasis when used in combination therapies.
- Increases tumor growth inhibition in ovarian cancer models when combined with other agents.
Medchemexpress LLC SP3N hydrochloride | 99.84% | 764.34 | 1 MG
SP3N hydrochloride is a specific degrader of the prolyl isomerase (FKBP12). The alkylamine of SP3N hydrochloride is metabolized to a reactive aldehyde (SP3CHO), which recruits the SCFFBXO22 ligase for FKBP12 degradation. SP3N hydrochloride may be used in research for cancer.
- Specific degrader of FKBP12.
- Metabolized to a reactive aldehyde (SP3CHO) which recruits SCFFBXO22 ligase for FKBP12 degradation.
- May be used in research for cancer.
Medchemexpress LLC Isoquinoline, 3,4-dihydro-1-phenyl- | 52250-50-7 | ≥96.0% | 207.28 | 5 G
1-Phenyl-3,4-dihydroisoquinoline is a chemical compound with the molecular formula C15H13N and a molecular weight of 207.28. This product appears as a liquid, ranging from light yellow to brown in color, and is confirmed to have a purity of at least 96.0% based on NMR analysis.
- Identified by CAS number 52250-50-7
- Minimum purity of 96.0%
- Consistent chemical structure confirmed by ¹H NMR spectrum
- Stable for extended periods when stored properly, with specific conditions for pure form and in solvent
Apexbio Technology LLC PROPACETAMOL-HYDROCHLORIDE
Propacetamol hydrochloride (CAS No 66532-86-3) is a prodrug of paracetamol commonly used in biomedical research for its analgesic and antipyretic properties It originates from the enzymatic conversion process where it rapidly hydrolyzes to release paracetamol which then exerts its effects by inhibiting cyclooxygenase enzymes and reducing the synthesis of prostaglandins in the central nervous system In vitro studies often show activity in the nanomolar to low micromolar range indicating its potent efficacy Typically it is used in cell models and animal studies to investigate pain management mechanisms and in drug screening strategies for analgesic development Experimental concentrations typically depend on the specific research design
Apexbio Technology LLC BARNIDIPINE-HYDROCHLORIDE
Barnidipine (hydrochloride) (CAS No 104757-53-1) is a calcium channel blocker used predominantly in cardiovascular research Originating from the dihydropyridine class of compounds it operates by inhibiting L-type calcium channels thereby reducing calcium influx into vascular smooth muscle cells and cardiac myocytes Its mechanism of action results in vasodilation and decreased vascular resistance contributing to its antihypertensive effects In vitro Barnidipine exhibits activity in the nanomolar to low micromolar range It is commonly applied in cell models such as vascular smooth muscle cells and cardiomyocytes as well as in animal studies to evaluate cardiovascular effects Barnidipine is also utilized in drug screening processes to assess potential therapeutic benefits and pharmacological properties Experimental concentrations typically depend on the specific research design
Apexbio Technology LLC LEE011-HYDROCHLORIDE-2MG
LEE011 hydrochloride (CAS No 1211443-80-9) is a potent cyclin-dependent kinase 4/6 (CDK4/6) inhibitor primarily utilized in oncology research It originates from the need to halt the progression of cancer cells by disrupting the cell cycle targeting the CDK4/6-Rb pathway In vitro LEE011 hydrochloride demonstrates efficacy in the nanomolar to low micromolar range effectively inhibiting cell proliferation across various cancer cell lines It is frequently employed in cell models and animal studies to evaluate its therapeutic potential and synergy with other anticancer agents Additionally this compound is widely used in drug screening and preclinical trials to assess its viability as a treatment option Experimental concentrations typically depend on the specific research design ensuring its application is tailored to the desired outcomes in scientific investigations
Medchemexpress LLC Cetylpyridinium chloride monohydrate | 6004-24-6 | 99.8% | 1 ML
Cetylpyridinium chloride monohydrate is a cationic quaternary ammonium compound that functions as an antiseptic, effectively killing bacteria and other microorganisms. It is commonly used in various oral hygiene products to prevent plaque and reduce gingivitis. This compound also exhibits biological activity against viruses and in cellular models, and has been studied in clinical trials for conditions such as SARS-CoV-2 infection and periodontal diseases.
- Cationic quaternary ammonium compound
- Functions as an antiseptic
- Kills bacteria and other microorganisms
- Prevents plaque and reduces gingivitis
- Used in mouthwashes, toothpastes, and throat/nasal sprays
- Disrupts influenza viral envelope
- Exhibits dose-dependent cytotoxicity in MDCK cells
- Enhances survival and reduces influenza-associated morbidity and mortality in mice
Medchemexpress LLC SBE13 Hydrochloride | 1052532-15-6 | C24H28Cl2N2O4 | 1 ML
SBE13 Hydrochloride is a potent and selective Plk1 inhibitor, with an IC50 of 200 pM. It poorly inhibits Plk2 (IC50>66 μM) or Plk3 (IC50=875 nM). This compound is for research use only.
- Potent and selective Plk1 inhibitor
- Induces apoptosis in HeLa cells
- Reduces cell proliferation
- Can be stored at 4°C for solid form, and -80°C or -20°C in solvent
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eMolecules 1225376-02-2 | (R)-2-Phenylmorpholine | J & W PharmLab LLC | MFCD18249849 | 163.220 | C10H13NO | 96.000 | C1CO[C@@H](CN1)c1ccccc1 | 1g | 525307271
(R)-2-Phenylmorpholine | J & W PharmLab LLC | 1225376-02-2 | MFCD18249849 | 163.220 | C10H13NO | 96.000 | C1CO[C@@H](CN1)c1ccccc1 | 1g | 525307271
Aobchem 2-Methyl-4-(methylsulfanyl)benzaldehyde | ≥95% | CAS 956612-78-5 | C9H10OS | 250mg
2-Methyl-4-(methylsulfanyl)benzaldehyde | ≥95% | CAS 956612-78-5 | C9H10OS | 250mg
Aobchem 4-Bromo-6-fluoro-2-methyl-2H-indazole | ≥97% | CAS 1425932-77-9 | C8H6BrFN2 | 250mg
4-Bromo-6-fluoro-2-methyl-2H-indazole | ≥97% | CAS 1425932-77-9 | C8H6BrFN2 | 250mg
Aobchem 1-(2-Isobutoxyphenyl)ethanone | ≥95% | CAS 137557-08-5 | C12H16O2 | 5g
1-(2-Isobutoxyphenyl)ethanone | ≥95% | CAS 137557-08-5 | C12H16O2 | 5g