Oxazinanes
Cayman Chemical CP 24 879 hydrochloride
A Δ5/Δ6 desaturase inhibitor; reduces liver arachidonate content by ~50% in mice at 3 mg/kg; increases mead acid content and inhibits leukotriene C4 synthesis in murine mastocytoma cells at 5 µM
Cayman Chemical PropenylLNIO hydrochloride
A potent, selective iNOS inhibitor (Kis = 17, 10.3 and 58.2 µM for iNOS, nNOS, and eNOS, respectively, for initial rate binding kinetics); demonstrates reversible tight binding inhibition that is selective for iNOS over nNOS (Kis = 0.56 and 6 µM, respectively)
Cayman Chemical SH1152 hydrochloride
A potent, specific, ATP-competitive, and cell permeable inhibitor of ROCK (Ki = 1.6 nM); more potent inhibitor of ROCK than either Y-27632 (Ki = 140 nM) or HA-1077 (Ki = 330 nM); poorly inhibits PKA, PKC, and MLCK
Sigma Aldrich Fine Chemicals Biosciences Ivabradine hydrochloride 950MG
Ivabradine hydrochloride 950MG
Cayman Chemical MethylLNIO hydrochloride
A competitive NOS inhibitor; more potent inhibitor of nNOS (Ki = 3.0 µM) than eNOS (Ki = 10.0 µM) or iNOS (Ki = 9.5 µM)
Cayman Chemical Leelamine hydrochloride
The hydrochloride of leelamine, an inhibitor of pyruvate dehydrogenase kinase.
Cayman Chemical EthylLNIO hydrochloride
A modestly selective NOS inhibitor with Ki values for inhibition of nNOS, eNOS, and iNOS of 5.3, 18, and 12 µM, respectively; however, does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (Ki/Km = 3.79, 5, and 0.96 µM, respectively)
![eMolecules 365215-38-9 | (R,R)-Bn-Pybox | ChemScene | MFCD23704922 | 397.478 | C25H23N3O2 | 95.000 | C([C@@H]1COC(=N1)c1cccc(n1)C1=N[C@H](Cc2ccccc2)CO1)c1ccccc1 | 1g | 536799837](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000188644.jpg-250.jpg)
eMolecules 365215-38-9 | (R,R)-Bn-Pybox | ChemScene | MFCD23704922 | 397.478 | C25H23N3O2 | 95.000 | C([C@@H]1COC(=N1)c1cccc(n1)C1=N[C@H](Cc2ccccc2)CO1)c1ccccc1 | 1g | 536799837
(R,R)-Bn-Pybox | ChemScene | 365215-38-9 | MFCD23704922 | 397.478 | C25H23N3O2 | 95.000 | C([C@@H]1COC(=N1)c1cccc(n1)C1=N[C@H](Cc2ccccc2)CO1)c1ccccc1 | 1g | 536799837
Medchemexpress LLC Pramipexole dihydrochloride | 104632-25-9 | MFCD00876894 | 99.7% | 284.25 g/mol | C10H19Cl2N3S | 10 MG
Pramipexole dihydrochloride is a research-grade dopamine D2-type receptor agonist provided as a white to off-white solid salt. It is commonly used in neuroscience and pharmacology studies, including models of Parkinson's disease and restless legs syndrome, where selective D2 agonism and blood-brain barrier penetration are required.
- High HPLC purity (99.73%).
- White to off-white solid for consistent handling.
- Suitable for in vitro and in vivo neuroscience research.
- Blood-brain barrier penetrant dopamine D2-type receptor agonist.
- Available in multiple small research pack sizes.
- Stable when stored sealed at 4°C; in solvent: -80°C (6 months), -20°C (1 month).
Cayman Chemical O2545 hydrochloride
A potent water-soluble agonist of CB1 and CB2 receptors with Ki values of 1.5 and 0.32 nM, respectively; when dissolved in saline, is highly efficacious in mouse behavioral models when administered either intravenously or intracerebroventricularly
Cayman Chemical SRT 1720 hydrochloride
A selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol; improves insulin sensitivity, lowers plasma, glucose and increases mitochondrial capacity in diet-induced obese and diabetic leptin-deficient ob/ob mice after one week of treatment with an oral dose of 100 mg/kg once daily.
Cayman Chemical Y27632 hydrochloride
A potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nM) and ROCK2 (IC50 = 800 nM); also inhibits PRK2 with an IC50 value of 600 nM
Cayman Chemical FR122047 hydrochloride
A selective COX-1 inhibitor (IC50 = 0.028 µM for the human enzyme); selective for COX-1 over COX-2 (IC50 = 65 µM); inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation in human platelet-rich plasma (IC50 = 180-200 nM); unlike aspirin, it does not induce gastric damage at 100 mg/kg, p.o.; has an anti-inflammatory effect in a rat models of collagen-induced arthritis
Cayman Chemical SH1152 hydrochloride
A potent, specific, ATP-competitive, and cell permeable inhibitor of ROCK (Ki = 1.6 nM); more potent inhibitor of ROCK than either Y-27632 (Ki = 140 nM) or HA-1077 (Ki = 330 nM); poorly inhibits PKA, PKC, and MLCK
Cayman Chemical ClAmidine hydrochloride
A PAD inhibitor (IC50s = 0.8, 6.2, and 5.9 µM for PAD1, PAD3, and PAD4, respectively); cytotoxic to HL-60, MCF-7, and HT-29 cancer cells (IC50s = 0.25, 0.05, and 1 μM, respectively); reduces ex vivo extracellular NET formation and increases survival in a mouse model of CLP-induced sepsis at 50 mg/kg; decreases the citrulline content in serum and joints and reduces the development of IgG autoantibodies in a mouse model of collagen-induced arthritis