Oxazinanes
Apexbio Technology LLC Sarpogrelate hydrochloride 135159-51-2 10mM (in 1mL DMSO)
Sarpogrelate hydrochloride (CAS 135159-51-2) is a selective antagonist of the 5-HT2A receptor exhibiting a binding affinity (Ki) of 8 39 nM comparable to ritanserin By inhibiting 5-HT2A receptor-mediated pathways sarpogrelate suppresses platelet aggregation thrombus formation and vascular smooth muscle cell proliferation In vitro its primary metabolite (M-1) blocks 5-HT-induced responses at the 5-HT2A receptor with minimal stereoselective difference Clinically oral administration of sarpogrelate in patients with peripheral arterial disease significantly enhances forearm and leg blood flow responses to reactive hyperemia indicating improved vascular function Sarpogrelate is employed in research on platelet function thrombosis and vascular disorders
Selleck Chemical LLC KHS101 hydrochloride
KHS101 is a small-molecule inhibitor of TACC3 which is a key component of centrosome-microtubule dynamic networks
Medchemexpress LLC Quisinostat (dihydrochloride) | 875320-31-3 | C21H28Cl2N6O2 | 5 MG
Quisinostat dihydrochloride is an orally active, potent pan-HDAC inhibitor with IC50s as low as 0.11 nM for HDAC1. This compound exhibits broad-spectrum antitumoral activity and can induce autophagy in neuroblastoma cells. It is intended for research use only.
- Orally active, potent pan-HDAC inhibitor
- Exhibits broad-spectrum antitumoral activity
- Induces autophagy in neuroblastoma cells
- Inhibits HDAC isozymes in vitro
- Shows broad-spectrum antiproliferative activity against cancer cell lines
- Induces apoptosis
- Induces H3 and H4 acetylation in A2780 ovarian carcinoma cells
- Inhibits growth of pre-established HCT116 colon xenografts in vivo
Medchemexpress LLC Prexasertib (dihydrochloride) | 1234015-54-3 | 99.7% | 438.31 | 50 MG
Prexasertib dihydrochloride is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with potent anti-tumor activity. It causes double-stranded DNA breakage and replication catastrophe, leading to apoptosis.
- Selective CHK1 inhibitor with Ki of 0.9 nM and IC50 of <1 nM
- Also inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM)
- Causes double-stranded DNA breakage
- Induces replication catastrophe and apoptosis
- Demonstrates potent anti-tumor activity
- Inhibits MELK (IC50=38 nM), SIK (IC50=42 nM), BRSK2 (IC50=48 nM), and ARK5 (IC50=64 nM)
- Requires CDC25A and CDK2 to induce DNA damage
- Causes chromosomal fragmentation in HeLa cells
- Induces replication stress and depletes RPA2 available for DNA binding
- Shows tumor growth inhibition in xenografts
Medchemexpress LLC S1ra (hydrochloride) | 1265917-14-3 | 99.9% | 373.88 | 250 MG
S1RA (E-52862) hydrochloride is an orally active and selective sigma-1 receptor (σ1R) antagonist with a Ki value of 17 nM. It demonstrates good selectivity against σ2R (Ki >1000 nM). This compound is also identified as a human 5-HT2B receptor antagonist with an IC50 value of 4.7 μM. S1RA hydrochloride has been shown to inhibit neuropathic pain and activity-induced spinal sensitization.
- Orally active and selective sigma-1 receptor (σ1R) antagonist
- High affinity for human and guinea pig σ1Rs
- Good selectivity against sigma-2 receptors (σ2R)
- Acts as a human 5-HT2B receptor antagonist
- Inhibits neuropathic pain
- Reduces activity-induced spinal sensitization
- Demonstrates analgesic effects on formalin-evoked nociceptive behaviors in mice
- Reverses capsaicin-induced mechanical hypersensitivity in mice
Selleck Chemical LLC Cefozopran hydrochloride
Cefozopran Hydrochloride is the hydrochloride salt form of cefozopran a semi-synthetic broad-spectrum fourth-generation cephalosporin with antibacterial activity
Selleck Chemical LLC Pargyline hydrochloride S3690-1g
Pargyline is an irreversible inhibitor of monoamine oxidase (MAO)-B with Ki values of 13 and 0 5 M for time-dependent inhibition of the activity of MAO-A and -B respectivey
Selleck Chemical LLC Triflupromazine hydrochloride
Triflupromazine hydrochloride (Fluopromazine) is an antipsychotic medication of the phenothiazine class
TARGETMOL CHEMICALS INC ATB107 HYDROCHLORIDE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ATB107 hydrochloride is a novel and potent inhibitor of indole-3-glycerol phosphate synthase (IGPS) with a KD of 3 uM.
Cayman Chemical PIK75 hydrochloride
A selective inhibitor of p110α with an IC50 value of 5.8 nM; inhibits p110γ and p110β with IC50 values of 0.076 µM and 1.3 µM, respectively
Medchemexpress LLC Inolitazone dihydrochloride | 223132-38-5 | 98.9% | 575.51 g/mol | C27H28Cl2N4O4S | 10 MG
Inolitazone dihydrochloride is a research-grade, high-affinity peroxisome proliferator-activated receptor gamma (PPARγ) agonist. It is PPARγ-dependent for its biological activity and has demonstrated potent growth-inhibitory effects (reported IC50 ≈ 0.8 nM). The compound is used in cell proliferation and combination therapy studies and is supplied for research use only.
- High-affinity PPARγ agonist with potent activity.
- Demonstrated growth inhibition with IC50 ≈ 0.8 nM.
- Upregulates p21 (WAF1/CIP1), useful in cell cycle studies.
- Suitable for cell proliferation and combination therapy research.
- Provided at high purity (≈98.9%) suitable for analytical assays.
- Available in multiple small pack sizes for laboratory use.
Selleck Chemical LLC Amodiaquine hydrochloride
Amodiaquine Hydrochloride is the hydrochloride salt of amodiaquine an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties
Selleck Chemical LLC Bevantolol hydrochloride S5042-25mg
Bevantolol hydrochloride (NC-1400) is a cardioselective beta adrenoceptor antagonist devoid of intrinsic sympathomimetic activity and with weak membrane-stabilizing and local anesthetic properties
Cayman Chemical CP 24 879 hydrochloride
A Δ5/Δ6 desaturase inhibitor; reduces liver arachidonate content by ~50% in mice at 3 mg/kg; increases mead acid content and inhibits leukotriene C4 synthesis in murine mastocytoma cells at 5 µM
Selleck Chemical LLC Rauwolscine hydrochloride S5337-25mg
Rauwolscine hydrochloride (Isoyohimbine -Yohimbine corynanthidine) is the hydrochloride salt form of Rauwolscine a specific and potent 2 antagonist with Ki of 12 nM