Oxazinanes
TARGETMOL CHEMICALS INC PCLX-001 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. PCLX-001 is a small-molecule compound that acts as an orally active inhibitor of N-myristoyltransferase (NMT) specifically targeting NMT1 and NMT2 with IC50 values of 5 nM and 8 nM respectively. This compound demonstrates anti-tumor effects and effectively inhibits the early signaling of B-cell receptor (BCR). Consequently PCLX-001 is a valuable tool for researching B-cell malignancies [1] [2]. purity: 98%
TARGETMOL CHEMICALS INC PNU112455A HYDROCHLORIDE 10MG
Also available in 2 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. PNU112455A hydrochloride is an ATP site competetive inhibitor of CDK2 and CDK5binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 uM respectively. purity: 100%
Selleck Chemical LLC Ribociclib hydrochloride S5187-25mg
Ribociclib (LEE011) hydrochloride is a highly specific dual inhibitor of CDK4 and CDK6 with IC50 of 10 nM and 39 nM respectively
Medchemexpress LLC RF9 hydrochloride | 00-00-0 | 99.9% | 519.08 | C26H39ClN6O3 | 1 ML
RF9 hydrochloride is a potent and selective antagonist of Neuropeptide FF (NPFF) receptors, with reported Ki values of 58 nM for hNPFF1R and 75 nM for hNPFF2R. It is supplied for research use as high-purity material, available as a 10 mM solution in DMSO or as dry powder in multiple vial sizes.
- Potent NPFF receptor antagonist (Ki = 58 nM for hNPFF1R; Ki = 75 nM for hNPFF2R).
- Molecular formula C26H39ClN6O3.
- Molecular weight 519.08.
- Purity >99.9%.
- Available as 10 mM solution in DMSO and as dry powders in multiple vial sizes.
- Intended for in vitro pharmacology and receptor binding studies.
TARGETMOL CHEMICALS INC PXS-6302 hydrochloride 1MG
Also available in 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. PXS-6302 hydrochloride is a potent irreversible lysine oxidase (LOX) inhibitor, inhibiting Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, and rh LOXL4 with IC50 of 3.7 uM, 3.4 uM, 0.4 uM, 1.5 uM, and 0.3 uM, respectively. PXS-6302 hydrochloride penetrates easily through the skin and is able to reduce collagen accumulation, significantly improving the appearance of scars. Purity 99.89%
TARGETMOL CHEMICALS INC Milnacipran hydrochloride
Also available in 10 mg, 25 mg, 50 mg, 200 mg, 500 mg and bulk. Please contact Fisher for quotes. Milnacipran hydrochloride (Savella) is a serotonin and norepinephrine reuptake inhibitor used to treat major depressive disorders. Milnacipran hydrochloride is an enantiomer of milnacipran, which is used to treat fibromyalgia. Milnacipran hydrochloride and milnacipran have been associated with a low rate of transient elevations in serum aminotransferase levels during treatment and with rare instances of clinically apparent acute liver injury with jaundice. Purity 100%
Cayman Chemical SRT 1720 hydrochloride
A selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol; improves insulin sensitivity, lowers plasma, glucose and increases mitochondrial capacity in diet-induced obese and diabetic leptin-deficient ob/ob mice after one week of treatment with an oral dose of 100 mg/kg once daily.
CSc3ccccc3)c(c2)S(=O)(=O)C(F)(F)F)C1)c1ccc(Cl)cc1 | 100mg | 348528136](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502697893.jpg-250.jpg)
eMolecules 923564-51-6 | Navitoclax | Target Molecule | MFCD12756219 | 974.610 | C47H55ClF3N5O6S3 | 0.000 | CC1(C)CCC(=C(CN2CCN(CC2)c2ccc(cc2)C(=O)NS(=O)(=O)c2ccc(N[C@H](CCN3CCOCC3)CSc3ccccc3)c(c2)S(=O)(=O)C(F)(F)F)C1)c1ccc(Cl)cc1 | 100mg | 348528136
Navitoclax | Target Molecule | 923564-51-6 | MFCD12756219 | 974.610 | C47H55ClF3N5O6S3 | 0.000 | CC1(C)CCC(=C(CN2CCN(CC2)c2ccc(cc2)C(=O)NS(=O)(=O)c2ccc(N[C@H](CCN3CCOCC3)CSc3ccccc3)c(c2)S(=O)(=O)C(F)(F)F)C1)c1ccc(Cl)cc1 | 100mg | 348528136
Selleck Chemical LLC Rauwolscine hydrochloride S5337-25mg
Rauwolscine hydrochloride (Isoyohimbine -Yohimbine corynanthidine) is the hydrochloride salt form of Rauwolscine a specific and potent 2 antagonist with Ki of 12 nM
eMolecules 1420898-14-1 | tert-Butyl 3-(cyclopropylamino)-3-methylpiperidine-1-carboxylate | ChemScene | MFCD24383571 | 254.374 | C14H26N2O2 | 97.000 | CC(C)(C)OC(=O)N1CCCC(C)(C1)NC1CC1 | 100mg | 811576827
tert-Butyl 3-(cyclopropylamino)-3-methylpiperidine-1-carboxylate | ChemScene | 1420898-14-1 | MFCD24383571 | 254.374 | C14H26N2O2 | 97.000 | CC(C)(C)OC(=O)N1CCCC(C)(C1)NC1CC1 | 100mg | 811576827
Cayman Chemical FR122047 hydrochloride
A selective COX-1 inhibitor (IC50 = 0.028 µM for the human enzyme); selective for COX-1 over COX-2 (IC50 = 65 µM); inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation in human platelet-rich plasma (IC50 = 180-200 nM); unlike aspirin, it does not induce gastric damage at 100 mg/kg, p.o.; has an anti-inflammatory effect in a rat models of collagen-induced arthritis
Medchemexpress LLC Sapropterin dihydrochloride | 69056-38-8 | 99.96% | C9H17Cl2N5O3 | 50 MG
Sapropterin dihydrochloride is an analytical standard used for research and analytical applications. It functions as an orally active phenylalanine hydroxylase (PAH) cofactor, helping to reduce blood phenylalanine concentrations. This compound is suitable for studying phenylketonuria (PKU). It is an analytical standard grade, commonly employed in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS.
- Analytical standard for research and analytical applications
- Orally active phenylalanine hydroxylase (PAH) cofactor
- Reduces blood phenylalanine concentrations
- Useful in the study of phenylketonuria (PKU)
- Suitable for HPLC, GC, and MS applications
Apexbio Technology LLC CBL0137 (hydrochloride) 1197397-89-9 2mg
CBL0137 (hydrochloride) (CAS 1197397-89-9) is a small-molecule curaxin that modulates transcriptional regulation by targeting the Facilitates Chromatin Transcription (FACT) complex This interaction leads to activation of p53 (EC50 0 37 M) and inhibition of NF- B signaling (EC50 0 47 M) pathways commonly dysregulated in cancer In vitro CBL0137 induces apoptosis in pancreatic cancer cell lines affecting both differentiated tumor cells and cancer stem cells In vivo studies demonstrate antitumor activity in models resistant to gemcitabine with additional combinatory effects attributed to transcriptional inhibition CBL0137 is under clinical evaluation in solid and hematological malignancies
![Medchemexpress LLC 4-[2-(methylthio)phenyl]-N-(1,2,3,4-tetrahydro-1-naphthalenyl)-1-piperazinehexanamide, monohydrochloride | 824958-12-5 | 98.1% | 488.13 | C27H38ClN3OS | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000247212.png-250.jpg)
Medchemexpress LLC 4-[2-(methylthio)phenyl]-N-(1,2,3,4-tetrahydro-1-naphthalenyl)-1-piperazinehexanamide, monohydrochloride | 824958-12-5 | 98.1% | 488.13 | C27H38ClN3OS | 1 ML
LP44 hydrochloride is the hydrochloride salt of LP44, a potent and selective 5-HT7 (serotonin 7) receptor agonist used as a research tool in neuroscience to probe receptor pharmacology and physiological responses.
- Selective 5-HT7 receptor agonist with nanomolar affinity.
- Available as a ready-to-use 10 mM solution in DMSO (1 mL) and in solid forms.
- High purity (~98.1%), suitable for research applications.
- Molecular formula C27H38ClN3OS; molecular weight 488.13.
- Supplied as a hydrochloride salt to improve solubility in DMSO.
Cayman Chemical Dimebolin hydrochloride
A neuroprotective agent; binds to histamine H1 and H2 receptors (IC50s = 3.8 and 287 nM, respectively), as well as α1A-, α1B-, α1D-, and α2A-ARs, imidazoline I2 receptors, and 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 receptors (Kis = 8-313 nM); inhibits NMDA-evoked currents and voltage-gated calcium channels in mouse primary striatal neurons (IC50s = 10 and 50 μM, respectively); inhibits glutamate-induced apoptosis in primary striatal neurons derived from the YAC128 transgenic mouse model of Huntington’s disease at 50 μM; inhibits cell death induced by amyloid-β (25-35) in cerebellar granule cells at 25 μM; inhibits decreases TWAA acquisition in a rat model of AF64A-induced Alzheimer’s disease at 1 mg/kg