Oxazinanes
TARGETMOL CHEMICALS INC ABEPRAZAN HYDROCHLORIDE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Abeprazan hydrochloride (Fexuprazan hydrochloride) is an effective reversible potassium-competitive acid blocker with oral activity inhibiting H+ K+ -atPase by competitive binding to potassium ions without acid activation. Abeprazan hydrochloride is a proton pump inhibitor (PPI) that acts by reducing gastric acid production and is used to treat gastric acid-related disorders such as gastroesophageal reflux disease (GERD) and peptic ulcers. purity: 98%
Apexbio Technology LLC Sotalol hydrochloride 959-24-0 10mM (in 1mL DMSO)
Sotalol hydrochloride (CAS 959-24-0) is a potent non-selective -adrenergic receptor antagonist and a potassium channel inhibitor In HEK cell models it exhibits an IC50 of approximately 1 2 mM for potassium channel inhibition As a class III antiarrhythmic agent sotalol hydrochloride increases the functional refractory period without reducing conduction velocity in ex vivo rabbit heart models of reentrant tachycardia In vivo studies in canine hearts demonstrate its ability to prolong atrial and ventricular monophasic action potential durations during constant atrial pacing Sotalol hydrochloride is frequently employed in research on arrhythmia mechanisms and rhythm control therapies particularly in the context of atrial fibrillation
Apexbio Technology LLC SM-102 100mg
SM-102 is an amino cationic lipid specifically used to form lipid nanoparticles (LNPs) to enhance the efficiency of mRNA delivery into cells Studies have shown that SM-102 effectively modulates erg-mediated potassium currents (i erg) in GH cells at concentrations ranging from 100 to 300 M thereby regulating specific signaling pathways Its applications include research on drug delivery technologies for mRNA therapies and vaccine development
TARGETMOL CHEMICALS INC Besipirdine hydrochloride 1MG
Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Besipirdine hydrochloride is a non-receptor-dependent cholinomimetic compound with alpha-adrenergic and cardiovascular activities.Besipirdine hydrochloride inhibits voltage-dependent sodium-potassium channels and inhibits biogenic amine uptake.Besipirdine hydrochloride reduces schedule-induced thirst and enhances cholinergic and adrenergic neurotransmission in the central nervous system in rats. Purity 98.4%
Apexbio Technology LLC KN-93 hydrochloride 1956426-56-4 1mg
KN-93 hydrochloride (CAS 1956426-56-4) is a selective inhibitor of Ca2 /calmodulin-dependent protein kinase II (CaMK II) binding competitively at the calmodulin site with a reported Ki of 0 37 M and an IC50 of 370 nM In isolated gastric parietal cells KN-93 suppresses acid secretion stimulated by carbachol and histamine with IC50 values of 0 15 M and 0 3 M respectively and inhibits mucin-stimulated aminopyrine uptake (IC50 0 6 M) Additionally KN-93 shows inhibitory activity against H /K -ATPase and directly blocks voltage-gated potassium (Kv) channels by promoting C-type inactivation KN-93 is widely used to probe CaMK II signaling and its downstream physiological effects in cellular and electrophysiological studies
Apexbio Technology LLC Xamoterol hemifumarate 73210-73-8 5mg
Xamoterol hemifumarate (CAS 73210-73-8) is a selective 1-adrenergic receptor agonist targeting cardiac 1 receptors It is designed to activate 1-adrenergic signaling pathways thereby modulating myocardial function and cardiac electrophysiological processes Xamoterol hemifumarate exerts its biological activity primarily through 1-adrenergic receptor stimulation influencing downstream intracellular signaling cascades related to cardiac rhythm regulation In experimental settings it is utilized in vitro with cellular cardiac models and in vivo with animal models to assess 1-adrenergic receptor-mediated effects particularly in the interaction with cardiac ion channels such as the rapid delayed rectifier potassium current (IKr) Based on these pharmacological properties Xamoterol hemifumarate holds research potential in the study of arrhythmogenesis mechanisms and cardiac electrophysiology
Apexbio Technology LLC Xamoterol hemifumarate 73210-73-8 10mg
Xamoterol hemifumarate (CAS 73210-73-8) is a selective 1-adrenergic receptor agonist targeting cardiac 1 receptors It is designed to activate 1-adrenergic signaling pathways thereby modulating myocardial function and cardiac electrophysiological processes Xamoterol hemifumarate exerts its biological activity primarily through 1-adrenergic receptor stimulation influencing downstream intracellular signaling cascades related to cardiac rhythm regulation In experimental settings it is utilized in vitro with cellular cardiac models and in vivo with animal models to assess 1-adrenergic receptor-mediated effects particularly in the interaction with cardiac ion channels such as the rapid delayed rectifier potassium current (IKr) Based on these pharmacological properties Xamoterol hemifumarate holds research potential in the study of arrhythmogenesis mechanisms and cardiac electrophysiology
Medchemexpress LLC ML133 hydrochloride | 1222781-70-5 | 313.82 g/mol | C19H20ClNO | 1 ML
ML133 hydrochloride is a selective inhibitor of Kir2 family inward-rectifier potassium channels used in ion channel research and electrophysiology. It displays pH-dependent potency with reported IC50 values of 1.8 μM at pH 7.4 and 290 nM at pH 8.5. Supplied as a hydrochloride salt and commonly provided as a 10 mM solution in DMSO for laboratory research use only.
- Selective Kir2 family inhibitor suitable for electrophysiology studies.
- pH-dependent potency with IC50 values at physiological and alkaline pH.
- Convenient 10 mM solution in DMSO for immediate experimental use.
- Hydrochloride salt form for improved solubility in polar solvents.
- Provided for research use only; not for human or veterinary use.
Apexbio Technology LLC Dequalinium Chloride 522-51-0 250mg
Dequalinium Chloride (CAS 522-51-0) is a small molecule inhibitor known to target protein kinase C (PKC) with reported IC50 values between 7 18 M PKC is a serine/threonine kinase involved in calcium- and lipid-dependent signaling pathways critical for cell growth and transformation Dequalinium Chloride also acts as a selective blocker of apamin-sensitive potassium channels exhibiting an IC50 of 1 1 M and inhibits angiotensin II-induced K loss (IC50 1 5 M) Notably dequalinium accumulates in mitochondria of cancer cells disrupts mitochondrial enzymes and impairs cellular energy production ultimately leading to cell death It has been used in studies of apoptosis mitochondrial function and as an adjunct in tumor models investigating sensitization to agents such as TNF
Apexbio Technology LLC KN-93 hydrochloride 1956426-56-4 10mM (in 1mL DMSO)
KN-93 hydrochloride (CAS 1956426-56-4) is a selective inhibitor of Ca2 /calmodulin-dependent protein kinase II (CaMK II) binding competitively at the calmodulin site with a reported Ki of 0 37 M and an IC50 of 370 nM In isolated gastric parietal cells KN-93 suppresses acid secretion stimulated by carbachol and histamine with IC50 values of 0 15 M and 0 3 M respectively and inhibits mucin-stimulated aminopyrine uptake (IC50 0 6 M) Additionally KN-93 shows inhibitory activity against H /K -ATPase and directly blocks voltage-gated potassium (Kv) channels by promoting C-type inactivation KN-93 is widely used to probe CaMK II signaling and its downstream physiological effects in cellular and electrophysiological studies
Apexbio Technology LLC Xamoterol hemifumarate 73210-73-8 25mg
Xamoterol hemifumarate (CAS 73210-73-8) is a selective 1-adrenergic receptor agonist targeting cardiac 1 receptors It is designed to activate 1-adrenergic signaling pathways thereby modulating myocardial function and cardiac electrophysiological processes Xamoterol hemifumarate exerts its biological activity primarily through 1-adrenergic receptor stimulation influencing downstream intracellular signaling cascades related to cardiac rhythm regulation In experimental settings it is utilized in vitro with cellular cardiac models and in vivo with animal models to assess 1-adrenergic receptor-mediated effects particularly in the interaction with cardiac ion channels such as the rapid delayed rectifier potassium current (IKr) Based on these pharmacological properties Xamoterol hemifumarate holds research potential in the study of arrhythmogenesis mechanisms and cardiac electrophysiology
AdipoGen Verapamil hydrochloride
Chemical. CAS 152-11-4. Formula C27H38N2O4 . HCl. MW 491.06. Synthetic Verapamil hydrochloride is an alpha-adrenergic receptor alpha-AR antagonist and calcium channel protein inhibitor that blocks the L-type Ca2 channels in smooth and cardiac muscle cells. Verapamil is an antiarrhythmic agent and vasodilator known to reduce the renal clearance of digoxin and induce apoptosis in primary and metastatic colon adenocarcinoma human cell lines in vitro. It has been observed that verapamil can induce currents by itself, presumably by acting on the potassium and chloride leakage. Verapamil has also been used as an inhibitor of drug efflux pump proteins such as Mdr P-glycoprotein. Verapamil is a substrate of CYP3A4 and CYP2C6. It is also used in fluorescent cell sorting for DNA content, as it blocks efflux of a variety of DNA-binding fluorophores such as Hoechst 33342. Recent research has shown verapamil to be an effective treatment for diabetes in animal models.
AdipoGen Verapamil hydrochloride
Chemical. CAS 152-11-4. Formula C27H38N2O4 . HCl. MW 491.06. Synthetic Verapamil hydrochloride is an alpha-adrenergic receptor alpha-AR antagonist and calcium channel protein inhibitor that blocks the L-type Ca2 channels in smooth and cardiac muscle cells. Verapamil is an antiarrhythmic agent and vasodilator known to reduce the renal clearance of digoxin and induce apoptosis in primary and metastatic colon adenocarcinoma human cell lines in vitro. It has been observed that verapamil can induce currents by itself, presumably by acting on the potassium and chloride leakage. Verapamil has also been used as an inhibitor of drug efflux pump proteins such as Mdr P-glycoprotein. Verapamil is a substrate of CYP3A4 and CYP2C6. It is also used in fluorescent cell sorting for DNA content, as it blocks efflux of a variety of DNA-binding fluorophores such as Hoechst 33342. Recent research has shown verapamil to be an effective treatment for diabetes in animal models.
AdipoGen Verapamil hydrochloride
Chemical. CAS 152-11-4. Formula C27H38N2O4 . HCl. MW 491.06. Synthetic Verapamil hydrochloride is an alpha-adrenergic receptor alpha-AR antagonist and calcium channel protein inhibitor that blocks the L-type Ca2 channels in smooth and cardiac muscle cells. Verapamil is an antiarrhythmic agent and vasodilator known to reduce the renal clearance of digoxin and induce apoptosis in primary and metastatic colon adenocarcinoma human cell lines in vitro. It has been observed that verapamil can induce currents by itself, presumably by acting on the potassium and chloride leakage. Verapamil has also been used as an inhibitor of drug efflux pump proteins such as Mdr P-glycoprotein. Verapamil is a substrate of CYP3A4 and CYP2C6. It is also used in fluorescent cell sorting for DNA content, as it blocks efflux of a variety of DNA-binding fluorophores such as Hoechst 33342. Recent research has shown verapamil to be an effective treatment for diabetes in animal models.