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Filtered Search Results
eMolecules 109-01-3 | 1-Methylpiperazine | Key Organics/BIONET | MFCD00005966 | 100.165 | C5H12N2 | 95.000 | CN1CCNCC1 | 5mg | 564171052
1-Methylpiperazine | Key Organics/BIONET | 109-01-3 | MFCD00005966 | 100.165 | C5H12N2 | 95.000 | CN1CCNCC1 | 5mg | 564171052
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Apexbio Technology LLC H-9 dihydrochloride 116700-36-8 10mg
H-9 dihydrochloride (CAS 116700-36-8) is a cell-permeable inhibitor of protein kinase A (PKA) used extensively to investigate protein kinase-dependent cellular signal transduction pathways By antagonizing PKA activity H-9 dihydrochloride has been shown to attenuate cellular excitatory responses induced by serotonin (5-HT) and to directly influence physiological functions in the pharyngeal region Additionally in epithelial cell models H-9 dihydrochloride inhibits epidermal growth factor (EGF)-dependent signaling cascades suppressing cell proliferation This compound is widely used in cell biology research to dissect kinase-mediated regulatory mechanisms
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1 CLICK CHEMISTRY
NC3901166 3-2-AMINOETHYL AMINO PROPANOIC
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Apexbio Technology LLC ML 120B dihydrochloride 783348-36-7 (free base) 10mg
ML 120B dihydrochloride is a selective agonist targeting the G-protein-coupled receptor 40 (GPR40) also known as free fatty acid receptor 1 (FFAR1) It is designed to activate GPR40 thereby modulating downstream signal transduction pathways that regulate glucose-stimulated insulin secretion in pancreatic -cells ML 120B dihydrochloride exerts its biological activity primarily through specific engagement of GPR40-mediated pathways Based on these pharmacological properties ML 120B dihydrochloride holds research potential in investigating mechanisms underlying glucose-dependent insulin secretion and in the development of therapeutic strategies for diabetes and related metabolic disorders
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Apexbio Technology LLC IT1t dihydrochloride 1092776-63-0 10mg
IT1t dihydrochloride (CAS 1092776-63-0) is a small-molecule antagonist targeting the chemokine receptor CXCR4 It is designed to inhibit CXCR4-mediated signaling by disrupting interactions with its natural ligand CXCL12 as well as the HIV envelope protein gp120 thereby interfering with cellular chemotaxis and viral entry mechanisms IT1t dihydrochloride exerts its biological activity primarily by antagonizing CXCR4 to inhibit receptor-mediated Ca2 mobilization and virus attachment In in vitro assays IT1t dihydrochloride demonstrates potent inhibition with IC50 values of approximately 8 nM in human CXCR4 receptor binding assays 1 1 nM in Ca2 mobilization assays and 7 nM in HIV attachment assays Based on these pharmacological properties IT1t dihydrochloride holds research potential in CXCR4-related signaling and HIV entry studies
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Apexbio Technology LLC GW 583340 dihydrochloride 10mg
GW 583340 dihydrochloride (CAS 1173023-85-2) is a small molecule inhibitor targeting the tyrosine kinase activity of both EGFR and ErbB2 exhibiting potent inhibitory effects with IC50 values of 0 01 M and 0 014 M respectively In addition to suppressing these receptor-mediated signaling pathways GW 583340 dihydrochloride has been shown to inhibit ABC transporters including ABCG2 and ABCB1 thereby reversing transporter-associated multidrug resistance This compound is utilized in tumor biology research to investigate the modulation of oncogenic signaling mechanisms underlying drug resistance and to explore potential therapeutic strategies
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Apexbio Technology LLC GW 583340 dihydrochloride 50mg
GW 583340 dihydrochloride (CAS 1173023-85-2) is a small molecule inhibitor targeting the tyrosine kinase activity of both EGFR and ErbB2 exhibiting potent inhibitory effects with IC50 values of 0 01 M and 0 014 M respectively In addition to suppressing these receptor-mediated signaling pathways GW 583340 dihydrochloride has been shown to inhibit ABC transporters including ABCG2 and ABCB1 thereby reversing transporter-associated multidrug resistance This compound is utilized in tumor biology research to investigate the modulation of oncogenic signaling mechanisms underlying drug resistance and to explore potential therapeutic strategies
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Chembridge Corporation 2-(4-METHYLPIPERAZIN-1-YL)ANIL
2-(4-methylpiperazin-1-yl)aniline; CAS: 180605-36-1
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Apexbio Technology LLC TMB dihydrochloride 64285-73-0 1g
TMB dihydrochloride (CAS 64285-73-0) is a water-soluble chromogenic substrate frequently employed in biochemical assays involving horseradish peroxidase (HRP) It is designed to enable enzyme-catalyzed colorimetric detection by generating an oxidized blue-colored product upon reaction with hydrogen peroxide TMB dihydrochloride exerts its functional role through HRP-catalyzed oxidation in the presence of hydrogen peroxide Based on its chemical reactivity it is also utilized as a probe for interactions with reactive oxygen and nitrogen species such as singlet oxygen hypochlorite hydrogen peroxide and nitrogen dioxide Based on these characteristics TMB dihydrochloride holds research potential in enzyme-linked immunosorbent assays (ELISA) immunohistochemical staining oxidative stress analysis and microbial metabolism studies
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Carbosynth LLC. Biosynth Chemical Compound, 3-(2-Methoxyethyl)oxolan-3-amine hydrochloride
Biosynth Chemical Compound, 3-(2-Methoxyethyl)oxolan-3-amine hydrochloride
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Selleck Chemical LLC H-1152 dihydrochloride
H-1152 dihydrochloride (2HCl) is a membrane-permeable and selective inhibitor of Rho-associated protein kinase (ROCK) H-1152 inhibits ROCK2 PKA PKC PKG AuroraA and CaMK2 with IC50 of 0 0120 M 3 03 M 5 68 M 0 360 M 0 745 M and 0 180 M respectively
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Apexbio Technology LLC Dilazep dihydrochloride 20153-98-4 50mg
Dilazep dihydrochloride is a small-molecule inhibitor targeting adenosine reuptake It is designed to block the cellular uptake of adenosine thereby increasing extracellular adenosine concentrations and regulating adenosine receptor-mediated pathways Dilazep dihydrochloride exerts its biological activity primarily through inhibition of adenosine reuptake resulting in vasodilation and suppression of platelet aggregation Based on these pharmacological properties Dilazep dihydrochloride holds research potential in studies of coronary blood flow regulation platelet aggregation mechanisms cardiomyocyte metabolism and protective cellular responses during ischemia-reperfusion injury
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Selleck Chemical LLC PI-1840
PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor with IC50 of 27 nM with little effects on the other two major proteasome proteolytic activities trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L)
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Apexbio Technology LLC IT1t dihydrochloride 1092776-63-0 100mg
IT1t dihydrochloride (CAS 1092776-63-0) is a small-molecule antagonist targeting the chemokine receptor CXCR4 It is designed to inhibit CXCR4-mediated signaling by disrupting interactions with its natural ligand CXCL12 as well as the HIV envelope protein gp120 thereby interfering with cellular chemotaxis and viral entry mechanisms IT1t dihydrochloride exerts its biological activity primarily by antagonizing CXCR4 to inhibit receptor-mediated Ca2 mobilization and virus attachment In in vitro assays IT1t dihydrochloride demonstrates potent inhibition with IC50 values of approximately 8 nM in human CXCR4 receptor binding assays 1 1 nM in Ca2 mobilization assays and 7 nM in HIV attachment assays Based on these pharmacological properties IT1t dihydrochloride holds research potential in CXCR4-related signaling and HIV entry studies
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Apexbio Technology LLC IT1t dihydrochloride 1092776-63-0 25mg
IT1t dihydrochloride (CAS 1092776-63-0) is a small-molecule antagonist targeting the chemokine receptor CXCR4 It is designed to inhibit CXCR4-mediated signaling by disrupting interactions with its natural ligand CXCL12 as well as the HIV envelope protein gp120 thereby interfering with cellular chemotaxis and viral entry mechanisms IT1t dihydrochloride exerts its biological activity primarily by antagonizing CXCR4 to inhibit receptor-mediated Ca2 mobilization and virus attachment In in vitro assays IT1t dihydrochloride demonstrates potent inhibition with IC50 values of approximately 8 nM in human CXCR4 receptor binding assays 1 1 nM in Ca2 mobilization assays and 7 nM in HIV attachment assays Based on these pharmacological properties IT1t dihydrochloride holds research potential in CXCR4-related signaling and HIV entry studies
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