Piperazinoazepines
Mianserin hydrochloride
CAS: 21535-47-7 Molecular Formula: C18H21ClN2 Molecular Weight (g/mol): 300.83 MDL Number: MFCD00055072 InChI Key: YNPFMWCWRVTGKJ-UHFFFAOYNA-N Synonym: mianserin hydrochloride,mianserine hydrochloride,mianserin hcl,athymil,bolvidon,tolvon,tolvin,org gb 94,lerivon PubChem CID: 68551 ChEBI: CHEBI:31843 IUPAC Name: hydrogen 5-methyl-2,5-diazatetracyclo[13.4.0.0²,⁷.0⁸,¹³]nonadeca-1(19),8,10,12,15,17-hexaene chloride SMILES: [H+].[Cl-].CN1CCN2C(C1)C1=CC=CC=C1CC1=CC=CC=C21
Mirtazapine, 98%
CAS: 85650-52-8 Molecular Formula: C17H19N3 Molecular Weight (g/mol): 265.35 InChI Key: RONZAEMNMFQXRA-UHFFFAOYSA-N Synonym: mirtazapine,remeron,mepirzepine,remergil,zispin,remergon,rexer,6-azamianserin,remeron soltab,mepirzapin PubChem CID: 4205 ChEBI: CHEBI:6950 SMILES: CN1CCN2C(C1)C3=CC=CC=C3CC4=C2N=CC=C4
Mirtazapine 98.0+%, TCI America™
CAS: 85650-52-8 Molecular Formula: C17H19N3 Molecular Weight (g/mol): 265.36 MDL Number: MFCD00865427 InChI Key: RONZAEMNMFQXRA-UHFFFAOYSA-N Synonym: mirtazapine,remeron,mepirzepine,remergil,zispin,remergon,rexer,6-azamianserin,remeron soltab,mepirzapin PubChem CID: 4205 ChEBI: CHEBI:6950 SMILES: CN1CCN2C(C1)C3=CC=CC=C3CC4=C2N=CC=C4
Mianserin Hydrochloride 98.0+%, TCI America™
CAS: 21535-47-7 Molecular Formula: C18H21ClN2 Molecular Weight (g/mol): 300.83 MDL Number: MFCD00055072 InChI Key: YNPFMWCWRVTGKJ-UHFFFAOYNA-N Synonym: mianserin hydrochloride,mianserine hydrochloride,mianserin hcl,athymil,bolvidon,tolvon,tolvin,org gb 94,lerivon PubChem CID: 68551 ChEBI: CHEBI:31843 IUPAC Name: hydrogen 5-methyl-2,5-diazatetracyclo[13.4.0.0²,⁷.0⁸,¹³]nonadeca-1(19),8,10,12,15,17-hexaene chloride SMILES: [H+].[Cl-].CN1CCN2C(C1)C1=CC=CC=C1CC1=CC=CC=C21
Medchemexpress LLC Mirtazapine | 85650-52-8 | 99.9% | 5 MG
Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. It functions as a 5-HT2, 5-HT3, histamine H1 receptor, and α2-adrenoceptor antagonist.
- Antagonizes adrenergic α2-autoreceptors and α2-heteroreceptors
- Blocks 5-HT2 and 5-HT3 receptors
- Enhances norepinephrine release and 5-HT1A-mediated serotonergic transmission
- Metabolized by cytochrome P450 isoenzymes CYP1A2, CYP2D6, and CYP3A4
- Reduces activation-induced release of cytokine/chemokine mediators from human CD14+ monocytes
- Inhibits Con A-induced liver injury
Medchemexpress LLC Mirtazapine (Standard) | 85650-52-8 | 99.9% | 5 MG
Mirtazapine (Standard) is the analytical standard of Mirtazapine, intended for research and analytical applications. This potent, orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent also functions as a 5-HT2, 5-HT3, histamine H1 receptor, and α2-adrenoceptor antagonist. It is commonly used in qualitative, quantitative, and methodological research experiments, including HPLC, GC, and MS.
- Analytical standard for Mirtazapine
- Potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA)
- Functions as a 5-HT2, 5-HT3, histamine H1 receptor, and α2-adrenoceptor antagonist
- Suitable for research and analytical applications
- Used in HPLC, GC, and MS experiments
- High purity of 99.95%
- White to off-white solid appearance
- Molecular weight of 265.36 and formula C₁₇H₁₉N₃
Medchemexpress LLC Mirtazapine | 85650-52-8 | 99.9% | 500 MG
Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. It functions as a 5-HT2, 5-HT3, histamine H1 receptor, and α2-adrenoceptor antagonist, influencing norepinephrine and 5-HT1A-mediated serotonergic transmission. It is primarily metabolized by CYP1A2, CYP2D6, and CYP3A4.
- Potent and orally active antidepressant
- Acts as a 5-HT2, 5-HT3, histamine H1 receptor, and α2-adrenoceptor antagonist
- Enhances release of norepinephrine
- Enhances 5-HT1A-mediated serotonergic transmission
- Reduces activation-induced release of cytokine/chemo kine mediators from human CD14+ monocytes in vitro
- Inhibits Con A-induced liver injury in vivo by suppressing hepatic macrophage/monocyte activation and pro-inflammatory cytokine production
Medchemexpress LLC Mirtazapine | 85650-52-8 | 99.9% | 200 MG
Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. It acts as a 5-HT2, 5-HT3, histamine H1 receptor, and α2-adrenoceptor antagonist. Its metabolism is primarily handled by cytochrome P450 isoenzymes CYP1A2, CYP2D6, and CYP3A4.
- Acts as a 5-HT2, 5-HT3, histamine H1 receptor, and α2-adrenoceptor antagonist
- Enhances norepinephrine and 5-HT1A-mediated serotonergic transmission
- Significantly reduces activation-induced release of cytokine/chemokine mediators from human CD14+ monocytes
- Inhibits Con A-induced liver injury by suppressing hepatic macrophage/monocyte activation
Medchemexpress LLC Mianserin hydrochloride | 21535-47-7 | 99.95% | 1 ML
Mianserin hydrochloride is an orally active H1 receptor antagonist that can also activate κ-opioid and octapamine receptors. It increases ERK1/2 and CREB phosphorylation, and antagonizes full κ-opioid agonist and dynorphin A-induced MAPK phosphorylation. This compound modulates social and exploratory behavior, raises electroconvulsive thresholds, and is used in research for neurological diseases like depression and epilepsy.
- Orally active H1 receptor antagonist
- Activates κ-opioid receptor and octopamine receptor
- Increases ERK1/2 and CREB phosphorylation
- Antagonizes κ-opioid agonist and dynorphin A-induced MAPK phosphorylation
- Modulates social and exploratory behavior
- Raises electroconvulsive thresholds
- Used for research of neurological diseases, including depression and epilepsy
Medchemexpress LLC Mirtazapine | 85650-52-8 | MFCD00865427 | 99.95% | 100 MG
Mirtazapine (Standard) is the analytical standard of Mirtazapine, intended for research and analytical applications. It is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also a 5-HT2, 5-HT3, histamine H1 receptor, and α2-adrenoceptor antagonist with pKi values of 8.05, 8.1, 9.3, and 6.95, respectively.
- Analytical standard for research and analytical applications
- Potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent
- 5-HT2, 5-HT3, histamine H1 receptor, and α2-adrenoceptor antagonist
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
Sigma Aldrich Fine Chemicals Biosciences Mirtazapine for system suitability European Pharmacopoeia (EP) Reference Standard | 85650-52-8 | MFCD00865427 |
Mirtazapine for system suitability European Pharmacopoeia (EP) Reference Standard | Mol Wt: 265.35 | 85650-52-8 | MFCD00865427 |
Medchemexpress LLC (S)-Mirtazapine | 61337-87-9 | 99.8% | 5 MG
(S)-Mirtazapine ((S)-Org3770) is an S(+)-enantiomer of Mirtazapine, exhibiting pronociceptive properties within an animal model of acute thermal nociception. It functions as a stereoselective 5-HT2 receptor antagonist and undergoes metabolism by CYP2D6 and CYP1A2.
- It is an S(+)-enantiomer of Mirtazapine.
- It has pronociceptive properties in an animal model of acute thermal nociception.
- It is a stereoselective 5-HT2 receptor antagonist.
- It is metabolized by CYP2D6 and CYP1A2.
- The molecular weight is 265.35.
- The chemical formula is C17H19N3.
- It appears as a solid.
- The color ranges from off-white to light yellow.
- The purity is 99.76%.
- The enantiomeric excess is 98.35%.
Apexbio Technology LLC Mirtazapine 85650-52-8 50mg
Mirtazapine is a small-molecule antagonist targeting central presynaptic 2-adrenergic receptors as well as serotonin 5-HT2 and 5-HT3 receptors and central histamine H1 receptors It is designed to modulate monoaminergic neurotransmission thereby affecting mood regulation pathways Mirtazapine exerts its biological activity primarily through selective antagonism of central presynaptic 2-adrenergic receptors inducing increased synaptic release of norepinephrine and serotonin It also antagonizes serotonin 5-HT2 and 5-HT3 receptors Based on these pharmacological properties mirtazapine holds research potential in the fields of neuroscience and psychopharmacology particularly for studies involving depressive disorders anxiety conditions and mood regulation
Medchemexpress LLC Pyrazino[2,1-a]pyrido[2,3-c]benzazepine, 1,2,3,4,10,14b-hexahydro-2-methyl-, (14bS)- | 61337-87-9 | 99.8% | 25 MG
(S)-Mirtazapine ((S)-Org3770) is an S(+)-enantiomer of Mirtazapine. It exhibits pronociceptive properties in an animal model of acute thermal nociception and acts as a stereoselective 5-HT2 receptor antagonist. It is metabolized by CYP2D6 and CYP1A2. The product is intended for research use only and is not sold to patients.
- S(+)-enantiomer of mirtazapine
- Exhibits pronociceptive properties in an animal model
- Acts as a stereoselective 5-HT2 receptor antagonist
- Metabolized by CYP2D6 and CYP1A2
- Purity: 99.8%
- Enantiomeric excess: 98.35%
- Molecular weight: 265.35
- Molecular formula: C17H19N3
- Appearance: Solid, off-white to light yellow
- Solubility in DMSO: ≥ 100 mg/mL
- Intended for research use only