Piperidines
Aobchem Methanone (4-bromophenyl)(3-fluorophenyl)- | ≥95% | CAS 951885-68-0 | C13H8BrFO | 1g
Methanone (4-bromophenyl)(3-fluorophenyl)- | ≥95% | CAS 951885-68-0 | C13H8BrFO | 1g
Aobchem Methanone (2 3-dichlorophenyl)-2-pyridinyl- | ≥95% | CAS 54523-80-7 | C12H7Cl2NO | 500mg
Methanone (2 3-dichlorophenyl)-2-pyridinyl- | ≥95% | CAS 54523-80-7 | C12H7Cl2NO | 500mg
![Medchemexpress LLC 1-[3-(2,3-dichlorophenyl)-2H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methylpiperidin-4-amine | 2160546-07-4 | 100.0% | C17H18Cl2N6 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000261615.png-250.jpg)
Medchemexpress LLC 1-[3-(2,3-dichlorophenyl)-2H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methylpiperidin-4-amine | 2160546-07-4 | 100.0% | C17H18Cl2N6 | 10MG
IACS-13909 is a selective, potent, orally active allosteric inhibitor of SHP2 (PTPN11) used as a research compound to probe MAPK pathway signaling and antitumor activity in RTK-dependent models. It provides defined potency, high supplied purity, and solubility/formulation data to support in vitro and in vivo pharmacology studies.
- Selective SHP2 allosteric inhibitor with IC50 15.7 nM and Kd 32 nM.
- High supplied purity (99.97%) suitable for biological assays.
- Soluble in DMSO at 10 mg/mL for in vitro use, with in vivo formulation options.
- Available in multiple solid and solution pack sizes for flexible dosing.
- Applicable to cellular and preclinical pharmacology studies of MAPK pathway signaling.
Medchemexpress LLC Nelfinavir mesylate | 159989-65-8 | C33H49N3O7S2 | 25 MG
Nelfinavir Mesylate, also known as AG 1343 Mesylate, is a potent and orally bioavailable HIV-1 protease inhibitor. It is also described as a broad-spectrum anticancer agent and an inhibitor of SARS-CoV 3CLpro.
- Potent HIV-1 protease inhibitor (Ki=2 nM)
- Inhibits proliferation of multiple myeloma cells (IC50 of 1-5 μM)
- Triggers apoptosis of myeloma cell lines
- Decreases phosphorylation of AKT, STAT-3, ERK1/2
- Activates the pro-apoptotic pathway of the unfolded protein response system
- Inhibits SARS-CoV 3CLpro (IC50 of 35.93 μM)
- Decreases multiple myeloma cell growth in animal models
Medchemexpress LLC Ropivacaine | 84057-95-4 | MFCD00078774 | 100.0% | 50 MG
Overview of Ropivacaine
Ropivacaine is a potent sodium channel blocker. It works by blocking impulse conduction through reversible inhibition of sodium ion influx in nerve fibers. Additionally, Ropivacaine acts as an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. It is utilized in the research of neuropathic pain management.
Features and Benefits
- Potent sodium channel blocker.
- Blocks impulse conduction by inhibiting sodium ion influx.
- Inhibits K2P TREK-1 (IC50 of 402.7 μM).
- Used for neuropathic pain management research.
- Epidural administration blocks neuropathic pain and delays its development.
- Inhibits pressure-induced increases in filtration coefficient.
- Prevents pressure-induced lung edema and hyperpermeability.
- Inhibits pressure-induced NO production.
eMolecules 854056-07-8 | Medchem Express | Ropivacaine (mesylate) | 10mg | 527573892 | HY-B0563C | MFCD08458442 | 370.51 | C18H30N2O4S
Medchem Express | Ropivacaine (mesylate) | 10mg | 527573892 | HY-B0563C | 854056-07-8 | MFCD08458442 | 370.510 | C18H30N2O4S
Medchemexpress LLC Levobupivacaine hydrochloride | 27262-48-2 | >99.8% | 5 MG
Levobupivacaine hydrochloride is a long-acting amide local agent that can suppress or relieve pain. It exerts analgesic effects through reversible blockade of neuronal sodium channels. It can inhibit impulse transmission and conduction in cardiovascular and other tissues, possessing certain cardiac and CNS toxicity. It is metabolized by hepatic cytochrome P450 (CYP450) enzymes in vivo and can also induce ferroptosis by miR-489-3p/SLC7A11 signaling in gastric cancer.
- Long-acting amide local agent
- Suppresses or relieves pain
- Exerts analgesic effects through reversible blockade of neuronal sodium channels
- Inhibits impulse transmission and conduction in cardiovascular and other tissues
- Metabolized by hepatic cytochrome P450 (CYP450) enzymes in vivo
- Induces ferroptosis by miR-489-3p/SLC7A11 signaling in gastric cancer
Med Vet International Zoetis Carbocaine-V 2% Sterile Aqueous Solution, 50mL
VET LICENSE NEEDS TO BE PROVIDED IN 3-4 BUSINESS DAYS OR ORDER WILL BE CANCELLED
CARBOCAINE-V Sterile Aqueous Solution (2% mepivacaine hydrochloride, USP) is recommended for infiltration, nerve block, intra-articular and epidural anesthesia for horses. It has also been found useful for topical anesthesia of the laryngeal mucosa prior to ventriculectomy.
Medchemexpress LLC Mepivacaine hydrochloride | 1722-62-9 | 99.68% | 1 G
Mepivacaine hydrochloride is a local anesthetic that inhibits nerve impulse initiation and conduction by binding to voltage-gated sodium ion channels in neuronal cell membranes. This action blocks sodium influx and membrane depolarization, leading to a reversible loss of sensation. It is characterized by a rapid onset and moderate duration of action compared to other local anesthetics.
- Exhibits a more rapid onset than some other local anesthetics.
- Provides a moderate duration of action.
- Shows preferential use-dependent block of Na(v)1.8 channels.
- For research use only.
Aobchem Methanone (2 4-dimethoxyphenyl)-2-pyridinyl- | ≥95% | CAS 898780-42-2 | C14H13NO3 | 1g
Methanone (2 4-dimethoxyphenyl)-2-pyridinyl- | ≥95% | CAS 898780-42-2 | C14H13NO3 | 1g