Piperidines
Medchemexpress LLC Nelfinavir | 159989-64-7 | C32H45N3O4S | 1 MG
Nelfinavir is a potent, orally bioavailable HIV-1 protease inhibitor, showing strong efficacy against HIV infection with a Ki of 2 nM. This compound also functions as a broad-spectrum anticancer agent.
- Potent and orally bioavailable HIV-1 protease inhibitor
- Broad-spectrum anticancer agent
- Inhibits proliferation of multiple myeloma cells
- Inhibits 26S chymotrypsin-like proteasome activity
- Triggers apoptosis in myeloma cell lines and fresh plasma cells
- Decreases phosphorylation of AKT, STAT-3, ERK1/2
- Activates pro-apoptotic pathway of the unfolded protein response system
- Decreases multiple myeloma cell growth in NOD/SCID mice
Medchemexpress LLC Nelfinavir Mesylate (AG 1343 Mesylate) | 159989-65-8 | C33H49N3O7S2 | 50 MG
Nelfinavir Mesylate is a potent, orally bioavailable inhibitor of HIV-1 protease (Ki=2 nM) used in the treatment of HIV infection. It also acts as a broad-spectrum anticancer agent.
- Potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection.
- Functions as a broad-spectrum anticancer agent.
- Inhibits the proliferation of multiple myeloma cells in a dose-dependent manner (IC50 of 1-5 μM).
- Impairs 26S chymotrypsin-like proteasome activity.
- Triggers apoptosis in myeloma cell lines and fresh plasma cells.
- Decreases the phosphorylation of AKT, STAT-3, and ERK1/2, and activates the pro-apoptotic pathway of the unfolded protein response system.
- Also identified as a SARS-CoV 3CLpro inhibitor with an IC50 of 35.93 μM.
Medchemexpress LLC IOWH-032 | 1191252-49-9 | 99.6% | 545.18 | 50 MG
IOWH-032 is a synthetic anti-secretory molecule and a potent CFTR inhibitor with an IC50 value of 8 μM. It also functions as an anti-diarrheal agent.
- Potent CFTR inhibitor with an IC50 value of 8 μM.
- Functions as an anti-diarrheal agent.
- Increases ACE-2 expression in SARS-CoV-2 infected CFBE41o- WT cells (10 μM; 0-72 h).
Apexbio Technology LLC Ropivacaine hydrochloride monohydrate 132112-35-7 50mg
Ropivacaine hydrochloride monohydrate (CAS 132112-35-7) is a long-acting amide local anesthetic widely studied for its pharmacological and electrophysiological properties It inhibits ATP-sensitive potassium (KATP) channels particularly SUR2A/Kir6 2 as demonstrated in COS-7 cell models where inhibition is concentration-dependent and reversible Reported IC50 values for SUR2A/Kir6 2 SUR2B/Kir6 1 SUR2B/Kir6 2 and Kir6 2 C36 channels are 249 11 2235 115 2442 132 and 2375 179 M respectively Additionally ropivacaine hydrochloride monohydrate suppresses sarcolemmal KATP channels in cardiovascular tissues via stereoselective and tissue-specific mechanisms supporting its utility in studies of ion channel pharmacology and cardiovascular safety profiles
Apexbio Technology LLC Ropivacaine HCl 98717-15-8 10mM (in 1mL H2O)
Ropivacaine HCl (CAS 98717-15-8) is a local anesthetic agent commonly employed in biomedical research to examine neuronal function and signal transmission Mechanistically ropivacaine hydrochloride acts by reversibly blocking the influx of sodium ions across neuronal membranes thereby inhibiting the conduction of nerve impulses Due to this mode of action it serves as a useful pharmacological tool in studies designed to elucidate pain signaling pathways sodium channel behavior and peripheral nerve function
Medchemexpress LLC Ropivacaine impurity 500mg
Ropivacaine impurity 1 hydrochloride is an impurity of Ropivacaine (HY-B0563)
Medchemexpress LLC (+)-Mepivacaine | 24358-84-7 | 99.7% | 10 MG
(+)-Mepivacaine is the (+) enantiomer of mepivacaine, an amide-type local anesthetic that blocks voltage-gated sodium channels to produce temporary loss of sensation. Supplied as a high-purity research chemical for pharmacological and electrophysiological studies.
- High purity (99.7%), suitable for research applications.
- Acts as a sodium channel blocker for studies of neuronal excitability.
- Available in small milligram quantities for laboratory use (5 mg, 10 mg, 25 mg).
- Molecular formula C15H22N2O; molecular weight 246.35.
- Offered as the (+) enantiomer for enantioselective research.
Medchemexpress LLC Zidebactam | 1436861-97-0 | 100 MG
Zidebactam is a beta-lactamase inhibitor and a penicillin-binding protein 2 (PBP2) inhibitor supplied for laboratory research use. It is used to study beta-lactam resistance and to evaluate combination antibiotic therapies.
- Acts as a beta-lactamase inhibitor and PBP2 inhibitor.
- Reported PBP2 IC50 ≈ 0.26 μg/mL, suitable for potency benchmarking.
- Intended for in vitro research applications; not for human use.
- Useful for studying antibiotic resistance mechanisms and adjuvant therapies.
- Characterized by CAS 1436861-97-0 and molecular weight 391.40 g/mol.
eMolecules 127779-20-8 | Medchem Express | Saquinavir | 10mg | 446268121 | HY-17007 | MFCD00866925 | 670.855 | C38H50N6O5
Ambeed | 5-Phenylthiophen-2-amine | 250mg | 600835659 | A261937 | 14770-85-5 | MFCD11904083 | 175.250 | C10H9NS
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Medchemexpress LLC Valopicitabine dihydrochloride | 640725-71-9 | MFCD34589916 | 99.8% | 429.30 g·mol⁻¹ | C15H26Cl2N4O6 | 25 MG
Valopicitabine dihydrochloride is the 3-O-valine ester prodrug of the nucleoside analog 2′-C-methylcytidine with antiviral activity against hepatitis C virus (HCV). Supplied as the dihydrochloride salt for research use, it is used in mechanism-of-action studies, preclinical pharmacology, and formulation development.
- High purity (99.8%) suitable for analytical and preclinical studies.
- Dihydrochloride salt form improves aqueous solubility for formulation work.
- Prodrug of 2′-C-methylcytidine enabling studies of prodrug activation.
- Available in small research quantities for assay development and screening.
- Characterized by CAS 640725-71-9 and molecular weight 429.30 g·mol⁻¹.