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Filtered Search Results
Medchemexpress LLC BSJ-4-116 | 2519823-34-6 | 99.9% | 837.38 | 100 MG
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BSJ-4-116 | 2519823-34-6 | 99.9% | 837.38 | 100 MG
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Apexbio Technology LLC PRIMA-1MET 5291-32-7 10mg
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PRIMA-1MET (CAS 5291-32-7) is a methylated derivative of PRIMA-1 developed to selectively restore the function of mutant p53 protein in tumor cells p53 encoded by the TP53 gene serves as a crucial regulator of the cell cycle apoptosis and genomic stability and is frequently mutated in human cancers leading to impaired apoptosis and uncontrolled proliferation PRIMA-1MET has demonstrated the ability to bind directly to mutant p53 reactivate its transcriptional activity and induce the expression of downstream targets associated with apoptosis and cell cycle arrest In cellular models PRIMA-1MET promoted mitochondrial apoptosis through caspase-2 activation and enhanced the cytotoxicity of chemotherapeutic agents such as cisplatin These properties make PRIMA-1MET a valuable tool for investigating mutant p53 reactivation in cancer research
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Enzo Life Sciences dBET1 (25mg). CAS: 1799711-21-9
dBET1 is a PROTAC, consisting of a BRD4-ligand JQ-1 linked to a cereblon E3 ligase ligand, targeting on BET bromodomain BRD4. Purity: ≥99%. Long Term Storage: -20°C.
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Medchemexpress LLC Pomalidomide 1 Ml | HY-10984
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Pomalidomide 1 Ml
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Medchemexpress LLC Avadomide | HY-100507
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Avadomide
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Chem-Impex International, Inc. 3-Tropanone | MFCD00005549 | 1G
3-Tropanone, MFCD00005549, 1G
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Medchemexpress LLC Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride | 2245697-85-0 | 95.0% | 25 MG
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Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride is a thalidomide-derived cereblon ligand-linker conjugate supplied as the hydrochloride salt. It is intended for use as a building block in PROTAC design and chemical biology studies to recruit the cereblon E3 ligase.
- Hydrochloride salt for improved stability and handling.
- Contains a PEG4 linker with a terminal C2 amine for facile conjugation.
- Suitable as an E3 ligase ligand in PROTAC design and CRBN recruitment studies.
- Supplied in small research quantities for medicinal chemistry applications.
- Characterized by molecular weight 587.02 and formula C25H35ClN4O10.
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![eMolecules ChemScene / Thalidomide-O-amido-C3-PEG3-C1-NH2 / 25mg / 572198149 / CS-0138144 / 0.000 / 1799711-29-7 / [null] / 648.589 / C27H35F3N4O11](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502480730.JPG-250.jpg)
eMolecules ChemScene / Thalidomide-O-amido-C3-PEG3-C1-NH2 / 25mg / 572198149 / CS-0138144 / 0.000 / 1799711-29-7 / [null] / 648.589 / C27H35F3N4O11
ChemScene / Thalidomide-O-amido-C3-PEG3-C1-NH2 / 25mg / 572198149 / CS-0138144 / 0.000 / 1799711-29-7 / [null] / 648.589 / C27H35F3N4O11
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Medchemexpress LLC W146 trifluoroacetate | 909725-62-8 | 98.2% | 456.39 g/mol | C18H28F3N2O6P | 10 MG
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W146 trifluoroacetate is a selective antagonist of the sphingosine-1-phosphate receptor 1 (S1PR1), provided as the trifluoroacetate salt for research use. It is used to inhibit S1P1-mediated signaling in pharmacology and cell-based studies.
- Selective S1PR1 antagonist (EC50 398 nM; Ki ≈ 70-80 nM).
- Supplied as a white to off-white trifluoroacetate solid.
- High purity (98.2%).
- Available in milligram pack sizes and as ready-to-use DMSO solutions.
- Store solid at 4°C; solutions stable at -80°C for up to 6 months.
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Chem-Impex International, Inc. 3-Tropanone | MFCD00005549 | 5G
3-Tropanone, MFCD00005549, 5G
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Medchemexpress LLC HY-112618A 100mg Medchemexpress, Thalidomide-O-amido-C6-NH2 (TFA) CAS:1950635-14-9 Purity:>98%
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Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].CAS# 1950635-14-9
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Medchemexpress LLC Pomalidomide-C12-NH2 hydrochloride | 2862774-02-3 | 97.1% | C25H37ClN4O4 | 50 MG
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Pomalidomide-C12-NH2 hydrochloride is an E3 ligase ligand-linker conjugate of PROTAC KRAS G12C degrader-1. This is a Cereblon-based KRASG12C degrader.
- E3 ligase ligand-linker conjugate
- Cereblon-based degrader
- Intended for research use only
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Medchemexpress LLC Pomalidomide-amino-PEG4-NH2 hydrochloride | 2331259-45-9 | >99.3% | 542.97 | 50 MG
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Pomalidomide-amino-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. This compound incorporates the Pomalidomide-based cereblon ligand and a linker, commonly utilized in PROTAC technology. PROTACs, or Proteolysis-targeting chimeras, are designed to selectively degrade target proteins by exploiting the intracellular ubiquitin-proteasome system through two distinct ligands connected by a linker: one targeting an E3 ubiquitin ligase and the other targeting the protein of interest.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Pomalidomide based cereblon ligand
- Used in PROTAC technology
- Target: E3 ligase ligand-linker conjugates
- Pathway: PROTAC
- Target: Cereblon
- Soluble in DMSO (250 mg/mL)
- Soluble in various in vivo solvent systems (≥ 6.25 mg/mL)
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Accela Chembio Inc Nortropinone Hydrochloride | 100g | 25602-68-0 | MFCD03613582 | 97+% | Shelf Life: 1440 Days | Moisture Sensitive/+4
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Nortropinone Hydrochloride | 100g | 25602-68-0 | MFCD03613582 | 97+% | Shelf Life: 1440 Days | Moisture Sensitive/+4
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Selleck Chemical LLC BSJ-4-116-5mg
BSJ-4-116 is a specific degrader of cyclin-dependent kinase 12 (CDK12). BSJ-4-116 exhibits potent antiproliferative effects.
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