Piperidines
Apexbio Technology LLC Piperine 94-62-2 1g
Piperine (CAS 94-62-2) is an alkaloid primarily found in black pepper (Piper nigrum) that has demonstrated diverse pharmacological activities It modulates several signaling pathways including inhibition of drug-metabolizing enzymes such as CYP3A4 and P-glycoprotein and affects cellular processes through regulation of MAPK and Akt phosphorylation Piperine has been studied for its potential to enhance the bioavailability of various therapeutic agents and for its anti-inflammatory anti-tumor and neuroprotective properties This compound is utilized in biomedical research to investigate drug-drug interactions signal transduction mechanisms and its impact on cellular proliferation and apoptosis
Apexbio Technology LLC Piperine 94-62-2 10mM (in 1mL DMSO)
Piperine (CAS 94-62-2) is an alkaloid primarily found in black pepper (Piper nigrum) that has demonstrated diverse pharmacological activities It modulates several signaling pathways including inhibition of drug-metabolizing enzymes such as CYP3A4 and P-glycoprotein and affects cellular processes through regulation of MAPK and Akt phosphorylation Piperine has been studied for its potential to enhance the bioavailability of various therapeutic agents and for its anti-inflammatory anti-tumor and neuroprotective properties This compound is utilized in biomedical research to investigate drug-drug interactions signal transduction mechanisms and its impact on cellular proliferation and apoptosis
Medchemexpress LLC Piperine | 94-62-2 | 99.0% | 285.34 | 10 MM * 1 ML
Piperine is an alkaloid isolated from pepper, which inhibits the activity of P-glycoprotein and CYP3A4. It has demonstrated in vitro cytotoxic activity and immunomodulatory, anti-oxidant, anti-asthmatic, anti-carcinogenic, anti-inflammatory, anti-ulcer, and anti-amoebic properties. It can enhance the bioavailability of other drugs.
- Inhibits activity of P-glycoprotein and CYP3A4
- Exhibits in vitro cytotoxic activity
- Possesses immunomodulatory, anti-oxidant, anti-asthmatic, anti-carcinogenic, anti-inflammatory, anti-ulcer, and anti-amoebic properties
- Enhances bioavailability of other drugs
- Inhibits phosphorylation of I-κB, p65, p38, ERK, and JNK
Medchemexpress LLC Piperine (E/Z-bioperine) | 7780-20-3 | MFCD00005839 | 98.9% | 285.34 g/mol | C17H19NO3 | 250 MG
(E/Z)-Piperine is an alkaloid research reagent isolated from black pepper that modulates drug metabolism and transport. It inhibits P-glycoprotein and CYP3A4 and has reported anti-inflammatory, immunomodulatory, neuroprotective, and anticancer activities. Supplied as a light yellow solid for laboratory research use.
- High purity: 98.9%.
- Light yellow solid suitable for research applications.
- Inhibits P-glycoprotein and CYP3A4, useful for metabolism studies.
- Reported anti-inflammatory and immunomodulatory effects.
- Available in laboratory pack sizes including 250 mg.
Medchemexpress LLC Migoprotafib | 2377352-49-1 | 98.81% | C25H26N8O | 100 MG
Migoprotafib (GDC-1971) is a SHP2 inhibitor that inhibits the MAPK/ERK signaling pathway and exhibits antitumor activity. It is for research use only.
- Inhibits the MAPK/ERK signaling pathway
- Exhibits antitumor activity
- Inhibits proliferation of RIT1 cells
- Demonstrates antitumor efficacy in RIT1 xenograft mouse models
Medchemexpress LLC HY-13223 100mg , Crenolanib CP-868596 CAS:670220-88-9 Purity:98%
Medchemexpress, HY-13223 100mg Crenolanib CP-868596 CAS:670220-88-9 Formula:C26H29N5O2 Kd: 2.1 nM (PDGFRα), 3.2 nM (PDGFRβ), 0.74 nM (FLT3) Purity:98% Crenolanib is a potent and selective inhibitor of PDGFRα/β , FLT3 with K d of 2.1 nM/3.2 nM, 0.74 nM, respectively, sensitive to D842V mutation not V561D mutation, and > 100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Enzo Life Sciences Alectinib. hydrochloride (100mg). CAS: 1256589-74-8
Alectinib hydrochloride is a selective anaplastic lymphoma kinase (ALK) inhibitor leading to inhibition of tumor cell proliferation and induction of cell death. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C.
STA Pharmaceutical 3-(N-Fmoc-amino)piperidine-3-carboxylic acid HCl | 100 g | CAS 368866-20-0 | MDL MFCD04113564
3-(N-Fmoc-amino)piperidine-3-carboxylic acid HCl is a Amino Acid reagent (Subcategory: Unusual AA) sold by WuXi TIDES. Offered in 100 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 368866-20-0
- MDL: MFCD04113564
- InChIKey: GZXZDFOJUNNXPX-UHFFFAOYSA-N
- Molecular Weight: 402.875
- Molecular Formula: C21H23ClN2O4
- Purity: ≥95%
- Container Type: 500 mL HDPE
- Pack Size: 100 g
- Net Weight: 100 g
- Gross Weight: 160.5 g
- Commodity Code: 29333999
- Country Of Origin: China
- IUPAC: 3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)piperidine-3-carboxylic acid hydrochloride
- SMILES: O=C(OCC1C2=CC=CC=C2C3=C1C=CC=C3)NC4(CCCNC4)C(O)=O.Cl
Aobchem 4-(4-Methylpiperidine-1-carbonyl)phenylboronic acid | ≥97% | CAS 850568-21-7 | C13H18BNO3 | 25g
4-(4-Methylpiperidine-1-carbonyl)phenylboronic acid | ≥97% | CAS 850568-21-7 | C13H18BNO3 | 25g
Active Motif UNC-2170
Active Motif's The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-stranded DNA breaks. UNC-2170, identified by screening, was found to be a uM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The compound functions as 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.