Piperidines
Medchemexpress LLC HY-111594 10mg Medchemexpress, Homo-PROTAC cereblon degrader 1 CAS:2244520-98-5 Purity:>98%
Medchemexpress, HY-111641 50mg 3'-Azido-3'-deoxy-5-fluorocytidine CAS:2095417-18-6 3'-Azido-3'-deoxy-5-fluorocytidine (Compound 12) is a cytidine derivative. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC (-)-p-Bromotetramisole (oxalate) | 62284-79-1 | 99.8% | 373.22 | 100 MG
(-)-p-Bromotetramisole oxalate is an alkaline phosphatase inhibitor that can be used in research related to erythroleukemia. This compound is applicable to research related to erythroleukemia. In Vitro, it potently inhibits terminal cell division-associated MEL DS-19 cell differentiation induced by 0.7% DMSO or 1.2 mM HMBA, reducing B+ cell levels. It also potently inhibits purified human liver, bone, spleen, and kidney alkaline phosphatase isoenzymes while minimally inhibiting purified human intestinal and placental alkaline phosphatase isoenzymes.
- Alkaline phosphatase inhibitor
- Applicable to research related to erythroleukemia
- Potently inhibits terminal cell division-associated MEL DS-19 cell differentiation
- Potently inhibits purified human liver, bone, spleen, and kidney alkaline phosphatase isoenzymes
- Minimally inhibits purified human intestinal and placental alkaline phosphatase isoenzymes
Medchemexpress LLC 1-Boc-2-piperidone | 85908-96-9 | >=98.0% | 199.25 | 10 G
1-Boc-2-piperidone is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It appears as a solid, ranging from white to light brown.
- Molecular weight of 199.25
- Purity of 98.0%
- Store powder at -20°C for 3 years, or 4°C for 2 years
- Solubility in DMSO is 200 mg/mL
Biotium Testosterone(4E1G2), CF594 conjugate, 0.1mg/mL
This MAb is highly specific to testosterone. Its affinity constant for testosterone is ~1010 M-1. In competitive binding immunoassay, it reacts with testosterone 100%, 11-beta-hydroxy testosterone 3.3%, 17-alpha-methyl testosterone <0.1%, 5-alpha DHT 0.8%, estradiol <0.1% and progesterone <0.1%. Testosterone, a steroid hormone from the androgen group, is derived from cholesterol. Testosterone is primarily secreted in the testes, but the ovaries and adrenal glands also produce smaller amounts. It is the principal male sex hormone and is responsible for the maturation of sex organs and the development of male secondary sex characteristics. The hormone is also involved in the growth of muscle mass and increases bone density and maturation. It functions by activating the androgen receptor and converting to estradiol and activation of estrogen receptors. Testosterone has been employed therapeutically to treat many conditions including infertility, lack of libido, osteopor
Medchemexpress LLC HY-16954 50mg , ARV-825 CAS:1818885-28-7 Purity:98%
Medchemexpress, HY-16954 50mg ARV-825 CAS:1818885-28-7 Formula:C46H47ClN8O9S Kd: 90 nM (Bromodomain 1 of BRD4), 28 nM (Bromodomain 2 of BRD4) Purity:98% ARV-825 is a BRD4 Inhibitor based on PROTAC technology. ARV-825 shows affinity to BD1 and BD2 of BRD4 with K d s of 90 and 28 nM, respectively. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Biotium Fibronectin(2755-8), CF647 conjugate, 0.1mg/mL
Fibronectin is an extracellular matrix glycoprotein present on most cell surfaces, in extracellular fluids and in plasma. A high molecular weight heterodimeric protein, it was originally discovered as a protein missing from the surfaces of virus-transformed cells, and it has been shown to be involved in various functions including cell adhesion, cell motility and wound healing. Alternative splicing and glycosylation give rise to several different forms of Fibronectin, some of which exhibit restricted tissue distribution or association with malignancies. It has been shown that Myofibroblasts phenotype formation correlates with the occurrence of glycosylated Fibronectin and Fibronectin splice variants in Dupuytren's disease.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for det
Medchemexpress LLC Pomalidomide-C12-NH2 hydrochloride | 2862774-02-3 | 97.1% | C25H37ClN4O4 | 100 MG
Pomalidomide-C12-NH2 hydrochloride is an E3 ligase ligand-linker conjugate of PROTAC KRAS G12C degrader-1 (HY-139186). This Cereblon-based KRASG12C degrader is intended for research use only and has not been fully validated for medical applications.
- E3 ligase ligand-linker conjugate
- Cereblon-based KRASG12C degrader
- Suitable for laboratory research
- Protect from light
- Stable under recommended storage conditions
Medchemexpress LLC As-99 trifluoroacetate | 99.2% | 707.71 | C29H31F6N5O5S2 | 5 MG
AS-99 trifluoroacetate is the trifluoroacetic acid (TFA) salt of AS-99, a potent and selective inhibitor of the ASH1L (KMT2H) histone methyltransferase. It is supplied as a research reagent for biochemical and cellular studies of epigenetic regulation and anti-leukemic activity.
- TFA salt form to aid solubility and handling.
- High purity (99.15%).
- Molecular formula C29H31F6N5O5S2 and molecular weight 707.71 Da.
- Available as 1-100 mg solid quantities and 10 mM in 1 mL DMSO solutions.
- Intended for biochemical and cellular assay use.
Biotium Fibronectin(2755-8), CF594 conjugate, 0.1mg/mL
Fibronectin is an extracellular matrix glycoprotein present on most cell surfaces, in extracellular fluids and in plasma. A high molecular weight heterodimeric protein, it was originally discovered as a protein missing from the surfaces of virus-transformed cells, and it has been shown to be involved in various functions including cell adhesion, cell motility and wound healing. Alternative splicing and glycosylation give rise to several different forms of Fibronectin, some of which exhibit restricted tissue distribution or association with malignancies. It has been shown that Myofibroblasts phenotype formation correlates with the occurrence of glycosylated Fibronectin and Fibronectin splice variants in Dupuytren's disease.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for det
Medchemexpress LLC Thalidomide-o-amido-PEG-C2-NH2 hydrochloride | 2204226-02-6 | 98.1% | 25 MG
Thalidomide-O-amido-PEG-C2-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand-linker conjugate provided as the hydrochloride salt for research use in PROTAC design and chemical biology applications.
- Thalidomide-derived CRBN ligand-linker conjugate for recruiting cereblon.
- Hydrochloride salt form for improved solubility and handling.
- High purity suitable for research (98.1%).
- Designed for conjugation and PROTAC synthesis workflows.
- Small 25 mg quantity appropriate for exploratory experiments.
eMolecules 87120-72-7 | 1-Boc-4-aminopiperidine | Combi-Blocks | MFCD01076201 | 200.282 | C10H20N2O2 | 98.000 | CC(C)(C)OC(=O)N1CCC(N)CC1 | 100g | 117518494
1-Boc-4-aminopiperidine | Combi-Blocks | 87120-72-7 | MFCD01076201 | 200.282 | C10H20N2O2 | 98.000 | CC(C)(C)OC(=O)N1CCC(N)CC1 | 100g | 117518494
eMolecules 2519823-34-6 | Medchem Express | BSJ-4-116 | 5mg | 603242380 | HY-139039 | 837.39 | C40H49ClN8O8S
Pharmablock | 1-methyl-2-methylsulfonyl-benzimidazole | 25mg | 713713267 | PBU8261 | 61078-14-6 | MFCD01470564 | 210.250 | C9H10N2O2S
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Biotium Thyroglobulin(6E1.), CF647 conjugate, 0.1mg/mL
Thyroglobulin is a 660 kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a
Chemscene ChemScene | 3-Bromopiperidine-2,6-dione | 10G | CS-0091177 | 0.98 | 62595-74-8| MFCD11053059 | 192.012
ChemScene | 3-Bromopiperidine-2,6-dione | 10G | CS-0091177 | 0.98 | 62595-74-8| MFCD11053059 | 192.012
Medchemexpress LLC Thalidomide-O-amido- 50mg | 2022182-58-5 | 502.4 g/mol | C20H21F3N4O8 | 50 MG
Thalidomide-O-amido-C3-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-based cereblon ligand with a short C3 linker. Supplied as the trifluoroacetate (TFA) salt, it is intended for use in PROTAC design and E3 ligase ligand-linker chemistry research.
- Synthesized cereblon ligand-linker conjugate for PROTAC research.
- Trifluoroacetate (TFA) salt form.
- Molecular formula C20H21F3N4O8, molecular weight 502.4 g/mol.
- Useful as a building block for E3 ligase recruitment in degrader design.
- Available in 50 MG packaging.